Journal
INTERFACE FOCUS
Volume 9, Issue 5, Pages -Publisher
ROYAL SOC
DOI: 10.1098/rsfs.2019.0030
Keywords
cervix; preterm birth; shear wave elastography imaging; shear wave speed
Categories
Funding
- National Institutes of Health [F31HD082911, R01HD072077]
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Intermountain Research and Medical Foundation
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We report here the results of a longitudinal study of cervix stiffness during pregnancy. Thirty women, ages ranging from 19 to 37 years, were scanned with ultrasound at five time points beginning at their normal first-trimester screening (8-13 weeks) through term pregnancy (nominally 40 week) using a clinical ultrasound imaging system modified with a special ultrasound transducer and system software. The system estimated the shear wave speed (its square proportional to the shear modulus under idealized conditions) in the cervix. We found a constant fractional reduction (about 4% per week) in shear wave speed with increasing gestational age. We also demonstrated a spatial gradient in shear wave speed along the length of the cervix (softest at the distal end). Results were consistent with our previous ex vivo and in vivo work in women. Shear wave elasticity imaging may be a potentially useful clinical tool for objective assessment of cervical softening in pregnancy.
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