Review
Immunology
Masoumeh Gholami, Mehdi Sadegh, Masoumeh Koroush-arami, Shaghayegh Norouzi, Rasoul Jafari Arismani, Erfan Asadi, Mohammad Amini, Nahid Khodayari
Summary: Acetylsalicylic acid (ASA) has cardiovascular benefits and potential neuroprotective effects. However, the impact of aspirin on dementia and cognitive decline is still debatable.
INFLAMMOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Christiana Magkrioti, Georgia Antonopoulou, Dionysios Fanidis, Vaia Pliaka, Theodore Sakellaropoulos, Leonidas G. Alexopoulos, Christoph Ullmer, Vassilis Aidinis
Summary: This study investigated the response of human proximal tubular epithelial cells to LPA and other pathological stimuli, identifying signaling pathways and inflammatory factors that may play a role in the pathogenesis of CKD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Allergy
Netali Ben-Baruch Morgenstern, Tetsuo Shoda, Yrina Rochman, Julie M. Caldwell, Margaret H. Collins, Vincent Mukkada, Philip E. Putnam, Scott M. Bolton, Jennifer M. Felton, Mark Rochman, Cristin Murray-Petzold, Kara L. Kliewer, Marc E. Rothenberg
Summary: This study examines the correlation between T cell populations in the stomach and the pathology of eosinophilic gastritis (EoG). The results show that EoG is associated with increased levels of gastric T-H(2) cells and cytokine production. Specifically, IL-4 levels in T-H(2) cells strongly correlate with the severity of histologic and endoscopic EoG scores. The findings suggest that EoG is a T-H(2) cell-associated disease, and T-H(2) cells play an important role in its pathology.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Chemistry, Medicinal
Daniel Baecker, Jessica Sagasser, Serhat Karaman, Anton Amadeus Hormann, Ronald Gust
Summary: The methylated cobalt-alkyne complexes with enhanced selectivity for COX-2 showed superior cytotoxicity towards COX-positive colon carcinoma cells compared to cisplatin, indicating their potential as alternative antitumor agents.
ARCHIV DER PHARMAZIE
(2022)
Article
Pharmacology & Pharmacy
Soomaayeh Heysieattalab, Jafar Doostmohammadi, Mahgol Darvishmolla, Negin Saeedi, Narges Hosseinmardi, Masoumeh Gholami, Mahyar Janahmadi, Samira Choopani
Summary: Long-term administration of ASA and SS may have detrimental effects on spatial learning and memory, as well as hippocampal synaptic plasticity, leading to impairments in memory acquisition and retrieval.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2021)
Article
Immunology
Hoang Oanh Nguyen, Tiziana Schioppa, Laura Tiberio, Fabrizio Facchinetti, Gino Villetti, Maurizio Civelli, Annalisa Del Prete, Francesca Sozio, Carolina Gaudenzi, Mauro Passari, Ilaria Barbazza, Silvano Sozzani, Valentina Salvi, Daniela Bosisio
Summary: This article reports the research results of an oral PDE4 inhibitor called Tanimilast, which can modulate the pro-inflammatory potential and Th1-polarizing potential of SCV2-RNA-induced DCs. Tanimilast did not affect the expression of maturation markers and lymph node homing receptor in DCs, but skewed towards Th2 phenotype. Both Tanimilast and the reference drug β-methasone blocked the increase of MHC-I molecules in activated DCs and restrained the proliferation and activation of cytotoxic CD8(+) T cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Rosangela Mayer Goncalves, Marina Delgobo, Jonathan Paulo Agnes, Raquel Nascimento das Neves, Marcelo Falchetti, Tuany Casagrande, Ana Paula Vargas Garcia, Thaynan Cunha Vieira, Nauana Somensi, Maciel Alencar Bruxel, Daniel Augusto Gasparin Bueno Mendes, Alex Rafacho, Andre Bafica, Daniel Pens Gelain, Jose Claudio Fonseca Moreira, Geovanni Dantas Cassali, Alexander James Roy Bishop, Alfeu Zanotto-Filho
Summary: Obesity is a major risk factor for breast cancer, especially in post-menopausal women. An obesogenic diet has been shown to promote mammary tissue inflammation and local estrogen production, accelerating mammary tumor formation in a COX-2-dependent manner. Treatment with a COX-2 inhibitor was found to decrease inflammation, estrogen levels, and mammary tumor formation, leading to prolonged animal survival.
