Article
Engineering, Multidisciplinary
Xiaofei Fan, Xiunan Wang, Zhenkun Wang
Summary: This study develops a reaction-diffusion model with positive feedback loop to describe gene expression. The focus is on the long-term behavior of the system, including the determination of invariant regions and the global stability of equilibria. The results contribute to understanding the heterogeneity of cell characterization.
APPLIED MATHEMATICAL MODELLING
(2023)
Article
Oncology
Boxuan Zhou, Jinhua Xue, Runxin Wu, Hongyu Meng, Ruixi Li, Zhaohong Mo, Hang Zhai, Xianyu Chen, Rongqiang Liu, Guie Lai, Xiaohong Chen, Taiyuan Li, Shiyang Zheng
Summary: This study firstly illustrated that the circPAPD4/miR-1269a/CREBZF/STAT3/ADAR1 positive feedback loop mediated breast cancer progression, and delivering CREBZF mRNA nanoparticles suppressed breast cancer progression in vitro and in vivo, which might provide novel insights into therapeutic strategies for breast cancer.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Oncology
Haiyan Piao, Lingfeng Fu, Yuxin Wang, Yang Liu, Yue Wang, Xiangyu Meng, Dong Yang, Xiang Xiao, Jun Zhang
Summary: This study identifies a positive feedback loop between macrophages and gastric cancer cells that contributes to tumor progression and patient outcome.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
Ran Hao, Lei Zhang, Yangming Si, Peng Zhang, Yipeng Wang, Bangchao Li, Jie Hu, Yixin Qi
Summary: This study identified aberrant circRNAs in breast cancer tissues, and found that circRRM2 was upregulated in tumor tissues of breast cancer patients. Functional experiments showed that circRRM2 promoted cell migration and invasion, and acted as an oncogene in breast cancer. Mechanistic studies revealed a positive feedback loop involving circRRM2/IGF2BP1/MYC in breast cancer.
CANCER CELL INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Liang Zhu, Lechen Liu, Aoli Wang, Jinwen Liu, Xin Huang, Tao Zan
Summary: Dermal fibrosis is a global disease that affects millions of people and causes physical and psychological distress. Fibroblast dysfunction plays a crucial role in the pathogenesis of dermal fibrosis, leading to excessive deposition of extracellular matrix. The positive feedback loop of fibroblast activation further worsens the condition. This review focuses on understanding the mechanisms and potential therapeutic targets to break this cycle.
Article
Oncology
Yanbin Liu, Zhicong Huang, Yanli Wei, Mingming Zhang, Xingzhi Li, Shulan Yang, Haihe Wang
Summary: The research identified a novel positive feedback loop between STXBP6 and IRF1 in regulating PD-L1 expression, which affects the response to immunotherapy targeting PD-L1 in cancer.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2021)
Article
Oncology
Qiang Li, Xiao Wang, Liheng Zhou, Mingyun Jiang, Guansheng Zhong, Shuguang Xu, Minjun Zhang, Yigan Zhang, Xiaodong Liang, Lei Zhang, Jianming Tang, Haibo Zhang
Summary: The study revealed that LINC00152 is significantly upregulated in breast cancer, serving as an indicator of poor prognosis. Knockdown of LINC00152 suppresses cell proliferation and tumorigenicity, and its interaction with KLF5 promotes tumor progression.
FRONTIERS IN ONCOLOGY
(2021)
Review
Geriatrics & Gerontology
Shun Liu, Weihua Nong, Lin Ji, Xiuhong Zhuge, Huimei Wei, Min Luo, Leguang Zhou, Shenghua Chen, Shun Zhang, Xiaocan Lei, Hua Huang
Summary: Inflammation and telomeres are involved in a feedback regulatory loop, where inflammation increases telomere attrition and telomere components participate in regulating the inflammatory response. The specific mechanism behind this feedback loop is not fully understood.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Yijun Mei, Lu Tang, Lidong Zhang, Jingyi Hu, Ziyao Zhang, Shun He, Jing Zang, Wei Wang
Summary: Combining immune checkpoint blockade therapy with other treatment modalities through nanotechnology can enhance immunity for effective cancer treatment. In this study, a three-in-one nanocomposite was fabricated, which could precisely target tumors and strengthen the antitumor efficacy through the interaction of different components. The combination therapy demonstrated a positive feedback-mediated multimodal antitumor effect and the potential for long-term tumor immune memory establishment.
