Article
Radiology, Nuclear Medicine & Medical Imaging
Xiao-Quan Xu, Yue Chu, Guang-Chen Shen, Gao Ma, Shan-Shan Lu, Sheng Liu, Hai-Bin Shi, Fei-Yun Wu
Summary: This study assessed the prognostic value of post-treatment DWI ASPECTS in predicting the clinical outcome of AIS patients after EVT, and found that both DWI ASPECTS and infarction volume were independent predictors of good clinical outcome, with high accuracy.
EUROPEAN RADIOLOGY
(2022)
Article
Food Science & Technology
Alessandro Picelli, Andrea Santamato, Michela Cosma, Alessio Baricich, Carmelo Chisari, Marzia Millevolte, Cristina Del Prete, Ilenia Mazzu, Paolo Girardi, Nicola Smania
Summary: This study aimed to investigate the relationship between the timing of BoNT-A injection and treatment outcomes in PSS patients. The results showed that initiating BoNT-A treatment within 3 months post-stroke can lead to greater reduction in muscle tone at 1 and 3 months follow-up.
Article
Neurosciences
Caitlyn Seim, Bingxian Chen, Chuzhang Han, David Vacek, Laura Song Wu, Maarten Lansberg, Allison Okamura
Summary: This study investigates the effectiveness of different approaches of vibrotactile stimulation in reducing spastic hypertonia in post-stroke patients. The results show that cutaneous stimulation of the hand is the most effective method in reducing spastic hypertonia, compared to muscle stimulation and antagonist muscle stimulation.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Behavioral Sciences
Ling-Yi Liao, Pei-Dong Xu, Xiang-Qin Fang, Qing-Hua Wang, Yong Tao, Huan Cheng, Chang-Yue Gao
Summary: This study analyzed 304 patients with intracerebral hemorrhage and found that lower NIHSS scores, younger age, and drinking increased the risk of post-stroke spasticity, while smoking and hemorrhage in the thalamus reduced the risk.
BRAIN AND BEHAVIOR
(2023)
Article
Clinical Neurology
Rien Anggraini Razak, Firdaus Fabrice Hannanu, Bernadette Naegele, Olivier Detante, Assia Jaillard
Summary: This study assessed ILH impairment in subacute stroke and found that it is frequent and predicts long-term outcomes. The researchers propose integrating ILH impairment into rehabilitation programs to improve recovery in stroke patients.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Medicine, General & Internal
Yu-Sheng Yang, Chi-Hsiang Tseng, Wei-Chien Fang, Ia-Wen Han, Shyh-Chour Huang
Summary: In this study, a new dynamic splint was found to significantly reduce wrist and finger flexor muscle spasticity in chronic stroke survivors, leading to improvements in functional movements. The experimental group showed better results compared to the control group after the intervention, with high user satisfaction reported for muscle tone reduction, comfort, and ease of use. These findings suggest that this new splint can be effectively used for at-home rehabilitation in chronic stroke patients with hemiparesis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Rehabilitation
Maria-Isabel Garcia-Bernal, Paula Gonzalez-Garcia, Maria Jesus Casuso-Holgado, Maria Dolores Cortes-Vega, Alberto Marcos Heredia-Rizo
Summary: This study aimed to investigate the effects of muscle position (relaxed vs stretched) on muscle mechanical properties and the ability of myotonometry to detect differences between sides, groups, and sites of testing in stroke patients. The results showed that measurements with the stretched muscle could help discriminate between spastic and nonspastic sides, but only at the biceps brachii. In addition, there was a significant increase in tone and stiffness in the chronic stroke group and in myotendinous sites compared with muscle belly sites.
ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION
(2022)
Review
Clinical Neurology
Stefano Tamburin, Mirko Filippetti, Elisa Mantovani, Nicola Smania, Alessandro Picelli
Summary: Spasticity is a common sequela of brain and spinal cord injury, impacting quality of life. Recent studies have proposed new definitions of spasticity, but further research is needed. Treatment-wise, cannabinoids are effective in multiple sclerosis spasticity, while botulinum neurotoxin injection is the first-line therapy for focal spasticity.