Review
Biochemistry & Molecular Biology
Malgorzata Szczuko, Igor Koziol, Dariusz Kotlega, Jacek Brodowski, Arleta Drozd
Summary: Cardiovascular diseases are leading causes of morbidity and mortality in developed countries, with ischemic stroke being a significant disorder. Acetylsalicylic acid (ASA) is a treatment modality that blocks cyclooxygenase, and measuring thromboxane B2 in serum is a potential biomarker of vascular disease risk. Further research is needed to determine the effectiveness of thromboxane as a clinical marker for ischemic stroke.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Dante Barreda, Cesar Santiago, Juan R. Rodriguez, Jose F. Rodriguez, Jose M. Casasnovas, Isabel Merida, Antonia Avila-Flores
Summary: Dendritic cells play a crucial role in the clinical evolution of SARS-CoV-2 infection, as their interaction with the virus's Spike protein promotes inflammatory response and effective immunity, linking individual variations to the degree of response against the virus.
Article
Medicine, Research & Experimental
Yusra Habib Khan, Sumera Qasim, Ambreen Malik Uttra, Nasser H. Alotaibi, Abdullah Salah Alanazi, Abdulaziz I. Alzarea, Ahmed D. Alatawi, Tauqeer Hussain Mallhi
Summary: Enalapril, with documented anti-inflammatory potential, was evaluated for its efficacy in treating arthritis. The study utilized a CFA-induced arthritic model and assessed various parameters such as paw volume, body weight, arthritic index, hematological and biochemical parameters, cytokine levels, radiographic analysis, and histopathological changes. The results showed that enalapril demonstrated significant anti-arthritic activity by reducing paw volume and arthritic index, while preserving body weight. It also normalized hematological and biochemical alterations, suppressed proinflammatory cytokines, and increased anti-inflammatory cytokines. Radiographic and histopathological analysis further confirmed enalapril's anti-arthritic properties. However, further mechanistic studies are needed to determine the exact mechanism of action.
Article
Neurosciences
Alireza Soltani Khaboushan, Niloufar Yazdanpanah, Nima Rezaei
Summary: Neuroinflammation plays a fundamental role in the development of epilepsy, and proinflammatory cytokines (PICs) are crucial contributors. Understanding the role of PICs in epilepsy could provide promising targets for treatment.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Immunology
Nina Geiger, Eva-Maria Koenig, Heike Oberwinkler, Valeria Roll, Viktoria Diesendorf, Sofie Faehr, Helena Obernolte, Katherina Sewald, Sabine Wronski, Maria Steinke, Jochen Bodem
Summary: The study found that aspirin and its metabolite salicylic acid can inhibit the replication of SARS-CoV-2 virus in cells. Although these compounds do not interfere with viral entry, they can inhibit post-entry pathways, thereby reducing the expression of viral RNA.
Article
Immunology
Xiaofang Guo, Nihan Semerci, Viviana De Assis, Umit A. Kayisli, Frederick Schatz, Thora S. Steffensen, Ozlem Guzeloglu-Kayisli, Charles J. Lockwood
Summary: SARS-CoV-2 infection in placental cells induces the release of pro-inflammatory cytokines, which may contribute to cytokine storms and placental dysfunction. In addition, the infection increases the risk of thrombosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Ramya Muthusamy, Srinivasan Karuppannan
Summary: This study successfully reveals the occurrence of liquid-liquid phase separation or oiling-out during the crystallization of polymorphic forms of aspirin. By rapidly cooling the saturated aspirin solutions from a water-acetonitrile mixed solvent medium, the induction time for LLPS and polymorphic nucleation is evaluated, and a phase diagram is constructed to map the preferred conditions for LLPS and polymorphic nucleation. The results show that the nucleation of form-I occurs in acetonitrile-rich compositions without LLPS, form-II occurs in water-rich compositions mostly with micro-level LLPS, and LLPS completely prevents the nucleation of aspirin polymorphs in intermediate compositions.