Review
Pharmacology & Pharmacy
Yang Chen, Yong-yao Wu, Hai-bo Si, Yan-rong Lu, Bin Shen
Summary: Regulation of chondrocyte mitochondrial quality control may play a crucial role in the pathogenesis and progression of osteoarthritis.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Alejandro H. Gutierrez, Marina S. Mazariegos, Susana Alemany, Yulia A. Nevzorova, Francisco Javier Cubero, Carlos Sanz-Garcia
Summary: In this study, the significance of TPL2 in chronic liver disease (CLD) and its impact on pathological and molecular transduction are investigated. This research could lead to important advancements in the diagnosis and treatment of CLD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Biology
Lauric Feugere, Victoria F. Scott, Quentin Rodriguez-Barucg, Pedro Beltran-Alvarez, Katharina C. Wollenberg Valero
Summary: This study found the existence of positive thermal stress feedback loops in zebrafish embryos, where heat stress can induce stress-like responses in conspecifics, though possibly operating through different molecular pathways. The stress medium and fluctuating high temperature significantly accelerated development and altered embryonic activity, leading to significant changes in the expression of molecular markers.
JOURNAL OF THERMAL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Mengting Du, Tingting Geng, Rongrong Yu, Gang Song, Hui Cheng, Yu Cao, Weidong He, Abdul Haleem, Qinglin Li, Rongfeng Hu, Shengqi Chen
Summary: This study presents a charge-reversible nanoparticle CRNP-GNA that can induce a positive feedback loop to enhance tumor vascular permeability and drug accumulation in tumors with low vascular density, thereby improving the efficacy of anti-vascular therapy.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biochemistry & Molecular Biology
Catera L. Wilder, Diane Lefaudeux, Raisa Mathenge, Kensei Kishimoto, Alma Zuniga Munoz, Minh A. Nguyen, Aaron S. Meyer, Quen J. Cheng, Alexander Hoffmann
Summary: Different types of IFNs, such as IFN-beta and IFN-lambda 3, regulate immune responses in different ways. IFN-beta can activate inflammatory gene expression, while IFN-lambda 3 can only activate antiviral gene expression. The study reveals a dynamic control mechanism of the JAK-STAT/IRF signaling network, mediated by the positive feedback loop between ISGF3 components IRF9 and STAT2, which determines the activation of the inflammatory gene program. This research provides insights into the dysregulation of type I IFN and potential therapeutic approaches.
MOLECULAR SYSTEMS BIOLOGY
(2023)
Article
Multidisciplinary Sciences
Qin Yu, Dan Wan, Rong Fu, Feng Li, Yutao Zhang
Summary: The overexpression of tumor progression locus 2 (TPL2) and peptidyl-prolyl cis-trans isomerase 1 (Pin1) plays significant roles in the occurrence and development of breast invasive ductal carcinoma (IDC). The expression levels of TPL2 and Pin1 are closely correlated with the malignancy and TNM staging of IDC. TPL2 overexpression may be an early molecular event in IDC development, and IDC patients with TPL2 overexpression may have a better prognosis.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Sebastian Drube, Sylvia Mueller, Franziska Weber, Philine Wegner, Romy Boettcher-Loschinski, Matthias Gaestel, Andreas Hutloff, Thomas Kamradt, Nico Andreas
Summary: IL-33 activates multiple signaling pathways by binding to its receptor ST2, leading to the activation of different kinases and crucial for the production of IL-6 and IL-2. Unlike SCF, IL-3 can modulate the regulation of T-reg subpopulations by altering cytokine profiles, shifting the balance of T-regs induced by IL-33 towards a specific subset.
Article
Cardiac & Cardiovascular Systems
Matthieu Ruiz, Maya Khairallah, Dharmendra Dingar, George Vaniotis, Ramzi J. Khairallah, Benjamin Lauzier, Simon Thibault, Joelle Trepanier, Yanfen Shi, Annie Douillette, Bahira Hussein, Sherin Ali Nawaito, Pramod Sahadevan, Albert Nguyen, Fatiha Sahmi, Marc-Antoine Gillis, Martin G. Sirois, Matthias Gaestel, William C. Stanley, Celine Fiset, Jean-Claude Tardif, Bruce G. Allen
Summary: The study showed that MK2(-/-) mice exhibited signs of possible early diastolic dysfunction at 12 weeks of age; they also had lower body temperature, decreased body weight, and altered expression of certain metabolic genes.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Biochemistry & Molecular Biology
Ravinder Kandi, Katharina Senger, Ani Grigoryan, Karin Soller, Vadim Sakk, Tanja Schuster, Karina Eiwen, Manoj B. Menon, Matthias Gaestel, Yi Zheng, Maria Carolina Florian, Hartmut Geiger
Summary: The Cdc42-Borg4-Septin7 axis is crucial for maintaining polarity and function in HSCs, with genetic deletion of Borg4 or Septin7 resulting in reduced polarity frequency and engraftment potential of HSCs.
