Article
Cardiac & Cardiovascular Systems
Radka Kockova, Hana Linkova, Zuzana Hlubocka, Karel Medilek, Martin Tuna, Jan Vojacek, Ivo Skalsky, Stepan Cerny, Jiri Maly, Jaroslav Hlubocky, Takuya Mizukami, Cristina De Colle, Martin Penicka
Summary: In asymptomatic severe aortic regurgitation (AR) patients, a multimodality and multiparametric model combining two imaging indices with natriuretic peptides showed high accuracy in predicting early disease decompensation.
CIRCULATION-CARDIOVASCULAR IMAGING
(2022)
Review
Clinical Neurology
Jiahui Wang, Jingxuan Wang, Zhouping Tang, Ping Zhang
Summary: This study reviewed the association of brain natriuretic peptide and N-terminal pro-brain natriuretic peptide levels with clinical outcome and disease severity assessment in patients with intracerebral hemorrhage over the past decade. The findings indicate that elevated levels of these peptides are correlated with increased risk of all-cause mortality, poor functional outcome, adverse cardiac events, and disease severity in patients with intracerebral hemorrhage.
FRONTIERS IN NEUROLOGY
(2021)
Review
Medicine, General & Internal
Gianmarco Alcidi, Giovanni Goffredo, Michele Correale, Natale Daniele Brunetti, Massimo Iacoviello
Summary: BNP and NT-proBNP play a key role as serum biomarkers in the management of heart failure. They can be used for diagnosis, prognostic stratification, monitoring and guiding therapy of HF, as well as evaluating the efficacy of new therapeutic strategies. However, their use is still limited due to the controversy surrounding their use in different clinical settings.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Kaiyi Shen, Shenbei Jiang
Summary: This study investigated the value of procalcitonin (PCT) and brain natriuretic peptide (BNP) in predicting the prognosis of sepsis. The results showed that plasma levels of PCT and BNP were elevated in sepsis patients and positively correlated with disease severity, suggesting that they can be used as prognostic indicators.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2023)
Article
Multidisciplinary Sciences
Masayuki Shiba, Takao Kato, Takeshi Morimoto, Hidenori Yaku, Yasutaka Inuzuka, Yodo Tamaki, Neiko Ozasa, Yuta Seko, Erika Yamamoto, Yusuke Yoshikawa, Takeshi Kitai, Yugo Yamashita, Moritake Iguchi, Kazuya Nagao, Yuichi Kawase, Takashi Morinaga, Mamoru Toyofuku, Yutaka Furukawa, Kenji Ando, Kazushige Kadota, Yukihito Sato, Yasuaki Nakagawa, Koichiro Kuwahara, Takeshi Kimura
Summary: This study investigated the association between changes in brain natriuretic peptide (BNP) levels and clinical outcomes in patients with acute heart failure (AHF). The results showed that the percent change in BNP was associated with an increased risk of all-cause death or hospitalization for HF. Therefore, monitoring changes in BNP levels can help in the management of patients with heart failure.
Review
Pharmacology & Pharmacy
Koichiro Kuwahara
Summary: Natriuretic peptides, such as ANP and BNP, are important in cardioprotection in heart failure by antagonizing the effects of angiotensin II, while CNP plays a role in regulating vascular tone and blood pressure. These peptides are also being studied for their potential as biomarkers and therapeutics in cardiovascular disease.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Cardiac & Cardiovascular Systems
Vasileios Kouranos, Rajdeep S. Khattar, Joseph Okafor, Raheel Ahmed, Alessia Azzu, John Arun Baksi, Kshama Wechalekar, Martin R. Cowie, Athol Umfrey Wells, Thomas F. Luscher, Rakesh Sharma
Summary: This study describes the baseline characteristics of a sizable and deeply phenotyped contemporary cohort of cardiac sarcoidosis (CS) patients and investigates the predictors of poor outcomes. The study found that CS is associated with significant morbidity and mortality, particularly in those with cardiac involvement as the first manifestation. Serum brain natriuretic peptide levels, left ventricular ejection fraction, and myocardial inflammation were identified as independent predictors of outcomes.