Article
Psychiatry
Naomichi Okamoto, Tomoya Natsuyama, Ryohei Igata, Yuki Konishi, Hirofumi Tesen, Atsuko Ikenouchi, Reiji Yoshimura
Summary: Patients with schizophrenia and healthy controls did not show significant differences in the levels of Kyn and its metabolites, proinflammatory cytokines, and BDNF. In the schizophrenia group, there was a significant positive correlation between TNF-alpha levels and Kyn as well as the Kyn/Trp value, which was not observed in the healthy control group. Associations between the Kyn pathway and proinflammatory cytokines, BDNF, or psychotic symptoms in hospitalized patients with chronic schizophrenia may be complex.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Nutrition & Dietetics
C. Alejandra Monraz-Mendez, Rebeca Escutia-Gutierrez, Jonathan Samael Rodriguez-Sanabria, Marina Galicia-Moreno, Hugo Christian Monroy-Ramirez, Laura Sanchez-Orozco, Jesus Garcia-Banuelos, Ricardo De la Rosa-Bibiano, Arturo Santos, Juan Armendariz-Borunda, Ana Sandoval-Rodriguez
Summary: This study found that Moringa oleifera aqueous extract has a hepatoprotective role in a model of NASH, improving biochemical, histological, and hepatic gene and miRNA expression.
Review
Oncology
Jorge Gutierrez-Cuevas, Silvia Lucano-Landeros, Daniel Lopez-Cifuentes, Arturo Santos, Juan Armendariz-Borunda
Summary: Hepatocellular carcinoma (HCC) is the most common primary liver cancer, often caused by chronic liver diseases. Nonalcoholic steatohepatitis (NASH) is a risk factor for HCC and is associated with obesity, hyperlipidemia, insulin resistance, and type 2 diabetes. This review discusses the molecular connections between HCC and NASH, focusing on metabolic alterations and genetic and epigenetic drivers, as well as therapeutic strategies.
Review
Food Science & Technology
Ingrid Rivera-Iniguez, Karina Gonzalez-Becerra, Omar Ramos-Lopez, Yolanda E. E. Perez-Beltran, Marian S. S. Chaguen-Hernandez, Erika Martinez-Lopez, Edgar J. J. Mendivil
Summary: This systematic review aims to identify genetic variants associated with lipid abnormalities for use in nutrigenetic interventions to prevent and treat dyslipidemia effectively.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yocasta Martinez-Alvarado, Eduardo Amezcua-Galvez, Judith Davila-Rodriguez, Ana Sandoval-Rodriguez, Marina Galicia-Moreno, Monica Almeida-Lopez, Silvia Lucano-Landeros, Arturo Santos, Hugo Christian Monroy-Ramirez, Juan Armendariz-Borunda
Summary: Ultraviolet radiation (UV) is the main cause of skin photodamage, which leads to histological degenerative changes and non-melanoma skin cancer. Retinoids have been commonly used to treat photoaging, but their adverse effects are recognized. Pirfenidone (PFD) has shown anti-inflammatory, antifibrogenic, and antioxidant properties. In this study, topical PFD was found to effectively reduce photodamage and inflammation in a UVB-induced model, making it a promising treatment for cell photodamage in humans. Clinical trials are needed to further investigate its potential.
Article
Biochemistry & Molecular Biology
Jose de Jesus Rodriguez-Romero, Alejandro Arce-Reynoso, Claudia G. Parra-Torres, Victor M. Zamora-Gasga, Edgar J. Mendivil, Sonia G. Sayago-Ayerdi
Summary: Through this study, it was found that Hibiscus sabdariffa has great potential to be used as an ingredient in products with natural-based ingredients. The content of bioactive compounds in Hibiscus beverages was characterized and their bioaccessibility was evaluated. Results showed significant differences in the content of bioactive compounds before and after in vitro intestinal digestion, indicating that digestion significantly affects the profile of bioactive compounds in the beverage.
Review
Medicine, General & Internal
Oscar Pizano-Martinez, Edgar Mendieta-Condado, Monica Vazquez-Del Mercado, Erika Aurora Martinez-Garcia, Efrain Chavarria-Avila, Daniel Ortuno-Sahagun, Ana Laura Marquez-Aguirre
Summary: Autoimmune rheumatic diseases are a group of heterogeneous disorders characterized by clinical symptoms such as pain, tissue damage, immune deregulation, and inflammation. Biologic disease-modifying antirheumatic drugs are effective treatments, but their complexity can induce the development of anti-drug antibodies. TNF inhibitors, widely used in rheumatoid arthritis, appear to be the main contributors to immunogenicity. This review provides an overview of the immunogenicity of biological agents in autoimmune rheumatic diseases, focusing on the prevalence of anti-drug antibodies.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Francisca Villanueva-Flores, Igor Garcia-Atutxa, Arturo Santos, Juan Armendariz-Borunda
Summary: Neural tissue engineering is a promising technological breakthrough in restoring brain function. However, the development of implantable scaffolds for neural culture that meet all necessary criteria is a remarkable challenge for material science.