CURRENT OPINION IN NEUROLOGY
(2022)
Article
Clinical Neurology
Liang Jiang, Zhengfei Miao, Huiyou Chen, Wen Geng, Wei Yong, Yu-Chen Chen, Hong Zhang, Shaofeng Duan, Xindao Yin, Zhiqiang Zhang
Summary: This study aimed to construct a prognostic model for patients with acute ischemic stroke by using diffusion-weighted imaging radiomics. The CrrScore model, based on clinical and imaging features, accurately predicted unfavorable outcomes and could potentially guide rehabilitation therapies.
Article
Rehabilitation
Mirko Filippetti, Rita Di Censo, Valentina Varalta, Alessio Baricich, Andrea Santamato, Nicola Smania, Alessandro Picelli
Summary: This study found a correlation between spastic calf muscles echo intensity and the outcome of tibial nerve motor branches selective block in patients with spastic equinovarus foot. Patients with higher spastic calf muscles echo intensity had a poor response to the nerve block.
JOURNAL OF REHABILITATION MEDICINE
(2022)
Article
Rehabilitation
Han-Chin Hsieh, Ruei-Dan Liao, Tsung-Hsun Yang, Chau-Peng Leong, Hui-Hsin Tso, Jia-Ying Wu, Yu-Chi Huang
Summary: The combined administration of kinesio taping (KT) and modified constraint-induced movement therapy (mCIMT) shows significant improvement in upper extremity function and spasticity in hemiplegic patients with stroke, providing extra benefit in motor performance with a more long-lasting effect.
EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE
(2021)
Article
Clinical Neurology
John W. Fitterer, Alessandro Picelli, Paul Winston
Summary: HSP is a common pain disorder after stroke, but treatment pathway is complex and lacks evidence. A diagnostic algorithm and DNB can help differentiate causes of painful shoulder and assist in selecting a systematic treatment pathway.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Bin Jiang, Nancy K. Hills, Rob Forsyth, Lori C. Jordan, Mahmoud Slim, Steven G. Pavlakis, Neil Freidman, Nomazulu Dlamini, Osman Farooq, Ying Li, Guangming Zhu, Heather Fullerton, Max Wintermark, Warren D. Lo
Summary: In childhood arterial ischemic stroke patients, larger infarct volume and younger age at stroke onset are associated with poorer outcomes, but the strength of these relationships is weak. Specific infarct locations are significantly associated with poorer outcomes, but lose significance when adjusted for infarct volume.
Article
Computer Science, Artificial Intelligence
Rocio Urrutia, Ane Miren Gutierrez-Muto, Clara B. Sanz-Morere, Arantxa Gomez, Angela M. Politi, Francesca Lunardini, Marco Baccini, Francesca Cecchi, Natacha Leon, Antonio Oliviero, Jesus Tornero
Summary: The objective of this study was to verify the reliability and concurrent and discriminant validity of spasticity measurements offered by a robotic device. By comparing the measurements with the Modified Ashworth Scale and conducting tests on stroke patients and healthy volunteers, the study confirmed the reliability of the measurements and the ability to discriminate between different groups.
FRONTIERS IN NEUROROBOTICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiao-Quan Xu, Guang-Chen Shen, Gao Ma, Yue Chu, Shan-Shan Lu, Sheng Liu, Hai-Bin Shi, Fei-Yun Wu
Summary: Post-treatment FVH may be an effective prognostic marker associated with clinical outcome in patients with acute ischemic stroke after EVT.
