Article
Cardiac & Cardiovascular Systems
Roman Witzel, Annika Block, Solvey Pollmann, Leandra Oetzel, Fenja Fleck, Gabriel A. Bonaterra, Ralf Kinscherf, Anja Schwarz
Summary: This study aimed to investigate the regulatory effects of PACAP and its receptor VPAC1 in different macrophage subtypes in relation to inflammatory processes and lipid homeostasis. The results showed that PACAP played an important role in regulating inflammatory processes in atherosclerotic plaques and lipid homeostasis in different macrophage subtypes, affecting foam cell formation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Immunology
Karin Heidbreder, Katrin Sommer, Maximilian Wiendl, Tanja M. Mueller, Imke Atreya, Kai Hildner, Markus F. Neurath, Sebastian Zundler
Summary: This study investigates the role of non-classical monocytes in large intestinal wound healing. By depleting non-classical monocytes in mice deficient for the transcription factor Nr4a1, the researchers found that wound healing was significantly delayed and there was a reduced presence of macrophages with a wound healing phenotype. The findings suggest that non-classical monocytes are biased towards wound healing macrophages, providing insights into the modulation of intestinal macrophage functions through monocyte recruitment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Wu Li, Wanyan Deng, Nan Zhang, Huijuan Peng, Yi Xu
Summary: The Rv2387 protein plays a crucial role in facilitating Mycobacterium tuberculosis to evade host immunity and acts as a key virulence factor.
Article
Immunology
Wenwen Liu, Yuting Deng, Aiping Tan, Fei Zhao, Ouqing Chang, Fang Wang, Yingtiao Lai, Zhibin Huang
Summary: This study investigated the interactions between N. seriolae and macrophages and deciphered the intracellular survival mechanism of N. seriolae. It was found that N. seriolae entered macrophages and induced apoptosis in the early infection stage, but inhibited apoptosis in the middle and later periods of infection to survive inside the cells. Furthermore, N. seriolae inhibited the production of reactive oxygen species and released large amounts of nitric oxide, which contributed to its intracellular survival.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Integrative & Complementary Medicine
Tsan-Hung Chiu, Chang-Wen Ku, Tsung-Jung Ho, Kun-Ling Tsai, Wei-Ching Hsu, Yu-An Chen, Hsiu-Chung Ou, Hsiu- Chen
Summary: Atherosclerotic cardiovascular diseases are a major cause of death worldwide. Oxidized low-density lipoprotein (oxLDL) is a main component of atherosclerotic plaques. Dietary supplementation with antioxidants can prevent atherogenic diseases. Schisanhenol (SAL) has shown to attenuate oxLDL-induced apoptosis and ROS generation, but its underlying molecular mechanisms are not fully known.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Hongyu Hu, Jiangang Huang, Yin Cao, Zhaolin Zhang, Fengming He, Xianfu Lin, Qi Wu, Shengxian Zhao
Summary: Nur77 plays an important role in the occurrence and development of various tumors. In this study, a series of novel compounds were synthesized, among which 9h exhibited the strongest anti-proliferative activity and induced apoptosis by upregulating Nur77 expression and triggering its nuclear export. The results suggest that 9h may be a promising lead compound for further research in anti-tumor therapy.
Article
Chemistry, Medicinal
Xuhuang Tu, Xiaohui Chen, Dongliang Zhang, Meichun Gao, Jingmei Liang, Guoliang Bao, Jie Zhang, Shuangzhou Peng, Xiaokun Zhang, Zhiping Zeng, Ying Su
Summary: By optimizing the structure of compound BI1071, we found that compound 10b exhibits stronger binding to Nur77 and enhanced apoptotic activity.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Lucinda Baatjies, Ilana G. van Rensberg, Candice J. Snyders, Andrea Gutschmidt, Andre Loxton, Monique Williams
Summary: Iron is important for Mycobacterium tuberculosis infection and survival. The SufR operon is involved in iron-sulphur biogenesis in M. tuberculosis and is induced during iron limitation and intracellular growth, indicating its relevance during infection. A fluorescent reporter was used to study sufR expression during intracellular growth, and while increased fluorescence was observed in a sub-set of the population, the immune response elicited by SufR in TB-infected individuals was low and did not show a strong immune response.
