Docking protein-1 promotes inflammatory macrophage signaling in gastric cancer

Comprehensive molecular characterization of clinical responses to PD-1 inhibition in metastatic gastric cancer

(2018) Seung Tae Kim et al.   NATURE MEDICINE

Antagonism of PPAR-γ signaling expands human hematopoietic stem and progenitor cells by enhancing glycolysis

(2018) Bin Guo et al.   NATURE MEDICINE

Computational measurement of tumor immune microenvironment in gastric adenocarcinomas

(2018) Young Hwan Chang et al.   Scientific Reports

Tumor mutational burden is a determinant of immune-mediated survival in breast cancer

(2018) Alexandra Thomas et al.   OncoImmunology

Molecular Profiling of Cohorts of Tumor Samples to Guide Clinical Development of Pembrolizumab as Monotherapy

(2018) Mark Ayers et al.   CLINICAL CANCER RESEARCH

Targeting macrophages: therapeutic approaches in cancer

(2018) Luca Cassetta et al.   NATURE REVIEWS DRUG DISCOVERY

Immune Activation and Benefit From Avelumab in EBV-Positive Gastric Cancer

(2017) Anshuman Panda et al.   JNCI-Journal of the National Cancer Institute

Methanosarcina Spherical Virus, a Novel Archaeal Lytic Virus Targeting Methanosarcina Strains

(2017) Katrin Weidenbach et al.   JOURNAL OF VIROLOGY

PD-1 expression by tumour-associated macrophages inhibits phagocytosis and tumour immunity

(2017) Sydney R. Gordon et al.   NATURE

Herpes simplex virus 1 infection of T cells causes VP11/12-dependent phosphorylation and degradation of the cellular protein Dok-2

(2017) Soumia Lahmidi et al.   VIROLOGY

Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression

(2017) Angel Garcia-Diaz et al.   Cell Reports

Impact of mutations in Toll-like receptor pathway genes on esophageal carcinogenesis

(2017) Daffolyn Rachael Fels Elliott et al.   PLoS Genetics

Immune Activation and Benefit From Avelumab in EBV-Positive Gastric Cancer

(2017) Anshuman Panda et al.   JNCI-Journal of the National Cancer Institute

The novel negative checkpoint regulator VISTA is expressed in gastric carcinoma and associated with PD-L1/PD-1: A future perspective for a combined gastric cancer therapy?

(2017) Christine Böger et al.   OncoImmunology

Loss of Dok-1 and Dok-2 in mice causes severe experimental colitis accompanied by reduced expression of IL-17A and IL-22

(2016) Masazumi Waseda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ESAP plus: a web-based server for EST-SSR marker development

(2016) Piyarat Ponyared et al.   BMC GENOMICS

Differential gene expression in human, murine, and cell line-derived macrophages upon polarization

(2016) Kara L. Spiller et al.   EXPERIMENTAL CELL RESEARCH

Dok1 and Dok2 Proteins Regulate Cell Cycle in Hematopoietic Stem and Progenitor Cells

(2016) Emilie Coppin et al.   JOURNAL OF IMMUNOLOGY

Dok-1 and Dok-2 Regulate the Formation of Memory CD8+T Cells

(2016) Constance Laroche-Lefebvre et al.   JOURNAL OF IMMUNOLOGY

CD68/macrosialin: not just a histochemical marker

(2016) Dimitry A Chistiakov et al.   LABORATORY INVESTIGATION

Clinical impact of tumour biology in the management of gastroesophageal cancer

(2016) Florian Lordick et al.   Nature Reviews Clinical Oncology

Subcellular compartmentalization of docking protein-1 contributes to progression in colorectal cancer

(2016) Teresa Friedrich et al.   EBioMedicine

The Future Prospects of Immune Therapy in Gastric and Esophageal Adenocarcinoma

(2016) Walid Shaib et al.   Journal of Clinical Medicine

Complement C5a induces PD-L1 expression and acts in synergy with LPS through Erk1/2 and JNK signaling pathways

(2016) Ling-Ling An et al.   Scientific Reports

Photoactivation of Dok1/ERK/PPARγ signaling axis inhibits excessive lipolysis in insulin-resistant adipocytes

(2015) Xiaoxiao Jiang et al.   CELLULAR SIGNALLING

Tumor-associated macrophages of the M2 phenotype contribute to progression in gastric cancer with peritoneal dissemination