Review
Food Science & Technology
Rebeca Escutia-Gutierrez, Ana Sandoval-Rodriguez, Marina Galicia-Moreno, Rebeca Rosas-Campos, Monica Almeida-Lopez, Arturo Santos, Juan Armendariz-Borunda
Summary: A systematic review and meta-analysis found that Mexican ancestral foods, such as cocoa, nopal, avocado, and common bean, can significantly reduce body mass index and improve lipid and glycemic control variables in obese patients.
Article
Rheumatology
Ryan Malcolm Hum, James B. Lilleker, Janine A. Lamb, Alexander G. S. Oldroyd, Guochun Wang, Lucy R. Wedderburn, Louise P. Diederichsen, Jens Schmidt, Maria Giovanna Danieli, Paula Oakley, Zoltan Griger, Thuy Nguyen Thi Phuong, Chanakya Kodishala, Monica Vazquez-Del Mercado, Helena Andersson, Boel De Paepe, Jan L. De Bleecker, Britta Maurer, Liza McCann, Nicolo Pipitone, Neil McHugh, Robert Paul New, William E. Ollier, Niels Steen Krogh, Jiri Vencovsky, Ingrid E. Lundberg, Hector Chinoy
Summary: This study compared the clinical characteristics of adult patients with anti-synthetase syndrome (ASyS) and dermatomyositis (DM), including cutaneous and extramuscular manifestations and malignancy. The results showed that DM-type rashes were frequent in ASyS patients, but there were distinct clinical differences between the two groups. Skin involvement in ASyS did not require increased surveillance for malignancy.
Article
Cell Biology
Jesus Garcia-Banuelos, Eden Oceguera-Contreras, Ana Sandoval-Rodriguez, Blanca Estela Bastidas-Ramirez, Silvia Lucano-Landeros, Daniela Gordillo-Bastidas, Belinda C. Gomez-Meda, Arturo Santos, Eira Cerda-Reyes, Juan Armendariz-Borunda
Summary: Intramuscular delivery of an adenoviral vector containing proMMP-8 gene cDNA (AdhMMP8) is safe and effective in achieving liver fibrosis regression, reducing inflammation and profibrogenic gene expression.
Article
Clinical Neurology
Luz M. Sanchez-Sanchez, Valentina Martinez-Montoya, Roberto Sandoval-Pacheco, Benjamin Torres-Octavo, Diana M. Anaya-Castro, Ofelia Padilla-de la Torre, Carmen A. Arellano-Valdez, Carmen A. Avila-Rejon, Pedro A. Aguilar-Juarez, Martin Espino-Pluma, Antonio Gonzalez-Santillanes Cruz, Ekaterina Kazakova, Rosa Martinez-Segovia, Dorian Olmos-Morfin, Pablo F. Radillo-Diaz, Ishar Solis-Sanchez, Monica Vazquez Del Mercado-Espinosa, Camilo E. Villarroel-Cortes, Jesus S. Velarde-Felix
Summary: This study describes the genotype and clinical characteristics of Mexican patients with late onset Pompe disease (LOPD). The disease progression is slow, leading to delayed diagnosis. The most common symptoms are axial and proximal muscle weakness, and evaluation of the paraspinal muscles is necessary. The pathogenic mutations found in our patients have been previously reported in genetic databases.
REVISTA DE NEUROLOGIA
(2022)
Review
Rheumatology
B. -t. Martin-Marquez, F. Sandoval-Garcia, F. -i. Corona-Meraz, M. -h. Petri, Y. -k. Gutierrez-Mercado, M. Vazquez-Del Mercado
Summary: This review highlights the role of osteopontin in systemic lupus erythematosus and neuropsychiatric SLE and discusses the associated immunopathology mechanisms.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2022)
