Article
Endocrinology & Metabolism
Ta-Wei Tai, Jawl-Shan Hwang, Chia-Chun Li, Jason C. Hsu, Chih-Wei Chang, Chih-Hsing Wu
Summary: Hip fracture patients receiving anti-osteoporosis treatment have reduced mortality rates. Oral bisphosphonates, ibandronate, zoledronic acid, and denosumab were associated with lower all-cause mortality rates among these patients.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
M. K. Skjodt, M. T. Ernst, S. Khalid, C. Libanati, C. Cooper, A. Delmestri, K. H. Rubin, M. K. Javaid, D. Martinez-Laguna, E. Toth, D. Prieto-Alhambra, B. Abrahamsen
Summary: This study reveals a significant and persistent treatment gap in anti-osteoporosis treatment in patients aged 50 years and older who suffered major osteoporotic fractures in Denmark between 2005 and 2014, even with the inclusion of hospital-administered treatments. Strengthened post-fracture care organization and secondary fracture prevention are urgently needed.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Shau-Huai Fu, Chen-Yu Wang, Chih-Chien Hung, Chia-Che Lee, Rong-Sen Yang, Chuan-Ching Huang, Chui-Jia Farn, Wei-Hsin Lin, Ho-Min Chen, Fei-Yuan Hsiao, Jou-Wei Lin, Chung-Yi Li
Summary: Discontinuation of denosumab resulted in an increased risk of major osteoporotic fractures, especially vertebral fractures. The increased risk tends to reveal within 1 year post-discontinuation and be greater after a longer treatment duration.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Medicine, General & Internal
Cathal J. McCarthy, Michael A. Kelly, Paddy J. Kenny
Summary: Hip fracture prevention is crucial in elderly care, with a history of prior fracture as a significant risk factor. This study evaluated the prevalence of previous fractures in hip fracture patients over a year and assessed their use of anti-osteoporotic medication. The results showed a high percentage of patients with prior fractures, with vertebrae fractures being the most common, and a majority of those without prior fractures were on preventative medication. Prescriptions rates were higher for females compared to males.
IRISH JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Endocrinology & Metabolism
Ta-Wei Tai, Chia-Chun Li, Chun-Feng Huang, Wing P. Chan, Chih-Hsing Wu
Summary: This nationwide study in Taiwan showed that anti-osteoporosis treatment after hip fracture surgery was associated with lower all-cause mortality. Patients who received longer durations of treatment had even lower mortality rates. Postoperative treatment for osteoporosis is crucial for improving outcomes in hip fracture patients.
Article
Endocrinology & Metabolism
Chor-Wing Sing, Tzu-Chieh Lin, Sharon Bartholomew, J. Simon Bell, Corina Bennett, Kebede Beyene, Pauline Bosco-Levy, Brian D. Bradbury, Amy Hai Yan Chan, Manju Chandran, Cyrus Cooper, Maria de Ridder, Caroline Y. Doyon, Cecile Droz-Perroteau, Ganga Ganesan, Sirpa Hartikainen, Jenni Ilomaki, Han Eol Jeong, Douglas P. Kiel, Kiyoshi Kubota, Edward Chia-Cheng Lai, Jeff L. Lange, E. Michael Lewiecki, Julian Lin, Jiannong Liu, Joe Maskell, Mirhelen Mendes de Abreu, James O'Kelly, Nobuhiro Ooba, Alma B. Pedersen, Albert Prats-Uribe, Daniel Prieto-Alhambra, Simon Xiwen Qin, Ju-Young Shin, Henrik T. Sorensen, Kelvin Bryan Tan, Tracy Thomas, Anna-Maija Tolppanen, Katia M. C. Verhamme, Grace Hsin-Min Wang, Sawaeng Watcharathanakij, Stephen J. Wood, Ching-Lung Cheung, Ian C. K. Wong
Summary: In this international study, the researchers analyzed the incidence of hip fractures, post-fracture treatment, and all-cause mortality following hip fractures across different countries and regions. They used patient-level healthcare data from 19 countries and identified 4,115,046 hip fractures from 2005 to 2018. The study revealed variations in the global epidemiology of hip fractures and post-fracture outcomes, highlighting the need for interventions to reduce the burden of osteoporotic fractures.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Orthopedics
Ioannis I. Daskalakis, Evangelos I. Kritsotakis, Apostolos H. Karantanas, Georgios M. Kontakis, Johannes D. Bastian, Theodoros H. Tosounidis
Summary: This study aimed to investigate the outcomes of applying a surgeon-led AO Foundation algorithm to hip fracture patients. The results showed that the in-hospital initiation of anti-osteoporotic treatment using this algorithm led to improved medication persistence and decreased incidence of secondary osteoporotic fractures.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2023)
Article
Endocrinology & Metabolism
Chi Chiu Mok, Ling Yin Ho, Stella Mei Tik Leung, Hoi Ning Cheung, Sammy Pak Lam Chen, Kwok Man Ma
Summary: In patients receiving long-term glucocorticoids, denosumab was superior to alendronate in increasing spine bone mineral density after 12 months, with both drugs being well-tolerated.
