Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 474, Issue 3, Pages 447-451Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2016.04.143
Keywords
Aging; Endothelial cell; Migration; Angiopoietin; Wound healing
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Funding
- Austrian Science Fund FWF [J3064]
- Association for the Promotion of Research on Arteriosclerosis, Thrombosis and Vascular Biology (ATVB)
- Ludwig Boltzmann Cluster for Cardiovascular Research
- Austrian Science Fund (FWF) [J3064] Funding Source: Austrian Science Fund (FWF)
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Aging endothelial cells are characterized by increased cell size, reduced telomere length and increased expression of proinflammatory cytokines. In addition, we describe here that aging reduces the migratory distance of endothelial cells. Furthermore, we observe an increase of the quiescence protein Ang1 and a decrease of the endothelial activation protein Ang2 upon aging. Supplementing Ang2 to aged endothelial cells restored their migratory capacity. We conclude that aging shifts the balance of the Ang1/Ang2 network favouring a quiescent state. Activation of endothelial cells in aging might be necessary to enhance wound healing capacities. (C) 2016 Elsevier Inc. All rights reserved.
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