Article
Cell Biology
Lu Chen, Wujiang Gao, Chunli Sha, Meiling Yang, Li Lin, Taoqiong Li, Hong Wei, Qi Chen, Jie Xing, Mengxue Zhang, Shijie Zhao, Wenlin Xu, Yuefeng Li, Xiaolan Zhu
Summary: The E3 ligase SIAH1 is decreased in epithelial ovarian cancer (EOC) and negatively correlated with RPS3 levels. Overexpression of SIAH1 can suppress tumor cell growth, invasion, and cisplatin resistance by promoting RPS3 degradation and subsequent NF-kappa B inactivation.
Article
Engineering, Environmental
Chenglong Wang, Xiaolin Xu, Shuhan Xiong, Peipei Zhang, Jia Yuan, Xuzhu Gao, Wencai Guan, Fanchen Wang, Xin Li, Tao Leng, Hongjing Dou, Guoxiong Xu
Summary: Chemoresistance is a major cause of chemotherapy failure and patient death. However, current approaches to reversing chemoresistance are limited. This study developed calcium-chelated nanoparticles that can replenish calcium ions in chemoresistant cancer cells. These nanoparticles released calcium ions more rapidly in the acidic tumor microenvironment, restoring calcium homeostasis and reversing chemoresistance in various cancer cells. Mechanistically, the nanoparticles affected the expression of chemoresistant genes and promoted cancer cell apoptosis through inhibiting the NF-kappa B signaling pathway. These findings provide insight into an effective approach for reversing chemoresistance, suggesting the potential applications of calcium-chelated nanoparticles in treating chemoresistant patients.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Integrative & Complementary Medicine
Ming-hui Wu, Kun Wu, Yuan-bing Zhu, Da-chuan Li, Huan Yang, Hong Zeng
Summary: The study aimed to investigate the molecular mechanisms underlying the effect of baicalin on prostate cancer progression. The results showed that baicalin exhibited a potential therapeutic effect on PCa via inhibiting the Notch1/NF-kappa B signaling pathway and its mediated cancer stemness.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2023)
Article
Oncology
Taoqiong Li, Li Lin, Qin Liu, Wujiang Gao, Lu Chen, Chunli Sha, Qi Chen, Wenlin Xu, Yuefeng Li, Xiaolan Zhu
Summary: The study revealed that exosomal transfer of miR-429 enhances chemoresistance and proliferation of epithelial ovarian cancer cells. NF-κB promotes miR-429 expression, affecting the calcium-sensing receptor pathway and leading to drug resistance in cells.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Cell Biology
Su-Lim Kim, Hack Sun Choi, Dong-Sun Lee
Summary: The BRD4/nuclear PD-L1/RelB axis plays an essential role in breast CSC formation. Nuclear PD-L1 regulates RelB, and the RelB/p65 complex induces IL6 and breast CSC formation. Targeting nuclear PD-L1 represents a potential and novel tool for immunotherapies of intractable BC.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Oncology
Ying Li, Qin Zhou, Jing Shen, Lixia Zhu
Summary: PSMD4 was identified as a core molecule in the carboplatin resistance regulatory network of epithelial ovarian cancer (EOC), with its up-regulated expression in carboplatin-resistant EOC tissues and cells. Inhibition of PSMD4 expression was found to increase the sensitivity of EOC to carboplatin.
TRANSLATIONAL CANCER RESEARCH
(2021)
Article
Cell & Tissue Engineering
Kun Wang, Yiyang Wang, Yuanjian Wang, Shujie Liu, Chunyan Wang, Shuo Zhang, Tianli Zhang, Xingsheng Yang
Summary: The study reveals that EIF5A2 positively regulates stemness in ovarian cancer cells through the E2F1/KLF4 pathway, indicating its potential as a target for CSCs-targeted therapy in ovarian cancer.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Multidisciplinary Sciences
Akira Nakazato, Mai Mochizuki, Rie Shibuya-Takahashi, Haruna Fujimori, Keitaro Fujii, Satoshi Saijoh, Shinkichi Morita, Tomoko Yamazaki, Takayuki Imai, Ikuro Sato, Kennichi Satoh, Kazunori Yamaguchi, Kazuo Sugamura, Jun Yasuda, Kazuto Matsuura, Hideo Shojaku, Yukinori Asada, Keiichi Tamai
Summary: This study found that RELA, a subunit of nuclear factor kappaB, is critical for the transcription of CD271 in hypopharyngeal cancer cells. RELA promotes CD271 transcription in squamous cell carcinoma cell lines, but not in normal epithelium and neuroblastoma cell lines. The specific region + 957 to + 1138 within the CD271 promoter sequence is important for RELA binding.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Evan A. Mulligan, Susan J. Tudhope, Jill E. Hunter, Arabella E. G. Clift, Sarah L. Elliott, Geoffrey P. Summerfield, Jonathan Wallis, Chris J. Pepper, Barabara Durkacz, Stephany Veuger, Elaine Willmore
Summary: This study demonstrates the importance of RelB in CLL, as high basal levels of RelB DNA binding correlate with nuclear RelB protein expression and are associated with poor clinical outcomes. CD40L stimulation promotes RelB activation and CLL cell proliferation. Inhibiting non-canonical NF-kappa B signalling may be a novel therapeutic approach for CLL.
