Article
Cell Biology
Zhiliang Chen, Zaosong Zheng, Yingwei Xie, Qiyu Zhong, Wentai Shangguan, Yishan Zhang, Dingjun Zhu, Wenlian Xie
Summary: circPPP6R3 is a highly expressed circular RNA in clear cell renal cell carcinoma (ccRCC), and it is associated with the severity and progression of the disease. It interacts with miR-1238-3p and upregulates the expression of CD44, promoting cancer cell proliferation and metastasis. This study provides new insights into biomarkers and potential therapeutic approaches for ccRCC.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Jingyu Zhang, Qingbo Lu, Haigang Pang, Min Zhang, Wenhai Wei
Summary: miR-103a-3p promotes renal cell carcinoma cell progression by regulating TMEM33. This finding may offer new insights into the identification of prognostic markers and therapeutic targets for RCC.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Cell Biology
Zhipeng Li, Ying Wang, Shuai Liu, Weibing Li, Zhigang Wang, Zhangjun Jia, Zeyu Zhu, Yuhua Bao
Summary: miRNA-200a-3p expression is significantly increased in both gastric cancer tissues and cells, promoting tumor growth and development via DLC-1 as an oncogene in GC cells. The miRNA-200a-3p/DLC axis may provide a theoretical basis for potential improvements in gastric cancer treatment strategies.
JOURNAL OF MOLECULAR HISTOLOGY
(2022)
Article
Medicine, General & Internal
Ming Li, Jie Li, Chaoyang Ye, Weiwu Wu, Yi Cheng
Summary: In this study, the posttranscriptional regulatory effect of miR-200a-3p on STAT4 and the prognostic significance of miR-200a-3p and STAT4 were evaluated in bladder cancer. The results showed that miR-200a-3p was downregulated while STAT4 was upregulated in bladder cancer tissues and cells. Both miR-200a-3p and STAT4 were validated as independent prognostic indicators for predicting overall survival and disease-free survival in bladder cancer patients. Furthermore, miR-200a-3p was found to directly target STAT4 and suppress its protein expression, thereby inhibiting bladder cancer cell growth and inducing apoptosis. These findings suggest that the miR-200a-3p/STAT4 signaling cascade plays a crucial role in bladder cancer progression and could serve as a potential target for targeted therapies.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Oncology
Yiguan Qian, Yang Li, Luwei Xu, Ke Chen, Ning Liu, Xiaobing Yang, Qian Lv, Rongfei Li, Changcheng Zhou, Zheng Xu, Ruipeng Jia, Yu-Zheng Ge
Summary: In this study, a novel circRNA called circ-PRKCI was found to promote the proliferation of renal cell carcinoma (RCC) through the miR-545-3p/CCND1 signaling pathway. It was also discovered that tumor cell-derived exosomal circ-PRKCI could enhance the proliferation, migration, and invasion of RCC cells while inhibiting apoptosis. This study provides new insights into the molecular mechanisms of RCC progression.
Article
Oncology
Nan Bao, Pengjie Zhang, Yanting Zhu, Peng Du, Gang Jin, Bing Wu, Tong Ding
Summary: The present study found that miR-378a-3p promotes cell proliferation, migration, and invasion in RCC by regulating TOB2.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Oncology
Yifei Liu, Wenqiang Fu, Feng Yin, Lianjie Xia, Yubo Zhang, Baocun Wang, Tengfei Li, Tingting Zhang, Ling Cheng, Yanbing Wei, Bin Gao
Summary: This study found that miR-141-3p interacts with NEK6 in CCRCC cells, and overexpression of miR-141-3p can inhibit cell proliferation, migration, invasion, and promote apoptosis in CCRCC. This study provides a foundation for understanding the pathogenesis and targeted therapies for CCRCC.
Article
Oncology
Bin Gao, Lijuan Wang, Na Zhang, Miaomiao Han, Yubo Zhang, Huancai Liu, Dongli Sun, Xiaolong Xiao, Yifei Liu
Summary: Our study reveals that miR-129-5p is down-regulated and SPN is up-regulated in ccRCC. Overexpressed miR-129-5p inhibits cell proliferation, migration, and invasion, induces cell cycle arrest, and promotes apoptosis. Dual-luciferase assay confirms the binding relationship between miR-129-5p and SPN, suggesting a potential target for precise treatment of ccRCC.
