Review
Public, Environmental & Occupational Health
Calen J. Smith, Perry Renshaw, Deborah Yurgelun-Todd, Chandni Sheth
Summary: The COVID-19 pandemic, caused by the SARS-CoV-2 virus, has had unprecedented adverse effects globally, impacting physical and neuropsychiatric health. Studies have shown various neuropsychiatric symptoms in COVID-19 patients during and after the acute phase of infection, highlighting the long-term implications of the disease.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Pharmacology & Pharmacy
Yu Fang, Chung-Yu Chen, Hsien-Chung Yu, Pei-Chin Lin
Summary: This retrospective cohort study used Taiwan's National Health Insurance Research Database to evaluate the difference in incidence of neuropsychological disorders (NPDs) between chronic hepatitis C patients receiving interferon therapy and direct-acting antivirals (DAAs) therapy. The study found that patients receiving DAA therapy had a lower risk of NPDs compared to those receiving interferon therapy during the 6-month period after treatment completion.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Psychology, Multidisciplinary
Sanjay Kumar, Alfred Veldhuis, Tina Malhotra
Summary: COVID-19 may have long-term mental health effects on patients, necessitating global recognition and planning to address mental health issues. Research indicates that patients may develop neurological symptoms and the virus could potentially cause damage to the nervous system, leading to long-term neuropsychiatric sequelae.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Clinical Neurology
Hong Kuang Tan, Kaavya Narasimhalu, Simon Kang Seng Ting, Shahul Hameed, Hui Meng Chang, Deidre Anne De Silva, Christopher Li Hsian Chen, Eng King Tan
Summary: This study aimed to examine the effect of B-vitamin supplementation on post-stroke cognitive decline, depressive symptoms, and anxiety symptoms. The results showed no benefit of B-vitamin supplementation for these sequelae, while depressive symptoms were associated with larger anterior cerebral infarcts.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Review
Biochemistry & Molecular Biology
Sen Zhang, Ying-Dan Zhang, Dong-Dong Shi, Zhen Wang
Summary: Oxytocin plays an important role and has therapeutic potential in stress-related neuropsychiatric disorders. This article summarizes the mechanism of oxytocin's anti-stress action, advances in its treatment applications, and methods to increase oxytocin levels in stress-related neuropsychiatric disorders.
CELL AND BIOSCIENCE
(2023)
Article
Medicine, General & Internal
Yuanyuan Wang, Jens H. Bos, Catharina C. M. Schuiling-Veninga, H. Marike Boezen, Job F. M. van Boven, Bob Wilffert, Eelko Hak
Summary: The study found that there was a lower incidence of NPAEs among general population using varenicline compared to nicotine replacement therapy, while there was no significant difference in NPAEs incidence between COPD patients using varenicline and NRT.
Review
Behavioral Sciences
Bruna Verzili, Marcel Valerio de Arruda, Flavio Herrmann, Marcelo B. Reyes, Ruth F. Galduroz
Summary: This article conducted a systematic review and meta-analysis on the effects of yoga on neuropsychiatric aspects in the elderly. The results showed that while the impact on anxiety, stress, and cognition remains uncertain, yoga has significant effects in reducing depression.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Public, Environmental & Occupational Health
Hua-Ying Xiong, Gaofu Zhang, Li Wang, Zhijuan Li, Qian Shen, Yuhong Li, Hongtao Zhu, Yue Du, Liangzhong Sun, Bo Zhao, Lijun Zhao, Haidong Fu, Xiaoyan Li, Xiaojie Gao, Sheng Hao, Juanjuan Ding, Zongwen Chen, Zhiquan Xu, Xiaorong Liu, Yuhong Tao, Aihua Zhang, Qiu Li, Mo Wang
Summary: During the COVID-19 pandemic, children with chronic kidney disease (CKD) and their guardians are experiencing significant psychological stress. Although there was no statistical difference in abnormal behaviors between CKD children and control children, these abnormal behaviors may exacerbate the anxiety and depression of both CKD and control group guardians. The study found that guardians in the CKD group had significantly higher levels of anxiety and depression compared to the control group. Guardians in the CKD group with lower annual income were more likely to experience anxiety. Furthermore, guardians of CKD children older than 11 years old may be more susceptible to anxiety compared to those aged 6-11. Additionally, CKD guardians who watched the news for 30-60 minutes daily were less likely to experience depression compared to those who watched less than 10 minutes. Subgroup results indicated that gender, news-watching time, annual income of guardians, and children's age may be critical factors influencing guardians' psychological burden.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Urology & Nephrology
Thalita Lauanna Ferreira, Heitor Siqueira Ribeiro, Alexandre Lima Araujo Ribeiro, Ana Clara Bonini-Rocha, Joana Marcela Sales Lucena, Poliana Alves de Oliveira, Francisco Rafael S. Amorim, Aparecido Pimentel Ferreira, Luiz Alexandre Viana Magno, Wagner Rodrigues Martins
