Article
Ophthalmology
Jae Hui Kim, Jong Woo Kim, Chul Gu Kim
Summary: This study investigated the incidence, risk factors, and impact on visual outcomes of SRH in patients with nAMD and PCV who discontinued treatment. SRH development led to poor visual prognosis in those who stopped treatment, and type 3 MNV had a relatively high risk of SRH occurrence.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Multidisciplinary Sciences
Daniel Duck-Jin Hwang, Seong Choi, Junseo Ko, Jeewoo Yoon, Ji In Park, Joon Seo Hwang, Jeong Mo Han, Hak Jun Lee, Joonhong Sohn, Kyu Hyung Park, Jinyoung Han
Summary: This study successfully distinguished between RAP and PCV cases in neovascular age-related macular degeneration using a deep learning model, showing high accuracy, sensitivity, and specificity. The novel model performed well in distinguishing between PCV and RAP, demonstrating better diagnostic performance than other models and comparable performance with ophthalmologists.
SCIENTIFIC REPORTS
(2021)
Article
Ophthalmology
Kentaro Kawai, Manabu Miyata, Sotaro Ooto, Hiroshi Tamura, Naoko Ueda-Arakawa, Ayako Takahashi, Akihito Uji, Yuki Muraoka, Masahiro Miyake, Kenji Yamashiro, Akitaka Tsujikawa
Summary: This study found that a thin subfoveal choroid at baseline and multiple anti-VEGF injections in a PRN regimen increase the risk of developing macular atrophy (MA) involving the fovea after photodynamic therapy (PDT) and PRN treatment.
Article
Biology
Kan Xing Wu, Natalie Jia Ying Yeo, Chun Yi Ng, Florence Wen Jing Chioh, Qiao Fan, Xianfeng Tian, Binxia Yang, Gunaseelan Narayanan, Hui Min Tay, Han Wei Hou, N. Ray Dunn, Xinyi Su, Chui Ming Gemmy Cheung, Christine Cheung
Summary: Research on PCV patients discovered that blood endothelial cells react differently under different flow speeds, and that inhibiting elevated hyaluronidase-1 in PCV patients can improve cell mechanosensitivity and repair barrier permeability.
Article
Medicine, General & Internal
Jae-Hui Kim, Jong-Woo Kim, Chul-Gu Kim
Summary: This study revealed a trend in the selection of ranibizumab and aflibercept for initial treatment of neovascular AMD and PCV, with ranibizumab preferred in older patients and those with type 3 MNV, and aflibercept highly preferred in patients with PCV. The variance in patient characteristics and efficacy of the two agents may have influenced this trend.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Ophthalmology
Matteo Airaldi, Alessandro Invernizzi, Vuong Nguyen, Stela Vujosevic, Federico Ricci, Pietro Monaco, Marco Nassisi, Daniel Barthelmes, Mark Gillies, Francesco Viola
Summary: This study compared the treatment outcomes of Vascular Endothelial Growth Factor (VEGF) inhibitors for Polypoidal Choroidal Vasculopathy (PCV) and type 1 Macular Neovascularization (MNV) in a Caucasian population. The results showed that PCV had slightly better visual acuity outcomes after 24 months of treatment compared to type 1 MNV, and received fewer anti-VEGF injections.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Review
Medicine, General & Internal
Kenji Yamashiro, Yasuo Yanagi, Hideki Koizumi, Hidetaka Matsumoto, Chui Ming Gemmy Cheung, Fumi Gomi, Tomohiro Iida, Akitaka Tsujikawa
Summary: Previous studies have shown inconsistent classification and understanding of pachychoroid neovasculopathy (PNV) and polypoidal choroidal vasculopathy (PCV). This study summarizes previous research and proposes a refined conceptual framework for future studies on PNV, PCV, and neovascular age-related macular degeneration (nAMD).
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Ophthalmology
Jakob Siedlecki, Julian Klaas, Leonie Keidel, Ben Asani, Johannes Schiefelbein, Dominik Knebel, Nikolaus Luft, Siegfried G. G. Priglinger, Benedikt Schworm
Summary: The study evaluated the misdiagnosis rate of non-aneurysmatic pachychoroid neovasculopathy (PNV) as aneurysmatic pachychoroid type 1 choroidal neovascularization/polypoidal choroidal vasculopathy (PAT1/PCV), and identified optical coherence tomography (OCT) features that help distinguish between the two conditions. It was found that a significant proportion of eyes diagnosed with PNV actually had PAT1/PCV, and measuring maximum pigment epithelium detachment (PED) height, sub-retinal hyperreflective material (SHRM), sub-retinal ring-like structures (SRRLS), and sub-RPE fluid can aid in the accurate diagnosis of PAT1/PCV.
