Article
Parasitology
Dominique Mieguim Ngninpogni, Cyrille Ndo, Patrick Ntonga Akono, Anicet Nguemo, Amine Nguepi, Danale Rosine Metitsi, Jeannette Tombi, Parfait Awono-Ambene, Charles Felix Bilong Bilong
Summary: High Plasmodium infection in Anopheles vectors, insufficient LLIN coverage and loss of effectiveness due to physical degradation, as well as high resistance to pyrethroid insecticides, are responsible for the persistence of high malaria transmission in the forested rural area of Mvoua, Cameroon.
PARASITES & VECTORS
(2021)
Article
Parasitology
Achille Jerome Binyang, Emmanuel Elanga-Ndille, Billy Tene-Fossog, Cyrille Ndo, Lynda Nouage, Tatiane Assatse, Yvan Fotso-Toguem, Raymond Tabue, Francis Zeukeng, Daniel Nguete Nguiffo, Josiane Etang, Flobert Njiokou, Charles S. Wondji
Summary: This study assessed the resistance of major malaria vectors in Cameroon to carbamates and organophosphates, and found resistance in some areas. The study also identified the presence of the Ace-1 target-site G119S mutation in An. gambiae populations, potentially impacting the effectiveness of IRS using these insecticides.
PARASITES & VECTORS
(2022)
Article
Entomology
Salomon Efa, Emmanuel Elanga-Ndille, Yacouba Poumachu, Billy Tene, Jacqueline Ze Mikande, Njoumemi Zakariaou, Charles S. Wondji, Cyrille Ndo
Summary: Monitoring insecticide resistance in major malaria vectors like Anopheles gambiae s.l. is crucial for designing effective vector control strategies and preventing the spread of resistance. This study in Ebolowa, Southern Cameroon, revealed high resistance to pyrethroid insecticides in Anopheles coluzzii, posing a risk to the efficacy of Long-Lasting Insecticidal Nets (LLINs) used for malaria control. Urgent implementation of resistance management strategies is needed to maintain the effectiveness of insecticide-based interventions.
Article
Parasitology
Emilie S. Ngongang-Yipmo, Magellan Tchouakui, Benjamin D. Menze, Leon M. J. Mugenzi, Flobert Njiokou, Charles S. Wondji
Summary: This study investigated the efficacy of different brands of LLINs against pyrethroid-resistant mosquitoes and their post-exposure effect. The results showed that standard bednets had reduced efficacy against resistant mosquitoes in the field, but still induced delayed mortality in exposed populations. The study also highlighted the importance of using new-generation nets that do not solely rely on pyrethroids.
PARASITES & VECTORS
(2022)
Article
Parasitology
Rosine Z. Wolie, Alphonsine A. Koffi, Ludovic P. Ahoua Alou, Eleanore D. Sternberg, Oulo N'Nan-Alla, Amal Dahounto, Florent H. A. Yapo, Kpahe M. H. Kanh, Soromane Camara, Welbeck A. Oumbouke, Innocent Z. Tia, Simon-Pierre A. Nguetta, Matthew B. Thomas, Raphael NGuessan
Summary: The insecticide target site mutations of Kdr L1014F and Ace-1(R) G119S showed no significant association with Plasmodium infection in wild Anopheles gambiae and Anopheles coluzzii, indicating similar competence of these species in transmitting Plasmodium in Bouake. Other factors such as behavioral and environmental influences should be considered in understanding vector competence.
PARASITES & VECTORS
(2021)
Article
Infectious Diseases
Magellan Tchouakui, Riccado F. Thiomela, Elysee Nchoutpouen, Benjamin D. Menze, Cyrille Ndo, Dorothy Achu, Raymond N. Tabue, Flobert Njiokou, Ateba Joel, Charles S. Wondji
Summary: The study found that compared to pyrethroid-only nets, the PBO-pyrethroid-chlorfenapyr and dual active ingredients nets were more effective against pyrethroid-resistant malaria vectors. Therefore, these new nets can be used for malaria control in Cameroon, but their effectiveness needs to be validated in other locations and on other major malaria vectors.
