Article
Immunology
Li Wu, Xuhui Fang, Fangting Lu, Yu Zhang, Yanshi Wang, Joanne Kwak-Kim
Summary: This study aimed to evaluate the effects of anticardiolipin (aCL) and/or anti-beta 2-glycoprotein-I (a beta 2GPI) antibodies, known as antiphospholipid antibodies (aPL), on in vitro fertilization (IVF) outcomes. The results showed that infertile women with aPL had worse outcomes in terms of oocyte quality, embryo quality, and implantation capacity. Imbalanced T cell subset ratios and elevated levels of certain cytokines were noticed in these women compared to controls.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Critical Care Medicine
Purnema Madahar, Kathleen M. Capaccione, Mary M. Salvatore, Briana Short, Romina Wahab, Darryl Abrams, Madhavi Parekh, Joshua D. Geleris, David Furfaro, Michaela R. Anderson, Jason Zucker, Daniel Brodie, Matthew J. Cummings, Max O'Donnell, Claire F. Mcgroder, Ying Wei, Christine K. Garcia, Matthew R. Baldwin
Summary: Approximately half of adults with COVID-19-associated chronic critical illness exhibit fibrotic-like patterns, which are associated with elevated levels of interleukin-6 at intubation. However, these patterns are not associated with longer time to liberation from mechanical ventilation or worse 6-month survival.
CRITICAL CARE MEDICINE
(2023)
Article
Clinical Neurology
Qi Liu, Xianwei Wang, Yilong Wang, Chunxue Wang, Xingquan Zhao, Liping Liu, Zixiao Li, Xia Meng, Li Guo, Yongjun Wang
Summary: The study revealed a significant association between low and high hemoglobin levels and adverse stroke outcomes, showing a U-shaped relationship. Patients with different hemoglobin levels had distinct post-stroke adverse events. Additionally, there were significant interactions between hemoglobin concentration and sex in terms of all-cause mortality and stroke recurrence.
CEREBROVASCULAR DISEASES
(2022)
Article
Multidisciplinary Sciences
Ahmed M. Shammaa, Thomas G. Powell, Imaan Benmerzouga
Summary: This study used real-world data from the FAERS database to analyze adverse outcomes and events associated with the treatment of Toxoplasma infections. Findings suggest that clindamycin and pyrimethamine may be strongly associated with death, and sulfonamide formulations may have a less favorable safety profile.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Kirti Wasnik, Pratima Mittal, Priti Ghope, Subash C. Sonkar, Geetika Arora, Daman Saluja
Summary: This study assessed the prevalence of seven RTIs/STIs in asymptomatic pregnant adolescents and found a significant correlation between infection and adverse pregnancy outcomes.
FRONTIERS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Tatjana Krama, Ronalds Krams, Maris Munkevics, Jonathan Willow, Sergejs Popovs, Didzis Elferts, Markus Rantala, Jorge Contreras-Garduno, Indrikis A. Krams
Summary: This study compared the reproductive success, elemental composition, and physiological stress of buff-tailed bumblebees in oilseed rape fields and old apple orchards. The results showed that bees in oilseed rape fields had higher reproductive output and lower C/N ratio, while bees in apple orchards had higher body nitrogen concentration.
Article
Gastroenterology & Hepatology
Annsa C. Huang, Joshua Grab, Jennifer A. Flemming, Jennifer L. Dodge, Roxanna A. Irani, Monika Sarkar
Summary: The incidence of cirrhosis in pregnancies from outside the United States is rising. This study found that pregnancies with cirrhosis more than doubled over the past decade in the United States. Cirrhosis in pregnancies was associated with an increased risk of adverse events, although maternal and perinatal mortality was low.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Daniel Lancini, Wei Lian Tan, Kristyan Guppy-Coles, Robert Boots, Sandhir Prasad, John Atherton, Paul Martin
Summary: This study aimed to determine the factors associated with subsequent atrial fibrillation (AF) diagnoses and other adverse outcomes in critical illness associated new onset AF (CI-NOAF) patients. The results showed that AF burden and left atrial size were independently associated with subsequent AF. It was also found that CI-NOAF is often under-recognized and subsequent AF diagnoses are common post-discharge.