Article
Ophthalmology
Federico Corvi, Shruti Chandra, Alessandro Invernizzi, Lucia Pace, Francesco Viola, Sobha Sivaprasad, Giovanni Staurenghi, Chui Ming Gemmy Cheung, Kelvin Yi Chong Teo
Summary: The study compared the multimodal imaging features of Asian and Caucasian eyes with PCV, finding that Asian eyes had more severe disease characteristics such as lower visual acuity, more hemorrhage, and wider lesion areas, while Caucasian eyes showed more drusen. Ethnic differences in disease characteristics of PCV were revealed through multimodal imaging analysis, suggesting varying pathophysiologic mechanisms based on ethnicity.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Medicine, General & Internal
Yukinori Sakaeda, Aki Kato, Soichiro Kuwayama, Shuichiro Hirahara, Norihiro Suzuki, Yuichiro Ogura, Yoko Nakazawa, Tsutomu Yasukawa
Summary: We assessed the long-term prognosis of PCV patients treated with PDT in real-world settings. In total, 60 eyes of 57 patients were retrospectively reviewed. Initial PDT showed effectiveness in 30% of cases, with good BCVA and no need for additional treatment. However, rescue PDT required additional treatment in most cases and vision decreased in many cases.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Figen Batioglu, Ozge Yanik, Ferhad Ozer, Sibel Demirel, Emin Ozmert
Summary: The study compares the choroidal characteristics of typical polypoidal choroidal vasculopathy (T-PCV) and polypoidal choroidal neovascularization (P-CNV) cases, and investigates the presence of intervortex venous anastomoses in these PCV subtypes using en face optical coherence tomography angiography (OCTA). Results show that T-PCV cases have significantly higher mean choroidal vascularity index (CVI) values and more dilated anastomotic vessels compared to P-CNV cases.
Article
Ophthalmology
Jae Hui Kim, Jong Woo Kim, Chul Gu Kim, Dong Won Lee
Summary: Approximately 27.9% of cases with prechoroidal cleft eventually regressed, resulting in relatively favorable visual outcomes. Neovascular age-related macular degeneration accompanied by prechoroidal cleft had a worse visual prognosis, requiring more caution.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Hidetaka Matsumoto, Junki Hoshino, Ryo Mukai, Kosuke Nakamura, Hideo Akiyama
Summary: Loading phase treatment with intravitreal brolucizumab may improve visual acuity and reduce exudative changes in eyes with nAMD associated with type 1 CNV, but careful monitoring for brolucizumab-related intraocular inflammation is necessary.
SCIENTIFIC REPORTS
(2021)
Article
Ophthalmology
Takahiko Izumi, Hideki Koizumi, Ichiro Maruko, Taiji Hasegawa, Tomohiro Iida
Summary: This study aimed to evaluate the flow signals in subretinal hyperreflective material (SHRM) that represent classic choroidal neovascularization (CNV) using OCT angiography (OCTA) in eyes with polypoidal choroidal vasculopathy. The study successfully differentiated true Type 2 macular neovascularization from pseudo classic CNV.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2022)
Article
Ophthalmology
Jorge M. Simao, Claudia V. Farinha, Joao P. Marques, Sandrina Nunes, Isabel M. Pires, Maria L. Cachulo, Joao P. Figueira, Joaquim N. Murta, Rufino M. Silva
Summary: This study aimed to characterize the morphological features of polypoidal choroidal vasculopathy (PCV) in a large Caucasian population. The results showed that the morphological features of PCV in Caucasians are similar to those reported in Asians, with nearly half of the cohort showing signs of pachychoroid. However, the higher prevalence of soft drusen, lower prevalence of large subretinal hemorrhages, and older age at presentation in Caucasians make PCV more similar to age-related macular degeneration in this ethnic group.
Article
Ophthalmology
Michael Stormly Hansen, Lene Terslev, Mads Radmer Jensen, Jane Maestri Brittain, Uffe Moller Dohn, Carsten Faber, Steffen Heegaard, Oliver Niels Klefter, Elisabeth Bay Konig, Yousif Subhi, Anne Katrine Wiencke, Steffen Hamann
Summary: This study assesses the diagnostic performance of temporal artery ultrasound and biopsy in the diagnosis of giant cell arteritis (GCA). The results show that both ultrasound and biopsy have relatively high sensitivity and specificity, although the overall diagnostic accuracy of ultrasound is slightly lower than that of biopsy.
