Article
Immunology
Ella Bhagyaraj, Hongbin Wang, Xinghong Yang, Carol Hoffman, Ali Akgul, Zakia Goodwin, David W. Pascual
Summary: znBAZ infection induces an increase and activation of lung NK cells in mice, which play a crucial role in promoting lung DC activation, migration, and the development of protective CD8(+) T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
David M. Schauder, Jian Shen, Yao Chen, Moujtaba Y. Kasmani, Matthew R. Kudek, Robert Burns, Weiguo Cui
Summary: During acute viral infections, CD8 T cells encounter various antigenic and inflammatory signals, leading to differentiation into memory cells or death. Research has shown that memory precursor effector cells maintain open enhancers for key memory genes, with a high enrichment of E2A binding sites. E2A directly regulates the accessibility of enhancers for memory-related genes, increasing the frequency of memory precursor effector cells and accelerating memory cell formation while reducing short-lived effector cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Huilei Zhang, Shuangqing Liu, Yanan Li, Jianru Li, Chen Ni, Ming Yang, Jun Dong, Zhaoqing Wang, Zhihai Qin
Summary: The study reveals that S100A4 drives dysfunction in CD8(+) T-EM cells, leading to the loss of their protective memory response and promoting asthma worsening. CD8(+) T-EM cells can be divided into dysfunctional subsets and subsets inclined towards apoptosis based on the expression of S100A4. S100A4 affects mitochondrial metabolism, leading to a decrease in acetyl-CoA levels, which impairs the transcription of effector genes (especially IFN-γ), facilitating cell survival, tolerance, and memory potential.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Oncology
Snehanshu Chowdhury, Anwesha Kar, Debaleena Bhowmik, Anupam Gautam, Debashree Basak, Ishita Sarkar, Puspendu Ghosh, Deborpita Sarkar, Alvina Deka, Paramita Chakraborty, Asima Mukhopadhyay, Shikhar Mehrotra, Soumen Basak, Sandip Paul, Shilpak Chatterjee
Summary: IL-12 stimulation increases intracellular acetyl CoA levels in CD8(+) T cells, allowing them to maintain effector function in nutrient-deprived tumor microenvironments. Inhibition of ATP-citrate lyase, an enzyme involved in the glucose-citrate-acetyl CoA pathway, impairs IFN gamma production and viability of CD8(+) T cells in nutrient-restricted conditions. CD8(+) T cells cultured in high pyruvate-containing media acquire metabolic features of IL-12-stimulated CD8(+) T cells and display improved antitumor potential.
Article
Oncology
Hemavathi Dhandapani, Hascitha Jayakumar, Abirami Seetharaman, Shirley Sunder Singh, Selvaluxmy Ganeshrajah, Nirmala Jagadish, Anil Suri, Rajkumar Thangarajan, Priya Ramanathan
Summary: Dendritic cell-based immunotherapy utilizing recombinant human SPAG9 shows promise in stimulating CD4(+) and CD8(+) T cell responses for cervical cancer patients. The study suggests rhSPAG9 as a strong immunogen for DC-based immunotherapy and highlights the potential of a combinatorial regimen with cisplatin for therapeutic intervention.
CANCER CELL INTERNATIONAL
(2021)
Article
Cardiac & Cardiovascular Systems
Janine van Duijn, Maaike J. M. de Jong, Naomi Benne, Romain J. T. Leboux, Marieke E. van Ooijen, Nicky Kruit, Amanda C. Foks, Wim Jiskoot, Ilze Bot, Johan Kuiper, Bram Slutter
Summary: In an atherosclerotic mouse model, a lesion-localized increase in Tc17 cells was found. Tc17 cells appeared to be non-atherogenic compared to their Tc0 counterparts.