CANCER CELL INTERNATIONAL
(2021)
Article
Biotechnology & Applied Microbiology
Weiyang Lou, Jing Chen, Bisha Ding, Weimin Fan
Summary: This study identified miR-3607-3p and miR-3607-5p as potential therapeutic targets and prognostic biomarkers in HCC, which inhibit HCC proliferation and induce apoptosis by targeting the common gene XIAP. Additionally, an XIAP-associated protein-protein interaction network was established to further understand their mechanism of action in HCC.
Article
Cell Biology
Bin Zhao, Cong Huang, Jie Pan, Hao Hu, Xiaojuan Liu, Kaoyuan Zhang, Fenli Zhou, Xin Shi, Jun Wu, Bo Yu, Xiaofan Chen, Wei Zhang
Summary: Recent evidence shows that circRNAs, particularly circPLIN2, play important regulatory roles in the development and progression of clear cell renal cell carcinoma (ccRCC) by increasing mRNA stability and competitively binding specific miRNA.
CELL DEATH & DISEASE
(2022)
Article
Andrology
Pei Wan, Zhilin Chen, Minzhi Huang, Huiming Jiang, Huajun Wu, Kaihua Zhong, Guodong Ding, Bing Wang
Summary: The study found that miR-200a-3p expression levels are elevated in human bladder cancer, and are significantly associated with distant metastasis and advanced stage. miR-200a-3p promotes bladder cancer cell proliferation, migration, invasion, and cell cycle progression, while inhibiting apoptosis. A20 was identified as a target gene of miR-200a-3p in bladder cancer cells.
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ying Wang, Yunjing Zhang, Xinwan Su, Qiongzi Qiu, Yuan Yuan, Chunhua Weng, Sailan Zou, Yan Tian, Weidong Han, Pengyuan Liu, Xingyi Guo, Jianhua Mao, Xianghui Fu, Ping Wang, Weiqiang Lin
Summary: This study found that circDVL1 is reduced in the serums and tissues from ccRCC patients, and negatively correlates with malignant features of ccRCC. Overexpression of circDVL1 inhibits proliferation and migration, induces apoptosis in ccRCC cells. Mechanistically, circDVL1 functions as a sponge for miR-412-3p, preventing its repression of target gene PCDH7 in ccRCC cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Oncology
Xiangke Xin, Zheng Xu, Jia Wei, Yicheng Zhang
Summary: Metallothionein1X (MT1X) is highly expressed in acute myeloid leukemia (AML) and acts as a candidate prognostic indicator. Inhibiting MT1X can suppress AML cell proliferation, induce apoptosis, and inhibit nuclear factor-kappa B (NF-kappa B) signaling. MiR-376a-3p negatively regulates MT1X, suppressing AML cell proliferation and inducing apoptosis. These findings suggest that elevated MT1X expression may contribute to AML progression and indicate that the miR-376a/MT1X axis could be a potential therapeutic target for AML patients.
CANCER BIOLOGY & THERAPY
(2022)
Article
Medicine, Research & Experimental
Min Gao, Tianyi Yu, Dan Liu, Yan Shi, Peilang Yang, Jie Zhang, Jizhuang Wang, Yan Liu, Xiong Zhang
Summary: The study investigated the effect of miR-1-3p on endothelial cells during sepsis, finding that miR-1-3p inhibits cell proliferation, promotes apoptosis and cytoskeleton contraction by targeting SERP1, leading to dysfunction of endothelial cells and weakening vascular barrier function. MiR-1-3p and SERP1 may be promising therapeutic candidates for sepsis-induced lung injury.
Article
Biochemistry & Molecular Biology
Xian Shi, Xidan Xu, Nian Shi, Yongjun Chen, Manni Fu
Summary: MiR-767-3p has been found to inhibit the expression of ASF1B, thus reducing melanoma tumorigenesis. This has potential implications for the treatment of melanoma.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)