Journal
BIOPHYSICAL JOURNAL
Volume 108, Issue 9, Pages 2097-2102Publisher
CELL PRESS
DOI: 10.1016/j.bpj.2015.03.051
Keywords
-
Categories
Funding
- Swiss National Science Foundation
- National Institutes of Health [P41-GM103311]
- California Institute for Quantitative Biosciences
- UCSF School of Pharmacy, Mary Anne Koda-Kimble Seed Award for Innovation
Ask authors/readers for more resources
Homology modeling predicts protein structures using known structures of related proteins as templates. We developed MULTIDOMAIN ASSEMBLER (MDA) to address the special problems that arise when modeling proteins with large numbers of domains, such as fibronectin with 30 domains, as well as cases with hundreds of templates. These problems include how to spatially arrange nonoverlapping template structures, and how to get the best template coverage when some sequence regions have hundreds of available structures while other regions have a few distant homologs. MDA automates the tasks of template searching, visualization, and selection followed by multidomain model generation, and is part of the widely used molecular graphics package UCSF CHIMERA (University of California, San Francisco). We demonstrate applications and discuss MDA's benefits and limitations.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available