Article
Biochemistry & Molecular Biology
Firda Nurul Auliah, Andi Nur Nilamyani, Watshara Shoombuatong, Md Ashad Alam, Md Mehedi Hasan, Hiroyuki Kurata
Summary: The PUP-Fuse is a new prediction model for pupylation site prediction that integrates multiple sequence representations and achieves good prediction results based on machine learning algorithms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Matthias F. Block, Cyrille L. Delley, Lena M. L. Keller, Timo T. Stuehlinger, Eilika Weber-Ban
Summary: Pupylation is a post-translational modification found in Mycobacterium tuberculosis and other Actinobacteria, which involves the attachment of prokaryotic ubiquitin-like protein (Pup) to lysines on target proteins by the ligase PafA. Proteomic studies suggest that hundreds of potential pupylation targets are modified by PafA. This study shows that the availability of surface lysines alone is not sufficient for interaction between PafA and target proteins, and identifies the structural recognition motif involved in PafA's recognition of authentic substrates.
NATURE COMMUNICATIONS
(2023)
Article
Plant Sciences
Lidan Cao, Yan Gao, Jinlan Yu, Shuqi Niu, Jiarui Zeng, Qingqing Yao, Xiang Wang, Zhigang Bu, Ting Xu, Xuanming Liu, Yonghua Zhu
Summary: The endophytic actinobacteria OsiSh-2 can enhance the resilience of host plants against iron deficiency stress by modulating iron acquisition and translocation, ultimately leading to improved plant fitness.
PLANT PHYSIOLOGY AND BIOCHEMISTRY
(2021)
Article
Microbiology
Tianyan Yun, Tao Jing, Xiaoping Zang, Dengbo Zhou, Kai Li, Yankun Zhao, Wei Wang, Jianghui Xie
Summary: Fusarium wilt of bananas caused by the soil-borne fungus Fusarium oxysporum f. sp. cubense tropical race 4 (Foc TR4) is severely impacting the sustainable development of the banana industry. Streptomyces hygroscopicus subsp. hygroscopicus 5-4, a strain with strong antifungal activity, was found to damage the cell membrane of Foc TR4, inhibiting its mycelial growth. Hygromycin B was identified as a potential key antimicrobial metabolite. These findings make Streptomyces hygroscopicus subsp. hygroscopicus 5-4 a promising candidate for controlling Fusarium wilt of bananas and provide a scientific basis for the practical application of hygromycin B as a biological control agent.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Microbiology
Yan Gao, Qing Ning, Yuanzhu Yang, Ying Liu, Shuqi Niu, Xiaochun Hu, Huairong Pan, Zhigang Bu, Ning Chen, Jinyou Guo, Jinlan Yu, Lidan Cao, Peng Qin, Junjie Xing, Bin Liu, Xuanming Liu, Yonghua Zhu
Summary: The endophytic actinomycetes Streptomyces hygroscopicus OsiSh-2 has been found to enhance resistance to rice blast while maintaining high yield in 4-year field trials. OsiSh-2 induces defense priming in rice and controls the expression of defense-related proteins, balancing defense and growth to optimize plant performance.
Article
Biotechnology & Applied Microbiology
Chang Liu, Zhiwei Zhang, Keisuke Fukaya, Naoya Oku, Enjuro Harunari, Daisuke Urabe, Yasuhiro Igarashi
Summary: Two classes of new polyketides, allopteridic acids A-C (1-3) and allokutzmicin (4), were isolated from an actinomycete of the genus Allokutzneria culture. The structures of 1-4 were determined through NMR and MS analysis. Compounds 1-3 have a similar carbon skeleton to pteridic acids but have distinct monocyclic core structures. Compound 4 is a linear polyketide with a unique guanidino-terminus and an epoxide modification. Compounds 1-3 significantly promoted lettuce seed root elongation at concentrations of 1 to 10 μM, while compound 4 inhibited seed growth. Compound 4 showed weak antimicrobial activity against Candida albicans with a minimum inhibitory concentration (MIC) of 25 μg mL(-1).
