In situ Vaccination by Direct Dendritic Cell Inoculation: The Coming of Age of an Old Idea?

Phase 1 Trial With the Cell-Based Immune Primer Ilixadencel, Alone, and Combined With Sorafenib, in Advanced Hepatocellular Carcinoma

(2019) Magnus Rizell et al.   Frontiers in Oncology

Unleashing Type-2 Dendritic Cells to Drive Protective Antitumor CD4+ T Cell Immunity

(2019) Mikhail Binnewies et al.   CELL

Intratumoral Activity of the CXCR3 Chemokine System Is Required for the Efficacy of Anti-PD-1 Therapy

(2019) Melvyn T. Chow et al.   IMMUNITY

Systemic clinical tumor regressions and potentiation of PD1 blockade with in situ vaccination

(2019) Linda Hammerich et al.   NATURE MEDICINE

Clinical and Antitumor Immune Responses in Relapsed/Refractory Follicular Lymphoma Patients after Intranodal Injections of IFNα-Dendritic Cells and Rituximab

(2019) M. Christina Cox et al.   CLINICAL CANCER RESEARCH

Targeted APC Activation in Cancer Immunotherapy to Enhance the Abscopal Effect

(2019) Nathan Suek et al.   Frontiers in Immunology

NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control

(2018) Jan P. Böttcher et al.   CELL

Cytokines Produced by Dendritic Cells Administered Intratumorally Correlate with Clinical Outcome in Patients with Diverse Cancers

(2018) Vivek Subbiah et al.   CLINICAL CANCER RESEARCH

First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma

(2018) Linda M. Liau et al.   Journal of Translational Medicine

Understanding the tumor immune microenvironment (TIME) for effective therapy

(2018) Mikhail Binnewies et al.   NATURE MEDICINE

A natural killer–dendritic cell axis defines checkpoint therapy–responsive tumor microenvironments

(2018) Kevin C. Barry et al.   NATURE MEDICINE

Personalized cancer vaccine effectively mobilizes antitumor T cell immunity in ovarian cancer

(2018) Janos L. Tanyi et al.   Science Translational Medicine

Monocyte-Derived Dendritic Cells Differentiated in the Presence of Lenalidomide Display a Semi-Mature Phenotype, Enhanced Phagocytic Capacity, and Th1 Polarization Capability

(2018) Juan López-Relaño et al.   Frontiers in Immunology

In Situ Vaccination with a TLR9 Agonist and Local Low-Dose Radiation Induces Systemic Responses in Untreated Indolent Lymphoma

(2018) Matthew J. Frank et al.   Cancer Discovery

Intratumoral Immunotherapy with XCL1 and sFlt3L Encoded in Recombinant Semliki Forest Virus–Derived Vectors Fosters Dendritic Cell–Mediated T-cell Cross-Priming

(2018) Alfonso R. Sánchez-Paulete et al.   CANCER RESEARCH

In vivo cancer vaccination: Which dendritic cells to target and how?

(2018) Cheryl Lai-Lai Chiang et al.   CANCER TREATMENT REVIEWS

Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12

(2018) Christopher S. Garris et al.   IMMUNITY

Tumor Mutational Burden and Response Rate to PD-1 Inhibition

(2017) Mark Yarchoan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy

(2017) Diego Chowell et al.   SCIENCE

Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors

(2017) Alexandra-Chloé Villani et al.   SCIENCE

Integrating Next-Generation Dendritic Cell Vaccines into the Current Cancer Immunotherapy Landscape

(2017) Abhishek D. Garg et al.   TRENDS IN IMMUNOLOGY

Trial watch: Dendritic cell-based anticancer immunotherapy

(2017) Abhishek D. Garg et al.   OncoImmunology

Intratumorally injected pro-inflammatory allogeneic dendritic cells as immune enhancers: a first-in-human study in unfavourable risk patients with metastatic renal cell carcinoma

(2017) Anna Laurell et al.   Journal for ImmunoTherapy of Cancer

Tumor-derived factors modulating dendritic cell function

(2016) Jinbao Zong et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Anti-EGFR Targeted Monoclonal Antibody Isotype Influences Antitumor Cellular Immunity in Head and Neck Cancer Patients

(2016) S. Trivedi et al.   CLINICAL CANCER RESEARCH

Expansion and Activation of CD103 + Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition

(2016) Hélène Salmon et al.   IMMUNITY

NK Cell Activation in the Antitumor Response Induced by IFN-α Dendritic Cells Loaded with Apoptotic Cells from Follicular Lymphoma Patients

(2016) Caterina Lapenta et al.   JOURNAL OF IMMUNOLOGY

Intratumoral Delivery of Immunotherapy—Act Locally, Think Globally

(2016) M. Angela Aznar et al.   JOURNAL OF IMMUNOLOGY

Predictive biomarkers for checkpoint inhibitor-based immunotherapy

(2016) Geoffrey T Gibney et al.   LANCET ONCOLOGY

Intratumoral injection of IFN-alpha dendritic cells after dacarbazine activates anti-tumor immunity: results from a phase I trial in advanced melanoma

