Article
Multidisciplinary Sciences
Marina B. Blanco, Lydia K. Greene, Robert Schopler, Cathy V. Williams, Danielle Lynch, Jenna Browning, Kay Welser, Melanie Simmons, Peter H. Klopfer, Erin E. Ehmke
Summary: The study investigated the hibernation behavior of captive fat-tailed dwarf lemurs. Factors such as ambient temperature, food ingestion, and night length influenced the duration of torpor bouts in lemurs. While captive dwarf lemurs showed physiological capability for hibernation, they displayed different behavior patterns compared to their wild counterparts, occasionally moving and eating during hibernation.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Yi-Ge Huang, Sarah J. Flaherty, Carina A. Pothecary, Russell G. Foster, Stuart N. Peirson, Vladyslav V. Vyazovskiy
Summary: The study found that during fasting-induced torpor, mice showed progressively deeper and longer bouts of hypothermia, affecting EEG and EMG. Despite a decrease in REM sleep during deep hypothermia, intense bursts of muscle activity were observed. These findings suggest important similarities between EEG signatures of fasting-induced torpor in mice and hibernation in other species.
Article
Multidisciplinary Sciences
Stephen R. Morairty, Yu Sun, Lawrence Toll, Michael R. Bruchas, Thomas S. Kilduff
Summary: This study evaluated the effects of two NOPR agonists on sleep/wake in rats, mice, and Cynomolgus macaques. The results showed that these agonists increased non-Rapid Eye Movement sleep and electroencephalogram slow wave activity, while suppressing Rapid Eye Movement sleep in all three species. These findings suggest that the N/OFQ-NOPR system may have a previously unrecognized role in sleep/wake control and could be a potential therapeutic target for insomnia.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Rawan Kawach, Victoria Diedrich, Andreas Gruber, Kerstin Leopold, Annika Herwig, Maja Vujic Spasic
Summary: This study investigates the effects of photoperiodic acclimation and food deprivation on iron metabolism in Djungarian hamsters. The results show that both short photoperiods and long-term food restriction lead to iron sequestration in the liver, accompanied by hypoferremia and mild reduction in hepcidin expression. In addition, the levels of manganese, selenium, and zinc in the liver are increased under food restriction.
Article
Biology
Molly C. Craig, Larissa O. Silva, Steven J. Swoap
Summary: The study found that fasted mice tend to prefer warmer ambient temperatures when given the choice, especially in a selective environment. Additionally, fasted mice are more likely to maintain a higher body temperature in warm environments, which is beneficial for metabolism.
JOURNAL OF THERMAL BIOLOGY
(2021)
Article
Biology
Larry D. Sanford, Austin M. Adkins, Alea F. Boden, Justin D. Gotthold, Ryan D. Harris, Dorela Shuboni-Mulligan, Laurie L. Wellman, Richard A. Britten
Summary: Sleep problems in astronauts can be caused by mission demands and stress, and can affect their health and ability to accomplish mission objectives. This study investigated the effects of space radiation on sleep, EEG spectra, activity, and core body temperature in rats and compared them to non-irradiated rats. The results showed that space radiation can alter sleep and temperature control, which could have implications for astronauts and their mission demands.
Article
Biology
Yaniv Sela, Marieke M. B. Hoekstra, Paul Franken
Summary: This study developed a mathematical tool to simulate and predict cortical temperature in mice based on a sleep-wake sequence, which accounted for 91% of the variance and demonstrated the significant influence of sleep-wake state on brain temperature.
Article
Ecology
Zenon J. Czenze, Mark Myers, Darin Collins, R. Mark Brigham
Summary: Free-ranging tawny frogmouths typically exhibit a pattern of maintaining higher body temperature during activity and allowing it to decrease during cold evenings, but this pattern is not observed in captive conditions.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2022)
Article
Clinical Neurology
Samuel Deurveilher, Stephanie M. Shewchuk, Kazue Semba
Summary: Chronic sleep insufficiency has negative impacts on cognitive and health. Sleep regulation may be altered, but subsequent homeostatic responses to acute sleep loss are not affected after a 4-day 3/1 sleep restriction protocol.
JOURNAL OF SLEEP RESEARCH
(2021)
Article
Biology
Anusha Shankar, Isabelle N. H. Cisneros, Sarah Thompson, Catherine H. Graham, Donald R. Powers
Summary: Many endotherms use torpor to save energy, but deep torpor in mammals may have potential costs. Deep torpor also occurs in birds, but the trade-offs are unknown. This study found that some hummingbird species are capable of both deep and shallow torpor, indicating a fine-scale regulation of avian torpid metabolism.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2022)
Article
Biology
M. B. Blanco, L. K. Greene, L. N. Ellsaesser, B. Schopler, M. Davison, C. Ostrowski, P. H. Klopfer, J. Fietz, E. E. Ehmke
Summary: This study analyzed the fatty acid composition of white adipose tissue in dwarf lemurs, which were subjected to high-sugar or high-fat diets and experienced cold or warm conditions during fattening and hibernation. The results showed that dwarf lemurs fed high-sugar diets had a white adipose tissue composition more similar to wild lemurs and depleted their fat reserves better during hibernation. This highlights the importance of PUFA metabolism in the ecology of tropical hibernators.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Review
Clinical Neurology
Christian D. Harding, Yossi Yovel, Stuart N. Peirson, Talya D. Hackett, Vladyslav V. Vyazovskiy
Summary: This article reexamines the evidence for the characterization of bats as extreme sleepers and discusses whether it accurately represents the sleep behavior of Chiroptera. The study finds interspecific variation in sleep duration among bats and suggests the need for future research in naturalistic environments.
