Article
Microbiology
Melissa C. Kordahi, Ian B. Stanaway, Marion Avril, Denise Chac, Marie-Pierre Blanc, Benjamin Ross, Christian Diener, Sumita Jain, Paul McCleary, Ana Parker, Vincent Friedman, Jennifer Huang, Wynn Burke, Sean M. Gibbons, Amy D. Willis, Richard P. Darveau, William M. Grady, Cynthia W. Ko, R. William DePaolo
Summary: This study provides fundamental insight into the microbial microenvironment of the pre-neoplastic polyp by highlighting strain-specific genomic and proteomic differences, as well as more broad compositional differences in the microbiome.
CELL HOST & MICROBE
(2021)
Article
Gastroenterology & Hepatology
Manon Oliero, Roy Hajjar, Thibault Cuisiniere, Gabriela Fragoso, Annie Calve, Francois Dagbert, Rasmy Loungnarath, Herawaty Sebajang, Frank Schwenter, Ramses Wassef, Richard Ratelle, Eric De Broux, Carole S. Richard, Manuela M. Santos
Summary: Both healthy controls and CRC patients showed similar levels of colonization by pks + bacteria and ETBF, potentially increasing the risk of developing CRC for both groups. Early-onset CRC patients had significantly lower colonization rates of pks + bacteria compared to late-onset CRC patients.
Article
Oncology
Nasibeh Khodaverdi, Habib Zeighami, Ahmad Jalilvand, Fakhri Haghi, Negar Hesami
Summary: The study revealed a higher concentration of E. faecalis and ETBF in FFPE samples of CRC patients compared to controls. Frequency of ETBF and E. faecalis was significantly higher in late stages of cancer. Additional investigations on fecal and fresh colorectal cancer tissue samples are needed to confirm this correlation.
Article
Pharmacology & Pharmacy
Suhang Guo, Yi Peng, Yan Lou, Lijuan Cao, Junqing Liu, Nengming Lin, Sheng Cai, Yu Kang, Su Zeng, Lushan Yu
Summary: The downregulation of FXR in colorectal cancer results in dysregulation of bile acid metabolism, affecting the concentration of secretory immunoglobulin A and gut microbiome, thereby increasing the risk of colorectal tumor development.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Oncology
Leila Dadgar-Zankbar, Aref Shariati, Narjess Bostanghadiri, Zahra Elahi, Shiva Mirkalantari, Shabnam Razavi, Fatemeh Kamali, Davood Darban-Sarokhalil
Summary: This study investigated the correlation between the gut microbiota B. fragilis and the expression of signaling pathway genes in colorectal cancer (CRC). The results showed that B. fragilis had a higher abundance in tumor samples and may contribute to CRC by altering cellular signaling pathways and gene expression. No correlation was found between this bacterium and the clinicopathological features of the tumor samples.
INFECTIOUS AGENTS AND CANCER
(2023)
Article
Genetics & Heredity
Shuaijie Lv, Xiaojian Wang, Shuaijie Jin, Shaoning Shen, Rui Wang, Peijian Tong
Summary: The study found that quercetin can alleviate knee osteoarthritis by mediating the TSC2-RHEB-mTOR signaling pathway. It reduces joint injury, suppresses inflammation, and promotes the survival and synthesis of chondrocytes.
Article
Oncology
Xiaonan Shen, Jialu Li, Jiaqi Li, Yao Zhang, Xiaobo Li, Yun Cui, Qinyan Gao, Xiaoyu Chen, Yingxuan Chen, Jing-Yuan Fang
Summary: This study identified a microbial signature (ETBF-P. stomatis-P. micra) that can accurately diagnose LSTs, with P. stomatis showing strong diagnostic value. P. stomatis was also associated with adenoma recurrence after LST resection, indicating its potential as a predictive biomarker.
FRONTIERS IN ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Julia Butt, Mazda Jenab, Jill Werner, Veronika Fedirko, Elisabete Weiderpass, Christina C. Dahm, Anne Tjonneland, Anja Olsen, Marie-Christine Boutron-Ruault, Joseph A. Rothwell, Gianluca Severi, Rudolf Kaaks, Renee Turzanski-Fortner, Krasimira Aleksandrova, Matthias Schulze, Domenico Palli, Valeria Pala, Salvatore Panico, Rosario Tumino, Carlotta Sacerdote, Bas Bueno-de-Mesquita, Carla H. Van Gils, Inger Torhild Gram, Marko Lukic, Nuria Sala, Maria Jose Sanchez Perez, Eva Ardanaz, Maria-Dolores Chirlaque, Richard Palmquist, Thyra Lowenmark, Ruth C. Travis, Alicia Heath, Amanda J. Cross, Heinz Freisling, Semi Zouiouich, Elom Aglago, Tim Waterboer, David J. Hughes
Summary: The study found that sero-positivity to E. coli and ETBF was associated with the development of CRC, with dual infection of these bacterial species potentially contributing to colorectal carcinogenesis. These findings call for further exploration in larger prospective studies and within different population groups.
