Functional role of carbohydrate residues in human immunoglobulin G and therapeutic monoclonal antibodies

Mannose metabolism in recombinant CHO cells and its effect on IgG glycosylation

(2016) Peter G. Slade et al.   BIOTECHNOLOGY AND BIOENGINEERING

Challenges of glycosylation analysis and control: an integrated approach to producing optimal and consistent therapeutic drugs

(2016) Peiqing Zhang et al.   DRUG DISCOVERY TODAY

N-glycosylation heterogeneity and the influence on structure, function and pharmacokinetics of monoclonal antibodies and Fc fusion proteins

(2016) Fabian Higel et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Enhanced sialylation of a human chimeric IgG1 variant produced in human and rodent cell lines

(2016) Yusuke Mimura et al.   JOURNAL OF IMMUNOLOGICAL METHODS

The Emerging Importance of IgG Fab Glycosylation in Immunity

(2016) Fleur S. van de Bovenkamp et al.   JOURNAL OF IMMUNOLOGY

Extensive glycosylation of ACPA-IgG variable domains modulates binding to citrullinated antigens in rheumatoid arthritis

(2015) Yoann Rombouts et al.   ANNALS OF THE RHEUMATIC DISEASES

Lectins from opportunistic bacteria interact with acquired variable-region glycans of surface immunoglobulin in follicular lymphoma

(2015) D. Schneider et al.   BLOOD

Antibody-Dependent Phagocytosis of Tumor Cells by Macrophages: A Potent Effector Mechanism of Monoclonal Antibody Therapy of Cancer

(2015) N. Gul et al.   CANCER RESEARCH

Functional knockout of FUT8 in Chinese hamster ovary cells using CRISPR/Cas9 to produce a defucosylated antibody

(2015) Tao Sun et al.   ENGINEERING IN LIFE SCIENCES

Using glyco-engineering to produce therapeutic proteins

(2015) Martina Dicker et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Fc receptors and their influence on efficacy of therapeutic antibodies for treatment of viral diseases

(2015) Kuan Rong Chan et al.   Expert Review of Anti-Infective Therapy

Fc glycans of therapeutic antibodies as critical quality attributes

(2015) Dietmar Reusch et al.   GLYCOBIOLOGY

The Current Status and Prospects of Antibody Engineering for Therapeutic Use: Focus on Glycoengineering Technology

(2015) Rinpei Niwa et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Antibodies to watch in 2016

(2015) Janice M. Reichert   mAbs

Rational design of therapeutic mAbs against aggregation through protein engineering and incorporation of glycosylation motifs applied to bevacizumab

(2015) Fabienne Courtois et al.   mAbs

Hinge-Region O-Glycosylation of Human Immunoglobulin G3 (IgG3)

(2015) Rosina Plomp et al.   MOLECULAR & CELLULAR PROTEOMICS

Molecular properties of human IgG subclasses and their implications for designing therapeutic monoclonal antibodies against infectious diseases

(2015) Vashti Irani et al.   MOLECULAR IMMUNOLOGY

Heterologous protein production using euchromatin-containing expression vectors in mammalian cells

(2015) Katalin Zboray et al.   NUCLEIC ACIDS RESEARCH

Core Concepts: Biosimilars

(2015) Stephen Ornes   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of FcγRI in complex with Fc reveals the importance of glycan recognition for high-affinity IgG binding

(2015) Jinghua Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multi-Angle Effector Function Analysis of Human Monoclonal IgG Glycovariants

(2015) Tetyana Dashivets et al.   PLoS One

The choice of mammalian cell host and possibilities for glycosylation engineering

(2014) Michael Butler et al.   CURRENT OPINION IN BIOTECHNOLOGY

Immunoglobulin G (IgG) Fab Glycosylation Analysis Using a New Mass Spectrometric High-throughput Profiling Method Reveals Pregnancy-associated Changes

(2014) Albert Bondt et al.   MOLECULAR & CELLULAR PROTEOMICS

Biopharmaceutical benchmarks 2014

(2014) Gary Walsh   NATURE BIOTECHNOLOGY

IgG Subclasses and Allotypes: From Structure to Effector Functions

(2014) Gestur Vidarsson et al.   Frontiers in Immunology

CHO cell line specific prediction and control of recombinant monoclonal antibodyN-glycosylation

(2013) Rhian K. Grainger et al.   BIOTECHNOLOGY AND BIOENGINEERING

Glycosylation: impact, control and improvement during therapeutic protein production

(2013) Ana Rita Costa et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

The availability of glucose to CHO cells affects the intracellular lipid-linked oligosaccharide distribution, site occupancy and the N-glycosylation profile of a monoclonal antibody

(2013) Bo Liu et al.   JOURNAL OF BIOTECHNOLOGY

Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies

(2013) Yannick Bulliard et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Effects of altered FcγR binding on antibody pharmacokinetics in cynomolgus monkeys

(2013) Maya K Leabman et al.   mAbs

CHO cell engineering to prevent polypeptide aggregation and improve therapeutic protein secretion

(2013) Valérie Le Fourn et al.   METABOLIC ENGINEERING

Recent advances in recombinant protein production

(2013) Renate Kunert et al.   Bioengineered

Production platforms for biotherapeutic glycoproteins. Occurrence, impact, and challenges of non-human sialylation