INFECTIOUS DISEASES OF POVERTY
(2023)
Review
Microbiology
Oswald Y. Djihinto, Adande A. Medjigbodo, Albert R. A. Gangbadja, Helga M. Saizonou, Hamirath O. Lagnika, Dyane Nanmede, Laurette Djossou, Romeo Bohounton, Pierre Marie Sovegnon, Marie-Joel Fanou, Romuald Agonhossou, Romaric Akoton, Wassiyath Mousse, Luc S. Djogbenou
Summary: Malaria is a major public health concern worldwide, especially in tropical regions. The control strategies targeting mosquito vectors, such as the use of chemical insecticides, are being hindered by the spread of resistance among mosquito populations. Therefore, there is a need to develop novel and environmentally friendly tools to improve vector control, such as utilizing the microbiota of mosquitoes.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Entomology
Natalie Lissenden, Mara D. Kont, John Essandoh, Hanafy M. Ismail, Thomas S. Churcher, Ben Lambert, Audrey Lenhart, Philip J. McCall, Catherine L. Moyes, Mark J. I. Paine, Giorgio Praulins, David Weetman, Rosemary S. Lees
Summary: Pyrethroids are the main strategy for controlling malaria vectors, but mosquito resistance exists and there are differences in mortality between different pyrethroids. Therefore, rotating between common pyrethroids is not advisable as an insecticide resistance management strategy in areas where resistance exists.
Article
Infectious Diseases
Magellan Tchouakui, Tatiane Assatse, Leon M. J. Mugenzi, Benjamin D. Menze, Daniel Nguiffo-Nguete, Williams Tchapga, Jonathan Kayondo, Francis Watsenga, Emile Zola Manzambi, Michael Osae, Charles S. Wondji
Summary: This study compares the susceptibility of malaria vectors to neonicotinoids using three different solvents. The results show that different solvents lead to different mortality rates, and it is recommended to use both acetone alone and acetone + MERO to monitor the resistance profile of mosquito populations.
INFECTIOUS DISEASES OF POVERTY
(2022)
Article
Infectious Diseases
Alphonsine A. Koffi, Soromane Camara, Ludovic P. Ahoua Alou, Welbeck A. Oumbouke, Rosine Z. Wolie, Innocent Z. Tia, Eleanore D. Sternberg, Florent H. Yapo, Fernand M. Koffi, Serge B. Assi, Jackie Cook, Matthew B. Thomas, Raphael N'Guessan
Summary: This study investigates the distribution and transmission dynamics of malaria vectors in Gbeke region, Central Cote d'Ivoire. It finds that Anopheles gambiae is the main vector responsible for malaria transmission, and transmission is particularly intense during the rainy season. The study emphasizes the need for additional vector control tools to effectively reduce the burden of the disease in this region.
Article
Multidisciplinary Sciences
Kamaraju Raghavendra, Manju Rahi, Vaishali Verma, Poonam Sharma Velamuri, Divya Kamaraju, Kalpana Baruah, Jyoti Chhibber-Goel, Amit Sharma
Summary: This study reports the widespread insecticide resistance in the primary malaria vector An. culicifacies in India. The findings highlight the importance of periodic monitoring of insecticide susceptibility and suggest proactive measures for insecticide resistance management to achieve malaria elimination in India.
Article
Parasitology
Amine M. Mustapha, Susan Musembi, Anthony K. Nyamache, Maxwell G. Machani, Jackline Kosgei, Lucy Wamuyu, Eric Ochomo, Neil F. Lobo
Summary: This study investigated the species compositions and bionomic traits of secondary malaria vectors in three high transmission sites in Kisumu County, western Kenya. The results show that these secondary vectors, primarily caught outdoors, have higher proportions of Plasmodium-infected individuals and exhibit susceptibility to insecticides, indicating their potential significant contribution to malaria transmission. Further studies on morphological and molecular identification of these vectors are needed for better understanding and monitoring of their roles in malaria transmission and development of insecticide resistance.
PARASITES & VECTORS
(2021)
Article
Biochemistry & Molecular Biology
O. Sy, P. C. Sarr, B. S. Assogba, M. Ndiaye, A. K. Dia, A. Ndiaye, M. A. Nourdine, O. K. Gueye, L. Konate, O. Gaye, O. Faye, E. A. Niang
Summary: Malaria transmission has been significantly reduced in central western Senegal due to effective control interventions, but residual transmission persists in certain areas, possibly due to the increase and spread of insecticide resistance genes among natural malaria vectors populations. Proper assessment of insecticide resistance is crucial for understanding and addressing residual transmission.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2021)
Article
Parasitology
Derciliano Lopes da Cruz, Marcelo Henrique Santos Paiva, Duschinka Ribeiro Duarte Guedes, Elainne Christine de Souza Gomes, Silvia Goncalves Pires, Lara Ferrero Gomez, Constancia Flavia Junqueira Ayres
Summary: The study revealed the presence of the L1014F allele in the An. arabiensis population from Cabo Verde for the first time, as well as an increase in the frequency of the kdr L1014S allele reported in a previous study. These results indicate the need to establish new approaches in vector control programs in Cabo Verde.