Article
Oncology
Marco Giordano, Alessandra Decio, Chiara Battistini, Micol Baronio, Fabrizio Bianchi, Alessandra Villa, Giovanni Bertalot, Stefano Freddi, Michela Lupia, Maria Giovanna Jodice, Paolo Ubezio, Nicoletta Colombo, Raffaella Giavazzi, Ugo Cavallaro
Summary: This study implicates L1CAM in the tumorigenic function of OCSC, showing that L1CAM promotes stemness-related properties in OC cells and tumor initiation. The L1CAM/FGFR1/SRC/STAT3 signaling pathway is identified as a novel driver of OC stemness, providing evidence for potential OC eradication through targeting this pathway.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Hui Yi, Long Liang, Haiqin Wang, Saiqun Luo, Lei Hu, Yanpeng Wang, Xiaokai Shen, Ling Xiao, Yibin Zhang, Hongling Peng, Chongwen Dai, Lingli Yuan, Ruijuan Li, Fanjie Gong, Zhenzhen Li, Mao Ye, Jing Liu, Hui Zhou, Ji Zhang, Xiaojuan Xiao
Summary: This study demonstrates the potential therapeutic effects of albendazole on multiple myeloma by inhibiting MM cell proliferation, reducing the number of MMSCs, and eliminating drug resistance induced by MMSCs through the inhibition of the NF-KB pathway.
Review
Cell Biology
Karli Mockenhaupt, Alexandra Gonsiewski, Tomasz Kordula
Summary: Neuroinflammation involves multiple cell types in the central nervous system, which coordinate their responses by secreting and responding to inflammatory mediators. Critical activation of NF-kappa B pathways is observed during neuroinflammation, with specific mechanisms and roles of RelB activation in different cell types being less understood. This review summarizes the mechanisms of RelB activation in specific cell types within the CNS and its specialized effects during neuroinflammation.
Article
Oncology
Yanyan Zhang, Shuyi Zhu, Yuanyuan Du, Fan Xu, Wenbo Sun, Zhi Xu, Xiumei Wang, Peipei Qian, Qin Zhang, Jifeng Feng, Yong Xu
Summary: This study elucidates the molecular mechanism by which tumorous RelB contributes to immune evasion by inhibiting T cell immunity through the amplification of the PD-L1/PD-1-mediated immune checkpoint.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Rahul D. Kamdar, Brittney S. Harrington, Emma Attar, Soumya Korrapati, Jyoti Shetty, Yongmei Zhao, Bao Tran, Nathan Wong, Carrie D. House, Christina M. Annunziata
Summary: Epithelial ovarian cancer (EOC) is the fifth leading cause of cancer-related death in women worldwide, and chemoresistant, stem-like tumor-initiating cells (TICs) contribute to disease relapse. The NF-κB pathway and its transcription factors (RelA and RelB) have been found to promote TIC survival and chemoresistance. This study demonstrates that NF-κB signaling differentially regulates miRNA expression through RelA and RelB in EOC cells, and the miRNAs, hsa-miR-452-5p and hsa-miR-335-5p, play a role in TIC persistence. These findings provide new insights into preventing EOC recurrence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Kehinde S. Olaniyi, Stephanie E. Areloegbe
Summary: This study investigated the effects of acetate on cardiometabolic abnormalities associated with polycystic ovarian syndrome (PCOS) in a rat model. The results suggest that acetate protects against cardiac inflammation by suppressing PCSK9 and NF-kB-dependent mechanisms.
