Article
Nanoscience & Nanotechnology
Ji-wook Kim, Jiyong Cheong, Hayeon Cheong, Jun Geol Yoon, Joon-Yong Jung, Jae-Hyun Lee, Tae-Hyun Shin
Summary: Inverted iron oxide nanoparticles (i-IONPs) show great potential for musculoskeletal imaging with stronger and longer-lasting contrast effects compared to clinical gadolinium-based contrast agents, providing clear visualization of anatomical details of the joint. Additionally, i-IONPs are completely eliminated from the joint cavity without accumulation or harmful effects and are excreted from the body through renal clearance.
ACS APPLIED NANO MATERIALS
(2021)
Article
Multidisciplinary Sciences
Meysam Soleymani, Amirhoushang Poorkhani, Solmaz Khalighfard, Mohammad Velashjerdi, Vahid Khori, Saeed Khodayari, Hamid Khodayari, Mohammad Dehghan, Nazila Alborzi, Shahram Agah, Ali Mohammad Alizadeh
Summary: Successful cancer treatment using magnetic hyperthermia therapy depends on the use of biocompatible magnetic nanoparticles that can accumulate in tumor tissues and generate heat when exposed to an AC magnetic field. In this study, folic acid-conjugated dextran-coated Zn0.6Mn0.4Fe2O4 nanoparticles were synthesized as smart nano heaters with self-regulating temperatures for the treatment of liver tumors. Animal studies showed no acute toxicity with the administration of these nanoparticles, and they were able to reach the desired therapeutic temperature range during exposure to safe AC magnetic fields. Additionally, the nanoparticles demonstrated efficacy in reducing tumor volume in liver-tumor-bearing mice.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Physical
Minhong Xu, Guoxiang Pan, Qiang Shen, Yuhua Guo, Mengyu Zhou, Qiu Liang
Summary: In this study, a novel iron oxide green pigment (FePc) was prepared by coating phthalocyanine blue (CuPc) and iron oxide yellow pigments (FeOOH) with sodium metasilicate hydrolysate and silane coupling agent KH602. The pigment showed improved heat resistance, hydrophobicity, and dispersibility. It exhibited good color properties and high near-infrared reflectance, making it suitable for applications in plastics and high-temperature coatings.
APPLIED SURFACE SCIENCE
(2023)
Article
Nanoscience & Nanotechnology
Chiseon Ryu, Hwangjae Lee, Hohyeon Kim, Seong Hwang, Yaser Hadadian, Ayeskanta Mohanty, In-Kyu Park, Beongki Cho, Jungwon Yoon, Jae Young Lee
Summary: We synthesized magnetic IONP/polymer nanocomposites (MNCs) by embedding IONPs in a poly(L-lactic acid) (PLA) matrix via nanoemulsion. The MNCs showed enhanced heating efficiency with over two-fold increase compared to nonembedded bare IONPs. In addition, the MNCs exhibited good colloidal stability under physiological conditions and maintained their heating efficiency during 48 h of incubation in cell culture medium.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Nhan Hau Tran, Vyacheslav Ryzhov, Andrey Volnitskiy, Dmitry Amerkanov, Fedor Pack, Aleksander M. Golubev, Alexandr Arutyunyan, Anastasiia Spitsyna, Vladimir Burdakov, Dmitry Lebedev, Andrey L. Konevega, Tatiana Shtam, Yaroslav Marchenko
Summary: In this study, the potential of iron oxide nanoparticles as radiosensitizers in glioblastoma cells was evaluated. The results showed that the nanoparticles can significantly enhance the effect of X-ray irradiation, while having a weaker or no effect on gamma and proton irradiation. The findings suggest that the nanoparticles may enhance radiation therapy by generating secondary electrons.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Bo-Hyun Moon, Younghwa Kim, Soo-Young Kim
Summary: Neovascular age-related macular degeneration (nAMD) is a major cause of blindness in the elderly population. Anti-VEGF drugs have made managing nAMD more feasible, but their effectiveness is limited and can decline over time. There is a need for continuous improvement in the efficacy and safety of these drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Mohamed S. A. Darwish, Hohyeon Kim, Minh Phu Bui, Tuan-Anh Le, Hwangjae Lee, Chiseon Ryu, Jae Young Lee, Jungwon Yoon
Summary: This study prepared multifunctional magnetic nanoparticles with high performance for hyperthermia and imaging functionality, showing promising potential for both diagnostic and therapeutic processes.