CARDIOVASCULAR RESEARCH
(2021)
Article
Immunology
Lang Jiang, Lu Liu, Miaomiao Zhang, Linxia Zhang, Cuisong Zhu, Qian He, Lilin Ye, Chen Zhao, Zejun Li, Jianqing Xu, Xiaoyan Zhang
Summary: Research has shown that CD8+ lung tissue resident memory T (T-RM) cells play a crucial role in protecting against respiratory viruses. By studying mouse infection models, it was found that lung CD8+ T-RM cells can quickly respond to antigen re-exposure and induce interferon-stimulated genes (ISGs) in the surrounding tissues. The study also revealed that the induction of certain important antiviral ISGs and the suppression of key inflammatory cytokines are dependent on IFN-gamma signaling.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Health Care Sciences & Services
Deni Ramljak, Martina Vukoja, Marina Curlin, Katarina Vukojevic, Maja Barbaric, Una Glamoclija, Bejana Purisevic, Olivera Peric, Violeta Soljic
Summary: The study suggests that CD8+ T cells with higher perforin-1 and lower Fas ligand expression in the early stages of COVID-19 infection may be associated with progression to moderate and severe forms of the disease later on. Additionally, the frequency of effector memory CD8+ T cells was lower in all COVID-19 patients, and the mRNA expression of perforin-1 and interferon-gamma were significantly downregulated.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Cell Biology
Qi Li, Simeng Wei, Yue Li, Fengjiao Wu, Xiaoling Qin, Zhongsha Li, Jingyu Li, Chang Chen
Summary: Blocking of PD-L1 promotes CD8+IFN-gamma+ T cell-mediated immune responses, exacerbating inflammation and increasing the burden of atherosclerosis under high-cholesterol diet. However, further studies are needed to explore whether PD-L1 activation could be a novel immunotherapy strategy for atherosclerosis.
INFLAMMATION RESEARCH
(2023)
Editorial Material
Immunology
Tiani L. Louis, John T. Chang
Summary: In this study, Hirai et al. demonstrate the competition for the cytokine TGF beta as a key factor in regulating the persistence and occupancy of CD8(+) tissue-resident memory T cells in the skin epidermal niche.
Article
Cell Biology
Hans-Joachim Paust, Ning Song, Donatella De Feo, Nariaki Asada, Selma Tuzlak, Yu Zhao, Jan-Hendrik Riedel, Malte Hellmig, Amirrtavarshni Sivayoganathan, Anett Peters, Anna Kaffke, Alina Borchers, Ulrich O. Wenzel, Oliver M. Steinmetz, Gisa Tiegs, Elisabeth Meister, Matthias Mack, Christian Kurts, Sibylle von Vietinghoff, Maja T. Lindenmeyer, Elion Hoxha, Rolf A. K. Stahl, Tobias B. Huber, Stefan Bonn, Catherine Meyer-Schwesinger, Thorsten Wiech, Jan-Eric Turner, Burkhard Becher, Christian F. Krebs, Ulf Panzer
Summary: Glomerulonephritis is an immune-mediated disease that causes kidney inflammation and is a major cause of end-stage renal disease. T cells play a significant role in the development of glomerulonephritis, but the specific mechanisms are not well understood. This study identifies GM-CSF-producing T cells as key players in the pathogenesis of glomerulonephritis and shows that targeting GM-CSF or MMP12 can reduce disease severity in mouse models. These findings provide a potential therapeutic target for glomerulonephritis.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Dermatology
Pawit Phadungsaksawasdi, Toshiharu Fujiyama, Kazuo Kurihara, Taisuke Ito, Tetsuya Honda, Yoshiki Tokura
Summary: In human psoriasis, PD-1 expressing CD8(+) CD103(+) T cells in the skin are associated with disease severity and histopathology, indicating a potential pathogenic subset that may play a role in psoriasis pathogenesis.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Oncology
Katarina Kolostova, Eliska Pospisilova, Rafal Matkowski, Jolanta Szelachowska, Vladimir Bobek
Summary: By using the CliniMACS Prodigy (R) machine and CTC lysates, we successfully generated Mo-DCs and demonstrated their potential to activate NTBC in co-cultures.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Immunology
Yana Hackler, Frank Siebenhaar, Marcus Maurer, Melba Munoz
