Article
Multidisciplinary Sciences
A. Emilia Arguello, Ang Li, Xuemeng Sun, Tanner W. Eggert, Elisabeth Mairhofer, Ralph E. Kleiner
Summary: Kleiner and his colleagues profile RNA 5-methylcytidine dioxygenase enzymes using an activity-based metabolic probing strategy, identifying ALKBH1 as the major writer of 5-formylcytidine. Their study characterizes modification sites across mRNA and tRNA, revealing the regulatory role of epitranscriptomic RNA modifications. They propose a chemoproteomic strategy to study RNA 5-methylcytidine dioxygenases in their native context and map oxidative m5C modifications. The research uncovers novel epitranscriptomic pathways for regulating RNA function.
NATURE COMMUNICATIONS
(2022)
Review
Biochemistry & Molecular Biology
Irina Gilyazova, Kadriia Enikeeva, Guzel Rafikova, Evelina Kagirova, Yuliya Sharifyanova, Dilara Asadullina, Valentin Pavlov
Summary: Bladder cancer is a common malignant tumor of the urogenital system, with over 500,000 new cases worldwide annually. Current diagnosis methods include cystoscopy and urine cytology, but they have limitations in sensitivity and invasiveness. There is a need to develop more reliable markers and tests for early detection of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Genetics & Heredity
Michela Saviana, Patricia Le, Lavender Micalo, Daniel Del Valle-Morales, Giulia Romano, Mario Acunzo, Howard Li, Patrick Nana-Sinkam
Summary: There is a crosstalk between DNA methylation and miRNA expression that plays a significant role in the pathogenesis of cancer. Understanding how miRNAs influence DNA methylation and vice versa is important for identifying therapeutic targets. Additionally, these epigenetic modifications may serve as potential biomarkers in cancer.
Article
Biotechnology & Applied Microbiology
Manu Shivakumar, Seonggyun Han, Younghee Lee, Dokyoon Kim
Summary: This study provides a higher resolution of molecular insight into the crosstalk between two epigenetic factors, DNA methylation and miRNA. Results showed that these interactions are important in cancer, and it is timely to identify and understand the underlying mechanisms based on epigenetic markers and their interactions in cancer, leading to alternative splicing with primary functional impact.
Article
Biochemistry & Molecular Biology
Yeong-Chin Jou, Shou-Chieh Wang, Yuan-Chang Dia, Shou-Tsung Wang, Min-Hua Yu, Hsin-Yi Yang, Lei-Chin Chen, Cheng-Huang Shen, Yi-Wen Liu
Summary: The study demonstrated that GSTM5 acts as a tumor suppressor in bladder cancer cells without significantly affecting chemoresistance to cisplatin and mitomycin C, and the cellular levels of GSH are key mechanisms underlying the anticancer effect of GSTM5. Low gene expression and high DNA methylation levels of GSTM5 may serve as tumor markers for bladder cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Lingyuan Ma, Chenyu Li, Hanlin Yin, Jiashu Huang, Shenghao Yu, Jin Zhao, Yongxu Tang, Min Yu, Jie Lin, Lei Ding, Qinghua Cui
Summary: Breast cancer is the most common cancer worldwide, and its treatment methods include radiotherapy, chemotherapy, targeted therapy, and surgery. The molecular subtype of breast cancer determines the specific treatment measures, making the exploration of molecular mechanisms and therapeutic targets essential. Abnormal methylation of tumor suppressor genes by DNMTs is associated with poor prognosis in breast cancer. MiRNAs, as non-coding RNAs, play crucial roles in breast cancer and their aberrant methylation can lead to drug resistance. Therefore, regulating miRNA methylation could be a potential therapeutic target in breast cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Andrea Palicelli, Stefania Croci, Alessandra Bisagni, Eleonora Zanetti, Dario De Biase, Beatrice Melli, Francesca Sanguedolce, Moira Ragazzi, Magda Zanelli, Alcides Chaux, Sofia Canete-Portillo, Maria Paola Bonasoni, Alessandra Soriano, Stefano Ascani, Maurizio Zizzo, Carolina Castro Ruiz, Antonio De Leo, Guido Giordano, Matteo Landriscina, Giuseppe Carrieri, Luigi Cormio, Daniel M. Berney, Jatin Gandhi, Davide Nicoli, Enrico Farnetti, Giacomo Santandrea, Martina Bonacini
Summary: Epigenetic alterations impact the expression of PD-L1 in prostate cancer, with DNA methylation and miRNAs being key factors. Histone modifiers and epigenetic drugs can reverse these alterations. miRNAs can regulate PD-L1 post-transcriptionally, offering potential clinical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Nikola Zmarzly, Szymon Januszyk, Pawel Mieszczanski, Emilia Morawiec, Paulina Buda, Konrad Dziobek, Marcin Oplawski, Dariusz Boron
Summary: This study found that the expression of endothelins changes in endometrial cancer, and this may be mainly due to the silencing of EDN3 activity caused by DNA methylation.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Kazutoshi Yamagishi, Yoshio Kikuta
Summary: Epigenetic modifications, such as DNA methylation, play a role in regulating gene expression in animals and plants. This study demonstrated that treatment with 5-aza-Cd can reactivate a silenced transgene in tobacco cells, but the reactivation is transient and can be attenuated over time. Additionally, derivatives of 5-mCs, such as 5-mCd and 5-mdCd, were shown to inhibit or reverse the reactivation induced by 5-aza-Cd.
