Article
Medicine, Research & Experimental
Yicheng Wang, Jingxuan Han, Lailiu Luo, Vivi Kasim, Shourong Wu
Summary: Salidroside can promote skeletal muscle cell viability and angiogenic potential under hyperglycemia by suppressing hyperglycemia-induced ferroptosis through promoting GPX4 expression. In diabetic HLI mice, salidroside/GPX4-mediated ferroptosis inhibition is crucial for promoting angiogenesis and blood perfusion recovery. This study highlights the potential of salidroside as a compound for treating diabetic HLI.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Danesh H. Sopariwala, Neah Likhite, Gungsheng Pei, Fnu Haroon, Lisa Lin, Vikas Yadav, Zhongming Zhao, Vihang A. Narkar
Summary: ERR alpha is induced in skeletal muscle by hindlimb ischemia or hypoxia, and its overexpression can drive a switch in myofiber type and activate gene programs related to angiogenesis in muscle. This leads to increased baseline capillarity and arterioles, as well as improved perfusion recovery in ischemic muscle, suggesting ERR alpha as a potential target for treating PAD/CLI.
Article
Cell Biology
Mattia Scalabrin, Viktor Engman, Amanda Maccannell, Annabel Critchlow, Lee D. Roberts, Nadira Yuldasheva, T. Scott Bowen
Summary: In hind limb ischemia (HLI), early-stage ischemic muscles show overt remodeling with excessive autophagy signaling, which normalizes over time. Early activation of the sestrin-AMPK signaling axis may regulate autophagy to stimulate rapid and overt muscle atrophy in HLI, which is normalized within weeks and accompanied by recovery of muscle mass. A complex interplay between Sestrins likely regulates autophagy signaling during early-to-late muscle remodeling in HLI.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Jing-xuan Han, Lai-liu Luo, Yi-cheng Wang, Makoto Miyagishi, Vivi Kasim, Shou-rong Wu
Summary: Gliflozins are a type of SGLT2 inhibitors commonly used to treat diabetes, but recent studies have shown that they may have additional effects beyond inhibiting glucose reabsorption. This study investigated the effects of gliflozins on skeletal muscle cell viability and paracrine function. The results demonstrated that gliflozins can promote cell survival and enhance paracrine function.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Engineering, Biomedical
Liang Gui, Youlu Chen, Yongpeng Diao, Zuoguan Chen, Jianwei Duan, Xiaoyu Liang, Huiyang Li, Kaijing Liu, Yuqing Miao, Qing Gao, Zhichao Li, Jing Yang, Yongjun Li
Summary: This study introduces a nanoparticle-based gene delivery system using CYP2J2 and EETs for the treatment of CLI, with demonstrated potential in angiogenesis promotion, biocompatibility, high transfection efficiency, and VEGF expression.
MATERIALS TODAY BIO
(2022)
Review
Biochemistry & Molecular Biology
Ashok Kumar, Vihang A. Narkar
Summary: This review proposes nuclear receptors as potential candidates for ischemic muscle repair in peripheral arterial disease (PAD), focusing on their roles in muscle angiogenesis, oxidative metabolism, mitochondrial biogenesis, and muscle regeneration. The article also identifies gaps in our understanding of nuclear receptor signaling in skeletal muscle and suggests future research directions.
Article
Cardiac & Cardiovascular Systems
Yiwen Xu, Aaron D. Ward, Daniel Goldman, Hao Yin, John-Michael Arpino, Zengxuan Nong, Jason J. Lee, Caroline O'Neil, J. Geoffrey Pickering
Summary: Machine learning and micromorphometry were used to analyze arteriolar landscape in regenerating muscles after ischemic injury in mice. The study found an increase in arteriolar density, decreased lumen caliber, and reduced smooth muscle content in the regenerated muscles. Computational modeling and experimental validation showed compromised arteriolar network function with diminished flow reserve.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Lai-liu Luo, Jing-xuan Han, Shou-rong Wu, Vivi Kasim
Summary: This study suggests that SGLT2 inhibitor sotagliflozin may serve as a potential therapeutic angiogenesis agent for diabetic hindlimb ischemia (HLI). The results demonstrate that sotagliflozin can reverse the detrimental effects of high glucose and hypoxia on skeletal muscle cells, increase the expression and secretion of angiogenic factors, enhance the migration and proliferation capabilities of vascular endothelial and smooth muscle cells, and promote the formation of functional blood vessels. In vivo experiments show that intramuscular injection of sotagliflozin effectively restores blood perfusion in diabetic HLI mice.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Cardiac & Cardiovascular Systems
Mary M. McDermott, Sudarshan Dayanidhi, Kate Kosmac, Sunil Saini, Joshua Slysz, Christiaan Leeuwenburgh, Lisa Hartnell, Robert Sufit, Luigi Ferrucci
Summary: Aerobic exercise has positive effects on mitochondrial activity and muscle mass in older adults, but its impact on patients with peripheral artery disease remains unclear. Studies show that walking exercise may increase lower extremity ischemia in PAD patients, and more research is needed to clarify the underlying mechanisms.