Summary: This study found that mast cells can directly activate virus-specific CD8(+) T cells and promote their antiviral response during viral infections. Mast cells cluster with virus-specific CD8(+) T cells and induce their activation and production of antiviral cytokines through direct cellular interaction. This finding contributes to a better understanding of the antiviral functions of mast cells and may provide new strategies for treating viral infections.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Choong-Hyun Koh, Suyoung Lee, Minkyeong Kwak, Byung-Seok Kim, Yeonseok Chung
Summary: CD8 T cells play crucial roles in immune defense, and emerging evidence suggests the existence of distinct subsets with unique functions and therapeutic potential. Understanding these subsets is important for understanding immune responses in different diseases, and developing immunotherapeutic approaches targeting specific CD8 T-cell subsets holds great promise.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Oncology
Choong-Hyun Koh, Il-Kyu Kim, Kwang-Soo Shin, Insu Jeon, Boyeong Song, Jeong-Mi Lee, Eun-Ah Bae, Hyungseok Seo, Tae-Seung Kang, Byung-Seok Kim, Yeonseok Chung, Chang-Yuil Kang
CANCER IMMUNOLOGY RESEARCH
(2020)
Article
Oncology
Jason R. Pitarresi, Robert J. Norgard, Anna M. Chiarella, Kensuke Suzuki, Basil Bakir, Varun Sahu, Jinyang Li, Jun Zhao, Benoit Marchand, Maximilian D. Wengyn, Antony Hsieh, Il-Kyu Kim, Amy Zhang, Karine Sellin, Vivian Lee, Shigetsugu Takano, Yoji Miyahara, Masayuki Ohtsuka, Anirban Maitra, Faiyaz Notta, Richard Kremer, Ben Z. Stanger, Anil K. Rustgi
Summary: The amplification of PTHrP in pancreatic cancer is related to tumor growth and metastasis, and its loss can significantly reduce tumor burden, eliminate metastasis, and enhance overall survival. Targeting PTHrP activity may be a novel therapeutic approach for treating pancreatic cancer.
Article
Immunology
Wonki Kim, Jeong-Hoon Jang, Xiancai Zhong, Hyungseok Seo, Young-Joon Surh
Summary: 15d-PGJ(2) promotes the resolution of intestinal colitis by reducing neutrophils and M1 macrophages, increasing M2 macrophage proportion, and decreasing the expression of pro-inflammatory cytokine IL-6 in macrophages.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Robert J. Norgard, Jason R. Pitarresi, Ravikanth Maddipati, Nicole M. Aiello-Couzo, David Balli, Jinyang Li, Taiji Yamazoe, Maximilian D. Wengyn, Ian D. Millstein, Ian W. Folkert, Derick N. Rosario-Berrios, Il-Kyu Kim, Jared B. Bassett, Riley Payne, Corbett T. Berry, Xiaodong Feng, Kathryn Sun, Michele Cioffi, Priyanka Chakraborty, Mohit Kumar Jolly, J. Silvio Gutkind, David Lyden, Bruce D. Freedman, J. Kevin Foskett, Anil K. Rustgi, Ben Z. Stanger
Summary: Epithelial-mesenchymal transition (EMT) is a form of cellular plasticity that gives tumor cells invasiveness and alters their sensitivity to drugs, posing a challenge to cancer therapy. Carcinoma cells in a partial EMT state have higher metastatic capacity than those in extreme states. Prolonged calcium signaling induces a partial EMT characterized by the internalization of membrane-associated E-cadherin and increased migration and invasion abilities.
Article
Immunology
Hyungseok Seo, Edahi Gonzalez-Avalos, Wade Zhang, Payal Ramchandani, Chao Yang, Chan-Wang J. Lio, Anjana Rao, Patrick G. Hogan
Summary: BATF and IRF4 cooperate to counter T cell exhaustion in mouse tumor models, promoting better tumor control by CAR T cells.
Article
Immunology
Jennifer L. Hope, Manzhi Zhao, Christopher J. Stairiker, Caoimhe H. Kiernan, Alison J. Carey, Yvonne M. Mueller, Marjan van Meurs, Inge Brouwers-Haspels, Dennis C. Otero, Eun-Ah Bae, Hannah A. Faso, Alex Maas, Hans de Looper, Paolo M. Fortina, Isidore Rigoutsos, Linda M. Bradley, Stefan J. Erkeland, Peter D. Katsikis
Summary: This study characterized the expression profile of miRNAs in antiviral CD8(+) T cells and found that miR-139 was highly downregulated in effector CTLs. However, the deficiency or overexpression of miR-139 did not affect the development and response of immune cells.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Jae-Won Cho, Seyeon Park, Gamin Kim, Heonjong Han, Hyo Sup Shim, Sunhye Shin, Yong-Soo Bae, Seong Yong Park, Sang-Jun Ha, Insuk Lee, Hye Ryun Kim
Summary: This study found that B cells, CXCL13-producing follicular helper CD4(+) T (T-FH)-like cells, and tissue-resident memory CD8(+) T (T-RM)-like cells decreased in EGFR mutant tumors. The proportion of T-RM-like cells is predictive for anti-PD-1 response in NSCLC.