Article
Gastroenterology & Hepatology
Rachel V. Purcell, Jessica Permain, Jacqueline I. Keenan
Summary: ETBF infection activates IL-8 gene and protein expression through Stat3, while the disruption of E-cadherin appears to be independent of Stat3 signaling.
Article
Food Science & Technology
Su Hyuk Ko, Jun Ho Choi, Jung Mogg Kim
Summary: Macroautophagy/autophagy plays important roles in maintaining cellular homeostasis and defense against infections. However, the role of autophagy in enterotoxigenic Bacteroides fragilis infection remains largely unknown. This study investigates the role of B. fragilis enterotoxin (BFT) in the autophagic process of intestinal epithelial cells (IECs) and finds that BFT can activate autophagy through the AMPK-FoxO3a pathway, inhibiting apoptosis during the early exposure of IECs to BFT.
Article
Biochemistry & Molecular Biology
Ana Jimenez-Alesanco, Ulrich Eckhard, Marta Asencio del Rio, Sonia Vega, Tibisay Guevara, Adrian Velazquez-Campoy, Francesc Xavier Gomis-Ruth, Olga Abian
Summary: Bacteroides fragilis is a commensal component of the human colon, but under dysbiotic conditions, enterotoxigenic B. fragilis (ETBF) can cause various diseases. ETBF is resistant to many antibiotics and its virulence is mainly related to a zinc-dependent metallopeptidase called B. fragilis toxin (BFT). Researchers have focused on a specific isoform of BFT, BFT-3, and found that certain approved drugs can be repurposed as BFT-3 inhibitors. These inhibitors bind to an allosteric site in the proBFT-3 zymogen structure, preventing the activation of the toxin and reducing its hydrolytic activity. This discovery provides a new approach for developing specific inhibitors for ETBF-mediated enteropathogenic conditions.
Article
Microbiology
Seyedesomaye Jasemi, Mohammad Emaneini, Zahra Ahmadinejad, Mohammad Sadegh Fazeli, Leonardo A. Sechi, Fatemah Sadeghpour Heravi, Mohammad Mehdi Feizabadi
Summary: Bacteroides fragilis showed high resistance to antibiotics but remained sensitive to metronidazole. tetQ, cepA, and ermF were the most common antibiotic resistance genes identified. Isolates with cepA, cfxA, and ermF genes had significantly different MIC values for cefoxitin, penicillin, and clindamycin.
ANNALS OF CLINICAL MICROBIOLOGY AND ANTIMICROBIALS
(2021)
Article
Immunology
Bruno Perichon, Julian Lichtl-Hafele, Emma Bergsten, Vincent Delage, Patrick Trieu-Cuot, Philippe Sansonetti, Iradj Sobhani, Shaynoor Dramsi
Summary: This study indicates that the prevalence and levels of bacteria associated with colorectal cancer vary during cancer development. Only the pathobiont B. fragilis was detected in early-stage adenoma patients.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Dengmei Gong, Amma G. Adomako-Bonsu, Maijian Wang, Jida Li
Summary: Colorectal cancer (CRC) develops from tubular adenomas and serrated polyps in the colon and rectum, and is associated with poor prognosis and high mortality rate. In addition to genetics, lifestyle, and chronic diseases, intestinal integrity and microbiota play important roles in promoting CRC development. This review focuses on the roles and mechanisms of enterotoxigenic Bacteroides fragilis, genotoxic Escherichia coli, and Fusobacterium nucleatum in CRC, and proposes their interaction during CRC initiation and progression. Understanding the relationship between gut microbiota and CRC development may provide valuable insights for therapeutic strategies and prevention strategies.
Article
Multidisciplinary Sciences
Alan Aitchison, John F. Pearson, Rachel Purcell, Frank A. Frizelle, Jacqueline Keenan
Summary: This study investigated the presence of F. nucleatum DNA in colorectal cancer (CRC) patients and primary care patients. The findings showed that F. nucleatum was present at similar rates in stool samples from both groups, indicating that it may be a biomarker for increased risk of disease. However, molecular evidence of F. nucleatum did not predict the progression of colonic lesions.
