Journal
BIOCHEMISTRY-MOSCOW
Volume 81, Issue 13, Pages 1676-1697Publisher
MAIK NAUKA/INTERPERIODICA/SPRINGER
DOI: 10.1134/S000629791613006X
Keywords
myosin light chain kinase; KRP/telokin; mylk1 gene organization and regulation; posttranslational modifications; protein-protein interactions; MLCK-dependent cellular reactions; MLCK in pathology
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Funding
- Russian Foundation for Basic Research [16-04-01742, 14-04-01813]
- Russian Science Foundation [14-35-00026]
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This review discusses and summarizes the results of molecular and cellular investigations of myosin light chain kinase (MLCK, MYLK1), the key regulator of cell motility. The structure and regulation of a complex mylk1 gene and the domain organization of its products is presented. The interactions of the mylk1 gene protein products with other proteins and posttranslational modifications of the mylk1 gene protein products are reviewed, which altogether might determine the role and place of MLCK in physiological and pathological reactions of cells and entire organisms. Translational potential of MLCK as a drug target is evaluated.
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