PARASITES & VECTORS
(2021)
Article
Genetics & Heredity
Nelly Armanda Kala-Chouakeu, Edmond Kopya, Vasileia Balabanidou, Borel Tchamen Djiappi, Kyriaki Maria Papapostolou, Timoleon Tchuinkam, Christophe Antonio-Nkondjio
Summary: This study assessed the resistance profile of Anopheles pharoensis to DDT in the far-north region of Cameroon and found high DDT resistance in some populations without kdr mutations. It also identified a high production of cuticular hydrocarbon in these populations. These findings describe the development of cuticle resistance in An. pharoensis for the first time.
Review
Biochemistry & Molecular Biology
Iason Psilopatis, Ioannis Karniadakis, Konstantinos Stylianos Danos, Kleio Vrettou, Kleita Michaelidou, Konstantinos Mavridis, Sofia Agelaki, Stamatios Theocharis
Summary: Lung cancer is the leading cause of cancer death in the United States. Erythropoietin-producing hepatocellular receptors (EPHs) and their ligands ephrins play a defining role in the development and progression of lung cancer. Targeting EPHs/ephrins may provide effective treatment options for precision cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agronomy
Konstantinos Mavridis, Aris Ilias, Kyriaki Maria Papapostolou, Kyriaki Varikou, Kleita Michaelidou, Anastasia Tsagkarakou, John Vontas
Summary: Molecular diagnostics have been developed for monitoring insecticide resistance in western flower thrips populations, providing evidence-based strategies for resistance management.
PEST MANAGEMENT SCIENCE
(2023)
Article
Virology
Sofia Balaska, Mattia Calzolari, Annalisa Grisendi, Mara Scremin, Michele Dottori, Konstantinos Mavridis, Romeo Bellini, John Vontas
Summary: The expanding distribution of sand flies, especially in Italy, is leading to an increase in the incidence of visceral leishmaniasis. Regular monitoring is needed to ensure the sustainability and effectiveness of vector control interventions, despite the widespread use of insecticides.
Article
Biochemistry & Molecular Biology
Adam Pym, John G. M. Mina, Bartlomiej J. Troczka, Angela Hayward, Eve Daum, Jan Elias, Russell Slater, John Vontas, Chris Bass, Christoph T. Zimmer
Summary: The tobacco whitefly, Bemisia tabaci, is a polyphagous crop pest that causes significant economic damage worldwide. Neonicotinoids are commonly used insecticides for the control of this species. Understanding the mechanisms responsible for resistance to neonicotinoids in B. tabaci is crucial for effective control and damage limitation. This study reveals that qualitative changes in the cytochrome P450 gene CYP6CM1 alter its metabolic capacity and enhance detoxification of neonicotinoids.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xueping Lu, Marilou Vandenhole, Dimitra Tsakireli, Spiros A. Pergantis, John Vontas, Wim Jonckheere, Thomas Van Leeuwen
Summary: Acequinocyl and bifenazate, as powerful acaricides, have been found to induce resistance development in spider mites. Target-site resistance resulting from mutations in the Qo pocket of cytochrome b has been identified as the main resistance mechanism. A new mutation, L258F, has been discovered in field populations of Tetranychus urticae, and its role in resistance has been confirmed. However, the resistance in this strain is likely due to a combination of target-site resistance and increased detoxification through P450 enzymes.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2023)
Article
Genetics & Heredity
Leon M. J. Mugenzi, Theofelix A. Tekoh, Sulaiman S. Ibrahim, Abdullahi Muhammad, Mersimine Kouamo, Murielle J. Wondji, Helen Irving, Jack Hearn, Charles S. Wondji
Summary: Insecticide resistance in vector species populations is posing a threat to the effectiveness of insecticide-based interventions against malaria. This study identified the overexpression of certain metabolic cytochrome P450 genes in resistant Anopheles funestus populations, which confers resistance to both pyrethroid and carbamate insecticides. Understanding the molecular basis of insecticide resistance is crucial for the development of suitable interventions.
