Article
Endocrinology & Metabolism
Hongping Gong, Yan Ren, Zhenyi Li, Panpan Zha, Raju Bista, Yan Li, Dawei Chen, Yun Gao, Lihong Chen, Xingwu Ran, Chun Wang
Summary: This study analyzed the clinical characteristics of diabetic inpatients with foot ulcers and explored the risk factors for lower extremity amputation. The study found that diabetic patients with amputation were older, had longer duration of diabetes, poor glycemic control, malnutrition, peripheral arterial disease, and severe foot ulcers with infection. A history of prior amputation, foot gangrene, and low ankle brachial index were independent predictors of lower extremity amputation.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Dermatology
Huiling Zhang, Chuanwang Huang, Jie Bai, Jing Wang
Summary: A meta-analysis study found that male gender, smoking, previous foot ulcer, osteomyelitis, gangrene, hypertension, and white blood cell count were risk factors for lower extremity amputation in patients with diabetic foot ulcers. However, caution should be exercised when using these results due to the small sample sizes of several selected studies.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Medicine, General & Internal
Angel Ortiz-Zuniga, Jordi Samaniego, Betina Biagetti, Nicolas Allegue, Anna Gene, Andrea Sallent, Almudena Crespo, Jordi Serracanta, Carme Torrents, Daniela Issa, Danilo Rivas, Maria Teresa Veintemillas, Nuria Fernandez-Hidalgo, Rosa Busquets, Josep Royo, Cristina Hernandez
Summary: The aim of this study was to compare the incidence of lower-extremity amputations (LEA-DFD) before and after the establishment of a Diabetic Foot Multidisciplinary Unit. The results showed a significant reduction in the rate of amputations due to foot disease in patients with diabetes after the establishment of the unit.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Cherng-Kang Perng, Hsuan-Yu Chou, Yu-Jen Chiu
Summary: The study identified independent risk factors for amputation in patients with diabetic foot ulcers, including peripheral arterial disease, C-reactive protein level, and hospital stay. Among patients with PAD who underwent amputation, endovascular intervention was found to be an independent protective factor against major amputation.
JOURNAL OF THE CHINESE MEDICAL ASSOCIATION
(2021)
Article
Medicine, General & Internal
Linru Wang, Qjang Li, Xiao Chen, Zhaowei Wang
Summary: This study aimed to investigate the risk factors of lower limb amputation in patients with diabetic foot. The results showed that male sex, larger ulcer size, higher grade of Wagner classification, peripheral arterial disease and osteomyelitis were independent risk factors for lower limb amputation in these patients.
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Infectious Diseases
Florian Haug, Felix W. A. Waibel, Marcus Lisy, Elin Winkler, Ilker Uckay, Madlaina Schoeni
Summary: This study investigated the impact of the total length of systemic antibiotic therapy (ABT) and its initial intravenous (IV) part on clinical failure (CF) and microbiological failure (MF) in diabetic foot infections. The results showed that shorter durations of ABT did not increase the risk of CF or MF. However, further prospective randomized trials are needed to determine the optimal treatment duration.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Endocrinology & Metabolism
David J. Ramsey, James T. Kwan, Arjun Sharma
Summary: Diabetic eye disease and diabetic foot ulcers (DFUs) are closely associated, both being complications of diabetes. Impaired wound healing, immune dysfunction, and peripheral vascular disease resulting from hyperglycemia and metabolic dysfunction in diabetes lead to tissue damage in both the lower extremities and the eyes. The coexistence of these diabetes-related complications necessitates comprehensive evaluations of both the eyes and feet, as well as optimizing diabetes management.
WORLD JOURNAL OF DIABETES
(2022)
Article
Endocrinology & Metabolism
Suman Baral, Satyan Rajbhandari
Summary: Nepal, a developing country, is facing a major health challenge with a high prevalence of diabetes (8.5%) affecting around 2 million people. Limited resources pose barriers to providing affordable and convenient diabetes care or regular screening for complications. There is no reliable data on the incidence, prevalence, and complications of diabetic foot problems in Nepal.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Immunology
Ofer Perzon, Avivit Cahn, Yechiel N. Gellman, Michal Leibovitch, Shahar Peled, Ofer Elishoov, Amir Haze, Karen Olshtain-Pops, Hila Elinav
Summary: Diabetic foot infections are often caused by multiple pathogens, and the relevance of each isolated pathogen is unclear. This study found that enterococcal infections have a high prevalence and pathogenicity in diabetic foot infections, but the impact of targeted treatment is still unknown.
OPEN FORUM INFECTIOUS DISEASES
(2023)
Article
Immunology
Shiwei Zhou, Brian M. Schmidt, Oryan Henig, Keith S. Kaye
Summary: Patients with diabetic foot osteomyelitis who deferred amputation and opted for medical therapy had a higher risk of mortality during the follow-up period compared to those who underwent amputation.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Article
Dermatology
Xiaofeng Peng, Dengqun Gou, Lu Zhang, Hemei Wu, Yu Chen, Xing Shao, Li Li, Ming Tao
Summary: This study aimed to investigate the influencing factors of lower limb amputation in patients with diabetic foot ulcers. Retrospective data of patients with diabetic foot ulcers hospitalized in a tertiary general hospital in Guizhou Province from January 2019 to March 2022 were collected and analyzed. The results showed that decreased levels of HDL cholesterol were associated with a higher risk of lower limb amputation in patients with diabetic foot ulcers. The findings suggest that decreased HDL cholesterol levels can serve as an independent predictor of amputation in this patient population.