Article
Pharmacology & Pharmacy
Cristina Chircov, Raluca-Elena Stefan, Georgiana Dolete, Adriana Andrei, Alina Maria Holban, Ovidiu-Cristian Oprea, Bogdan Stefan Vasile, Ionela Andreea Neacsu, Bianca Tihauan
Summary: This study focuses on the use of dextran-coated iron oxide nanoparticles as drug-delivery supports for curcumin, a natural compound with antimicrobial, anticancer, and antioxidant properties. The nanoparticles were synthesized and characterized, and the results showed promising antimicrobial efficiency and the ability to control the properties of the nanosystems.
Article
Chemistry, Multidisciplinary
Liliana P. Ferreira, Cesar P. Reis, Tiago T. Robalo, M. E. Melo Jorge, Paula Ferreira, Joana Goncalves, Abdollah Hajalilou, Maria Margarida Cruz
Summary: Magnetite nanoparticles were synthesized using gelatin, agar-agar, or pectin as additives, achieving a higher reproducibility of the particle morphology and magnetic characteristics.
Article
Chemistry, Analytical
Shipeng Gao, Rebeca M. Torrente-Rodriguez, Maria Pedrero, Jose M. Pingarron, Susana Campuzano, Javier Rocha-Martin, Jose M. Guisan
Summary: This work focuses on improving the performance of immunosensors by studying the conjugation of magnetic nanoparticles (MNPs) with antibodies. By using suitable linkers and manipulation of oxidation variables, stable antibody-MNP conjugates were prepared with optimal analytical performance. The study also found that polyaldehyde-dextrans were superior to polycarboxylated-dextrans as multivalent antibody crosslinkers, and immunosensors constructed with carboxylated magnetic microbeads outperformed MNPs-based immunoplatforms.
Article
Biochemistry & Molecular Biology
Jiacheng Yu, Changqian Cao, Fengjiao Fang, Yongxin Pan
Summary: Iron oxide nanoparticles, especially magnetoferritins, have shown potential for magnetic hyperthermia therapy due to their biocompatibility and high thermal conversion efficiency. In this study, a novel magnetoferritin particle with a larger magnetite/maghemite core size and higher saturation magnetization was synthesized using a recombinant ferritin from the hyperthermophilic archaeon Pyrococcus furiosus as a template at 90 degrees C. The enhanced magnetic properties of this magnetoferritin suggest its potential application in tumor magnetic hyperthermia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pharmacology & Pharmacy
Silviu-Adrian Predoi, Simona Liliana Iconaru, Daniela Predoi
Summary: The toxicity of dextran coated iron oxide aqueous magnetic fluids was assessed in vitro and in vivo. In vitro studies showed that high concentrations of the fluid significantly increased certain blood parameters, while in vivo studies on rats showed a similar trend. However, when administered in concentrations lower than 250 μg/mL, the fluid was considered safe for medical and pharmaceutical applications.
Article
Materials Science, Multidisciplinary
Lihua He, Rong Zheng, Jie Min, Fulin Lu, Changqiang Wu, Yunfei Zhi, Shaoyun Shan, Hongying Su
Summary: Hydrogel nanocomposites incorporated with magnetic nanoparticles were prepared and studied for environment-responsive drug delivery. The study demonstrated the magnetic properties of the microgels and their potential as stimuli-sensitive drug delivery systems, showing a controlled release of the drug doxorubicin in response to pH and magnetic fields.
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2021)
Article
Polymer Science
Gabriel Predoi, Carmen Steluta Ciobanu, Simona Liliana Iconaru, Daniela Predoi, Dragana Biliana Dreghici, Andreea Groza, Florica Barbuceanu, Carmen Cimpeanu, Monica-Luminita Badea, Stefania-Felicia Barbuceanu, Ciprian Florin Furnaris, Cristian Belu, Liliana Ghegoiu, Mariana Stefania Raita
Summary: The study reported the synthesis of a dextran coated iron oxide nanoparticles thin layer on glass substrate. Various analytical techniques were used to analyze the surface morphology and chemical composition of the DIO-NPs thin layer. The results showed a continuous and homogeneous layer with the presence of Fe-CO metal carbonyl vibration bonds indicating the linkage between iron oxide nanoparticles and dextran. Furthermore, cytotoxicity assays demonstrated that the DIO-NPs layers did not exhibit toxic effects towards HepG2 cells.