Article
Environmental Sciences
Yingchun Zhang, Shuang Li, Jin Wu, Yuan Peng, Jialei Bai, Baoan Ning, Xinxing Wang, Yanjun Fang, Dianpeng Han, Shuyue Ren, Sen Li, Ruipeng Chen, Kang Li, Hongwei Du, Zhixian Gao
Summary: BPA, an environmental endocrine disruptor, can induce neuronal apoptosis through down-regulation of Nur77 and inhibition of the NF-kappa b/Bcl-2 pathway.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Medicine, Research & Experimental
Acharya Balkrishna, Vivek Gohel, Nishit Pathak, Rani Singh, Meenu Tomer, Malini Rawat, Rishabh Dev, Anurag Varshney
Summary: Atherosclerosis is a major pathological process of cardiovascular diseases, which can begin early in life and remain silent before symptoms manifest. The formation of foamy macrophages due to dysregulated lipid metabolism is important in atherosclerotic plaque development. Current pharmacotherapy for atherosclerosis is limited, but "Lipidom" has shown potential with its antioxidant, lipid-lowering, and anti-inflammatory properties. This study aimed to characterize the pharmacological effects of "Lipidom" using experimental models.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Neurosciences
Lu Liu, Di Ma, La Zhuo, Xinyuan Pang, Jiulin You, Jiachun Feng
Summary: Nur77, a member of the nuclear receptor superfamily, can be rapidly increased in expression and activation through various physiological and pathological stimuli. It plays a regulatory role in cell differentiation, apoptosis, metabolism, mitochondrial homeostasis, and other processes. Although research on Nur77 in CNS diseases is limited, evidence suggests its potential therapeutic value in various neurological disorders.
CURRENT NEUROPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Chenli Chang, Fengming He, Mingtao Ao, Jun Chen, Tao Yu, Weiyu Li, Baicun Li, Meijuan Fang, Ting Yang
Summary: Chronic obstructive pulmonary disease (COPD), a leading cause of death worldwide, causes inflammation and injury in airway epithelial cells. Nur77 is involved in lipopolysaccharide-induced inflammation and injury, and its expression increased in COPD-related inflammation and injury induced by cigarette smoke extract (CSE). The flavonoid derivative B6 effectively reduced inflammatory cytokine expression and secretion, as well as apoptosis in CSE-stimulated airway epithelial cells.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Plant Sciences
Chengqiang Wang, Gen Liu, Guojun Dou, Yi Yang, Lu Chen, Hui Ma, Zhuyun Jiang, Haoyue Ma, Chenglong Li, Li Li, Mingdong Jiang, Qianwei Lu, Pan Li, Hongyi Qi
Summary: The study demonstrates that Z-LIG selectively inhibits the viability of human AML cells, suppresses proliferation and colony formation, and restores Nur77 and NOR-1 expression in AML cells, thereby promoting apoptosis and differentiation.
Article
Multidisciplinary Sciences
Tala Shekarian, Carl P. Zinner, Ewelina M. Bartoszek, Wandrille Duchemin, Anna T. Wachnowicz, Sabrina Hogan, Manina M. Etter, Julia Flammer, Chiara Paganetti, Tomas A. Martins, Philip Schmassmann, Steven Zanganeh, Francois Le Goff, Manuele G. Muraro, Marie-Francoise Ritz, Darci Phillips, Salil S. Bhate, Graham L. Barlow, Garry P. Nolan, Christian M. Schuerch, Gregor Hutter
Summary: This study demonstrated that ex vivo immunotherapy of GBM explants can induce an active antitumoral immune response within the tumor center, providing a framework for multidimensional personalized assessment of tumor response to immunotherapy.
Article
Cell Biology
Jeremy F. Brooks, Corey Tan, James L. Mueller, Kenta Hibiya, Ryosuke Hiwa, Vivasvan Vykunta, Julie Zikherman
Summary: The expression of the nuclear receptor NUR77/Nr4a1 in B cells is associated with antigen stimulation and helps restrain B cell expansion. NUR77 plays a role in regulating GC size, particularly in curbing immunodominance under conditions of diverse clonal populations competing for a limited niche.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)