CIRCULATION RESEARCH
(2021)
Article
Medicine, Research & Experimental
Lijing Jia, Peilin Zheng, Hongbo Wang, Lin Kang, Han Wu, Xiaobing Fu
Summary: The study investigated the therapeutic role of VEGF in diabetic foot by exploring its effects on skeletal muscle fiber type switch. VEGF overexpression in muscle enhanced citrate synthase activity, altered muscle fiber types, and ameliorated lower limb ischemia in diabetic mice. Moreover, VEGF treatment in C2C12 myotubes promoted HUVEC cell migration and tubule formation, suggesting a potential approach for VEGF-mediated angiogenesis and disease treatment.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Heng Yang, Wanqi Lan, Wu Liu, Tingtao Chen, Yanhua Tang
Summary: Our study demonstrates that dapagliflozin significantly accelerates blood flow recovery and reduces limb necrosis in a mouse model of hindlimb ischemia. This effect is mediated through enhanced angiogenesis, reduced muscle fibrosis, and induction of macrophage phenotypic shift from M1 to M2 and decreased expression of inflammatory factors. Dapagliflozin may exert these effects partially through modulation of the NF-κB signaling pathway. Furthermore, dapagliflozin enhances endothelial cell proliferation, migration, and tube formation in vitro.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Yan Yang, Qinqin Xu, Tao Li, Shiying Shao
Summary: The study found that Trimetazidine (TMZ) can alleviate hindlimb ischaemic damage in db/db mice, partly through enhancing angiogenesis and promoting myogenesis. TMZ intervention could improve hindlimb ischaemic damage and stimulate angiogenesis and myogenesis in the ischemic region.
ANNALS OF MEDICINE
(2021)
Article
Immunology
Qun Dong, Jing Tian, Weiwei Zheng, Qiuxiang Fan, Xiaoyong Wu, Yanli Tang, Tao Liu, Hui Yin
Summary: Peripheral vascular disease often results in vascular injury and inflammation. This study investigates the role of IL-33 in hindlimb ischemic injury and its potential mechanisms. The findings suggest that IL-33 promotes blood flow restoration and enhances repair in ischemic hindlimb by modulating the proangiogenic function of endothelial cells through the Akt/eNOS pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Physiology
Sarah E. Dyer, J. David Remer, Kelsey E. Hannifin, Aishwarya Hombal, Joseph C. Wenke, Thomas J. Walters, George J. Christ
Summary: This study investigated the efficacy of a sodium percarbonate (SPO)-based particulate oxygen generator (POG) formulation in reducing ischemic damage in a rat hindlimb during tourniquet application. The results showed that the low-dose POG formulation mitigated the impact of ischemic tissue injury, thus improving contractile function after tourniquet application.
JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Plant Sciences
Wei Sun, Lusha Zhang, Zhirui Fang, Lifeng Han, Qianyi Wang, Yuze Leng, Mengyao Li, Yuejin Xue, Yongsheng Wu, Zhenguo Li, Hong Wang, Lu Chen
Summary: This study found that SXT injection promotes angiogenesis and improves function recovery in hindlimb ischemia mice. Moreover, SXT injection and its active peptides induce cell migration and tube formation in endothelial cells through activating specific pathways.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hong Ji, Can Huang, Shourong Wu, Vivi Kasim
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2019)
Article
Medicine, General & Internal
Can Huang, Shourong Wu, Wenfang Li, Arin Herkilini, Makoto Miyagishi, Hezhao Zhao, Vivi Kasim
Article
Oncology
Ke Lei, Wenfang Li, Can Huang, Yanjun Li, Leader Alfason, Hezhao Zhao, Makoto Miyagishi, Shourong Wu, Vivi Kasim
Article
Pharmacology & Pharmacy
Dyah Ari Nugrahaningrum, Olivia Marcelina, Caiping Liu, Shourong Wu, Vivi Kasim
FRONTIERS IN PHARMACOLOGY
(2020)
Review
Cell Biology
Lang Li, Yanjun Li, Ian Timothy Sembiring Meliala, Vivi Kasim, Shourong Wu
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2020)
Article
Chemistry, Multidisciplinary
Wen-fang Li, Arin Herkilini, Yu Tang, Ping Huang, Guan-bin Song, Makoto Miyagishi, Vivi Kasim, Shou-rong Wu
Summary: PBX3 is involved in the progression of various cancers, and its silencing leads to p21 upregulation, resulting in increased apoptosis and decreased proliferation and colony formation in colorectal cancer cells. PBX3 is highly expressed in clinical CRC patients, and it regulates tumor growth through the p53/p21 axis.
