Article
Nutrition & Dietetics
Christine Bobin-Dubigeon, Hassan Nazih, Mikael Croyal, Jean-Marie Bard
Summary: According to the findings from clinical and laboratory data, researchers discovered a correlation between EPA and DHA carried by non-HDL lipoproteins and breast cancer severity, suggesting a potential protective effect on the proliferation of breast cancer in HR- tumors.
Review
Health Care Sciences & Services
Takeshi Yamashina, Masaaki Shimatani, Masahiro Takeo, Kotaro Sasaki, Masahiro Orino, Natsuko Saito, Hironao Matsumoto, Takeshi Kasai, Masataka Kano, Shunsuke Horitani, Kimi Sumimoto, Toshiyuki Mitsuyama, Takafumi Yuba, Toshihito Seki, Makoto Naganuma
Summary: This review summarizes the available literature on the relationship between the development of esophageal, gastric, and colorectal cancers and their corresponding viruses, revealing that research on the association between colorectal cancer and viruses is still in its infancy compared to other types of cancer.
Article
Nutrition & Dietetics
Kamila P. Liput, Adam Lepczynski, Agata Nawrocka, Ewa Polawska, Magdalena Ogluszka, Aneta Jonczy, Weronika Grzybek, Michal Liput, Agnieszka Szostak, Pawel Urbanski, Agnieszka Roszczyk, Chandra S. Pareek, Mariusz Pierzchala
Summary: This study evaluated the impact of different high-fat diets on the proteomic profile of mouse liver, revealing that high-PUFA diets significantly affected proteins involved in carbohydrate metabolism and had varying effects on plasma total cholesterol and glucose levels. The study identified crucial liver proteins affected by different high-fat diets.
Article
Nutrition & Dietetics
Gudrun Feuchtner, Christian Langer, Fabian Barbieri, Christoph Beyer, Wolfgang Dichtl, Guy Friedrich, Wilfried Schgoer, Gerlig Widmann, Fabian Plank
Summary: The study found that Omega-3 PUFA supplementation is associated with reduced burden of non-calcified coronary plaques and lower prevalence of high-risk plaques, indicating its anti-atherogenic effects.
CLINICAL NUTRITION
(2021)
Review
Chemistry, Medicinal
Guy Rousseau
Summary: Omega-3 polyunsaturated fatty acids have cardioprotective effects by restoring gut microbiota balance and reducing inflammation, which may impact cardiovascular health.
Article
Endocrinology & Metabolism
Ke Sui, Ali Yasrebi, Natasha Malonza, Zehra H. Jaffri, Samuel E. Fisher, Isaac Seelenfreund, Brandon D. McGuire, Savannah A. Martinez, Avery T. MacDonell, Kevin M. Tveter, Candace R. Longoria, Sue A. Shapses, Sara C. Campbell, Diana E. Roopchand, Troy A. Roepke
Summary: Depletion of 17 ss-estradiol in menopausal and postmenopausal women increases the risk of obesity, cardiovascular disease, osteoporosis, and gut dysbiosis. A diet high in omega-6 PUFAs, particularly linoleic acid (LA), and low in SFAs and omega-3 PUFAs may worsen symptoms of estrogen deficiency. This study found that a balanced dietary fatty acid profile with SFAs and a lower ratio of omega-6:omega-3 FAs is more effective in alleviating metabolic disorders during E2 deficiency.
Article
Biochemistry & Molecular Biology
Suyeon Han, Hyunsu Choi, Hyerim Park, Jwa-Jin Kim, Eu-Jin Lee, Young-Rok Ham, Ki-Rayng Na, Kang-Wook Lee, Yoon-Kyung Chang, Dae-Eun Choi
Summary: This study found that omega-3 polyunsaturated fatty acids (PUFAs) can attenuate kidney injury caused by unilateral ureteral obstruction (UUO) and exert their effects by enhancing autophagy.
Review
Biochemistry & Molecular Biology
Kamila P. Liput, Adam Lepczynski, Magdalena Ogluszka, Agata Nawrocka, Ewa Polawska, Agata Grzesiak, Brygida Slaska, Chandra S. Pareek, Urszula Czarnik, Mariusz Pierzchala
Summary: It is recommended to reduce saturated fatty acids (SFA) and increase polyunsaturated fatty acids (PUFAs) n-3 and n-6 in the diet to lower the risk of metabolic disorders. Western-type diet often contains excessive n-6 PUFAs and a high n-6/n-3 ratio. Oxylipins derived from n-3 and n-6 PUFAs play a role in inflammation, while PUFAs have varying effects on cell growth, proliferation, and neoplastic lesion progression, as observed in in vitro studies, animal models, and epidemiological studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Food Science & Technology
Charlotte Jacobsen, Simone Andrea Warncke, Sussie Hjorth Hansen, Ann-Dorit Moltke Sorensen
Summary: The intake of omega-3 polyunsaturated fatty acids (PUFA) is generally low among average consumers, leading to the popularity of dietary supplements high in omega-3 PUFA, such as fish oils. This study investigated the potential new source of omega-3 PUFA-rich oils in livers of different lean fish species. The lipid content and composition of livers from cod, hake, ling, coalfish and monkfish were determined, revealing similar seasonal variations and no significant effect from storage conditions. Monkfish livers were found to be less suitable for omega-3 oil production, while cod, hake, and ling were the most suitable species.
