Article
Cell Biology
Haiyan Yang, Zhi Li, Zhangwei Wang, Xu Zhang, Xinyuan Dai, Guoren Zhou, Qiang Ding
Summary: The study found that HM13 is highly expressed in breast cancer and is associated with poor prognosis. Downregulation of HM13 can suppress the proliferation and metastasis abilities of breast cancer cells, activate autophagy, and inhibit the PI3K-AKT-mTOR pathway. It was also discovered that miR-760 directly targets HM13 and has tumor-suppressive effects in breast cancer.
CELL DEATH & DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Vivek Makwana, Santosh Rudrawar, Shailendra Anoopkumar-Dukie
Summary: Hexosamine biosynthetic (HBP) and PI3K/AKT/mTOR pathways play crucial roles in the proliferation and survival of prostate cancer cells by increasing androgen receptor expression and protein levels. Inhibition of a single pathway is insufficient to halt disease progression, suggesting that targeting multiple pathways at common junctions may be beneficial for effective management of prostate cancer.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Cell Biology
Ruiyuan Xu, Jianlu Song, Rexiati Ruze, Yuan Chen, Xinpeng Yin, Chengcheng Wang, Yupei Zhao
Summary: This study reveals squalene epoxidase (SQLE) as a novel oncogene that promotes pancreatic cancer (PC) growth by mitigating endoplasmic reticulum stress and activating lipid raft-regulated Src/PI3K/Akt signaling pathway. SQLE facilitates cell proliferation, induces cell cycle progression, and inhibits apoptosis in vitro, while promoting tumor growth in vivo. SQLE inhibitors effectively suppress PC cell proliferation and xenograft tumor growth, highlighting the potential of SQLE as a therapeutic target for PC.
CELL DEATH & DISEASE
(2023)
Article
Environmental Sciences
Zheng Cheng, Yufu Shu, Xin Li, Yutao Li, Sitong Zhou, Honggui Liu
Summary: The study revealed that L-selenomethionine supplementation inhibited ammonia-induced cardiac autophagy by activating the PI3K/AKT/mTOR signaling pathway, which alleviated the cardiac injury caused by excessive ammonia inhalation to some extent. L-selenomethionine could potentially provide a valuable intervention for ammonia toxicity in the future.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Neurosciences
Xin Ding, Lili Zhang, Xinping Zhang, Yang Qin, Ke Yu, Xiaokun Yang
Summary: Intranasal insulin can improve traumatic brain injury by regulating autophagy and ER stress-mediated apoptosis through the PI3K/AKT/mTOR signaling pathway.
Article
Oncology
Lei Wang, Zhiyu Fang, Peixiang Gao, Junfang Zheng
Summary: This study reveals a novel tumor-suppressing role of GLUD1 in ccRCC, providing new insights into inhibiting PI3K/Akt/mTOR activation and immune microenvironment.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Junbao Yang, Weilong Ding, Xiangyu Wang, Yongsheng Xiang
Summary: REV7 is highly expressed in glioma tissues and plays a crucial role in the chemosensitivity of glioma cells by regulating proliferation, apoptosis, and sensitivity to chemotherapy through the phosphoinositide 3-kinase signaling pathway. Targeting DNA polymerase zeta via REV7 may improve the sensitivity of glioma cells to chemotherapy.
Article
Genetics & Heredity
Xiaofeng Wang, Rui He, Li Geng, Jing Yuan, Huijie Fan
Summary: This study aimed to investigate whether Ginsenoside Rg3 can alleviate cisplatin resistance and enhance cisplatin-induced apoptosis in gastric cancer cells, and to explore the underlying molecular mechanisms. It was found that miR-429, expression of which was restored by Ginsenoside Rg3 treatment, was associated with cisplatin resistance in gastric cancer cells. The study also demonstrated that miR-429 contributed to chemosensitivity in gastric cancer cells partly through the regulation of SOX2. Overall, Ginsenoside Rg3 enhanced chemosensitivity and inhibited migration of cisplatin-resistant gastric cancer cells mainly by targeting miR-429 and modulating PI3K/AKT/mTOR signaling.
FRONTIERS IN GENETICS
(2022)
Article
Pharmacology & Pharmacy
Yuwei Fang, Kangpei Shi, Haining Lu, Lin Lu, Bo Qiu
Summary: Mingmu Xiaomeng tablets can protect the diabetic retina by inhibiting the PI3K/Akt/mTOR signaling pathway, promoting autophagy, and improving retinal function.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Dongmei Lan, Chao Yao, Xue Li, Haijiang Liu, Dan Wang, Yan Wang, Shengcai Qi
Summary: Tocopherol protects bone marrow-derived mesenchymal stem cells (BMSCs) from oxidative stress damage by inhibiting ferroptosis. This study found that tocopherol maintained cell viability, reduced intracellular oxidative stress levels, and promoted osteogenic differentiation, possibly through modulation of the PI3K/AKT/mTOR pathway.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Oncology
Liangui Nie, Maojun Liu, Jian Chen, Qian Wu, Yaling Li, Jiali Yi, Xia Zheng, Jingjing Zhang, Chun Chu, Jun Yang
Summary: The study found that hydrogen sulfide (H2S) has a protective effect on doxorubicin-induced myocardial fibrosis, possibly by upregulating the PI3K/AKT/mTOR signaling pathway to inhibit endoplasmic reticulum stress and autophagy.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biotechnology & Applied Microbiology
Yingnan Dai, Yeping Chen, Guoqian Wei, Li Zha, Xueqi Li
Summary: This study demonstrated that Ivabradine attenuated myocardial infarction in rats by enhancing autophagy, and the PI3K/AKT/mTOR/p70S6K pathway might be involved in this process. Activation of autophagy by Ivabradine could be a potential therapeutic strategy for the treatment of myocardial infarction.
Article
Pharmacology & Pharmacy
Jin-Long Pang, Lian-Song Xu, Qian Zhao, Wen-Wen Niu, Xiang-Yu Rong, Shan-Shan Li, Xian Li
Summary: This study found that sodium cantharidate (SCA) promotes apoptosis of breast cancer cells by inhibiting the PI3K-Akt-mTOR pathway and inducing autophagy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Medicinal
Pengzhan He, Yang He, Jingjing Ma, Yinghui Liu, Chuan Liu, Yu Baoping, Weiguo Dong
Summary: In this study, it was found that thymoquinone inhibited the proliferation of gastric cancer cells and induced concentration-dependent apoptosis and autophagy. These effects were mediated through the inhibition of the PI3K/Akt/mTOR pathway. The findings provide new insights into the specific mechanism of thymoquinone as an anti-gastric cancer drug.
PHYTOTHERAPY RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Qingsong Yang, Sizhen Li, Zixiu Zhou, Xiaodong Yang, Yating Liu, Kuanxiao Hao, Min Fu
Summary: The study found that Trimetazidine (TMZ) can inhibit excessive autophagy by activating the PI3K/Akt/mTOR pathway, thereby improving retinal endothelial dysfunction induced by high glucose.