(2015) Takahisa Yamaguchi et al.   Gastric Cancer

Erosion of the chronic myeloid leukaemia stem cell pool by PPARγ agonists

(2015) Stéphane Prost et al.   NATURE

The dual role of iNOS in cancer

(2015) Federica Vannini et al.   Redox Biology

Dok1 and Dok2 proteins regulate natural killer cell development and function

(2014) Javier Celis‐Gutierrez et al.   EMBO JOURNAL

Infiltration of diametrically polarized macrophages predicts overall survival of patients with gastric cancer after surgical resection

(2014) Heng Zhang et al.   Gastric Cancer

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

DOK3 Is Required for IFN-β Production by Enabling TRAF3/TBK1 Complex Formation and IRF3 Activation

(2014) Susana Soo-Yeon Kim et al.   JOURNAL OF IMMUNOLOGY

Comprehensive molecular characterization of gastric adenocarcinoma

(2014) Adam J. Bass et al.   NATURE

Adaptor protein DOK3 promotes plasma cell differentiation by regulating the expression of programmed cell death 1 ligands

(2014) X. Ou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epstein-Barr Virus Down-Regulates Tumor Suppressor DOK1 Expression

(2014) Maha Siouda et al.   PLoS Pathogens

Pattern-Recognition Receptors and Gastric Cancer

(2014) Natalia Castaño-Rodríguez et al.   Frontiers in Immunology

Deficiency of caveolin-1 in Apcmin/+ mice promotes colorectal tumorigenesis

(2013) Teresa Friedrich et al.   CARCINOGENESIS

The role of macrophages polarization in predicting prognosis of radically resected gastric cancer patients

(2013) Francesco Pantano et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Dok-1 overexpression promotes development of γδ natural killer T cells

(2012) Gilles Besin et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity

(2012) Jordi Barretina et al.   NATURE

TFAP2E–DKK4and Chemoresistance in Colorectal Cancer

(2012) Matthias P.A. Ebert et al.   NEW ENGLAND JOURNAL OF MEDICINE

WNT6 is a novel target gene of caveolin-1 promoting chemoresistance to epirubicin in human gastric cancer cells

(2012) G Yuan et al.   ONCOGENE

Prognostic Significance of Tumor-Associated Macrophages in Solid Tumor: A Meta-Analysis of the Literature

(2012) Qiong-wen Zhang et al.   PLoS One

The cBio Cancer Genomics Portal: An Open Platform for Exploring Multidimensional Cancer Genomics Data: Figure 1.

(2012) Ethan Cerami et al.   Cancer Discovery

DOK2 as a Marker of Poor Prognosis of Patients with Gastric Adenocarcinoma After Curative Resection

(2011) Hiromichi Miyagaki et al.   ANNALS OF SURGICAL ONCOLOGY

Aberrant DNA methylation of cancer-associated genes in gastric cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC–EURGAST)

(2011) Karen Balassiano et al.   CANCER LETTERS

Oncogenic Tyrosine Kinases Target Dok-1 for Ubiquitin-Mediated Proteasomal Degradation To Promote Cell Transformation

(2011) J. A. Janas et al.   MOLECULAR AND CELLULAR BIOLOGY

The Ras Inhibitors Caveolin-1 and Docking Protein 1 Activate Peroxisome Proliferator-Activated Receptor   through Spatial Relocalization at Helix 7 of Its Ligand-Binding Domain

(2011) E. Burgermeister et al.   MOLECULAR AND CELLULAR BIOLOGY

Mice lacking Dok-1, Dok-2 and Dok-3 succumb to aggressive histiocytic sarcoma

(2010) Ryuichi Mashima et al.   LABORATORY INVESTIGATION

Identification of DOK genes as lung tumor suppressors

(2010) Alice H Berger et al.   NATURE GENETICS

p21waf1/CIP1, a CDK inhibitor and a negative feedback system that controls macrophage activation

(2009) Jorge Lloberas et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The roles of Dok family adapters in immunoreceptor signaling

(2009) Ryuichi Mashima et al.   IMMUNOLOGICAL REVIEWS

A Concerted Kinase Interplay Identifies PPARγ as a Molecular Target of Ghrelin Signaling in Macrophages

(2009) Annie Demers et al.   PLoS One

Dok1 mediates high-fat diet–induced adipocyte hypertrophy and obesity through modulation of PPAR-γ phosphorylation

(2008) Tetsuya Hosooka et al.   NATURE MEDICINE