Article
Biology
Jan Okrouhlik, Radim Sumbera, Brett Gardner, Keegan Schoemann, Matej Lovy, Nigel Charles Bennett
Summary: Heterothermy is an adaptive mechanism used by African mammals, especially in the face of limited food and water resources. African mole-rats, lacking torpor, may be more vulnerable to ongoing global climate change.
JOURNAL OF THERMAL BIOLOGY
(2021)
Article
Biology
Sjoerd J. van Hasselt, Luisa Epifani, Danique Zantinge, Kornelija Vitkute, Martien J. H. Kas, Giancarlo Allocca, Peter Meerlo
Summary: In this study, the effects of low temperature on REM sleep in tree shrews were investigated. It was found that exposure to low temperature significantly suppressed REM sleep, but the loss of REM sleep was not recovered during the subsequent day and night. These findings support the high sensitivity of REM sleep to environmental temperature but do not support the homeostatic regulation of REM sleep in this species.
Article
Cell Biology
Maria-Efstratia Tsimpanouli, Anjesh Ghimire, Anna J. Barget, Ridge Weston, Henry L. Paulson, Maria do Carmo Costa, Brendon O. Watson
Summary: This study quantitatively characterized sleep electroencephalography (EEG) in SCA3 transgenic mice and found that sleep architecture and EEG spectral power were dysregulated, indicating a potential shared etiology between mouse and human SCA3 phenotypes.
Article
Neurosciences
Mansi P. Saraf, Pooja Balaram, Fabien Pifferir, Razvan Gamanut, Henry Kennedy, Jon H. Kaas
JOURNAL OF COMPARATIVE NEUROLOGY
(2019)
Article
Neurosciences
Mansi P. Saraf, Pooja Balaram, Fabien Pifferi, Henry Kennedy, Jon H. Kaas
JOURNAL OF COMPARATIVE NEUROLOGY
(2019)
Correction
Multidisciplinary Sciences
Katarzyna Bozek, Ekaterina E. Khrameeva, Jane Reznick, Damir Omerbasic, Nigel C. Bennett, Gary R. Lewin, Jorge Azpurua, Vera Gorbunova, Andrei Seluanov, Pierrick Regnard, Fanelie Wanert, Julia Marchal, Fabien Pifferi, Fabienne Aujard, Zhen Liu, Peng Shi, Svante Paeaebo, Florian Schroeder, Lothar Willmitzer, Patrick Giavalisco, Philipp Khaitovich
SCIENTIFIC REPORTS
(2019)
Review
Pharmacology & Pharmacy
Fabien Pifferi, Jacques Epelbaum, Fabienne Aujard
FRONTIERS IN PHARMACOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Hanane Hadj-Moussa, Jing Zhang, Fabien Pifferi, Martine Perret, Kenneth B. Storey
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2020)
Review
Clinical Neurology
Fabien Pifferi, Fabienne Aujard
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2019)
Review
Nutrition & Dietetics
Fabien Pifferi, Stephen C. Cunnane, Philippe Guesnet
Article
Biology
Clara Hozer, Fabien Pifferi
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2020)
Review
Behavioral Sciences
Julie Royo, Stephanie J. Forkel, Pierre Pouget, Michel Thiebaut de Schotten
Summary: Animal models in clinical neuroscience research offer valuable insights into human brain function and pathologies. While rodent models are commonly used due to their similarities with humans, some disorders require primate models like macaques. However, limitations such as high costs and small sample sizes hinder primate model research, making squirrel monkeys a potential bridge to complement and improve translational discoveries in brain pathology research.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Review
Zoology
Yohann Chaudron, Fabien Pifferi, Fabienne Aujard
Summary: Gray mouse lemur, a species with relatively slow aging, presents similarities to human pathological aging in terms of cognitive decline, brain atrophy, amyloidosis, and glucoregulatory imbalance. Studying aging in mouse lemurs offers promising insights for understanding, preventing, and treating pathological aging in humans, with potential focus on nutrition as a nonpharmacological antiaging strategy.
AMERICAN JOURNAL OF PRIMATOLOGY
(2021)
Article
Biology
Clara Hozer, Fabien Pifferi
Summary: This study examined the relationship between endogenous period and biomarkers of aging, finding that a deviation of endogenous period from 24 h led to increased oxidative stress, decreased IGF-1 concentrations, and impaired learning performances. These results support the circadian resonance theory, demonstrating a connection between endogenous period and lifespan, aging, and biological performance.
CHRONOBIOLOGY INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Julien Claron, Julie Royo, Fabrice Arcizet, Thomas Deffieux, Mickael Tanter, Pierre Pouget
Summary: The activity of the medial prefrontal cortex (SEF) is found to be related to pupil dynamics, and manipulating pupil diameter can affect the neurovascular activity in SEF. These findings provide a novel understanding of the physiological links between pupil and SEF.
Article
Multidisciplinary Sciences
Thomas Orset, Julie Royo, Mathieu David Santin, Pierre Pouget, Michel Thiebaut de Schotten
Summary: This study created a high-resolution, multishell diffusion-weighted dataset for non-human primates, specifically Saimiri sciureus. The dataset fills a gap in diffusion imaging data for this species and provides valuable resources for primate evolution studies. The data are openly available for analysis and further research.
Article
Public, Environmental & Occupational Health
Geoffroy Berthelot, Stacey Johnson, Philippe Noirez, Juliana Antero, Adrien Marck, Francois-Denis Desgorces, Fabien Pifferi, Patrick A. Carter, Michael Spedding, Archana Singh Manoux, Jean-Francois Toussaint
ARCHIVES OF PUBLIC HEALTH
(2019)