JOURNAL OF ANTIBIOTICS
(2023)
Article
Multidisciplinary Sciences
Manon Mani Vellingiri, Parimala Gnana Soundari Arockiam Jeyasundar, Brindha Priyadarisini Venkatesan, Wen-chao Liu, Balamuralikrishnan Balasubramanian
Summary: This study focused on developing a statistical approach to optimize the cultivation conditions for maximum CPSM yield from Streptomyces hygroscopicus AVS7, which showed antimicrobial properties. The results indicated a cost-effective method for producing CPSM with potential medicinal and industrial applications.
ARABIAN JOURNAL FOR SCIENCE AND ENGINEERING
(2021)
Review
Biochemistry & Molecular Biology
Sanjeev K. Ganesh, C. Subathra Devi
Summary: The advancement in pharmaceutical research has led to the discovery and development of new combinatorial life-saving drugs, such as rapamycin and its derivatives. Rapamycin has been gaining attention for its activity against cytokine storm in COVID-19 patients. It has multiple potential applications as an anti-fungal drug, immunosuppressant, anti-cancer, anti-viral, and anti-aging agent. There is a growing demand for effective rapamycin derivatives and further studies are needed to explore its molecular mechanisms and improvement in production.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Infectious Diseases
Loeki Enggar Fitri, Agustina Tri Endharti, Hafshah Yasmina Abidah, Alif Raudhah Husnul Khotimah, Heni Endrawati
Summary: The study aimed to investigate the effectiveness and cytotoxicity of fractions 14 and 36K of Streptomyces hygroscopicus subsp. Hygroscopicus metabolite extract as antimalarial compounds against Plasmodium berghei in vitro. The results showed that both fractions have antimalarial activity, with fraction 14 having higher potency.
INFECTION AND DRUG RESISTANCE
(2023)
Article
Biochemistry & Molecular Biology
Nemanja Vuksanovic, Trevor R. Melkonian, Dante A. Serrano, Alan W. Schwabacher, Nicholas R. Silvaggi
Summary: In this study, the enzyme MppQ from Streptomyces hygroscopicus was characterized. The crystal structures of MppQ complexed with PLP and PMP were determined, showing its similarity to PLP-dependent aminotransferases. Functional analysis revealed that MppQ is the final enzyme involved in the biosynthesis of L-End. Additionally, MppQ was found to have a potential role in increasing the efficiency of L-End biosynthesis by converting 2-ketoarginine back to l-arginine.
Article
Microbiology
Jianrong Wang, Ping Wang, Mujin Zhu, Wei Chen, Si Yu, Bin Zhong
Summary: In this study, a chitosanase gene was cloned and optimized to obtain a recombinant strain with high activity for chitosan oligosaccharide preparation. The purified chitosanase showed stability and high activity towards colloidal chitosan, and could control the production of chitosan oligosaccharides with different degrees of polymerization.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Engineering, Chemical
Ivana Mitrovic, Natasa Lukic, Mila Grahovac, Aleksandar Jokic, Jelena Dodic, Jovana Grahovac
Summary: This study aimed to optimize main scale-up parameters using genetic algorithms, and found that increasing aeration rate maximized the production of biocontrol agents effective against storage apple pathogens of the Alternaria and Fusarium genera. Simultaneously, increasing aeration rate allowed for lower stirrer speed and shorter bioprocess duration to support profitability.
CHEMICAL ENGINEERING & TECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shumpei Asamizu, Abrory Agus Cahya Pramana, Sung-Jin Kawai, Yoshichika Arakawa, Hiroyasu Onaka
Summary: In this study, a coculture method was used to investigate the potential for secondary metabolite biosynthesis by Streptomyces species. Specific antibacterial activity was discovered in a combined-culture of Streptomyces hygroscopicus HOK021 and Tsukamurella pulmonis TP-B0596. Molecular networking and genomic data analysis revealed the formation of a previously unidentified conjugate between FabF inhibitor and catechol-type siderophore, named harundomycin A. The study demonstrated the transformation of existing natural products to bifunctional molecules driven by bacterial interaction.
ACS CHEMICAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Dai Wei, Li Meng-Miao, Zhang Jun-Jie
Summary: The Pup-proteasome system (PPS) is a prokaryotic protein degradation pathway involved in stress response and biological regulation. It is closely related to the pathogenicity of Mycobacterium tuberculosis and has potential as a target for anti-tuberculosis drug development. PPS has also been used in biotechnology research, particularly in protein-protein interaction studies.
