Article
Endocrinology & Metabolism
John P. Kirwan, Anita P. Courcoulas, David E. Cummings, Allison B. Goldfine, Sangeeta R. Kashyap, Donald C. Simonson, David E. Arterburn, William F. Gourash, Ashley H. Vernon, John M. Jakicic, Mary Elizabeth Patti, Kathy Wolski, Philip R. Schauer
Summary: The objective of this study is to assess the durability and longer-term effectiveness of metabolic surgery compared with medical/lifestyle management in patients with type 2 diabetes. The results demonstrate that metabolic/bariatric surgery is more effective and durable than medical/lifestyle intervention in remission of type 2 diabetes, with significant improvements in glycemic control, body weight, and biomarkers.
Article
Endocrinology & Metabolism
Matthew C. Riddle, William T. Cefalu, Philip H. Evans, Hertzel C. Gerstein, Michael A. Nauck, William K. Oh, Amy E. Rothberg, Carel W. le Roux, Francesco Rubino, Philip Schauer, Roy Taylor, Douglas Twenefour
Summary: Improvement of glucose levels in people with diabetes can occur spontaneously or after medical interventions. Newer forms of treatment may lead to more sustained improvement. However, the terminology and objective measures for defining this process are not established, and the long-term risks and benefits are not well understood. An international expert group proposed the term "remission" and HbA1c < 6.5% as the usual diagnostic criterion. They also suggested active observation and further research on predictors and outcomes of remission.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Surgery
Mohamed AbdAlla Salman, Ahmed Rabiee, Ahmed Salman, Ahmed Elewa, Mohamed Tourky, Ahmed Abdelrahman Mahmoud, Ahmed Moustafa, Hossam El-Din Shaaban, Ahmed Abdelaziz Ismail, Khaled Noureldin, Mohamed Issa, Mohamed Farah, Hesham Barbary, Mujahid Gasemelseed Fadlallah Elhaj, Haitham S. E. Omar
Summary: This study aimed to identify predictors of diabetes remission after two types of bariatric procedures. The results showed that nearly half of the patients achieved complete remission of T2DM two years after surgery. The duration of diabetes and preoperative BMI and C-peptide levels were independent factors predicting complete remissions.
ASIAN JOURNAL OF SURGERY
(2022)
Article
Endocrinology & Metabolism
Gladys Wojciechowska, Lukasz Szczerbinski, Marek Kretowski, Magdalena Niemira, Hady Razak Hady, Adam Kretowski
Summary: This study suggests that four serum miRNAs may serve as predictive biomarkers for type 2 diabetes remission 12 months after sleeve gastrectomy. Further validation studies are needed to confirm the findings.
Article
Endocrinology & Metabolism
Matthew C. Riddle, William T. Cefalu, Philip H. Evans, Hertzel C. Gerstein, Michael A. Nauck, William K. Oh, Amy E. Rothberg, Carel W. le Roux, Francesco Rubino, Philip Schauer, Roy Taylor, Douglas Twenefour
Summary: Remission of diabetes refers to the improvement of glucose levels into the normal range in some patients, either spontaneously or through medical interventions, which can persist after withdrawal of glucose-lowering pharmacotherapy. Current terminology and objective measures for this process are not well established, and the long-term risks versus benefits are not fully understood.
Article
Endocrinology & Metabolism
Naomi Holman, Sarah H. Wild, Kamlesh Khunti, Peter Knighton, Jackie O'Keefe, Chirag Bakhai, Bob Young, Naveed Sattar, Jonathan Valabhji, Edward W. Gregg
Summary: The incidence of remission of type 2 diabetes is generally low in routine care settings, but it may be a reasonable goal for patients who lose a significant amount of weight shortly after diagnosis. Factors associated with higher odds of remission include shorter duration of diagnosis, non-prescription of glucose-lowering medication, lower HbA(1c) and BMI levels, White ethnicity, female sex, and lower socioeconomic deprivation.
Article
Endocrinology & Metabolism
Matthew C. Riddle, William T. Cefalu, Philip H. Evans, Hertzel C. Gerstein, Michael A. Nauck, William K. Oh, Amy E. Rothberg, Carel W. le Roux, Francesco Rubino, Philip Schauer, Roy Taylor, Douglas Twenefour
Summary: Continuous improvement in blood sugar levels for diabetes patients may be more common now due to newer forms of treatment. An international expert group convened by the American Diabetes Association proposed standardized terminology and diagnostic criteria to address this issue.
