Journal
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
Volume 14, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s13018-019-1310-y
Keywords
Lactobacillus casei Shirota; Distal radius fracture; Michigan Hand Questionnaire; Hand function; Elder patients
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Funding
- Key Scientific and Technological Research Projects of Hebei Health and Family Planning Commission [20180411]
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Background To evaluate the effect of oral Lactobacillus casei Shirota (LcS) administration on recovery of hand functions in senior patients diagnosed with an acute distal radius fracture. Methods This clinical trial is double-blind and placebo-controlled, in which 293 senior patients with distal radius fracture were initially enrolled. After exclusion, 264 eligible patients were randomly assigned to receive oral placebo or LcS daily for a period of 3 months after the fracture. Treatment outcomes were Michigan Hand Questionnaire (MHQ) score, radial deviation and inclination, and ulnar deviation and variance, all of which were monitored and measured every month. Results Throughout the length of this study, MHQ score, radial deviation and inclination, and ulnar deviation and variance of patients on oral LcS displayed a significantly faster improvement in comparison to those receiving placebo, over the 3-month intervention period. Conclusion Oral administration of LcS dramatically accelerated hand function recovery in senior patients with distal radius fracture.
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