Summary: This study suggests that exercise is more effective in improving depression and anxiety symptoms in chronic kidney disease patients compared to sedentary control and other active control groups.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2021)
Review
Clinical Neurology
Alberto Galimberti, Martin Tik, Giovanni Pellegrino, Anna-Lisa Schuler
Summary: This study provides a systematic review and meta-analysis on the effectiveness of repetitive transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS) for post-traumatic brain injury (TBI) symptoms. The results show that non-invasive brain stimulation techniques have a small overall effect on TBI sequelae, with significant effects observed for anxiety and headache. However, larger randomized controlled trials with longer follow-ups, optimized stimulation parameters, and standardized methodology are needed to establish the efficacy of these techniques in addressing TBI sequelae.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2024)
Article
Pharmacology & Pharmacy
Sule Aydin, Zeynep Gul Yazici, Cansu Kilic, Birce Ercelen Ozozturk, Fatma Sultan Kilic
Summary: This study investigated the effects of Topiramate (TPM) on depression, anxiety, learning, memory, and neurobiological changes in rats exposed to chronic unpredictable mild stress (CUMS). The findings showed that TPM had different effects on cognition and neurobiological changes in rats under CUMS at different doses.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Clinical Neurology
Erin E. Sundermann, Bin Tang, Michelle Kim, Emily W. Paolillo, Robert K. Heaton, Raeanne C. Moore
Summary: This study examined the impact of depression and anxiety, the most common neuropsychiatric symptoms, on cognitive change in persons with HIV (PWH) and compared it to persons without HIV (PWoH). The results showed that depression and anxiety symptoms were more strongly associated with worse cognitive functioning in PWH, particularly in learning and memory, compared to PWoH. These associations seemed to persist for at least one year.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Keera N. Fishman, Andrea R. Ashbaugh, Richard H. Swartz
Summary: The study found that goal setting had a positive impact on cognitive function after stroke, particularly in executive function, attention/working memory, and verbal learning. This suggests that more than 3 months after stroke, vascular cognitive impairment is not a fixed deficit, and motivation may play a role in improvement.
Article
Neurosciences
Marco Colizzi, Maddalena Peghin, Maria De Martino, Giulia Bontempo, Stefania Chiappinotto, Federico Fonda, Miriam Isola, Carlo Tascini, Matteo Balestrieri, Alvisa Palese
Summary: COVID-19 survivors are at risk of long-term neuropsychiatric sequalae, but there is a lack of prospective evidence. In a cohort of 230 patients, we prospectively assessed mental-health-related symptoms over a 24-month period and found that 36.1% still had at least one symptom. There was a significant reduction in overall symptoms, but symptom prevalence remained unchanged between the 12- and 24-month follow-ups, with mental-health-related symptoms being the most frequently reported.
Review
Immunology
Wenhui Lei, Yiwen Cheng, Jie Gao, Xia Liu, Li Shao, Qingming Kong, Nengneng Zheng, Zongxin Ling, Weiming Hu
Summary: Accumulating evidence suggests that the bacterium Akkermansia muciniphila has positive effects on host health by improving immunological and metabolic functions, making it a promising potential probiotic. Recent research has shown that A. muciniphila plays a vital role in neuropsychiatric disorders through the microbiota-gut-brain axis (MGBA). It can improve symptoms by restoring the gut microbiota, enhancing the gut mucosal barrier, modulating host immunity and reducing inflammation, although its exact mechanisms of action are still controversial.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Review
Neurosciences
Lais B. Martins, Ana L. M. Silveira, Antonio L. Teixeira
Summary: This study aims to provide a comprehensive overview of the involvement of the kynurenine pathway (KP) in the pathophysiology of Alzheimer's disease (AD) and Parkinson's disease (PD) and discuss potential therapeutic opportunities. The results showed altered levels of KP metabolites in the brains of AD and PD patients, and associations between peripheral levels of KP metabolites and cognitive function in these patients.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Pediatrics
Eduardo A. Oliveira, Maria Christina L. Oliveira, Enrico A. Colosimo, Ana Cristina Simoes e Silva, Robert H. Mak, Mariana A. Vasconcelos, Ludmila R. Silva, Daniella B. Martelli, Clara C. Pinhati, Hercilio Martelli-Junior
Summary: The objective of this study was to estimate the vaccine effectiveness against hospitalization and severe illness in adolescents due to infection with SARS-CoV-2 variants. The study found that the vaccine effectiveness against COVID-19 hospitalization dropped to 59% during the omicron-predominant period. These findings suggest that the current two-dose vaccine regimen may be insufficient for the protection against SARS-CoV-2 variants.
