Journal
BIOMED RESEARCH INTERNATIONAL
Volume 2019, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2019/3456719
Keywords
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Funding
- Zhejiang Medical and Health Science and Technology Plan Project [2015KYB182, 2016ZDA008, 2017KY382, 2019KY080]
- National Natural Science Foundation of China [81871759, 81672147]
- Zhejiang Provincial Natural Science Foundation of China [LY18H060003, LY16H060003, LQ18H050005]
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Dihydroartemisinin (DHA), which is considered to be one of the active compounds within Artemisia annua, has extensively been used in recent years as the most effective drug against malaria, having many biological functions including anticancer, antifungal, and immunomodulatory activities. However, DHA plays a role in the regulation of the proliferation and human mesenchymal stem cells (hMSCs) osteogenic differentiation that remains unknown. We explored DHA's effect on hMSCs' proliferation as well as the osteogenic differentiation, together with its underlying mechanisms of action. We showed that DHA enhanced osteogenic differentiation but had no significant effect on hMSCs' proliferation. It probably exerted its functions through the signaling pathways of ERK1/2 as well as Wnt/beta. Because DHA has low toxicity and costs, it might be regarded as an important drug for fracture treatment and tissue engineering.
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