Review
Biochemistry & Molecular Biology
Mansor Fazliana, Zubaidah Nor Hanipah
Summary: This article reviews the mechanisms and outcomes of metabolic surgery on the endocrine system, microbiome, metabolomics, and molecular level. It summarizes the changes in hormones, adipokines, microbiota, microRNAs, and metabolomics following metabolic surgery in human and animal models for the treatment of obesity and diabetes. The review considers the most relevant studies in this field over the past 17 years. In most cases, metabolic procedures, especially those with intestinal bypass components, have shown significant improvement in type 2 diabetes through weight-independent mechanisms.
Article
Endocrinology & Metabolism
Gladys Wojciechowska, Lukasz Szczerbinski, Marek Kretowski, Magdalena Niemira, Hady Razak Hady, Adam Kretowski
Summary: This study suggests that four serum miRNAs may serve as predictive biomarkers for type 2 diabetes remission 12 months after sleeve gastrectomy. Further validation studies are needed to confirm the findings.
Article
Surgery
Xinqiang Zhu, Gang Zhou, Xingwei Gu, Xuetong Jiang, Hailong Huang, Sainan You, Gong Zhang
Summary: This study aimed to compare the clinical outcomes of bariatric surgery and medical treatment for obese adolescents with type 2 diabetes. The results showed that bariatric surgery was more effective than medical treatment in controlling weight loss and type 2 diabetes, with LRYGB surgery having better effects on weight loss and glycemic control.
ASIAN JOURNAL OF SURGERY
(2023)
Editorial Material
Endocrinology & Metabolism
Samuel Klein, Randy J. Seeley
Summary: Many individuals with obesity and type 2 diabetes experience diabetes remission after Roux-en-Y gastric bypass surgery, but there is disagreement regarding the underlying mechanisms. We present our perspective on conflicting datasets suggesting that the remission could be attributed solely to weight loss or weight loss-independent factors.
Review
Endocrinology & Metabolism
Rexiati Ruze, Tiantong Liu, Xi Zou, Jianlu Song, Yuan Chen, Ruiyuan Xu, Xinpeng Yin, Qiang Xu
Summary: The prevalence of obesity and diabetes mellitus (DM) is increasing globally due to shared genetic and environmental factors. Obesity amplifies the impact of genetic susceptibility and environmental factors on DM by interfering with metabolic balance and causing insulin resistance. The dysregulation of immunometabolism through low-grade systemic inflammation leads to the loss of functional beta-cells and elevated blood glucose. Treatment approaches for obesity and type 2 DM have interconnected effects, and surgical procedures like bariatric surgery are more effective. More research is needed to improve the efficacy and safety of available and new treatments.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Brianna N. Lauren, Francesca Lim, Abraham Krikhely, Elsie M. Taveras, Jennifer A. Woo Baidal, Brandon K. Bellows, Chin Hur
Summary: This study evaluated the cost-effectiveness of medical therapy, sleeve gastrectomy (SG), and Roux-en-Y gastric bypass (RYGB) in patients with severe obesity and type 2 diabetes (T2D). The results showed that RYGB is the most cost-effective treatment strategy, resulting in the highest number of quality-adjusted life-years (QALYs) gained.
Article
Endocrinology & Metabolism
Rinki Murphy, Lindsay D. Plank, Michael G. Clarke, Nicholas J. Evennett, James Tan, David D. W. Kim, Richard Cutfield, Michael W. C. Booth
Summary: SR-LRYGB provided superior diabetes remission and weight loss compared with LSG at 5 years, with similar low risks of complications.
Article
Endocrinology & Metabolism
Maddalena Ardissino, Francesca Watson, Ravi Amin, Peter Collins, Osama Moussa, Sanjay Purkayastha
Summary: This study demonstrates that bariatric surgery can improve atherosclerotic cardiovascular disease outcomes and reduce mortality in patients with obesity and type 2 diabetes.
JOURNAL OF DIABETES
(2021)
Article
Chemistry, Multidisciplinary
Arianna Bonizzi, Marta Sevieri, Leopoldo Sitia, Andrea Rizzi, Lorenzo Conti, Fabio Corsi, Carlo Morasso, Serena Mazzucchelli
Summary: The study revealed that despite the improvements in weight, glycemic control, and lipid profile of type 2 diabetes mellitus patients after bariatric surgery, Raman spectroscopy indicated that their metabolic profiles were not fully restored post-surgery.