Review
Health Care Sciences & Services
Ramona Dobre, Dan Alexandru Niculescu, Razvan-Cosmin Petca, Razvan-Ionut Popescu, Aida Petca, Catalina Poiana
Summary: A systematic review found that anti-osteoporotic treatment after hip fracture can reduce mortality rates, with conflicting data on re-fracture risk. More data are needed to validate the actual effects of such treatment on secondary prevention.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Endocrinology & Metabolism
Ji Sup Hwang, Sanguk Lee, Hyun Sik Gong
Summary: This study found that in patients with recent distal radius fractures receiving oral anti-resorptive agents, bone turnover markers decreased significantly at six months, and the percentage decrease could predict improvements in bone mineral density at one year. Bisphosphonate users had higher sensitivity and specificity, while SERM users did not have identifiable cutoff points. Adjusted cutoff points may be necessary to increase sensitivity for detecting patients responsive to ARA treatment after a new DRF.
Article
Medicine, General & Internal
Hong Jin Kim, Ha Kyun Chang, Dong-Gune Chang, JiYun Ha, Byeong-Rak Keum, Gun-Hwa Kim
Summary: This study aimed to analyze the incidence of bisphosphonate treatment failure, associated radiological factors, and effect of fracture healing in postmenopausal women with osteoporotic vertebral fractures. The non-response group had significantly lower initial BMD values than the response group, and the initial BMD value of the spine and the FRAX hip were identified as radiological factors influencing bisphosphonate non-response. These findings provide insights into the possible mechanisms and factors influencing bisphosphonate treatment failure in osteoporosis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Chen-Yu Wang, Chih-Hsing Wu, Ho-Min Chen, Jou-Wei Lin, Chih-Cheng Hsu, Yin-Fan Chang, Ta-Wei Tai, Shau-Huai Fu, Jawl-Shan Hwang
Summary: This study evaluated the cost and effectiveness of anti-osteoporosis medications (AOM) therapy in Taiwan using the National Health Insurance Research Database. The study found that initiating AOM treatment reduced non-vertebral fractures and mortality rates among individuals aged 70 years and above, while also reducing medical resource consumption in the national insurance healthcare system.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Critical Care Medicine
Mustafa Caner Okkaoglu, Erdi Ozdemir, Ugur Yaradilmis, Murat Altay
Summary: This study investigated the relationship between radiographic osteoporotic hip morphology and mortality in patients with intertrochanteric femur fractures. The results showed that patients with Dorr type C femur had a 2.1 times increased mortality rate at 6 months following the fracture.
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED
(2022)
Article
Endocrinology & Metabolism
Namki Hong, Heajeong Park, Chang Oh Kim, Hyeon Chang Kim, Jin-Young Choi, Hwiyoung Kim, Yumie Rhee
Summary: Dual-energy X-ray absorptiometry (DXA)-based bone radiomics scores from hip images may improve hip fracture prediction in older women. The study showed that an increase in bone radiomics score was associated with an elevated risk of incident hip fracture.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Hiroki Iida, Yoshihito Sakai, Taisuke Seki, Tsuyoshi Watanabe, Norimitsu Wakao, Hiroki Matsui, Shiro Imagama
Summary: The study investigates the impact of bisphosphonate (BP) on mortality post osteoporotic vertebral fracture (OVF), and finds that BP medication is significantly associated with reduced all-cause mortality after OVF.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Orthopedics
Yizhong Li, Jinkuang Lin, Peiwen Wang, Xuedong Yao, Haiming Yu, Huafeng Zhuang, Linlin Zhang, Yanjun Zeng
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2014)
Article
Orthopedics
Siqing Cai, Haiming Yu, Yizhong Li, Xiaobo He, Lisheng Yan, Xueqing Huang, Peiwen Wang
SKELETAL RADIOLOGY
(2020)
Article
Orthopedics
Qunlong Pan, Haiming Yu, Xiaoyu He, Yiyong Weng, Rongmou Zhang, Hanshi Wang, Yizhong Li
Summary: The study aimed to investigate the incidence and clinical characteristics of lumbar sympathetic trunk (LST) injury after oblique lumbar interbody fusion (OLIF). The results showed that 16 patients (29.6%) were diagnosed with LST injury after surgery, and the difference in skin temperature between the two legs lasted for 1.5 to 12 months. Most patients with LST injury experienced moderate discomfort. The incidence of LST injury was higher in patients with multi-segment OLIF than in those with single-segment OLIF.
ORTHOPAEDIC SURGERY
(2023)
Article
Geriatrics & Gerontology
Peiwen Wang, Yizhong Li, Huafeng Zhuang, Haiming Yu, Siqing Cai, Hao Xu, Zhenhui Chen, Jinkuang Lin, Xuedong Yao
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2019)
Article
Orthopedics
Huafeng Zhuang, Yizhong Li, Jinkuang Lin, Donglu Cai, Siqing Cai, Lisheng Yan, Xuedong Yao
BMC MUSCULOSKELETAL DISORDERS
(2017)
Article
Medicine, Research & Experimental
Yizhong Li, Jinkuang Lin, Siqing Cai, Lisheng Yan, Yuancheng Pan, Xuedong Yao, Huafeng Zhuang, Peiwen Wang, Yanjun Zeng
BOSNIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2016)