(2015) Carmela Rozera et al.   Journal of Translational Medicine

In situ vaccination: Cancer immunotherapy both personalized and off-the-shelf

(2015) Linda Hammerich et al.   Molecular Oncology

Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy

(2015) A. Sivan et al.   SCIENCE

Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota

(2015) M. Vetizou et al.   SCIENCE

A dendritic cell vaccine increases the breadth and diversity of melanoma neoantigen-specific T cells

(2015) B. M. Carreno et al.   SCIENCE

Sequential intranodal immunotherapy induces antitumor immunity and correlated regression of disseminated follicular lymphoma

(2014) Arne Kolstad et al.   BLOOD

Natural Killer Cells: The Secret Weapon in Dendritic Cell Vaccination Strategies

(2014) Catharina H.M.J. Van Elssen et al.   CLINICAL CANCER RESEARCH

Clinical use of dendritic cells for cancer therapy

(2014) Sébastien Anguille et al.   LANCET ONCOLOGY

PD-1 blockade induces responses by inhibiting adaptive immune resistance

(2014) Paul C. Tumeh et al.   NATURE

Cetuximab-Activated Natural Killer and Dendritic Cells Collaborate to Trigger Tumor Antigen-Specific T-cell Immunity in Head and Neck Cancer Patients

(2013) R. M. Srivastava et al.   CLINICAL CANCER RESEARCH

Tumoricidal activity of human dendritic cells

(2013) Jurjen Tel et al.   TRENDS IN IMMUNOLOGY

Dendritic Cells in Cancer Immunotherapy Clinical Trials: Are We Making Progress?

(2013) Lisa H. Butterfield   Frontiers in Immunology

Immunogenic cell death in radiation therapy

(2013) Lorenzo Galluzzi et al.   OncoImmunology

Therapeutic effect of intratumoral administration of DCs with conditional expression of combination of different cytokines

(2012) Chun Huang et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Serial assessment of lymphocytes and apoptosis in the prostate during coordinated intraprostatic dendritic cell injection and radiotherapy

(2012) Steven Eric Finkelstein et al.   Immunotherapy

Clinical Trial of the Intratumoral Administration of Labeled DC Combined With Systemic Chemotherapy for Esophageal Cancer

(2012) Shinichi Fujiwara et al.   JOURNAL OF IMMUNOTHERAPY

IFN-  enhances cross-presentation in human dendritic cells by modulating antigen survival, endocytic routing, and processing

(2011) F. Spadaro et al.   BLOOD

In situ vaccination against mycosis fungoides by intratumoral injection of a TLR9 agonist combined with radiation: a phase 1/2 study

(2011) Y. H. Kim et al.   BLOOD

Regulatory dendritic cells in the tumor immunoenvironment

(2011) Galina V. Shurin et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Monocyte-derived DC maturation strategies and related pathways: a transcriptional view

(2011) Luciano Castiello et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Combination of External Beam Radiotherapy (EBRT) With Intratumoral Injection of Dendritic Cells as Neo-Adjuvant Treatment of High-Risk Soft Tissue Sarcoma Patients

(2011) Steven E. Finkelstein et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Phase I trial of preoperative intratumoral injection of immature dendritic cells and OK-432 for resectable pancreatic cancer patients

(2011) Hisahito Endo et al.   Journal of Hepato-Biliary-Pancreatic Sciences

A Novel Dendritic Cell-based Immunization Approach for the Induction of Durable Th1-polarized Anti-HER-2/neu Responses in Women With Early Breast Cancer

(2011) Gary K. Koski et al.   JOURNAL OF IMMUNOTHERAPY

Interferon-α-Conditioned Human Monocytes Combine a Th1-Orienting Attitude with the Induction of Autologous Th17 Responses: Role of IL-23 and IL-12

(2011) Stefano M. Santini et al.   PLoS One

Induction of complete and molecular remissions in acute myeloid leukemia by Wilms' tumor 1 antigen-targeted dendritic cell vaccination

(2010) V. F. Van Tendeloo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dendritic cell-based therapeutic cancer vaccines: what we have and what we need

(2009) Pawel Kalinski et al.   Future Oncology

Dendritic Cell Maturation With Poly(I:C)-based Versus PGE2-based Cytokine Combinations Results in Differential Functional Characteristics Relevant to Clinical Application

(2009) Ines Möller et al.   JOURNAL OF IMMUNOTHERAPY

Immunotransplantation preferentially expands T-effector cells over T-regulatory cells and cures large lymphoma tumors

(2008) J. D. Brody et al.   BLOOD

Plasmacytoid dendritic cells induce NK cell–dependent, tumor antigen–specific T cell cross-priming and tumor regression in mice

(2008) Chengwen Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanisms Involved in Radiation Enhancement of Intratumoral Dendritic Cell Therapy

(2008) Seagal Teitz-Tennenbaum et al.   JOURNAL OF IMMUNOTHERAPY