EUROPEAN RADIOLOGY
(2022)
Article
Clinical Neurology
Isabelle Crassard, Karine Berthet, Philippa Lavallee, Marion Houot, Didier Payen, Jean-Claude Baron, Pierre Amarenco, Anne-Claire Lukaszewicz
Summary: This study analyzed the effects of LBPP on cerebral blood flow velocities in patients with recently symptomatic isolated carotid occlusion/tight stenosis. The results showed that LBPP significantly improved blood flow velocities in the affected and unaffected middle cerebral artery as well as the basilar artery.
INTERNATIONAL JOURNAL OF STROKE
(2022)
Article
Clinical Neurology
Jean-Claude Baron, Gregoire Boulouis, Joseph Benzakoun, Corentin Schwall, Catherine Oppenheim, Guillaume Turc, Pascale Varlet
Summary: Diagnosis of probable cerebral amyloid angiopathy (CAA) after lobar intra-cerebral hemorrhage (l-ICH) currently relies on MRI, with potential value of subarachnoid hemorrhage (SAH) and finger-like projections (FLP) on acute CT. In a cohort of patients who survived the initial event, SAH showed perfect sensitivity and better performance than FLP in diagnosing CAA, suggesting the importance of SAH as an additional marker. Further studies in larger samples are needed for validation.
JOURNAL OF NEUROLOGY
(2022)
Article
Behavioral Sciences
Lucile Dupin, Macarena Cuenca, Jean-Claude Baron, Marc A. Maier, Pavel G. Lindberg
Summary: This study examines spatial representations of the body and external objects and their relationship with age and sensorimotor practice. The findings suggest that age affects spatial hand representations but not spatial object representations, indicating partially shared characteristics between body and object representations.
Article
Radiology, Nuclear Medicine & Medical Imaging
Joseph Benzakoun, Marc-Antoine Deslys, Laurence Legrand, Ghazi Hmeydia, Guillaume Turc, Wagih Ben Hassen, Sylvain Charron, Clement Debacker, Olivier Naggara, Jean-Claude Baron, Bertrand Thirion, Catherine Oppenheim
Summary: Synthetic fluid-attenuated inversion recovery (FLAIR) exhibits diagnostic performances comparable to real FLAIR in assessing diffusion-weighted imaging-FLAIR mismatch and identifying patients with early acute ischemic stroke, thereby potentially accelerating MRI protocols.
Article
Rehabilitation
Maxime Teremetz, Alicia Garcia Alvarez, Sylvain Hanneton, Agnes Roby-Brami, Nicolas Roche, Djamel Bensmail, Pavei Lindberg, Johanna V. G. Robertson
Summary: This study compared the effects of upper limb rehabilitation using interactive gaming (Nintendo Wii) and conventional therapy on individuals with chronic stroke. The results showed that Wii therapy resulted in similar recovery of elbow extension and did not enhance compensatory trunk movement. However, more sessions may be needed for greater improvements.
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2022)
Article
Clinical Neurology
Jean-Claude Baron, Ulf Jensen-Kondering, Simona Sacco, Sacha Posener, Joseph Benzakoun, Johan Pallud, Catherine Oppenheim, Pascale Varlet, Guillaume Turc
Summary: Lobar hematomas are common and have high mortality and morbidity. Distinguishing between hypertensive arteriolopathy (HA) and cerebral amyloid angiopathy (CAA) is important. Current diagnostic criteria for probable CAA have limitations, and new imaging biomarkers are proposed to improve diagnosis. Testing clinical-radiological biomarkers for positive diagnosis of HA in lobar hematomas is also suggested.