ACTA PHARMACOLOGICA SINICA
(2021)
Review
Biochemistry & Molecular Biology
Farwa Altaf, Shourong Wu, Vivi Kasim
Summary: Thrombosis, a major cause of deaths in the modern era, often requires treatment with classical drugs that may have unwanted side effects and high costs. Therefore, there is an urgent need to develop novel and low-cost drugs for thrombosis treatment. Fibrinolytic enzymes, as potential compounds for thrombosis therapy, have the advantage of high efficacy in eliminating thrombi.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Chemistry, Medicinal
Caiping Liu, Jingxuan Han, Olivia Marcelina, Dyah Ari Nugrahaningrum, Song Huang, Meijuan Zou, Guixue Wang, Makoto Miyagishi, Yun He, Shourong Wu, Vivi Kasim
Summary: The study identified a novel glycoside scaffold compound, C-30, which was more effective than salidroside in enhancing HIF-1α protein accumulation, stimulating the paracrine functions of skeletal muscle cells, significantly increasing angiogenic potential, and inducing the formation of mature, functional blood vessels. This offers a promising small-molecule-based therapeutic strategy for treating hind limb ischemia.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Zhuolin Li, Yuxin He, Yanjun Li, Juan Li, Hezhao Zhao, Guanbing Song, Makoto Miyagishi, Shourong Wu, Vivi Kasim
Summary: NeuroD1 is positively correlated with G6PD in colorectal cancer cells, and its regulation alters tumor cell metabolism by stimulating the pentose phosphate pathway, leading to increased production of nucleotides and NADPH, while decreasing reactive oxygen species levels.
Review
Biochemistry & Molecular Biology
Xinxin Luo, Leader Alfason, Mankun Wei, Shourong Wu, Vivi Kasim
Summary: X-box binding protein 1 (XBP1) is a transcription factor involved in unfolded protein response and other physiological pathways. Its spliced isoform XBP1-s plays a critical role in inflammation, neurodegenerative diseases, and tumor progression. Meanwhile, the unspliced isoform XBP1-u also plays a key role in autophagy and tumorigenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Yanjun Li, Juan Li, Zhuolin Li, Mankun Wei, Hezhao Zhao, Makoto Miyagishi, Shourong Wu, Vivi Kasim
Summary: YY2 induces tumor cell ferroptosis and suppresses tumorigenesis by inhibiting SLC7A11 transcription, leading to decreased glutathione biosynthesis. YY2 and YY1 competitively bind to the same DNA binding site in the SLC7A11 promoter and antagonistically regulate tumor cell ferroptosis, providing a mechanistic explanation for their opposite regulation on tumorigenesis.
Review
Oncology
Fuqiang Zhao, Lei Zhang, Mankun Wei, Wei Duan, Shourong Wu, Vivi Kasim
Summary: Tumor cells alter their characteristics and behaviors in response to the mechanical signals from the tumor microenvironment. Piezo1, a mechanically sensitive ion channel protein, is overexpressed in tumors and is involved in tumor development through various mechanisms. Its discovery provides new insights into the mechanism of tumor progression under a mechanical microenvironment.
Review
Oncology
Lei Zhang, Fuqiang Zhao, Wenfang Li, Guanbin Song, Vivi Kasim, Shourong Wu
Summary: MEG3 is an important lncRNA that plays a key role in regulating tumor characteristics and suppressing tumor growth. Dysfunctions in MEG3 have been associated with poor prognosis and drug resistance in various cancers. MEG3 exerts inhibitory effects on tumor cell proliferation, invasion, metastasis, angiogenesis, and metabolic reprogramming, making it a potential clinically valuable marker and therapeutic target for cancer.
Article
Medicine, Research & Experimental
Yanjun Li, Vivi Kasim, Xuesong Yan, Lang Li, Ian Timothy Sembiring Meliala, Can Huang, Zhuolin Li, Ke Lei, Guanbin Song, Xiaodong Zheng, Shourong Wu