Review
Ophthalmology
Marie Louise Roed Rasmussen, Maria D'Souza, Divan Gabriel Topal, Josefine Gradman, Dorte Ancher Larsen, Bettina Behrmann Lehrmann, Henrik Fomsgaard Kjaer, Line Kessel, Yousif Subhi
Summary: This study aimed to determine the prevalence of allergic sensitization in patients with vernal keratoconjunctivitis (VKC) and provided an overview of published studies on this topic. The results showed that the prevalence of allergic sensitization in patients with VKC is 57.7%, with a higher focus on inhaled allergens. The most common positive allergens identified were house dust mites and pollen. These findings can be useful in managing VKC, such as avoiding contact with environmental allergens or pursuing allergy-specific treatment.
ACTA OPHTHALMOLOGICA
(2023)
Article
Genetics & Heredity
Florence Thirion, Finn Sellebjerg, Yong Fan, Liwei Lyu, Tue H. Hansen, Nicolas Pons, Florence Levenez, Benoit Quinquis, Evelina Stankevic, Helle B. Sondergaard, Thomas M. Dantoft, Casper S. Poulsen, Sofia K. Forslund, Henrik Vestergaard, Torben Hansen, Susanne Brix, Annette Oturai, Per Soelberg Sorensen, Stanislav D. Ehrlich, Oluf Pedersen
Summary: This study found significant differences in the gut microbiota of patients with multiple sclerosis, which are directly associated with inflammation markers. In treatment-naive cases, the bacterial richness is positively linked to disease activity. However, two symbiotic bacterial species that produce beneficial immune-modulating compounds were found in non-disease-active cases, providing a rationale for testing these bacteria as adjunct therapeutics in future clinical trials.
Article
Multidisciplinary Sciences
Kathrine Gotfredsen, Charlotte Liisborg, Vibe Skov, Lasse Kjaer, Hans Carl Hasselbalch, Torben Lykke Sorensen
Summary: Immune responses play a key role in the pathogenesis and progression of MPN and AMD. This study found that serum levels of IL-4 and IL-33 may be involved in drusen development in MPN patients, supporting the association between chronic inflammation and drusen.
SCIENTIFIC REPORTS
(2023)
Article
Health Care Sciences & Services
Yousif Subhi, Ivan Potapenko, Javad Nouri Hajari, Morten la Cour
Summary: This study analyzed the incidence rates of diabetic macular edema (DME) patients receiving anti-VEGF therapy and developed a model to forecast the future number of patients in active treatment. The results showed higher incidence rates among male and 60-80 years old patients. The number of patients in active treatment followed an exponential decay curve and is expected to remain relatively stable until 2023 with a minimal increase.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Biology
Michael S. S. Hansen, Oliver N. N. Klefter, Lene Terslev, Mads R. R. Jensen, Jane M. M. Brittain, Uffe M. M. Dohn, Carsten Faber, Steffen Heegaard, Anne K. K. Wiencke, Yousif Subhi, Steffen Hamann
Summary: Giant cell arteritis (GCA) is an ophthalmological emergency that requires prompt treatment. A study investigated the diagnostic value of platelet count, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) in patients with suspected GCA. The results showed that platelet count and CRP can be used for initial evaluation without waiting for ESR, allowing faster decision-making.
