Journal
CANCERS
Volume 11, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/cancers11081130
Keywords
microRNA-361; EMT; angiogenesis; tumor microenvironment; cancer diagnosis; cancer treatment
Categories
Funding
- JSPS [18K09278, 19K09769]
- Science and Technology Planning Project of Guangdong Province, China [2014A020212124]
- NIH/NCI [1R21CA216585-01A1]
- Grants-in-Aid for Scientific Research [18K09278, 19K09769] Funding Source: KAKEN
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MicroRNA-361-5p (miR-361) expression frequently decreases or is lost in different types of cancers, and contributes to tumor suppression by repressing the expression of its target genes implicated in tumor growth, epithelial-to-mesenchymal transition (EMT), metastasis, drug resistance, glycolysis, angiogenesis, and inflammation. Here, we review the expression pattern of miR-361 in human tumors, describe the mechanisms responsible for its dysregulation, and discuss how miR-361 modulates the aggressive properties of tumor cells and alter the tumor microenvironment by acting as a novel tumor suppressor. Furthermore, we describe its potentials as a promising diagnostic or prognostic biomarker for cancers and a promising target for therapeutic development.
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