APPLIED SCIENCES-BASEL
(2021)
Review
Endocrinology & Metabolism
Paolo Gentileschi, Emanuela Bianciardi, Domenico Benavoli, Michela Campanelli
Summary: Bariatric surgery has been shown to promote remission or significant improvement of Type II Diabetes Mellitus and related comorbidities in obese patients. Different gastrointestinal procedures may have varying effects and mechanisms of action on glucose metabolism. Metabolic surgery integrates knowledge and multidisciplinary expertise to provide a combination of conservative and surgical treatments for Type II diabetes.
ACTA DIABETOLOGICA
(2021)
Article
Endocrinology & Metabolism
Kaisheng Yuan, Bing Wu, Ruiqi Zeng, Fuqing Zhou, Ruixiang Hu, Cunchuan Wang
Summary: This study aimed to investigate factors influencing diabetes remission (DR) in patients with obesity and T2DM after bariatric metabolic surgery (BMS), and develop a predictive model using a nomogram. Glycated haemoglobin, triglycerides, duration of diabetes, insulin requirement, and hypercholesterolaemia were identified as independent factors for DR. The nomogram showed good efficacy in both training and validation cohorts.
DIABETES OBESITY & METABOLISM
(2023)
Review
Biology
Yanmin Du, Jianlu Zhang, Guanyang Chen, Zhipeng Sun
Summary: Bariatric surgery has undergone a long and difficult development process, gradually becoming the gold standard for treating morbid obesity with metabolic diseases. Constant improvement and evolving procedures, along with the in-depth study of the mechanism of metabolic weight loss surgery, are effectively promoting the rapid development of bariatric surgery.
Review
Endocrinology & Metabolism
Zhang-Liu Jin, Wei Liu
Summary: The global incidence of type 2 diabetes is on the rise, and bariatric surgical procedures are effective in providing relief. The mechanisms of these surgeries involve increased satiety and alterations in gastrointestinal hormones. Understanding these mechanisms can aid in developing better non-surgical treatments for type 2 diabetes.
WORLD JOURNAL OF DIABETES
(2021)
Article
Cell Biology
Filipa P. Ferreira, Sofia S. Pereira, Madalena M. Costa, Marta Guimaraes, Nicolai J. Wewer Albrechtsen, Jens J. Holst, Mario Nora, Mariana P. Monteiro
Summary: This study aims to investigate the distribution of neurotensin in the human small intestine and compare the density of neurotensin-expressing cells in individuals with and without type 2 diabetes undergoing bariatric surgery for obesity treatment. The results show that the density of neurotensin-expressing cells increases along the human small intestine, and individuals with type 2 diabetes have a higher density of these cells. This finding suggests a potential role for neurotensin in the mechanisms of disease and type 2 diabetes improvement observed after bariatric surgery.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Guanhua Lu, Huanhuan Gao, Zhiyong Dong, Shuwen Jiang, Ruixiang Hu, Cunchuan Wang
Summary: This study investigated the differences in miRNA expression in obese patients with and without T2DM, as well as before and after bariatric surgery in obese T2DM patients. The study found 16 up-regulated and 32 down-regulated miRNAs in T2DM patients compared to non-T2DM patients. Improvement in metabolic metrics after bariatric surgery was correlated with changes in miRNA expression. Seven intersecting miRNAs with opposite changes were identified, and their target genes were enriched in pathways associated with T2DM. These miRNAs and their target genes may be potential targets for regulating T2DM.
