Journal
JOURNAL OF THORACIC DISEASE
Volume 11, Issue 9, Pages 3887-+Publisher
AME PUBL CO
DOI: 10.21037/jtd.2019.09.11
Keywords
Acute type A aortic dissection (TAAD); in-hospital mortality; APACHE II score; peri-operative risk factor
Categories
Funding
- Natural Science Foundation of Guangdong Province, China [2016A030313763]
- Guangzhou Science, Technology and Innovation Commission [201707010322]
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Background: Acute type A aortic dissection (TAAD) is cardiovascular emergency and requires surgical interventions. In-hospital mortality rate of surgical-treated TAAD patients remains high. We aim to examine the prognostic implications of peri-operative parameters to identify high-risk patient for in-hospital mortality. Methods: A total of 264 surgically treated TAAD patients were included in this study. The association between in-hospital mortality and peri-operative parameters were examined. Results: Thirty patients (11.36%) died during hospitalization. Patients with higher Apache II score had a significantly higher rate of in-hospital mortality when compared with patients scored <= 20 in unadjusted model [Score 21-25: HR =12.9 (1.7-100.8), P=0.0148; Score >25: HR =94.5 (12.6-707.6), P<0.0001]. Patients with Sbp >120 mmHg, Cr >200 mmol/L (both at admission and after surgery), BUN >8.2 mmol/L (both at admission and after surgery), AST >80 mu/L, aortic cross-clamping time >120 min and cardiopulmonary bypass time (CPBT) >230 min were also significantly related to higher rate of in-hospital mortality in univariate analysis. In multivariable analysis, APACHE II score [Score 21-25: HR =9.5 (1.2-74.4), P=0.032; Score >25: HR =51.0 (6.7-387.7), P=0.0001], AST >80 mu mol/L [HR =2.3 (1.1-4.8), P=0.0251], aortic cross-clamping time >120 min (HR =2.9 (1.1-7.7), P=0.0315) remained significant in predicting TAD in-hospital mortality. Conclusions: APACHE II score could be a useful tool to predict TAAD in-hospital mortality. AST >80 mu/L and aortic cross-clamping time >120 min were also independent predictors.
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