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Biochemistry & Molecular Biology
Iza Mirela Rodini Garcia-Princival, Jefferson Luiz Princival, Emmanuel Dias da Silva, Sandrine Maria de Arruda Lima, Jhonattas Carvalho Carregosa, Alberto Wisniewski Jr, Caio Cezar Oliveira de Lucena, Fernando Halwass, Jose Adonias Alves Franca, Luiz Felipe Gomes Rebello Ferreira, Marcelo Zaldini Hernandes, Karina Lidianne Alcantara Saraiva, Christina Alves Peixoto, Blandine Baratte, Thomas Robert, Stephane Bach, Dayene Correia Gomes, Patricia Maria Guedes Paiva, Pascal Marchand, Maria Desterro Rodrigues, Teresinha Goncalves da Silva
Summary: The study demonstrated cytotoxic activity of Nigericin against several cancer cell lines, especially HL-60 and HCT-116. Nigericin induced apoptosis and autophagy in HCT-116 cells. Additionally, Nigericin was able to inhibit JAK3 and GSK-3 beta kinases in vitro and its binding affinities were mapped through intermolecular interactions with each target in silico.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Pauline Texier, Patricia Bordes, Jyotsna Nagpal, Ambre Julie Sala, Moise Mansour, Anne-Marie Cirinesi, Xibing Xu, David Andrew Dougan, Pierre Genevaux
Summary: Bacterial toxin-antitoxin systems, including TAC modules with SecB-like chaperones, are widespread in bacterial genomes. Deletion of endogenous AAA(+) proteases bypasses the need for a dedicated chaperone, and the ClpXP1 P2 complex is identified as the main protease involved in TAC antitoxin degradation.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Yujie Zhou, Lei Cheng, Binyou Liao, Yangyang Shi, Yulong Niu, Chengguang Zhu, Xingchen Ye, Xuedong Zhou, Biao Ren
Summary: The CHK1 gene in Candida albicans plays a key role in oral mucosal infection by damaging epithelial cells and inducing the production of ROS and IL-1 alpha to increase pathogenicity. However, it is not directly related to the adhesion and invasion of epithelial cells.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiaoyan Fan, Yitao Wang, Tinghui Jiang, Tao Liu, Yuelei Jin, Kailong Du, Yulong Niu, Chunxue Zhang, Zhongyu Liu, Yunlong Lei, Youquan Bu
Summary: The study revealed the critical role of B-Myb in colorectal cancer, showing its promotion of malignant phenotypes and its interaction with E2F2. They form a positive feedback loop, contributing to the progression of the tumor malignancy.
Article
Microbiology
Kathrin Wippel, Ke Tao, Yulong Niu, Rafal Zgadzaj, Niklas Kiel, Rui Guan, Eik Dahms, Pengfan Zhang, Dorthe B. Jensen, Elke Logemann, Simona Radutoiu, Paul Schulze-Lefert, Ruben Garrido-Oter
Summary: The study reveals that commensal bacteria in root microbiota exhibit host preferences, which are associated with their invasiveness into established root-associated communities, as shown in systematic analyses of synthetic bacterial communities in a gnotobiotic system.
NATURE MICROBIOLOGY
(2021)
Article
Microbiology
Yao Hu, Yulong Niu, Xingchen Ye, Chengguang Zhu, Ting Tong, Yujie Zhou, Xuedong Zhou, Lei Cheng, Biao Ren
Summary: The mixed species of Staphylococcus aureus and Candida albicans can synergistically cause skin and mucosal infections, leading to increased proliferation and biofilm formation of S. aureus, as well as upregulation of drug-resistant genes. The synergistic effects on drug resistance to both antibacterial and antifungal agents emphasize the importance of targeting microbial interactions in polyspecies-associated infections.
Article
Biochemistry & Molecular Biology
Guomin Shen, Chaokun Li, Qing Cao, Abhin Kumar Megta, Shuang Li, Meng Gao, Hongli Liu, Yan Shen, Yixiang Chen, Haichuan Yu, Sanqiang Li, Weikai Li
Summary: This study reveals the structural features of the epoxide reductase activity carried out by a subset of the VKOR family in the membrane environment. It also demonstrates that a representative bacterial VKOR homolog can be converted to an epoxide reductase that is also inhibitable by warfarin.