Article
Clinical Neurology
Pinni Yang, Zhengbao Zhu, Yuhan Zang, Xiaoqing Bu, Tian Xu, Chongke Zhong, Aili Wang, Hao Peng, Daoxia Guo, Xiaowei Zheng, Tan Xu, Jing Chen, Yonghong Zhang, Jiang He
Summary: This study found that elevated serum complement C3 levels were associated with increased risks of adverse clinical outcomes in patients with ischemic stroke, suggesting that serum complement C3 may serve as a valuable prognostic biomarker for ischemic stroke.
Article
Cardiac & Cardiovascular Systems
Jessica Heibel, Eric M. Graham, William T. Mahle, Aurelie Roux, David Graham, Cedric Manlhiot, Allen D. Everett
Summary: In this study, targeted metabolomic analysis of plasma from neonates undergoing heart surgery with cardiopulmonary bypass was conducted to determine associations with clinical outcomes. The results showed that perioperative metabolites were associated with postoperative outcomes and improved clinical model outcome associations in neonatal cardiac surgery. Preoperative metabolite levels alone may improve risk models and provide a basis for optimizing perioperative care.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Clinical Neurology
Ori J. Lieberman, Seonjoo Lee, Jeffrey Zabinski
Summary: The use of donepezil may improve outcomes and reduce delirium in patients with dementia during critical illness.
ALZHEIMERS & DEMENTIA
(2023)
Article
Environmental Sciences
Mary E. Ingle, Lidia Minguez-Alarcon, Courtney C. Carignan, Heather M. Stapleton, Paige L. Williams, Jennifer B. Ford, Molly B. Moravek, Marie S. O'Neill, Lu Wang, Russ Hauser, John D. Meeker
Summary: This study found that there were differences in PBDEs and OH-BDEs concentrations between males and females during IVF, with no clear patterns of adverse IVF outcomes associated with PBDEs and OH-BDEs, but some decreases in associations with IVF outcomes were observed in isolated quartiles.
ENVIRONMENTAL RESEARCH
(2021)
Review
Engineering, Environmental
Xueyu Weng, Qingqing Zhu, Chunyang Liao, Guibin Jiang
Summary: The decline in global birth rates is attributed to the potential effects of environmental pollutants on female reproductive health. Phthalates, widely used in plastic containers, toys, and medical devices, have raised concerns due to their endocrine-disrupting potential. As phthalates are being banned, alternative substances such as DINCH, DEHA, and DEHTP are gaining popularity and have shown various effects on female reproductive function. Studies have shown that these alternatives may disrupt the estrous cycle, cause follicular atresia, and prolong the gestational cycle, highlighting the need for a comprehensive understanding of their effects and underlying mechanisms on female reproductive health.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Orthopedics
Ahmed K. Emara, Daniel Grits, Alison K. Klika, Robert M. Molloy, Viktor E. Krebs, Wael K. Barsoum, Carlos Higuera-Rueda, Nicolas S. Piuzzi
Summary: Preoperative high-risk drug use, as reflected by higher NarxCare scores, is dose-dependently associated with adverse outcomes after total hip arthroplasty, but specific threshold effects remain unclear.
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Kathleen Colman, Tarek Alsaied, Adam Lubert, Harry B. Rossiter, Wayne A. Mays, Adam W. Powell, Sandra Knecht, Danielle Poe, Nicholas Ollberding, Zhiqian Gao, Clifford Chin, Gruschen R. Veldtman
Summary: The study demonstrates a strong association between elevated peripheral venous pressure (PVP) during exercise and adverse outcomes in Fontan patients. Monitoring PVP during exercise could be a useful tool for identifying individuals at higher risk for Fontan-related morbidities.