Review
Oncology
Mehmet Yalchin, Ann-Marie Baker, Trevor A. Graham, Ailsa Hart
Summary: Patients with colonic inflammatory bowel disease (IBD) are at an increased risk of developing colorectal cancer (CRC), and are enrolled into a surveillance programme aimed at detecting dysplasia or early cancer. Current surveillance programmes are guided by clinical, endoscopic or histological predictors of colitis-associated CRC (CA-CRC). There has been significant progress in understanding predictors of disease progression and improvements in endoscopic technique and management, leading to a decrease in the incidence of CA-CRC over the past 50 years. However, there is still room for improvement in our molecular understanding of CA-CRC progression and better risk stratification for patients with IBD.
Article
Chemistry, Multidisciplinary
Wojciech Kolanowski
Summary: This study assessed the omega-3 VLC PUFA content in selected salmonid fish present on the food market and found differences in fat content and fatty acid composition among different species, but all are rich sources of these desirable fatty acids in the human diet.
APPLIED SCIENCES-BASEL
(2021)
Article
Agronomy
Daniela Eliza Marin, Andrei Cristian Anghel, Cristina Valeria Bulgaru, Iulian Grosu, Gina Cecilia Pistol, Ana Elena Cismileanu, Ionelia Taranu
Summary: In conclusion, the nutritional intervention of using agro-industrial wastes rich in omega-3 PUFA can effectively improve piglets' gut health by reducing proinflammatory cytokines and increasing the expression of junction proteins. This eco-friendly approach can help counteract the negative effects of weaning stress on piglets.
Article
Nutrition & Dietetics
Dan-Dan Shi, Yu-Jing Fang, Yi-Ling Jiang, Ting Dong, Zhuo-Lin Zhang, Ting Ma, Ruo-Lin Zhou, Qing-Jian Ou, Cai-Xia Zhang
Summary: This case-control study found that higher levels of serum alpha-linolenic acid (ALA), docosapentaenoic acid (DPA), docosahexaenoic acid (DHA), long-chain n-3 PUFA, and total n-3 PUFA were inversely associated with the risk of colorectal cancer in the Chinese population.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Nutrition & Dietetics
Peder L. Myhre, Trygve Berge, Are A. Kalstad, Sjur H. Tveit, Kristian Laake, Erik B. Schmidt, Svein Solheim, Harald Arnesen, Ingebjorg Selje, Arnljot Tveit
Summary: Recent clinical trials have raised concerns about the potential adverse effects of n-3 polyunsaturated fatty acid supplementation on atrial fibrillation (AF) risk. This study aimed to assess the risk and potential mediators of AF and 'micro-AF' from n-3 PUFA in post-MI patients. The results showed that supplementation of n-3 PUFA increased the risk of 'micro-AF' and AF, and changes in EPA seemed to play an important role in mediating this effect. Rating: 8 out of 10.