Article
Infectious Diseases
Tatiane Assatse, Magellan Tchouakui, Leon Mugenzi, Benjamin Menze, Daniel Nguiffo-Nguete, Williams Tchapga, Sevilor Kekeunou, Charles S. Wondji
Summary: The susceptibility of Anopheles funestus mosquitoes to neonicotinoids was evaluated across Africa, and diagnostic doses of acetamiprid and imidacloprid were established. The study revealed that populations of An. funestus in Africa are susceptible to neonicotinoids, indicating the potential for using this insecticide class to control malaria transmission. However, the presence of cross-resistance calls for regular monitoring of resistance in the field.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Charles Grant, Kumar Saurabh Singh, Angela Hayward, Benjamin J. Hunt, Bartlomiej J. Troczka, Adam Pym, Seung-Joon Ahn, Bin Zeng, Cong-Fen Gao, Alicia Leroux, Eve Daum, Philip Sueess, Dariane Souza, Jan Elias, Richard H. ffrench-Constant, John Vontas, Emmanouil Roditakis, Pablo Bielza, Christoph T. Zimmer, Chris Bass
Summary: Spanish strains of the tomato leafminer exhibit high levels of resistance to the insecticide chlorantraniliprole, which is caused by the overexpression of a UDP-glycosyltransferase gene. The genomic resources generated in this study provide important insights for further research and development of sustainable management strategies for this pest.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Article
Entomology
Oumou Kalsom Gueye, Abdoulaye Niang, Mouhamed Bassir Faye, Abdoulaye Kane Dia, Amblat Ali Ahmed, Ousmane Sy, Frederic Tripet, Lassana Konate, Ibrahima Dia, Charles Sinclair Wondji, Oumar Gaye, Ousmane Faye, Abdoulaye Diabate, El Hadji Amadou Niang
Summary: In Senegal, there is a clear difference in the mating swarms of An. coluzzii and An. gambiae, the malaria vector species, with no hybridization observed. The study reveals that while they do not hybridize, they exhibit distinct swarming behaviors. However, a high hybridization rate is still found in the hybridization zones, indicating the need for further extensive studies.
JOURNAL OF MEDICAL ENTOMOLOGY
(2023)
Article
Parasitology
France-Paraudie A. Kouadio, Nadja C. Wipf, Angele S. Nygble, Behi K. Fodjo, Christabelle G. Sadia, John Vontas, Konstantinos Mavridis, Pie Mueller, Chouaibou S. Mouhamadou
Summary: This study aims to investigate the impact of different agricultural practices on phenotypic insecticide resistance and associated molecular resistance mechanisms in Anopheles gambiae s.l. The results show that mosquito populations from all agricultural sites were resistant to several insecticides, with variation in the frequency of resistance mutations and gene expression levels. The findings suggest that agricultural practices might have a role in shaping insecticide resistance profiles in malaria vectors.
PARASITES & VECTORS
(2023)
Article
Agronomy
Maria K. Sakka, Konstantinos Mavridis, Kyriaki Maria Papapostolou, Maria Riga, John Vontas, Christos G. Athanassiou
Summary: This study developed a high-throughput molecular diagnostic method for monitoring phosphine resistance in stored product insects. The results showed variation in the frequency of resistance mutations among populations from different regions, indicating the need for further research and confirmation.
PEST MANAGEMENT SCIENCE
(2023)
Article
Agronomy
Christine Njiru, Corinna Saalwaechter, Konstantinos Mavridis, John Vontas, Sven Geibel, Nicky Wybouw, Thomas Van Leeuwen
Summary: A target site mutation in a spider mite pest has been found to confer resistance to certain acaricides and has significant fitness costs. These findings highlight the importance of considering multiple factors in assessing the impact of resistance mutations on pest populations.
PEST MANAGEMENT SCIENCE
(2023)
Article
Microbiology
Francis N. Nkemngo, Lymen W. Raissa, Daniel N. Nguete, Cyrille Ndo, Jerome Fru-Cho, Flobert Njiokou, Samuel Wanji, Charles S. Wondji
Summary: Molecular surveillance of malaria is essential for detecting and tracking parasite resistance to anti-malarial drugs. This study conducted molecular techniques to determine the prevalence and genetic diversity of Plasmodium falciparum and Plasmodium malariae resistance markers in humans and mosquitoes in Cameroon. The results showed high prevalence of malaria and the emergence of drug-resistant alleles. The findings highlight the importance of continued surveillance and intervention strategies to prevent the spread of resistance.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2023)
Article
Microbiology
Irina Bemba, Arsene Lenga, Herman Parfait Awono-Ambene, Christophe Antonio-Nkondjio
Summary: Although the incidence of Human African Trypanosomiasis (HAT) has significantly decreased in the Republic of Congo, the disease still persists in some active areas. A study was conducted to assess the knowledge and practices of the population regarding HAT and the prevalence of trypanosomes in animals in three HAT foci. The study found a high rate of trypanosome infection in domestic animals and the use of personal measures to prevent tsetse fly bites. Regular monitoring and control of tsetse fly populations, along with updating information on the HAT animal reservoir and population knowledge, are crucial for the elimination of gHAT in the Republic of Congo.
MICROBIOLOGY RESEARCH
(2023)