NATURE COMMUNICATIONS
(2021)
Article
Oncology
Zhen Lu, Eun-Ah Bae, Ioannis I. Verginadis, Hongru Zhang, Christina Cho, Noreen McBrearty, Subin S. George, J. Alan Diehl, Constantinos Koumenis, Linda M. Bradley, Serge Y. Fuchs
Summary: The immune suppressive factors in the tumor microenvironment can weaken the viability and activities of CD8 + T cells, and activating transcription factor-4 (ATF4) plays an important role in maintaining the survival and activities of CD8 + T cells in the tumor microenvironment.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Oncology
Samantha B. Kemp, Noah Cheng, Nune Markosyan, Rina Sor, Il-Kyu Kim, Jill Hallin, Jason Shoush, Liz Quinones, Natalie V. Brown, Jared B. Bassett, Nikhil Joshi, Salina Yuan, Molly Smith, William P. Vostrejs, Kia Z. Perez-Vale, Benjamin Kahn, Feiyan Mo, Timothy R. Donahue, Caius G. Radu, Cynthia Clendenin, James G. Christensen, Robert H. Vanderheide, Ben Z. Stanger
Summary: This study evaluated the efficacy of a small-molecule KRASG12D inhibitor, MRTX1133, in PDAC models with an intact immune system. The results showed that MRTX1133 can induce deep tumor regressions and alter the tumor microenvironment, demonstrating its potential as a novel therapy for PDAC patients. Further clinical testing is warranted.
Article
Cell Biology
Jennifer L. Hope, Dennis C. Otero, Eun-Ah Bae, Christopher J. Stairiker, Ashley B. Palete, Hannah A. Faso, Michelle Lin, Monique L. Henriquez, Sreeja Roy, Hyungseok Seo, Xue Lei, Eric S. Wang, Savio Chow, Roberto Tinoco, Gregory A. Daniels, Kevin Yip, Alexandre Rosa Campos, Jun Yin, Peter D. Adams, Anjana Rao, Linda M. Bradley
Summary: PSGL-1 is a T cell-intrinsic checkpoint regulator that acts upstream of PD-1 and requires co-ligation with the TCR to attenuate T cell activation and drive terminal T cell exhaustion. PSGL-1 directly restrains TCR signaling via Zap70 and maintains expression of the Zap70 inhibitor Sts-1. Deficiency of PSGL-1 empowers CD8+ T cells to respond to low-affinity TCR ligands and inhibit the growth of PD-1-blockade-resistant melanoma.
Article
Immunology
Hoyoung Lee, Min Kyung Jung, Ji Yun Noh, Su-Hyung Park, Yeonseok Chung, Sang-Jun Ha, Eui-Cheol Shin
Summary: The first conference on 'Infection and Immunity' focused on the biology of CD8+ T cells in the context of viral disease and cancer.
Meeting Abstract
Immunology
Hyungseok Seo, Edahi Gonzales-Avalos, Wade Zhang, Chan Lio, Anjana Rao, Patrick Hogan
JOURNAL OF IMMUNOLOGY
(2021)
Article
Oncology
Jinyang Li, Salina Yuan, Robert J. Norgard, Fangxue Yan, Yu H. Sun, Il-Kyu Kim, Allyson J. Merrell, Yogev Sela, Yanqing Jiang, Natarajan Bhanu, Benjamin A. Garcia, Robert H. Vonderheide, Andres Blanco, Ben Z. Stanger
Summary: This study identifies lysine demethylase 3A (KDM3A) as an epigenetic regulator that affects the response to immunotherapy in pancreatic ductal adenocarcinoma by modulating the expression of epidermal growth factor receptor (EGFR) through Krueppel-like factor 5 (KLF5) and SMAD family member 4 (SMAD4). Inhibition of EGFR can reshape the immune microenvironment, offering a potential immunotherapy-sensitizing strategy for PDA.