Article
Clinical Neurology
Malte Roar, Amalie Rhode Hogh Nielsen, Jonas Munksgaard Berg, Georgi Sirakov, Morten Stilund, Jakob Schafer, Rikke Ratzer, Jette Frederiksen, Nasrin Asgari, Said Nasim Ashna, Henrik Boye Jensen, Matthias Kant, Asta Theodorsdottir, Zsolt Illes, Finn Sellebjerg, Melinda Magyari, Louise Mose Schlosser, Hilde Nordborg, Stig Wergeland, Tobias Sejbaek
Summary: This study investigated the rates and reasons for discontinuation of dimethyl fumarate (DMF) among multiple sclerosis (MS) patients in Denmark. The results showed significant differences between clinics in terms of discontinuation rates and reasons. Adverse events, disease activity, pregnancy, and other factors were identified as the main reasons for discontinuation. Management strategies during DMF treatment could potentially reduce discontinuation rates.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Clinical Neurology
C. Ammitzboll, T. B. Dyrby, L. Bornsen, K. Schreiber, R. Ratzer, J. Romme Christensen, P. Iversen, M. Magyari, H. Lundell, P. E. H. Jensen, P. S. Sorensen, H. R. Siebner, F. Sellebjerg
Summary: This study investigated the relationship between serum concentrations of neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) and disease activity and severity in progressive multiple sclerosis (MS). The results showed that serum concentrations of NfL and GFAP were higher in progressive MS patients compared to healthy controls, and serum NfL was correlated with the EDSS score. Regression analyses revealed that high serum NfL was independently associated with decreased fractional anisotropy (FA) and increased mean diffusivity (MD) in normal-appearing white matter (NAWM), while high serum GFAP was independently associated with decreased MD in NAWM and decreased MD and increased FA in cortical gray matter (CGM).
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Immunology
Marina Rode von Essen, Helene Hojsgaard Chow, Rikke Holm Hansen, Sophie Buhelt, Finn Sellebjerg
Summary: The study analyzed the repopulation of peripheral lymphocytes following treatment with alemtuzumab, a monoclonal antibody approved for relapsing-remitting multiple sclerosis. It found that alemtuzumab treatment significantly alters the phenotype of circulating lymphocytes and leads to a reconstituted immune system with increased regulatory control of certain T cell populations and decreased control of B cells. However, there were no apparent associations between immune cell subsets and disease activity or development of secondary autoimmune diseases during alemtuzumab treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Health Care Sciences & Services
Samim Azizi, Yousif Subhi, Marie Louise Roed Rasmussen
Summary: This systematic review examined the surgical treatment methods and effects of shield ulcers in VKC. The results showed that almost all patients experienced resolution or improvement of their ulcers regardless of the surgical approach. However, there is a risk of recurrence and potential side effects, highlighting the importance of careful post-operative treatment and follow-ups.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Ophthalmology
Ivan Potapenko, Lasse Malmqvist, Yousif Subhi, Steffen Hamann
Summary: Optic disc drusen (ODD) are benign and asymptomatic deposits in the optic nerve head. This study examines the accuracy of ChatGPT responses to typical patient questions about ODD. The results showed that ChatGPT generally provides accurate answers, but inaccuracies may arise when discussing treatment and prognosis.
OPHTHALMOLOGY AND THERAPY
(2023)
Article
Medicine, Research & Experimental
Julie Schjodtz Hansen, Fernando Boix, Jorgen Bo Hasselstrom, Lambert Kristiansen Sorensen, Mads Kjolby, Stefan Gustavsen, Rikke Middelhede Hansen, Thor Petersen, Finn Sellebjerg, Helge Kasch, Peter Vestergaard Rasmussen, Nanna Brix Finnerup, Eva Aggerholm Saedder, Kristina Bacher Svendsen
Summary: This exploratory study aimed to evaluate the pharmacokinetics and pharmacodynamics of orally administered cannabis-based medicine in patients with multiple sclerosis. The study found that there was considerable variation in daily dose and pharmacokinetics between individuals in a steady state, but comparable with previous reports from healthy controls. The study also found no effect on the pharmacodynamics parameters, but a significant placebo response.
CTS-CLINICAL AND TRANSLATIONAL SCIENCE
(2023)
Review
Clinical Neurology
Per Soelberg Sorensen, Melinda Magyari, Finn Sellebjerg
Summary: The combination of two platform therapies for multiple sclerosis did not have additional effect. Add-on therapies with repurposed drugs have been negative, except for monthly methylprednisolone which had low tolerability. Combination therapy for neuroprotection/remyelination showed some interesting results, but awaits phase III trial results. The combination of new effective neuroprotective/remyelinating drugs and highly effective anti-inflammatory treatments may benefit people with MS.
EXPERT REVIEW OF NEUROTHERAPEUTICS
(2023)
Meeting Abstract
Ophthalmology
Benjamin Thinggaard, Katrine Hartmund Frederiksen, Yousif Subhi, Soren Moller, Ryo Kawasaki, Jakob Grauslund, Lonny Stokholm
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Meeting Abstract
Ophthalmology
Sebastian Dinesen, Lonny Stokholm, Thiusius Rajeeth Savarimuthu, Yousif Subhi, Tunde Peto, Jakob Grauslund
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)