Article
Ophthalmology
Kristine A. Tsantilas, Whitney M. Cleghorn, Celia M. Bisbach, Jeremy A. Whitson, Daniel T. Hass, Brian M. Robbings, Martin Sadilek, Jonathan D. Linton, Austin M. Rountree, Ana P. Valencia, Mariya T. Sweetwyne, Matthew D. Campbell, Huiliang Zhang, Connor S. R. Jankowski, Ian R. Sweet, David J. Marcinek, Peter S. Rabinovitch, James B. Hurley
Summary: The study revealed that aged mice had reduced retinal responses to light stimuli, with relatively stable metabolic flux and ATP levels in retinal tissues. However, there was a decrease in glutamine utilization in the Krebs Cycle in eyecups while other metabolic parameters remained constant. This suggests that external factors may play a role in influencing ocular metabolism in vivo.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Ophthalmology
Sengul Ozdek, Ahmet Yucel Ucgul, M. Elizabeth Hartnett, Muberra Akdogan, Parveen Sen, Muna Bhende, Cagri Giray Besirli, Murat Karacorlu, Vaidehi Dedania, Barbara Parolini, Sangeet Mittal, Alay Banker, Ehab El Rayes, Mohamed Tawfik, Wei-Chi Wu, Yamini Attiku, Eric Hansen, David Portney, Chintan Sarvaiya, Ozlem Sahin, Huseyin Baran Ozdemir, Gokhan Gurelik
Summary: This study reports on the outcomes of pediatric patients with combined hamartoma of the retina and the retina pigment epithelium who were treated conservatively or underwent pars plana vitrectomy. The results showed that vitreoretinal surgery was safe and effective in improving vision and reducing retinal distortion in Zone 1 lesions of combined hamartoma.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
Letter
Ophthalmology
Benjamin K. Young, Min Hwang, Mark W. Johnson, Cagri G. Besirli, Thomas J. Wubben
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Jessie E. Magnani, Omar Moinuddin, Mercy Pawar, Sanjana Sathrasala, Harlan McCaffery, Rebecca J. Vartanian, Cagri G. Besirli
Summary: The purpose of the study was to determine whether cytokines involved in the pathophysiology of ROP can be reliably collected and analyzed from infant tears. The results showed that tear volume was correlated with corrected gestational age, and tear cytokine levels differed among different stages of ROP.
Article
Ophthalmology
Nimesh A. Patel, Luis A. Acaba-Berrocal, Sandra Hoyek, Kenneth C. Fan, Maria Ana Martinez-Castellanos, Caroline R. Baumal, C. Armitage Harper, Audina M. Berrocal
Summary: This study aimed to compare the types and dosages of anti-vascular endothelial growth factors (VEGFs) and determine whether specific dosages or types of injection were associated with retreatment in clinical practice in the United States. The results showed that ranibizumab and lower-dose bevacizumab use were associated with an increased rate of retreatment compared to higher-dose bevacizumab.
Letter
Ophthalmology
Nikhil Bommakanti, Cagri G. Besirli, Peter Y. Zhao
Summary: This case report discusses the progression of posterior subcapsular cataract and retinal neovascularization in a patient with posterior polar annular choroidal dystrophy.
JAMA OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Han-Tung Hsu, Eugene Yu-Chuan Kang, Michael P. Blair, Michael Shapiro, Rahul Komati, Baker G. Hubbard, Kenneth W. Price, Antonio Capone Jr, Kim A. Drenser, Michael T. Trese, Ryan Shields, Hiroyuki Kondo, Itsuka Matsushita, Yoshihiro Yonekawa, Samir N. Patel, Shunji Kusaka, Fukutaro Mano, Karl R. Olsen, Anna Ells, Atchara Amphornphruet, Mark K. Walsh, Cagri G. Besirli, Omar Moinuddin, Caroline R. Baumal, Ana Bety Enriquez, Yih-Shiou Hwang, Chi-Chun Lai, Wei-Chi Wu
Summary: The purpose of this study was to investigate late vitreoretinal complications and visual outcomes in patients with regressed retinopathy of prematurity (ROP). The results showed that patients with ROP are at high risk of vision-threatening complications throughout childhood and adulthood. Continual follow-up and timely surgical intervention are essential for favorable visual outcomes in these patients.