Review
Biochemistry & Molecular Biology
Mansor Fazliana, Zubaidah Nor Hanipah
Summary: This article reviews the mechanisms and outcomes of metabolic surgery on the endocrine system, microbiome, metabolomics, and molecular level. It summarizes the changes in hormones, adipokines, microbiota, microRNAs, and metabolomics following metabolic surgery in human and animal models for the treatment of obesity and diabetes. The review considers the most relevant studies in this field over the past 17 years. In most cases, metabolic procedures, especially those with intestinal bypass components, have shown significant improvement in type 2 diabetes through weight-independent mechanisms.
Article
Medicine, General & Internal
Zohaib Iqbal, Helene A. Fachim, J. Martin Gibson, Ivona Baricevic-Jones, Amy E. Campbell, Bethany Geary, Rachelle P. Donn, Dashne Hamarashid, Akheel Syed, Anthony D. Whetton, Handrean Soran, Adrian H. Heald
Summary: Bariatric surgery induces metabolic pathway recalibration, potentially contributing to the remission of type 2 diabetes mellitus. Analysis of plasma samples identified several proteins that may serve as biomarkers for T2DM remission after surgery.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Mara Suleiman, Lorella Marselli, Miriam Cnop, Decio L. Eizirik, Carmela De Luca, Francesca R. Femia, Marta Tesi, Silvia Del Guerra, Piero Marchetti
Summary: Recent studies have shown that recovery of beta cell function may lead to remission of T2D in patients after specific treatments. This suggests the possibility of promoting T2D remission by directly targeting pancreatic beta cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
A. Turquetil, R. Morello, M. Joubert, Y. Le Roux, Y. Reznik
Summary: This study demonstrated that the glycaemic patterns in obese subjects post-bariatric surgery can predict the remission of type 2 diabetes 1 year later. Time spent above range and standard deviation of glucose levels were strong predictors of diabetes remission, with a combination of criteria showing high positive predictive value, sensitivity, and specificity.
DIABETES & METABOLISM
(2021)
Review
Endocrinology & Metabolism
Paolo Gentileschi, Emanuela Bianciardi, Domenico Benavoli, Michela Campanelli
Summary: Bariatric surgery has been shown to promote remission or significant improvement of Type II Diabetes Mellitus and related comorbidities in obese patients. Different gastrointestinal procedures may have varying effects and mechanisms of action on glucose metabolism. Metabolic surgery integrates knowledge and multidisciplinary expertise to provide a combination of conservative and surgical treatments for Type II diabetes.
ACTA DIABETOLOGICA
(2021)
Article
Chemistry, Multidisciplinary
Arianna Bonizzi, Marta Sevieri, Leopoldo Sitia, Andrea Rizzi, Lorenzo Conti, Fabio Corsi, Carlo Morasso, Serena Mazzucchelli
Summary: The study revealed that despite the improvements in weight, glycemic control, and lipid profile of type 2 diabetes mellitus patients after bariatric surgery, Raman spectroscopy indicated that their metabolic profiles were not fully restored post-surgery.
APPLIED SCIENCES-BASEL
(2021)
Review
Nutrition & Dietetics
Dimitra Vasdeki, Theocharis Koufakis, Georgios Tsamos, Luca Busetto, Pantelis Zebekakis, Kalliopi Kotsa
Summary: Type 2 diabetes mellitus is a progressive disease that can potentially be managed through lifestyle changes, obesity surgery, and glucose-lowering therapy, but there are still some unknowns regarding its long-term effects on diabetic complications.