(2012) Darius Ghaderi et al.   Biotechnology & Genetic Engineering Reviews

Mogamulizumab

(2012) Joshuan M. Subramaniam et al.   DRUGS

Selective Deactivation of Serum IgG: A General Strategy for the Enhancement of Monoclonal Antibody Receptor Interactions

(2012) Kavitha Baruah et al.   JOURNAL OF MOLECULAR BIOLOGY

Galactosylation variations in marketed therapeutic antibodies

(2012) T. Shantha Raju et al.   mAbs

Increased serum clearance of oligomannose species present on a human IgG1 molecule

(2012) Leslie Alessandri et al.   mAbs

Generation of recombinant antibodies and means for increasing their affinity

(2011) E. P. Altshuler et al.   BIOCHEMISTRY-MOSCOW

Enhanced sialylation of recombinant human erythropoietin in Chinese hamster ovary cells by combinatorial engineering of selected genes

(2011) Y.-D. Son et al.   GLYCOBIOLOGY

Computational approach for understanding and improving GS-NS0 antibody production under hyperosmotic conditions

(2011) Yingswan Ho et al.   JOURNAL OF BIOSCIENCE AND BIOENGINEERING

Acceptable changes in quality attributes of glycosylated biopharmaceuticals

(2011) Martin Schiestl et al.   NATURE BIOTECHNOLOGY

NMR analysis demonstrates immunoglobulin G N-glycans are accessible and dynamic

(2011) Adam W Barb et al.   Nature Chemical Biology

Unique carbohydrate-carbohydrate interactions are required for high affinity binding between Fc RIII and antibodies lacking core fucose

(2011) C. Ferrara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A variant human IgG1-Fc mediates improved ADCC

(2011) Ross Stewart et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Potential impact of the non-human sialic acid N-glycolylneuraminic acid on transplant rejection risk

(2011) Vered Padler-Karavani et al.   XENOTRANSPLANTATION

Analysis of monoclonal antibody product heterogeneity resulting from alternate cleavage sites of signal peptide

(2010) Ruchi B. Kotia et al.   ANALYTICAL BIOCHEMISTRY

Highly efficient deletion of FUT8 in CHO cell lines using zinc-finger nucleases yields cells that produce completely nonfucosylated antibodies

(2010) Laetitia Malphettes et al.   BIOTECHNOLOGY AND BIOENGINEERING

A single-use purification process for the production of a monoclonal antibody produced in a PER.C6 human cell line

(2010) Michael Kuczewski et al.   Biotechnology Journal

Effects of aging, body mass index, plasma lipid profiles, and smoking on human plasma N-glycans

(2010) Ana Knežević et al.   GLYCOBIOLOGY

Engineering host cell lines to reduce terminal sialylation of secreted antibodies

(2010) Michael F. Naso et al.   mAbs

Post-translational Modifications Differentially Affect IgG1 Conformation and Receptor Binding

(2010) Damian Houde et al.   MOLECULAR & CELLULAR PROTEOMICS

Chinese hamster ovary cells can produce galactose-α-1,3-galactose antigens on proteins

(2010) Carlos J Bosques et al.   NATURE BIOTECHNOLOGY

Identification and characterization of asparagine deamidation in the light chain CDR1 of a humanized IgG1 antibody

(2009) Josef Vlasak et al.   ANALYTICAL BIOCHEMISTRY

Increasing the sialylation of therapeutic glycoproteins: The potential of the sialic acid biosynthetic pathway

(2009) Kaya Bork et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Glycosylation as a strategy to improve antibody-based therapeutics

(2009) Roy Jefferis   NATURE REVIEWS DRUG DISCOVERY

Immunoglobulin G galactosylation and sialylation are associated with pregnancy-induced improvement of rheumatoid arthritis and the postpartum flare: results from a large prospective cohort study

(2009) Fleur E van de Geijn et al.   ARTHRITIS RESEARCH & THERAPY

Structure and Stability Changes of Human IgG1 Fc as a Consequence of Methionine Oxidation

(2008) Dingjiang Liu et al.   BIOCHEMISTRY

Specificity and affinity of human Fc  receptors and their polymorphic variants for human IgG subclasses

(2008) P. Bruhns et al.   BLOOD

Terminal sugars of Fc glycans influence antibody effector functions of IgGs

(2008) T Shantha Raju   CURRENT OPINION IN IMMUNOLOGY

Cetuximab-Induced Anaphylaxis and IgE Specific for Galactose-α-1,3-Galactose

(2008) Christine H. Chung et al.   NEW ENGLAND JOURNAL OF MEDICINE

Aglycosylated immunoglobulin G1 variants productively engage activating Fc receptors

(2008) S. L. Sazinsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recapitulation of IVIG Anti-Inflammatory Activity with a Recombinant IgG Fc

(2008) R. M. Anthony et al.   SCIENCE

Effect of Production Method and Gene Amplification on the Glycosylation Pattern of a Secreted Reporter Protein in CHO Cells

(2005) Matthew L. Lipscomb et al.   BIOTECHNOLOGY PROGRESS