CLINICAL NUTRITION
(2023)
Article
Agriculture, Multidisciplinary
Xiao-Quan Yang, Gao-Shang Wang, Hong-Yu Chen, Guang-Xin Feng, Yang Yuan, Zhi-Li Wan, Jian Guo, Jin-Mei Wang
Summary: This article introduces a novel formulation technology to prepare oleogels for the co-delivery of n-3 FAs and polyphenols. The study shows that these protein oleogels overcome challenges associated with n-3 oils and provide improved sensory and textural properties. The protein oleogel system has the potential to be used in the care of vulnerable populations, such as children, the elderly, and patients.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Clinical Neurology
Leyre Martinez-Merino, Marina Iridoy, Arkaitz Galbete, Miren Roldan, Adriana Rivero, Blanca Acha, Pilar Irun, Cecilia Canosa, Miguel Pocovi, Maite Mendioroz, Ivonne Jerico
NEURODEGENERATIVE DISEASES
(2018)
Article
Cardiac & Cardiovascular Systems
Jorge J. Cebolla, Pilar Irun, Pilar Mozas, Pilar Giraldo
Article
Computer Science, Information Systems
Laura Lopez de Frutos, Jorge J. Cebolla, Pilar Irun, Ralf Kohler, Pilar Giraldo
METHODS OF INFORMATION IN MEDICINE
(2019)
Article
Medical Laboratory Technology
Pilar Irun, Jorge J. Cebolla, Laura Lopez de Frutos, Isabel De Castro-Oros, Mercedes Roca-Espiau, Pilar Giraldo
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2020)
Article
Biochemistry & Molecular Biology
Laura Lopez de Frutos, Jorge J. Cebolla, Luis Aldamiz-Echevarria, Angela de la Vega, Sinziana Stanescu, Carlos Lahoz, Pilar Irun, Pilar Giraldo
MOLECULAR BIOLOGY REPORTS
(2020)
Article
Medicine, General & Internal
Laura Lopez de Frutos, Pilar Alfonso, Carlos Lahoz, Pilar Irun, Pilar Giraldo
Letter
Pediatrics
Pablo del Villar-Guerra, Celia Reig, Pilar Irun, Blanca Moreno, Pilar Giraldo, Jorge J. Cebolla
ANALES DE PEDIATRIA
(2021)
Meeting Abstract
Endocrinology & Metabolism
Laura Lopez de Frutos, Elena Garcia-Gonzalez, Carlos Lahoz, Beatriz Garcia-Rodriguez, Yolanda Gonzalez-Irazabal, Irene Serrano-Gonzalo, Pilar Irun, Pilar Giraldo
MOLECULAR GENETICS AND METABOLISM
(2021)
Article
Clinical Neurology
Alejandra Darling, Pilar Irun, Pilar Giraldo, Judith Armstrong, Laura Gort, Alvaro Diaz-Conradi, Delia Yubero, Alfonso Luis De Oryazabal Sanz, Aida Ormazabal, Rafael Artuch, Angels Garcia-Cazorla, Mar O'Callaghan
Summary: This study described two siblings with neuronopathic Gaucher disease with an intermediate form between type 2 and 3, who presented with a systemic and neurological phenotype. The complex neurological picture included a hypokinetic-rigid and tremor syndrome that improved with levodopa treatment. The findings suggest a potential link between GBA and parkinsonian features, highlighting the importance of lysosomal mechanisms in parkinsonism pathogenesis and potential therapeutic implications.
PARKINSONISM & RELATED DISORDERS
(2021)
Review
Gastroenterology & Hepatology
L. Lopez de Frutos, J. J. Cebolla, I. de Castro-Oros, P. Irun, P. Giraldo
Summary: The study evaluated the incidence of Niemann-Pick type C (NPC) in infants with neonatal cholestasis and suspicion of lysosomal storage disease (LSD), finding 29.4% of patients with NPC. The results emphasize the necessity to study NPC when neonatal cholestasis and visceral enlargement occur in newborns or infants.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2021)
Article
Multidisciplinary Sciences
Pilar Irun, Rafael Gracia, Elena Piazuelo, Julian Pardo, Elena Morte, Jose Ramon Pano, Julio Boza, Patricia Carrera-Lasfuentes, Gustavo A. Higuera, Angel Lanas
Summary: COVID-19 patients show increased levels of pro-inflammatory lipid mediators, while the role of anti-inflammatory mediators is less explored. This study analyzed the lipid mediator metabolome in COVID-19 patients and found significant increases in several inflammation-related substances in severe cases. These findings highlight the complexity of the inflammatory response in COVID-19 and suggest the need for further research to identify new therapeutic targets.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Pilar Irun, Patricia Carrera-Lasfuentes, Marta Sanchez-Luengo, Ursula Belio, Maria Jose Domper-Arnal, Gustavo A. Higuera, Malena Hawkins, Xavier de la Rosa, Angel Lanas
Summary: Omega-3 polyunsaturated fatty acids (PUFAs) are important for human health and the management of inflammatory diseases. Specialized pro-resolving mediators (SPMs) derived from omega-3 PUFAs play a crucial role in resolving inflammation. This experimental study found that oral supplementation with SPM-enriched products can increase SPM levels, highlighting the importance of these bioactive compounds.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medical Laboratory Technology
Laura Lopez de Frutos, Elena Garcia-Gonzalez, Beatriz Garcia-Rodriguez, Yolanda Gonzalez-Irazabal, Carlos Lahoz, Pilar Irun, Jorge J. Cebolla, Pilar Giraldo
CLINICA CHIMICA ACTA
(2020)
Article
Medicine, General & Internal
MSoledad Noya, Marcio Andrade-Campos, Pilar Irun, Laura Lopez de Frutos, MFernanda Lopez-Fernandez, Pilar Giraldo
CLINICAL CASE REPORTS
(2018)