JOURNAL OF PEDIATRICS
(2023)
Review
Dentistry, Oral Surgery & Medicine
Jose Alcides Almeida de Arruda, Fernanda Vieira Heimlich, Victor Zanetti Drumond, Lauren Frenzel Schuch, Manoela Domingues Martins, Lucas Guimaraes Abreu, Antonio Lucio Teixeira, Ricardo Alves Mesquita, Tarcilia Aparecida Silva
Summary: This systematic review examined the potential association between anxiety and depression and chemo/radiotherapy-induced oral mucositis. The results showed that there is a connection between anxiety and depression and the severity of oral mucositis in a significant number of participants. However, the limited number of cases and heterogeneity in the data hindered a conclusive conclusion about this association.
Article
Clinical Neurology
Kelly Santana, Eduardo Franca, Joao Sato, Ana Silva, Maria Queiroz, Julia de Farias, Danniely Rodrigues, Iara Souza, Vanessa Ribeiro, Egas Caparelli-Daquer, Antonio L. Teixeira, Leigh Charvet, Abhishek Datta, Marom Bikson, Suellen Andrade
Summary: This study investigated the potential therapeutic effects of High-Definition transcranial Direct Current Stimulation (HD-tDCs) combined with a rehabilitation program for the management of PASC-related fatigue. The results showed that active HD-tDCS significantly reduced fatigue, decreased anxiety, and improved quality of life compared to sham HD-tDCS.
Article
Cardiac & Cardiovascular Systems
Pedro E. P. Carvalho, Thiago M. A. Veiga, Ana C. C. Simoes e Silva, Douglas M. Gewehr, Caroline S. Dagostin, Amanda Fernandes, Guilherme Nasi, Rhanderson Cardoso
Summary: A systematic review of nine randomized controlled trials involving 2,824 patients found that the addition of SGLT2i to standard diuretic therapy reduced all-cause death, readmissions for heart failure (HF), and the composite of cardiovascular death or readmissions for HF. Furthermore, SGLT2i increased diuresis and decreased the dose of loop diuretics without increasing the risk of worsening renal function.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Article
Nutrition & Dietetics
Daniela Mayumi Usuda Prado Rocha, Ana Paula Silva Caldas, Ana Cristina Simoes e Silva, Josefina Bressan, Helen Hermana Miranda Hermsdorff
Summary: Evidence suggests that nut consumption promotes prolonged satiety response. In this study, the authors evaluated the effects of Brazilian nuts on food intake, appetite, and peptide hormones in an energy-restricted intervention. The results showed that while acute intake of Brazilian nuts did not affect food intake, appetite, or peptide hormones, an 8-week intervention with Brazilian nuts decreased postprandial ghrelin levels, indicating their potential in reducing hunger in women at cardiometabolic risk.
NUTRITION RESEARCH
(2023)
Article
Hematology
Andre Rolim Belisario, Ana Cristina Simoes e Silva, Isabel Cristina Gomes Moura, Anna Barbara Carneiro-Proietti, Ester Cerdeira Sabino, Paula Loureiro, Claudia Maximo, Miriam V. Flor-Park, Daniela de Oliveira Werneck Rodrigues, Mina Cintho Ozahata, Rosimere Afonso Mota, Carla Luana Dinardo, Shannon Kelly, Brian Custer
Summary: Chronic kidney disease significantly affects the morbidity and mortality of sickle cell disease. This study aimed to evaluate the prevalence and risk factors for reduced estimated glomerular filtration rate (eGFR) among adults with sickle cell disease in Brazil. The results showed that one-quarter of the adults had eGFR below 90, and older age, male sex, higher diastolic blood pressure, lower hemoglobin, and lower reticulocyte levels were associated with decreased eGFR.
ANNALS OF HEMATOLOGY
(2023)
Article
Neurosciences
Natalia Pessoa Rocha, Eduarda Xavier Carreira, Ana Carolina de Almeida Prado, Fabiola Tavares, Mayra Tavares, Francisco Cardoso, Antonio Jaeger, Leonardo Cruz de Souza, Antonio Lucio Teixeira
Summary: The International Parkinson's Disease and Movement Disorder Society (MDS) developed diagnostic criteria for mild cognitive impairment (MCI) and dementia in Parkinson disease (PD). However, the applicability of these criteria was limited for PD patients with low levels of formal education in Brazil. There is a need for revision of the guidelines to account for differences among populations, especially related to educational level.
ARQUIVOS DE NEURO-PSIQUIATRIA
(2023)
Review
Cardiac & Cardiovascular Systems
Pedro E. P. Carvalho, Thiago M. A. Veiga, Henrique Lacerda, Matheus R. Tofanelli, Douglas M. Gewehr, Maria C. P. Nunes, Ana C. Simoes e C. Silva
Summary: This study found that the use of new potassium binders (Patiromer or SZC) can improve medication optimization and reduce the risk of hyperkalemia in patients with heart failure. However, it also increases the prevalence of hypokalemia.