Article
Endocrinology & Metabolism
Kaisheng Yuan, Bing Wu, Ruiqi Zeng, Fuqing Zhou, Ruixiang Hu, Cunchuan Wang
Summary: This study aimed to investigate factors influencing diabetes remission (DR) in patients with obesity and T2DM after bariatric metabolic surgery (BMS), and develop a predictive model using a nomogram. Glycated haemoglobin, triglycerides, duration of diabetes, insulin requirement, and hypercholesterolaemia were identified as independent factors for DR. The nomogram showed good efficacy in both training and validation cohorts.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Maria Mylona, Stavros Liatis, Georgios Anastasiadis, Christos Kapelios, Alexander Kokkinos
DIABETES RESEARCH AND CLINICAL PRACTICE
(2020)
Review
Endocrinology & Metabolism
John Doupis, Georgios Festas, Christos Tsilivigos, Vasiliki Efthymiou, Alexander Kokkinos
Article
Endocrinology & Metabolism
Emmanouil Korakas, Ignatios Ikonomidis, Foteini Kousathana, Konstantinos Balampanis, Aikaterini Kountouri, Athanasios Raptis, Lina Palaiodimou, Alexander Kokkinos, Vaia Lambadiari
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2020)
Review
Endocrinology & Metabolism
Dimitrios Tsilingiris, Stavros Liatis, Maria Dalamaga, Alexander Kokkinos
CURRENT OBESITY REPORTS
(2020)
Review
Nutrition & Dietetics
Georgia Argyrakopoulou, Stamatia Simati, George Dimitriadis, Alexander Kokkinos
Article
Endocrinology & Metabolism
A. Kokkinos, C. Liaskos, K. Alexiadou, I Papassotiriou, A. Margeli, G. Argyrakopoulou, D. Perrea, A. Alexandrou, N. Katsilambros, T. Diamantis, N. Tentolouris
Summary: Obesity is associated with low-grade inflammation, and weight loss following bariatric surgery leads to a consistent decline in plasma hsCRP levels, while plasma suPAR levels increase at 3 months and decline by 12 months.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Chrysi Koliaki, Evangelia Tzeravini, Eleftheria Papachristoforou, Ioanna Severi, Elina El Deik, Melina Karaolia, Marina Noutsou, Anastasia Thanopoulou, Aikaterini Kountouri, Konstantinos Balampanis, Vaia Lambadiari, Nicholas Tentolouris, Alexander Kokkinos
FRONTIERS IN ENDOCRINOLOGY
(2020)
Article
Endocrinology & Metabolism
Chrysi Koliaki, Stavros Liatis, Maria Dalamaga, Alexander Kokkinos
CURRENT OBESITY REPORTS
(2020)
Review
Endocrinology & Metabolism
Emmanouil Korakas, Aikaterini Kountouri, Athanasios Raptis, Alexander Kokkinos, Vaia Lambadiari
FRONTIERS IN ENDOCRINOLOGY
(2020)
Editorial Material
Immunology
Vaia Lambadiari, Foteini Kousathana, Athanasios Raptis, Konstantinos Katogiannis, Alexander Kokkinos, Ignatios Ikonomidis
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Endocrinology & Metabolism
Charilaos Dimosthenopoulos, Stavros Liatis, Elias Kourpas, Elpida Athanasopoulou, Stamatina Driva, Konstantinos Makrilakis, Alexander Kokkinos
Summary: Comparing the effects of three different dietary patterns in patients with type 1 diabetes, the high-protein/low-carbohydrate diet showed better glycaemic control and reduced time spent in hypoglycaemia compared to the Mediterranean/low-glycaemic index and reference diets.
DIABETES OBESITY & METABOLISM
(2021)
Article
Cell Biology
Sophia Athanasopoulou, Dimitrios Simos, Maria Charalampopoulou, Nikolaos Tentolouris, Alexandros Kokkinos, Flora Bacopoulou, Elena Aggelopoulou, Eleni Zigkiri, George P. Chrousos, Christina Darviri, Efstathios S. Gonos
Summary: This study investigated the effects of stress on aging pathways, particularly on leucocyte telomere length (LTL) and proteasome levels. By applying the Pythagorean Self Awareness Intervention (PSAI), improvements were observed in aging biomarkers, psycho-/bio-factors, psychometric, anthropometric, and key metabolic features, as well as hair cortisol in both healthy adults and patients with type 2 diabetes. These findings suggest potential key targets for interventions and prognostic tools for assessing aging pace in clinical practice.
MECHANISMS OF AGEING AND DEVELOPMENT
(2021)
Article
Nutrition & Dietetics
Konstantinos Stefanakis, Alexander Kokkinos, Stamatia Simati, Georgia Argyrakopoulou, Sofia K. Konstantinidou, Matina Kouvari, Ajay Kumar, Bhanu Kalra, Christos S. Mantzoros
Summary: This study measured the levels of all proglucagon-derived peptides (PGDPs) in response to three mixed meal tolerance tests (MMTs), comparing postprandial PGDP responses between lean and obese subjects and between high-fat and high-carbohydrate meals. The results showed that the fat and carbohydrate content of a meal can significantly affect the postprandial levels of PGDPs, and the presence of leanness or obesity also influences the circulating levels of select PGDPs.
CLINICAL NUTRITION
(2023)
Meeting Abstract
Sport Sciences
Costas Chryssanthopoulos, Roxane Tenta, Evangelia Tzeravini, Elias Zacharogiannis, Alexander Kokkinos, Maria Maridaki, Michael Koutsilieris, Anastassios Philippou
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2020)
Meeting Abstract
Endocrinology & Metabolism
D. Tsilingiris, A. Tentolouris, I. Eleftheriadou, I. Anastasiou, O. Kosta, C. Dimosthenopoulos, A. Kokkinos, N. Katsilambros, N. Tentolouris