OPHTHALMOLOGY RETINA
(2023)
Letter
Ophthalmology
Benjamin K. Young, Min Hwang, Mark W. Johnson, Cagri G. Besirli, Thomas J. Wubben
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Michel Michaelides, Nashila Hirji, Sui Chien Wong, Cagri G. Besirli, Serena Zaman, Neruban Kumaran, Anastasios Georgiadis, Alexander J. Smith, Caterina Ripamonti, Irene Gottlob, Anthony G. Robson, Alberta Thiadens, Robert H. Henderson, Penny Fleck, Eddy Anglade, Xiangwen Dong, George Capuano, Wentao Lu, Pamela Berry, Thomas Kane, Stuart Naylor, Michalis Georgiou, Angelos Kalitzeos, Robin R. Ali, Alexandria Forbes, James Bainbridge
Summary: This study evaluated the safety and efficacy of AAV8-hCARp.hCNGB3 in patients with CNGB3-associated achromatopsia (ACHM). The results showed that AAV8-hCARp.hCNGB3 demonstrated an acceptable safety and tolerability profile, and favorable changes were observed in some efficacy parameters. These findings support continued investigation of this gene therapy approach.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Emily Chang, Yunshu Zhou, David Musch, Amy Edmonds, Laura Sedig, Raymond Hutchinson, Neeraj Chaudhary, Hakan Demirci
Summary: The purpose of this study was to compare the efficacy of intraarterial chemotherapy (IAC) for retinoblastoma delivered via the ophthalmic artery (OA) division of the internal carotid artery (ICA) versus alternative branches of the external carotid artery (ECA). The results showed that when delivery of chemotherapeutic agents via the OA is no longer feasible, the utilization of alternative routes for IAC safely allows for continuation of therapy and results in similar rates of globe salvage, reduction in tumor thickness, and reduction in basal diameter.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Shefali Sood, Mina M. Naguib, David S. Portney, Cagri G. Besirli, Cole A. Martin, C. Armitage Harper III, Maria P. Fernandez, Audina M. Berrocal, Polly A. Quiram, Peter Belin, Noreen Clarke, Aaron Nagiel, Melissa Chandler, Christopher Bair, M. Elizabeth Harnett, Vaidehi S. Dedania
Summary: The study examined the impact of pandemic-related lockdown measures on the characteristics and management of retinopathy of prematurity (ROP). The findings showed a decrease in the number of patients screened for ROP during the lockdown period, with a higher use of indirect ophthalmoscopy for screening.
Article
Genetics & Heredity
Adam Jacobson, Cagri G. G. Besirli, Brenda L. L. Bohnsack
Summary: Stickler Syndrome is a genetic disorder characterized by ophthalmic and systemic manifestations. COL2A1 mutations are commonly associated with this syndrome, but there is a lack of genotype-phenotype correlations. Further research is needed to understand the molecular basis for phenotypic differences and how they relate to the COL2A1 gene.
Article
Chemistry, Medicinal
Thomas J. Wubben, Sraboni Chaudhury, Brennan T. Watch, Jeanne A. Stuckey, Eric Weh, Roshini Fernando, Moloy Goswami, Mercy Pawar, Jason C. Rech, Cagri G. Besirli
Summary: This study developed a new generation of small-molecule PKM2 activators specifically designed for delivery into the eye to prevent photoreceptor death and vision loss.
Article
Ophthalmology
Shubha Subramanya, Roshini Fernando, Moloy Goswami, Cagri G. Besirli, Eric Weh, Thomas J. Wubben
Summary: Researchers have developed flow cytometry-based assays to detect and quantify retinal cell death, which can also evaluate oxidative stress and neuroprotective agents. These methods increase efficiency and reduce analysis time without compromising sensitivity, making them valuable for studying retinal cell neuroprotection.
EXPERIMENTAL EYE RESEARCH
(2023)
Article
Cell Biology
Eric Weh, Moloy Goswami, Sraboni Chaudhury, Roshini Fernando, Nick Miller, Heather Hager, Sarah Sheskey, Vikram Sharma, Thomas J. Wubben, Cagri G. Besirli
Summary: HK2 and PKM2 play different roles in promoting photoreceptor (PR) neuroprotection and their identification has important implications for developing therapeutic options for combating PR loss during retinal disease. A study generated double conditional (dcKO) mice lacking HK2 and PKM2 expression in rod PRs, and found that their loss resulted in early shortening of PR inner/outer segments and accelerated PR degeneration. The study also revealed significant alterations to central glucose metabolism without changes to mitochondrial function prior to PR degeneration, highlighting the importance of HK2 and PKM2 in PR survival.
Article
Ophthalmology
Juan Caceres, Yibing Zhang, Lawrence Boe, Yunshu Zhou, Cagri Besirli, Yannis M. Paulus, Julie M. Rosenthal
Summary: The study confirms the feasibility of using a portable handheld camera for diabetic retinopathy screening in resource limited environments like Vanuatu, where there is a high prevalence of diabetes and a scarcity of ophthalmologists. The findings show that retinal images of sufficient quality can be obtained using this camera. The study also reveals a relatively high prevalence (24%) of referral-warranted diabetic retinopathy in Vanuatu.
CLINICAL OPHTHALMOLOGY
(2023)