Journal
FRONTIERS IN NEUROSCIENCE
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fnins.2019.00709
Keywords
neuroimaging; connectivity; ventral striatum; medial shell; lateral shell
Categories
Funding
- National Natural Science Foundation of China [91432302, 31620103905, 81501179, 61472270]
- Frontier Science Program of the Chinese Academy of Sciences [QYZDJ-SSW-SMC019]
- National Key R&D Program of China [2017YFA0105203]
- Beijing Municipal Science and Technology Commission [Z161100000216152, Z161100000216139]
- Natural Science Foundation of Shanxi Province of China [201801D121135]
- Guangdong Pearl River Talents Plan [2016ZT06S220]
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Limited in part by the spatial resolution of typical in vivo magnetic resonance imaging (MRI) data, recent neuroimaging studies have only identified a connectivity-based shell-core-like partitioning of the nucleus accumbens (Acb) in humans. This has hindered the process of making a more refined description of the Acb using non-invasive neuroimaging technologies and approaches. In this study, high-resolution ex vivo macaque brain diffusion MRI data were acquired to investigate the tractography-based parcellation of the Acb. Our results identified a shell-core-like partitioning in macaques that is similar to that in humans as well as an alternative solution that subdivided the Acb into four parcels, the medial shell, the lateral shell, the ventral core, and the dorsal core. Furthermore, we characterized the specific anatomical and functional connectivity profiles of these Acb subregions and generalized their specialized functions to establish a fine-grained macaque Acb brainnetome atlas. This atlas should be helpful in neuroimaging, stereotactic surgery, and comparative neuroimaging studies to reveal the neurophysiological substrates of various diseases and cognitive functions associated with the Acb.
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