JOURNAL OF NEUROLOGY
(2023)
Correction
Clinical Neurology
Jean-Claude Baron, Ulf Jensen-Kondering, Simona Sacco, Sacha Posener, Joseph Benzakoun, Johan Pallud, Catherine Oppenheim, Pascale Varlet, Guillaume Turc
JOURNAL OF NEUROLOGY
(2023)
Editorial Material
Clinical Neurology
Jean-Claude Baron
Review
Clinical Neurology
Sacha Posener, Ghazi Hmeydia, Joseph Benzakoun, Catherine Oppenheim, Jean-Claude Baron, Guillaume Turc
Summary: This systematic review and meta-analysis examined the prevalence, associated factors, and presumed causes of remote diffusion-weighted imaging lesions (RDWILs) in patients with spontaneous intracerebral hemorrhage (ICH). The results showed that RDWILs were detected in approximately 25% of acute ICH patients and were associated with neuroimaging features of microangiopathy, atrial fibrillation, clinical severity, elevated blood pressure, ICH volume, and the presence of subarachnoid or intraventricular hemorrhage. RDWILs were also associated with poor functional outcome at 3 months. Further studies are needed to investigate the impact of specific ICH treatment strategies on reducing RDWILs and improving outcomes.
Review
Endocrinology & Metabolism
Adrien ter Schiphorst, Guillaume Turc, Wagih Ben Hassen, Catherine Oppenheim, Jean-Claude Baron
Summary: The reported incidence of impaired microvascular reperfusion (IMR) after complete recanalization varies widely, possibly due to differences in definitions, operational definitions, and consideration of alternative causes. Based on a systematic review, IMR after true complete recanalization appears relatively rare, and reported incidence depends on the definitions used and consideration of confounding factors.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Engineering, Biomedical
Maxime Teremetz, Sonia Hamdoun, Florence Colle, Eloise Gerardin, Claire Desvilles, Loic Carment, Sylvain Charron, Macarena Cuenca, David Calvet, Jean-Claude Baron, Guillaume Turc, Marc A. Maier, Charlotte Rosso, Jean-Louis Mas, Pavel G. Lindberg
Summary: The efficacy of Dextrain Manipulandum training in post-stroke rehabilitation was compared to conventional therapy. Although there was no significant difference in gross dexterity improvement between the two treatments in the short term, Dextrain Manipulandum training enhanced recovery of multiple dexterity components and reported hand-use.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2023)
Article
Psychiatry
Quentin Le Boterff, Ayah Rabah, Loic Carment, Narjes Bendjemaa, Maxime Teremetz, Anaelle Alouit, Agnes Levy, Guillaume Tanguy, Valentine Morin, Isabelle Amado, Macarena Cuenca, Guillaume Turc, Marc A. A. Maier, Marie-Odile Krebs, Pavel G. Lindberg
Summary: This study found that first-episode psychosis (FEP) patients have impairments in manual dexterity, with slower reaction times, higher errors, and higher variability in tablet-based tasks. These findings suggest that tablet-based measures of dexterity could be promising markers for detection of FEP in clinical practice.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Rehabilitation
Gaia Valentina Pennati, Loic Carment, Alison K. Godbolt, Jeanette Plantin, Jorgen Borg, Pavel G. Lindberg
Summary: The study aimed to validate the NeuroFlexor foot module and assess its intra-rater reliability, as well as establish normative cut-off values. Patients with chronic stroke and healthy subjects were examined using the NeuroFlexor at controlled velocities. Results showed that the neural component was higher in stroke patients, increased with stretch velocity, and correlated with electromyography amplitude. Cut-off values were established based on data from healthy subjects. Overall, the NeuroFlexor may provide a feasible and non-invasive method for quantifying lower limb spasticity.
JOURNAL OF REHABILITATION MEDICINE
(2023)
Article
Clinical Neurology
Jeanette Plantin, Alison K. Godbolt, Gaia Pennati, Evaldas Laurencikas, Peter Fransson, Jean Claude Baron, Marc A. Maier, Jorgen Borg, Pavel G. Lindberg
Summary: Plantin et al. found that grip force release, early after stroke, explains variance of dexterous hand use recovery not explained by conventional motor measures. Prolonged force release was related to corticospinal, somatosensory and fronto-striatal tract lesion. Thus, motor inhibition (subserving release) is essential for post-stroke recovery of dexterous hand use.
BRAIN COMMUNICATIONS
(2022)