PLANT BIOTECHNOLOGY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Eva Kowalinski, Juan D. Alfonzo
Summary: METTL8, initially considered an mRNA modifier, is actually a tRNA-specific mitochondrial enzyme crucial for mitochondrial translation and function. Paradoxically, increased expression of METTL8 is linked to high respiratory rates in pancreatic cancers.
Review
Pharmacology & Pharmacy
Laboni Roy, Oishika Chatterjee, Debopriya Bose, Ananya Roy, Subhrangsu Chatterjee
Summary: The epigenetic landscape plays a crucial role in cellular homeostasis and its disruption can lead to cancer. Noncoding RNA networks, through regulation of processes like histone modification and DNA methylation, are key intracellular components involved in controlling cellular epigenetic characteristics. Understanding the effects of these RNA networks on epigenetic programming is important for the development of targeted cancer therapeutics.
DRUG DISCOVERY TODAY
(2023)
Article
Oncology
Mansheng Zhu, Qixiang Liang, Tao Chen, Qian Kong, Gengtai Ye, Shitong Yu, Xunjun Li, Qinglie He, Hao Liu, Yanfeng Hu, Jiang Yu, Guoxin Li
Summary: This study revealed the significant suppression of miRNA miR-129-2-3p in EBVaGC due to hypermethylation, and its role in promoting GC cell functions was demonstrated. The comprehensive analysis integrated multi-source data and provided insights into the relationships between methylated miRNA, differentially expressed genes (DEGs), and immune cell infiltration. Further experimental and clinical investigations are needed to validate these findings and explore the underlying mechanisms.
CLINICAL EPIGENETICS
(2021)
Review
Oncology
Weiwei Xie, Huizhen Sun, Xiaoduan Li, Feikai Lin, Ziliang Wang, Xipeng Wang
Summary: Ovarian cancer is associated with activation of oncogenes and inactivation of tumor suppressor genes, with epigenetic processes playing a key role in tumorigenesis. MicroRNA and long non-coding RNA are promising molecular markers for precision medicine in OC. Clinical application of epigenetic approaches is currently limited by hurdles such as heterogeneity of OC and insufficient sample sizes, but holds promise for future clinical investigation into diagnosis, treatment, and prognosis.
CANCER CELL INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Cheng Zhang, Yong-Zhi Li, Dong-Qiu Dai
Summary: This study revealed that FOXF2 is downregulated in gastric cancer due to aberrant DNA methylation, and the degree of methylation in the FOXF2 promoter region is related to patient prognosis. Additionally, FOXF2 may play a vital biological regulation role in gastric cancer through the FOXF2/miRNAs/target genes axis.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Tianxiao Huang, Yan Li, Wei Wang, Le Xu, Jingrui Li, Yijun Qi
Summary: This study reannotated lmiRNAs and their targets in rice, revealing that most lmiRNAs are derived from MITEs and suggesting co-evolution between lmiRNAs and their targets through MITE amplification. The study also found dynamic changes of lmiRNAs under stress conditions and enrichment of stress-responsive genes among lmiRNA targets, indicating the widespread involvement of lmiRNAs in plant stress responses. Furthermore, the study constructed the evolutionary histories of lmiRNAs and their targets, highlighting the importance of MITEs in the origin of lmiRNAs and suggesting a role for the evolution of lmiRNA-target regulatory modules in rice adaptation to environmental changes.
JOURNAL OF INTEGRATIVE PLANT BIOLOGY
(2022)