DIABETES & METABOLISM JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Yapeng Su, Dan Yuan, Daniel G. Chen, Rachel H. Ng, Kai Wang, Jongchan Choi, Sarah Li, Sunga Hong, Rongyu Zhang, Jingyi Xie, Sergey A. Kornilov, Kelsey Scherler, Ana Jimena Pavlovitch-Bedzyk, Shen Dong, Christopher Lausted, Inyoul Lee, Shannon Fallen, Chengzhen L. Dai, Priyanka Baloni, Brett Smith, Venkata R. Duvvuri, Kristin G. Anderson, Jing Li, Fan Yang, Caroline J. Duncombe, Denise J. McCulloch, Clifford Rostomily, Pamela Troisch, Jing Zhou, Sean Mackay, Quinn DeGottardi, Damon H. May, Ruth Taniguchi, Rachel M. Gittelman, Mark Klinger, Thomas M. Snyder, Ryan Roper, Gladys Wojciechowska, Kim Murray, Rick Edmark, Simon Evans, Lesley Jones, Yong Zhou, Lee Rowen, Rachel Liu, William Chour, Heather A. Algren, William R. Berrington, Julie A. Wallick, Rebecca A. Cochran, Mary E. Micikas, Terri Wrin, Christos J. Petropoulos, Hunter R. Cole, Trevan D. Fischer, Wei Wei, Dave S. B. Hoon, Nathan D. Price, Naeha Subramanian, Joshua A. Hill, Jennifer Hadlock, Andrew T. Magis, Antoni Ribas, Lewis L. Lanier, Scott D. Boyd, Jeffrey A. Bluestone, Helen Chu, Leroy Hood, Raphael Gottardo, Philip D. Greenberg, Mark M. Davis, Jason D. Goldman, James R. Heath
Summary: Post-acute sequelae of COVID-19 (PASC) is an emerging global crisis, and the quantifiable risk factors and biological associations are not well understood. In this study, a deep multi-omic investigation was conducted on 309 COVID-19 patients, and four PASC-anticipating risk factors were identified at the time of initial diagnosis. The study also observed changes in immune states during recovery from COVID-19.
Review
Biochemistry & Molecular Biology
Felipe Padilla-Martinez, Gladys Wojciechowska, Lukasz Szczerbinski, Adam Kretowski
Summary: This review summarizes recent studies on biomarkers for type 2 diabetes (T2D) based on circulating nucleic acids using genomic, transcriptomic, and epigenomic technologies. Several candidate biomarkers have been identified for the risk and diagnosis of T2D, the prognosis of T2D complications, and the pharmacodynamics of T2D treatments. Further validation in larger samples and non-invasive samples is needed to support the realization of precision medicine for T2D.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Gladys Wojciechowska, Lukasz Szczerbinski, Marek Kretowski, Magdalena Niemira, Hady Razak Hady, Adam Kretowski
Summary: This study suggests that four serum miRNAs may serve as predictive biomarkers for type 2 diabetes remission 12 months after sleeve gastrectomy. Further validation studies are needed to confirm the findings.
Article
Medicine, General & Internal
Angelika Buczynska, Iwona Sidorkiewicz, Ahsan Hameed, Adam Jacek Kretowski, Monika Zbucka-Kretowska
Summary: This review provides novel insights into the pathogenesis of trisomy 13 and 18, with a particular focus on oxidative stress. Evaluating oxidative stress is important for understanding disrupted metabolic pathways, mitochondrial dysfunction, and epigenetics. Additionally, unifying research protocols related to trisomy could have potential medical targets.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Agnieszka Adamska, Andrzej Raczkowski, Zofia Stachurska, Marcin Kondraciuk, Adam Jacek Kretowski, Marcin Adamski, Irina Kowalska, Karol Adam Kaminski
Summary: This study investigated the relationships between thyroid hormones and body composition, as well as the distribution of fat in different regions. The results showed that in men, TSH was associated with visceral adipose tissue, while fT3 was positively correlated with total fat mass, android fat mass, and gynoid fat mass. These associations were not observed in women.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Oncology
Angelika Buczynska, Iwona Sidorkiewicz, Adam Jacek Kretowski, Monika Zbucka-Kretowska, Agnieszka Adamska
Summary: Metformin treatment has pleiotropic actions, such as inhibiting inflammatory processes, enhancing antioxidant capacity, and improving glycemic and lipid metabolism, making it an attractive drug candidate for human trials. Promising results of metformin in various clinical trials are also summarized in this review.
Article
Nutrition & Dietetics
Lucyna Ostrowska, Joanna Smarkusz-Zarzecka, Anna Muszynska, Edyta Adamska-Patruno, Maria Gorska, Adam Kretowski
Summary: This study analyzed the impact of a high-fat meal and a high-carbohydrate meal on energy expenditure, substrate oxidation, glucose, insulin, triglycerides, and homocysteine concentration in men with different nutritional statuses. The findings revealed that men with excess body weight metabolized nutrients differently and had different postprandial insulin secretion compared to men with normal body weight. Consumption of a high-fat meal increased the concentration of potential risk factors for cardiovascular disease in overweight/obese men.