Article
Oncology
Tian-Tian Sun, Jie He, Qian Liang, Lin-Lin Ren, Ting-Ting Yan, Ta-Chung Yu, Jia-Yin Tang, Yu-Jie Bao, Ye Hu, Yanwei Lin, Danfeng Sun, Ying-Xuan Chen, Jie Hong, Haoyan Chen, Weiping Zou, Jing-Yuan Fang
Article
Oncology
Ting-Ting Yan, Lin-Lin Ren, Chao-Qin Shen, Zhen-Hua Wang, Ya-Nan Yu, Qian Liang, Jia-Yin Tang, Ying-Xuan Chen, Dan-Feng Sun, Witold Zgodzinski, Marek Majewski, Piotr Radwan, Ilona Kryczek, Ming Zhong, Jinxian Chen, Qiang Liu, Weiping Zou, Hao-Yan Chen, Jie Hong, Jing-Yuan Fang
Article
Cell Biology
Jia-Yin Tang, Chen-Yang Yu, Yu-Jie Bao, Lu Chen, Jinxian Chen, Sheng-Li Yang, Hao-Yan Chen, Jie Hong, Jing-Yuan Fang
Article
Cell Biology
Lin-Lin Ren, Ting-Ting Yan, Chao-Qin Shen, Jia-Yin Tang, Xuan Kong, Ying-Chao Wang, Jinxian Chen, Qiang Liu, Jie He, Ming Zhong, Hao-Yan Chen, Jie Hong, Jing-Yuan Fang
CELL DEATH & DISEASE
(2018)
Article
Oncology
Tian-Tian Sun, Jia-Yin Tang, Wan Du, Hui-Jun Zhao, Gang Zhao, Sheng-Li Yang, Hao-Yan Chen, Jie Hong, Jing-Yuan Fang
INTERNATIONAL JOURNAL OF CANCER
(2015)
Article
Biochemistry & Molecular Biology
Chen-Yang Yu, Ji-Xuan Han, Junfang Zhang, Penglei Jiang, Chaoqin Shen, Fangfang Guo, Jiayin Tang, Tingting Yan, Xianglong Tian, Xiaoqiang Zhu, Dan Ma, Ye Hu, Yuanhong Xie, Wan Du, Ming Zhong, Jinxian Chen, Qiang Liu, Danfeng Sun, Yingxuan Chen, Weiping Zou, Jie Hong, Haoyan Chen, Jing-Yuan Fang
Article
Multidisciplinary Sciences
Jiayin Tang, Tingting Yan, Yujie Bao, Chaoqin Shen, Chenyang Yu, Xiaoqiang Zhu, Xianglong Tian, Fangfang Guo, Qian Liang, Qiang Liu, Ming Zhong, Jinxian Chen, Zhizheng Ge, Xiaobo Li, Xiaoyu Chen, Yun Cui, Yingxuan Chen, Weiping Zou, Haoyan Chen, Jie Hong, Jing-Yuan Fang
NATURE COMMUNICATIONS
(2019)
Article
Cell Biology
Hongsheng Fang, Yizhou Huang, Yang Luo, Jiayin Tang, Minhao Yu, Yan Zhang, Ming Zhong
Summary: The study found that high SIRT1 expression in colorectal cancer promotes cancer progression by modulating immune cell responses in the tumor microenvironment.
CELLULAR IMMUNOLOGY
(2022)
Article
Geriatrics & Gerontology
Hongsheng Fang, Yunlan Du, Shuting Pan, Ming Zhong, Jiayin Tang
Summary: The study showed a significantly decreased risk of colorectal cancer in patients with Parkinson's disease, with this lower risk observed across different regions.
Article
Cell Biology
Tianying Tong, Jie Zhang, Xiaoqiang Zhu, Pingping Hui, Zhimin Wang, Qiong Wu, Jiayin Tang, Haoyan Chen, Xianglong Tian
Summary: This study identified an autophagy-related risk model through integrative analysis of bulk RNA sequencing and single-cell RNA sequencing, which can predict the prognosis of gastric cancer patients independently of other clinical variables. Further investigation using single-cell RNA sequencing revealed that this model might be associated with dysfunctional characteristics of T cells in the high-risk group, and the high-risk group showed lower expression of immune checkpoint markers. This model has potential significance in predicting the immunotherapy response in gastric cancer patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Oncology
Qian Liang, Dan Ma, Xiaoqiang Zhu, Zhenhua Wang, Tian-Tian Sun, Chaoqin Shen, Tingting Yan, Xianglong Tian, TaChung Yu, Fangfang Guo, JiaYin Tang, Yanwei Lin, Huimin Chen, Chao Zhou, Zhizheng Ge, Ming Zhong, Jinxian Chen, Qiang Liu, Zheng Wang, Jing-Yuan Fang, Haoyan Chen, Jie Hong
CLINICAL CANCER RESEARCH
(2018)
Article
Biochemistry & Molecular Biology
Jin Qian, Yueyuan Li, Han Yao, Haiying Tian, Huanbin Wang, Luoyan Ai, Yuanhong Xie, Yujie Bao, Lunxi Liang, Ye Hu, Yao Zhang, Jilin Wang, Chushu Li, Jiayin Tang, Yingxuan Chen, Jie Xu, Jing-Yuan Fang
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2017)