INTERNATIONAL WOUND JOURNAL
(2023)
Article
Medicine, General & Internal
Konstantin Koreyba, Ekaterina Silina, Dmitry Tsyplakov, Petr Litvitskiy, Natalia Manturova, Zalim Balkizov, Raghu Ram Achar, Nithya Rani Raju, Victor Stupin
Summary: This study analyzed histological and immunohistochemical features of tissues and cells in different sections of wounds from patients with diabetic foot ulcers. The results showed a correlation between tissue characteristics and treatment outcomes, indicating the potential for more effective surgical strategies to reduce treatment time and cost.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Dermatology
Rebecca A. Burmeister, Christine Jarocki, Crystal M. Holmes, Gary M. Rothenberg, Michael E. Munson, Brian M. Schmidt
Summary: The study found that patients discharged to skilled nursing facilities after diabetes-related limb salvage surgery had longer healing time, increased risk of rehospitalization and subsequent major lower-extremity amputation on the same side, as well as a higher mortality rate compared to patients discharged home.
INTERNATIONAL WOUND JOURNAL
(2021)
Article
Infectious Diseases
Parichehr Hadi, Sanjiv Rampal, Vasantha Kumari Neela, Manraj Singh Cheema, Sandeep Singh Sarawan Singh, Eng Kee Tan, Ajantha Sinniah
Summary: Diabetes mellitus is a global pandemic, particularly in Southeast Asia, and diabetic foot infection is a common and serious complication of this disease. However, there is a lack of locally published data on the types of microorganisms and antibiotics prescribed. This study aims to address this gap by examining the local microorganism culture and antibiotic prescription trends among diabetic foot patients in a tertiary care hospital in central Malaysia. The findings of this study could greatly contribute to the development of empirical therapy guidelines for treating diabetic foot infections in the future.
Article
Endocrinology & Metabolism
Taavy A. Miller, James H. Campbell, Nick Bloom, Shane R. Wurdeman
Summary: This study examined the timing variations of lower-limb amputation (LLA) among diabetic foot ulcer (DFU) patients by race/ethnicity and sex, finding that Black/African Americans were more likely to have earlier LLA after DFU compared to non-Hispanic/Whites, and more men received earlier LLA than women.
Article
Endocrinology & Metabolism
Shih-Yuan Hung, Jir-Shiong Tsai, Jiun-Ting Yeh, Kuan-Hsing Chen, Chia-Ni Lin, Hui-Mei Yang, Cheng-Wei Lin, Hsin-Yun Chen, Chung-Huei Huang, Huan Yu-Yao
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2019)
Article
Multidisciplinary Sciences
Yueh-Hsiang Huang, Szu-Tah Chen, Feng-Hsuan Liu, Sheng-Hwu Hsieh, Chia-Hung Lin, Miaw-Jene Liou, Chih-Ching Wang, Chung-Huei Huang, Geng-Hao Liu, Jr-Rung Lin, Lan-Yan Yang, Tzu-Yang Hsu, Ming-Chung Lee, Chun-Teng Huang, Yi-Hong Wu
Article
Endocrinology & Metabolism
Cheng-Wei Lin, David G. Armstrong, Chia-Hung Lin, Pi-Hua Liu, Shih-Yuan Hung, Shu-Ru Lee, Chung-Huei Huang, Yu-Yao Huang
BMJ OPEN DIABETES RESEARCH & CARE
(2019)
Article
Endocrinology & Metabolism
Cheng-Wei Lin, I-Wen Chen, Ying-Tzu Lin, Hsin-Yun Chen, Shih-Yuan Hung
BMJ OPEN DIABETES RESEARCH & CARE
(2020)
Article
Endocrinology & Metabolism
Shih-Yuan Hung, Cheng-Hsun Chiu, Chung-Huei Huang, Cheng-Wei Lin, Jiun-Ting Yeh, Hui-Mei Yang, Yu-Yao Huang
Summary: This study investigated the association between specific bacterial pathogens and treatment outcome in patients with limb-threatening diabetic foot infection. Gram-negative bacterial infection was found to be independently associated with poor outcomes. Specific pathogens such as E. coli, Proteus spp., and Pseudomonas aeruginosa were identified as being associated with poor treatment outcomes.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Article
Medicine, General & Internal
Ya-Tzu Tsao, Wei-Chen Lee, Chung-Huei Huang, I-Hsin Lin, Yu-Yao Huang
Summary: In patients who have received living donor liver transplant (LDLT), the prognostic nutritional index (PNI) and psoas muscle mass index (PMI) at the third month post-LDLT were found to be highly associated with 5-year survival. Combining these two indexes is suggested to provide better prognostic information in patients with lower levels of PNI-3m or PMI-3m.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Endocrinology & Metabolism
Chia-Hung Lin, David G. Armstrong, Pi-Hua Liu, Cheng-Wei Lin, Chung-Huei Huang, Yu-Yao Huang
Summary: This study analyzed the long-term survival outcomes of individuals with type 2 diabetes following first diagnosis of diabetic foot complications (FDDFC). The results showed that cardiovascular comorbidities and the status of lower-extremity amputations at the event of FDDFCs were both associated with patient survival outcomes. Early identification of this population could potentially improve survival rates.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, Research & Experimental
Cheng-Wei Lin, Shih-Yuan Hung, I-Wen Chen
Summary: The use of sodium-glucose co-transporter 2 inhibitors is not commonly associated with ketoacidosis, but the concomitant use of pioglitazone increases the risk of ketosis.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2022)
Article
Medicine, General & Internal
C. H. Huang, C. P. Chen, Y. Y. Huang, B. R. S. Hsu
JOURNAL OF POSTGRADUATE MEDICINE
(2020)