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Cardiac & Cardiovascular Systems
Mi-Jeong Kim, Jung Sun Cho, Kyusup Lee, Woojin Kwon, Chaeryeon Ohn, Myunhee Lee, Dae-Won Kim, Tae-Seok Kim, Mahn-Won Park
Summary: This study aims to predict long-term outcomes of heart failure patients by combining various non-invasive cardiac examinations. The results showed that the combination of plasma NT-proBNP level and echocardiographic findings (Echo-LVFP) could stratify patients into three groups and predict adverse outcomes. Left atrial mechanics and exercise capacity further improved the accuracy of prognosis.
Review
Clinical Neurology
Felipe A. Montellano, Kathrin Ungethuem, Laura Ramiro, Aliona Nacu, Simon Hellwig, Felix Fluri, William N. Whiteley, Alejandro Bustamante, Joan Montaner, Peter U. Heuschmann
Summary: Based on the systematic review, the number of studies on prognostic blood-based biomarkers in ischemic stroke has increased 3.5-fold between January 2007 and August 2018. While some biomarkers show consistent association with poor outcomes in higher-quality studies, there are variations in the association reported in lower quality studies.
Review
Medicine, General & Internal
Edoardo Sciatti, Anna Merlo, Claudio Scangiuzzi, Raul Limonta, Mauro Gori, Emilia D'Elia, Alberto Aimo, Giuseppe Vergaro, Michele Emdin, Michele Senni
Summary: In recent years, there has been a growing interest in using multiple biomarkers, such as soluble suppression of tumorigenicity-2 (sST2), to stratify the risk and identify pathophysiological processes associated with heart failure. sST2 is produced in response to myocardial stress and is associated with both cardiac and immune cells. This article aims to review the prognostic value of sST2 in chronic and acute heart failure and provides a flowchart for its potential use in clinical practice.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Francesco Lapi, Ettore Marconi, Gerardo Medea, Damiano Parretti, Carlo Piccinni, Aldo Pietro Maggioni, Claudio Cricelli
Summary: Heart failure is a chronic disease that causes a significant number of deaths each year. Type 2 Diabetes Mellitus is a major risk factor for heart failure, and investigating NT-proBNP may help identify heart failure in diabetic patients. This study aims to characterize diabetic patients prescribed with NT-proBNP in primary care settings.
Article
Medicine, General & Internal
Thierry Carrel, Thoralf M. Sundt, Yskert von Kodolitsch, Martin Czerny
Summary: Despite advancements in the prevention, diagnosis, and treatment of acute aortic dissection, it remains a complex cardiovascular event with high mortality and morbidity rates. Recent research has improved our understanding of the disease's pathophysiology and led to reevaluations of existing classifications. There is a shift towards a unified naming system based on morphology and function. The location and extent of the initial tear, as well as the affected aortic segments, determine the appropriate management approach - emergency surgery, endovascular intervention, or medical treatment. Ongoing scientific evidence continues to shape the management and follow-up of acute aortic dissection, the most severe form of acute aortic syndrome.
Article
Cardiac & Cardiovascular Systems
Lucas Yixi Xing, Soren Zoga Diederichsen, Soren Hojberg, Derk W. Krieger, Claus Graff, Ruth Frikke-Schmidt, Morten S. Olesen, Axel Brandes, Lars Kober, Ketil Jorgen Haugan, Jesper Hastrup Svendsen
Summary: This study aimed to investigate the potential of NT-proBNP as a marker for AF screening efficacy and stroke prevention. The results showed that in individuals over 70 years old with additional stroke risk factors, ILR screening was associated with a significant reduction in stroke risk among those with higher NT-proBNP levels.
Article
Medicine, General & Internal
Nadia Aspromonte, Luigi Cappannoli, Pietro Scicchitano, Francesco Massari, Ivan Pantano, Massimo Massetti, Filippo Crea, Roberto Valle
Summary: The study found that low pre-discharge BNP levels were associated with low rates of cardiovascular events in HF patients, independently of the frequency of follow-up. Additionally, age, creatinine, and BNP were identified as independent predictors of events in HF patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Vittoriano Della Corte, Gaetano Pacinella, Federica Todaro, Rosaria Pecoraro, Antonino Tuttolomondo
Summary: Natriuretic peptides are a complex molecular network with pleiotropic effects on various organs and tissues, primarily maintaining cardiovascular homeostasis and regulating water-salt balance. Increasing knowledge of their receptors, molecular mechanisms, and discovery of new peptides has led to a better understanding of their physiological and pathophysiological roles, with potential therapeutic applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)