Article
Cell Biology
Mathilde Soulez, Pierre-Luc Tanguay, Florence Do, Junio Dort, Colin Crist, Alexey Kotlyarov, Matthias Gaestel, Mathieu Ferron, Nicolas A. Dumont, Sylvain Meloche
Summary: The ERK3 and its substrate MK5 constitute a signaling pathway that plays an important regulatory role in postnatal muscle differentiation.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Medicine, Research & Experimental
Mohammad Shafiq, Zahid Rasool Lone, Pragya Bharati, Himalaya Singh, Kumaravelu Jagavelu, Neeraj Kumar Verma, Jimut Kanti Ghosh, Matthias Gaestel, Kashif Hanif
Summary: This study demonstrates the important role of MK2 in inflammation and endothelial microparticle generation, suggesting that its inhibition may help improve endothelial function in patients with pulmonary hypertension.
Article
Biochemistry & Molecular Biology
Akhil Kumar, Nishank Goyal, Nandhini Saranathan, Sonam Dhamija, Saurabh Saraswat, Manoj B. Menon, Perumal Vivekanandan
Summary: This study reveals that the depletion of CpG dinucleotides in SARS-CoV-2 genomes is not uniform and varies over time. The rate of CpG depletion is highest during early evolution in humans and gradually reaches an equilibrium. The study also shows that CpG depletion occurs mainly at specific positions within codons and SARS-CoV-2 genomes selectively lose CpGs-motifs from a U-rich context.
MOLECULAR BIOLOGY AND EVOLUTION
(2022)
Article
Cell Biology
Manoj B. Menon, Tatiana Yakovleva, Natalia Ronkina, Abdulhadi Suwandi, Ivan Odak, Sonam Dhamija, Inga Sandrock, Florian Hansmann, Wolfgang Baumgaertner, Reinhold Foerster, Alexey Kotlyarov, Matthias Gaestel
Summary: This study used genetic modification to delete septin7 in mice and found that septin7 plays an important role in macrophage cytokinesis but not macrophage function. Additionally, septin7 seems to be essential for oncogenic Kras-driven lung tumorigenesis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Natalia Ronkina, Matthias Gaestel
Summary: Mitogen-activated protein kinase-activated protein kinases (MAPKAPKs) are exclusively activated by MAPKs and play a role in regulating gene expression, RNA processing, and protein synthesis. They are promising targets for cancer therapy and treatments for conditions of inflammation.
ANNUAL REVIEW OF BIOCHEMISTRY
(2022)
Editorial Material
Cell Biology
Manoj B. Menon, Matthias Gaestel
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Lucia Privitera, Ellen L. Hogg, Marcia Lopes, Luana B. Domingos, Matthias Gaestel, Juergen Mueller, Mark J. Wall, Sonia A. L. Correa
Summary: The aim of Alzheimer disease research is to develop efficient therapies to prevent and delay cognitive impairments. This study investigates the effects of mGluR-LTD in a rodent model of the disease, finding that its enhancement is associated with impaired LTP and altered synaptic plasticity. The researchers also identify the MK2 cascade as a potential pharmacological target to correct the over-activation of mGluR signaling.
Editorial Material
Oncology
Fadia Boudghene-Stambouli, Mathilde Soulez, Natalia Ronkina, Anneke Doerrie, Alexey Kotlyarov, Ole-Morten Seternes, Matthias Gaestel, Sylvain Meloche
Summary: Patients with triple-negative breast cancer face poor outcomes due to the aggressive nature of the disease and the lack of effective treatments. Identifying new therapeutic targets is essential, and recent research suggests that the protein kinase ERK4 may be a promising candidate. However, there are concerns about the experimental methods used to validate the oncogenic function of ERK4 in breast cancer.
Article
Cell Biology
Chanchal Chauhan, Ana Martinez-Val, Rainer Niedenthal, Jesper Velgaard Olsen, Alexey Kotlyarov, Simon Bekker-Jensen, Matthias Gaestel, Manoj B. Menon
Summary: The TNF receptor-interacting protein kinases (RIPK)-1 and 3 regulate cell death response pathways. RIPK1 determines cell survival or death by associating with distinct complexes, while RIPK3 is a target of PRMT5-mediated arginine dimethylation. This study uncovers PRMT5-mediated RIPK3 methylation as a novel modulator of RIPK1-dependent signaling.
CELL DEATH DISCOVERY
(2023)
Article
Virology
Mark Windheim, Thomas F. Reubold, Khadija Aichane, Matthias Gaestel, Hans-Gerhard Burgert
Summary: Human adenoviruses (HAdVs) are widespread pathogens that can cause mild infections in immunocompetent individuals but severe or fatal diseases in immunocompromised patients. They have developed immunomodulatory proteins to counteract the host immune defenses.
JOURNAL OF VIROLOGY
(2023)
Article
Medicine, General & Internal
Boya Nugraha, Renate Scheibe, Christoph Korallus, Matthias Gaestel, Christoph Gutenbrunner
Summary: The study revealed higher activity of the p38/MK2 pathway in FMS patients, suggesting its involvement in the pathomechanism of FMS and its potential as a target for pain management in FMS patients.
MEDICINA-LITHUANIA
(2021)