Article
Oncology
Massimo Fantini, Justin M. David, Hing C. Wong, Christina M. Annunziata, Philip M. Arlen, Kwong Y. Tsang
CANCER BIOTHERAPY AND RADIOPHARMACEUTICALS
(2019)
Article
Oncology
Mary L. Disis, Matthew H. Taylor, Karen Kelly, J. Thaddeus Beck, Michael Gordon, Kathleen M. Moore, Manish R. Patel, Jorge Chaves, Haeseong Park, Alain C. Mita, Erika P. Hamilton, Christina M. Annunziata, Hans Juergen Grote, Anja von Heydebreck, Jaspreet Grewal, Vikram Chand, James L. Gulley
Meeting Abstract
Oncology
Maria Pia Morelli, Justin M. David, Nicole D. Houston, Stan Lipkowitz, Jung-min Lee, Alexandra Dos Santos Zimmer, Farah Z. Zia, Irene Ekwede, Erin Nichols, Mira Pavelova, Rebecca Trupp, Stephen M. Hewitt, Massimo Fantini, Philip M. Arlen, Kwong Y. Tsang, Christina M. Annunziata
JOURNAL OF CLINICAL ONCOLOGY
(2019)
Article
Oncology
Alexandra S. Zimmer, Erin Nichols, Ashley Cimino-Mathews, Cody Peer, Liang Cao, Min-Jung Lee, Elise C. Kohn, Christina M. Annunziata, Stanley Lipkowitz, Jane B. Trepel, Rajni Sharma, Lekha Mikkilineni, Margaret Gatti-Mays, William D. Figg, Nicole D. Houston, Jung-Min Lee
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2019)
Article
Biochemistry & Molecular Biology
Yaowu He, Claire M. Davies, Brittney S. Harrington, Linh Hellmers, Yonghua Sheng, Amy Broomfield, Thomas McGann, Kate Bastick, Laurie Zhong, Andy Wu, Grace Maresh, Shannon McChesney, Kuan Yau Wong, Mark N. Adams, Ryan C. Sullivan, James S. Palmer, Lez J. Burke, Adam D. Ewing, Xin Zhang, David Margolin, Li Li, Rohan Lourie, Admire Matsika, Bhuvana Srinivasan, Michael A. McGuckin, John W. Lumley, John D. Hooper
Article
Oncology
Tashbib Khan, Yaowu He, Thomas Kryza, Brittney S. Harrington, Jennifer H. Gunter, Mitchell A. Sullivan, Tahleesa Cuda, Rebecca Rogers, Claire M. Davies, Amy Broomfield, Madeline Gough, Andy C. Wu, Thomas McGann, S. John Weroha, Paul Haluska, Josephine M. Forbes, Jane E. Armes, Sinead C. Barry, Jermaine I. Coward, Nisha Jagasia, Naven Chetty, Cameron E. Snell, Rohan Lourie, Lewis C. Perrin, John D. Hooper
Article
Oncology
Brittney S. Harrington, Michelle K. Ozaki, Michael W. Caminear, Lidia F. Hernandez, Elizabeth Jordan, Nicholas J. Kalinowski, Ian S. Goldlust, Rajarshi Guha, Marc Ferrer, Craig Thomas, Jyoti Shetty, Bao Tran, Nathan Wong, Carrie D. House, Christina M. Annunziata
Article
Oncology
Anne M. Noonan, Amanda Cousins, David Anderson, Kristen P. Zeligs, Kristen Bunch, Lidia Hernandez, Yusuke Shibuya, Ian S. Goldlust, Rajarshi Guha, Marc Ferrer, Craig J. Thomas, Christina M. Annunziata
Article
Biochemistry & Molecular Biology
Thomas Kryza, Tashbib Khan, Scott Lovell, Brittney S. Harrington, Julia Yin, Sean Porazinski, Marina Pajic, Hannu Koistinen, Juha K. Rantala, Tobias Dreyer, Viktor Magdolen, Ute Reuning, Yaowu He, Edward W. Tate, John D. Hooper
Summary: The study identifies uPA as the master regulator of CDCP1 proteolysis, acting by directly cleaving CDCP1 and activating plasmin. Co-expression of uPA and CDCP1 predicts poor disease outcome in multiple cancers, and uPA-mediated CDCP1 proteolysis promotes metastasis in clinical models. These results suggest CDCP1 cleavage as a potential target for disrupting cancer, and establish sbABP technology as a novel approach for identifying disease-relevant proteases.
NATURE CHEMICAL BIOLOGY
(2021)
Editorial Material
Oncology
Amy E. Turriff, Christina M. Annunziata, Diana W. Bianchi
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Review
Oncology
Kwong Yok Tsang, Massimo Fantini, Sharon A. Mavroukakis, Anjum Zaki, Christina M. Annunziata, Philip M. Arlen
Summary: This article describes a tumor-targeting monoclonal antibody called NEO-201, which can inhibit tumor growth through multiple mechanisms. NEO-201 kills tumor cells by engaging with immune cells through antibody-dependent cell-mediated cytotoxicity and complement dependent cytotoxicity, and it can also block interactions between tumor cells and other cells to enhance anti-cancer activity.
Article
Oncology
Kwong Y. Tsang, Massimo Fantini, Anjum Zaki, Sharon A. Mavroukakis, Maria Pia Morelli, Christina M. Annunziata, Philip M. Arlen
Summary: Glycosylation is an important post-translational modification that occurs on mammalian proteins and lipids. Disruption of O-glycosylation patterns, especially the truncation of O-glycans, has been observed in cancer cells. Monoclonal antibodies targeting truncated O-glycans in cancer cells can be an effective strategy to counter tumor growth.
Article
Medicine, Research & Experimental
Brittney S. Harrington, Yaowu He, Tashbib Khan, Simon Puttick, Paul J. Conroy, Thomas Kryza, Tahleesa Cuda, Kamil A. Sokolowski, Brian W. C. Tse, Katherine K. Robbins, Buddhika J. Arachchige, Samantha J. Stehbens, Pamela M. Pollock, Sarah Reed, S. John Weroha, Paul Haluska, Carlos Salomon, Rohan Lourie, Lewis C. Perrin, Ruby H. P. Law, James C. Whisstock, John D. Hooper