Review
Biochemistry & Molecular Biology
Beata Podgorska, Marta Wielogorska-Partyka, Joanna Godzien, Julia Sieminska, Michal Ciborowski, Malgorzata Szelachowska, Adam Kretowski, Katarzyna Siewko
Summary: This review discusses the application of metabolomics in disorders of calcium metabolism and highlights its potential in discovering biomarkers and elucidating pathological mechanisms. Metabolomics can assist in identifying biomarkers for common endocrine disorders and mapping related metabolic pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Aleksandra Golonko, Adam Jan Olichwier, Renata Swislocka, Lukasz Szczerbinski, Wlodzimierz Lewandowski
Summary: This paper reviews the synergy between a series of flavonoids and the anticancer drug anthracycline, including the disruption of DNA integrity, modulation of antioxidant response pathways, and inhibition of drug transport. The study shows that the synergy between flavonoids and anthracycline can improve the effectiveness of cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Sebastian Solomacha, Pawel Sowa, Lukasz Kiszkiel, Piotr Pawel Laskowski, Maciej Alimowski, Lukasz Szczerbinski, Andrzej Szpak, Anna Moniuszko-Malinowska, Karol Kaminski
Summary: The COVID-19 pandemic has led to a shift from in-person visits to telemedicine services in the healthcare system. This study examines how Polish patients perceive telemedicine in the context of the pandemic. Two surveys were conducted on a representative sample of the Polish population, allowing for an understanding of changing attitudes towards telemedicine over time. The study reveals both the need for adaptation to healthcare innovations and significant concerns that affect the perception of telemedicine.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Immunology
Lukasz Szczerbinski, Michal Andrzej Okruszko, Maciej Szablowski, Jedrzej Warpechowski, Adam Paszko, Anna Citko, Paulina Konopka, Witold Bauer, Adam Jacek Kretowski
Summary: Obesity and diabetes are connected to severe outcomes of COVID-19. Vaccines for SARS-CoV-2 have shown to be protective, but it is unclear how metabolically burdened individuals respond to these vaccines.
Article
Biochemistry & Molecular Biology
E. Zmyslowska-Polakowska, T. Ploszaj, S. Skoczylas, P. Mojsak, M. Ciborowski, A. Kretowski, M. Lukomska-Szymanska, A. Szadkowska, W. Mlynarski, A. Zmyslowska
Summary: The study compared the oral microbiome and metabolome in Wolfram syndrome (WFS) patients with type 1 diabetes mellitus (T1DM) patients and healthy controls. The analysis showed specific microbial components and metabolites in the oral cavity of WFS patients, which may be associated with neurodegenerative disorders and potential therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Paulina Gluszynska, Aleksander Lukaszewicz, Inna Diemieszczyk, Jan Chilmonczyk, Joanna Reszec, Anna Citko, Lukasz Szczerbinski, Adam Kretowski, Hady Razak Hady
Summary: This study aimed to evaluate the effect of laparoscopic sleeve gastrectomy on the resolution of non-alcoholic fatty liver disease. The results showed that the surgery led to a significant improvement in weight loss parameters and Non-Alcoholic Fatty Liver Fibrosis Score, with only 21 patients still having features of liver steatosis after the surgery.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Angelika Buczynska, Iwona Sidorkiewicz, Maria Kosciuszko, Agnieszka Adamska, Katarzyna Siewko, Janusz Dzieciol, Piotr Szumowski, Janusz Mysliwiec, Anna Poplawska-Kita, Adam Jacek Kretowski
Summary: Markers of oxidative status, including total oxidative status (TOS), total antioxidant capacity (TAC), tumor protein 53 (p53), nuclear factor kappa B (NF-?B), forkhead box protein O1 (FOXO), and sirtuin 1 (SIRT1), play important roles in oxidative homeostasis and the progression of papillary thyroid cancer (PTC). Analyzing these markers can help determine eligibility for radioiodine (RAI) treatment. This study evaluated the relationship between oxidative status markers and qualification for RAI treatment in PTC patients.
Review
Immunology
Jedrzej Warpechowski, Paula Leszczynska, Dominika Juchnicka, Adam Olichwier, Lukasz Szczerbinski, Adam Jacek Kretowski
Summary: The SARS-CoV-2 pandemic had a major impact on healthcare systems worldwide, with patients with underlying medical conditions being more vulnerable. The effectiveness of COVID-19 vaccines in individuals with metabolic disorders is still limited. This review aims to provide an overview of the post-vaccination response in the context of metabolic comorbidities such as diabetes, insulin resistance, and obesity, focusing on the common COVID-19 vaccines.