CLINICAL RESEARCH IN CARDIOLOGY
(2023)
Review
Nutrition & Dietetics
Gabriela Barbosa Pires Fagundes, Jenneffer Rayane Braga Tibaes, Mariele Lino Silva, Marina Marcolino Braga, Ana Leticia Malheiros Silveira, Antonio Lucio Teixeira, Adaliene Versiani Matos Ferreira
Summary: The objective of this study was to evaluate the effects of 8 weeks of time-restricted eating (TRE) with a caloric restriction on metabolic profile, metabolic rate, symptoms of mood and eating disorders, and weight loss in women with overweight or obesity. The results showed that subjects in the TRE group experienced more pronounced weight loss, body fat mass loss, and fat-free mass loss compared to those in the non-TRE group. However, these losses were not associated with changes in resting metabolic rate, metabolic profile, or symptoms of eating or mood disorders. In conclusion, 8 weeks of TRE does not influence behavioral parameters in individuals with overweight or obesity, but may lead to weight loss.
Article
Medicine, Research & Experimental
Antonio L. Teixeira, Lais Bhering Martins, Thiago Macedo e Cordeiro, Lijin Jose, Robert Suchting, Holly M. Holmes, Ron Acierno, Hyochol Ahn
Summary: This study aims to evaluate the feasibility, safety, and efficacy of home-based transcranial direct current stimulation (tDCS) for the treatment of apathy in Alzheimer's disease (AD). A randomized, sham-controlled pilot clinical trial will be conducted involving 40 subjects with AD, with their caregivers administering tDCS at home under remote televideo supervision. The findings from this study will contribute to the development of non-pharmacological treatment strategies and have great potential for clinical translation.
PILOT AND FEASIBILITY STUDIES
(2023)
Review
Urology & Nephrology
Stanley de Almeida Araujo, Barbara Caroline Dias Faria, Julia Cunha Vasconcelos, Aniel Feitosa da Cruz, Vitor Santos de Souza, David Campos Wanderley, Ana Cristina Simoes-e-Silva
Summary: This narrative overview provides an overview of the nephrotoxicity of diethylene glycol (DEG) and its main metabolite diglycolic acid (DGA). DEG poisoning can cause renal injury, manifested by proximal tubular necrosis and resulting in anuria and uremia. Clinical presentation includes gastrointestinal symptoms, anion gap metabolic acidosis, renal failure, encephalopathy, and neuropathy. Diagnosis can be challenging and management involves supportive care, gastric decontamination, correction of acid-base disorders, and hemodialysis.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Review
Biology
A. T. da Silva, A. C. Simoes e Silva, A. Petroianu
Summary: Immuno-oncology focuses on studying the immune system's role in cancer. Immune therapy has demonstrated positive outcomes in the treatment of advanced and metastatic cancers. It works by stimulating the patient's own immune system to enhance immune responses against tumor cells. This review explores the use of biomarkers in understanding immune system mechanisms and their application in immunotherapy for head and neck squamous cell carcinoma (HNSCC). Current clinical drugs for HNSCC include pembrolizumab and nivolumab, both being checkpoint inhibitors. These immunobiological agents have improved patient survival and quality of life. However, selecting patients based on PD-L1 (a primary ligand expressed by tumor cells) dose has proven to be an unreliable biomarker. Therefore, identifying reliable biomarkers is crucial for effective immunotherapy.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2023)
Article
Immunology
Char Leung, Li Su, Ana Cristina Simoes-e-Silva, Luisamanda Selle Arocha, Karina Mary de Paiva, Patricia Haas
Summary: This study analyzed Brazilian national registry data and found that pediatric patients with Down syndrome are more likely to experience severe illness and death in COVID-19 patients. It suggests the development of COVID-19 management guidelines specifically for pediatric patients with Down syndrome to improve outcomes.
EMERGING INFECTIOUS DISEASES
(2023)
Review
Pediatrics
Thiago M. A. Veiga, Pedro E. P. Carvalho, Felipe S. L. Machado, Gabriel V. Porto, Luiza F. Raymundo, Ana Cristina Simoes e Silva
Summary: This study aims to investigate if Antibiotic Prophylaxis (AP) can prevent wound and/or systemic infection in pediatric patients who underwent Percutaneous Endoscopic Gastrostomy (PEG). Four studies, including one randomized controlled trial (RCT), with a total of 568 patients were included. The use of AP during PEG reduced the incidence of systemic infection, but no statistical difference was found for wound infection and the composite outcome of any kind of infection.
PEDIATRIC SURGERY INTERNATIONAL
(2023)