Article
Ecology
Lisa K. Mahdi, Shingo Miyauchi, Charles Uhlmann, Ruben Garrido-Oter, Gregor Langen, Stephan Wawra, Yulong Niu, Rui Guan, Senga Robertson-Albertyn, Davide Bulgarelli, Jane E. Parker, Alga Zuccaro
Summary: Plant root-associated bacteria can protect against pathogen infections, while root endophytic fungi combined with core bacterial members provide synergistic protection. The early growth promotion benefits of these interactions are dependent on the host and microbiota composition, and are associated with modulation of microbial effectors and carbohydrate-active enzymes instead of extensive host transcriptional reprogramming.
Article
Biochemistry & Molecular Biology
Guomin Shen, Meng Gao, Qing Cao, Weikai Li
Summary: This article systematically summarizes the structural and functional characteristics of FIX and the pathogenic mechanisms of identified mutations in hemophilia B patients. It discusses various mechanisms of FIX deficiency caused by different types of mutations, such as deletions, insertions, duplications, and point mutations, and their effects on bleeding phenotypes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Moise Mansour, Emmanuel Giudice, Xibing Xu, Hatice Akarsu, Patricia Bordes, Valerie Guillet, Donna-Joe Bigot, Nawel Slama, Gaetano D'urso, Sophie Chat, Peter Redder, Laurent Falquet, Lionel Mourey, Reynald Gillet, Pierre Genevaux
Summary: This study reveals the mechanism of action of the toxin in the Mycobacterium tuberculosis TAC system. The researchers discovered that the TAC toxin is a genuine ribonuclease and identified the cleavage sites on mRNA targets on a transcriptome-wide scale. Additionally, they determined the specific mechanism by which the TAC toxin interacts with the ribosome and tRNA through cryo-electron microscopy.
NATURE COMMUNICATIONS
(2022)
Review
Hematology
Shixuan Liu, Guomin Shen, Weikai Li
Summary: Vitamin K antagonists, such as warfarin, are commonly used oral anticoagulants for treating and preventing thromboembolic diseases. Understanding the mechanistic actions of these drugs at the cellular and structural levels is crucial for addressing their limitations and improving anticoagulation strategies targeting the vitamin K cycle.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Meeting Abstract
Biochemistry & Molecular Biology
K. Wippel, Y. Niu, P. Schulze-Lefert, R. Garrido-Oter
MOLECULAR PLANT-MICROBE INTERACTIONS
(2021)
Meeting Abstract
Biochemistry & Molecular Biology
L. K. Mahdi, S. Miyauchi, C. Uhlmann, R. Garrido-Oter, G. Langen, S. Wawra, Y. Niu, S. Robertson-Albertyn, D. Bulgarelli, J. E. Parker, A. Zuccaro
MOLECULAR PLANT-MICROBE INTERACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Guomin Shen, Weidong Cui, Qing Cao, Meng Gao, Hongli Liu, Gaigai Su, Michael L. Gross, Weikai Li
Summary: The study reveals that the partially oxidized state of hVKOR also exhibits catalytic activity in cells, although lower than the fully reduced state. Despite more partially oxidized hVKOR in cells, both reactive states contribute equally to overall hVKOR activity.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Plant Sciences
Ka-Wai Ma, Yulong Niu, Yong Jia, Jana Ordon, Charles Copeland, Aurelia Emonet, Niko Geldner, Rui Guan, Sara Christina Stolze, Hirofumi Nakagami, Ruben Garrido-Oter, Paul Schulze-Lefert
Summary: Plants grown in natural soil are colonized by phylogenetically structured communities of microbes known as the microbiota. Some beneficial commensal bacteria can suppress part of the plant innate immune system, ultimately leading to commensal-host homeostasis.
Article
Multidisciplinary Sciences
Shixuan Liu, Shuang Li, Guomin Shen, Narayanasami Sukumar, Andrzej M. Krezel, Weikai Li
Summary: Vitamin K antagonists act by mimicking key interactions and conformational changes required for the VKOR catalytic cycle, which is crucial for their anticoagulant effect.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
