Article
Urology & Nephrology
Mona Khurana, Gunter F. Egger, Lynne Yao, Aliza Thompson, Chrissi Pallidis, Stuart L. Goldstein, Benjamin L. Laskin, Shamir Tuchman, Meaghan A. Malley, Katrin Uhlig
Summary: Children with CKD need safe and effective medicines, but conducting trials for pediatric drug development remains a challenge. There are difficulties in recruitment and completion, as well as a significant time lag between adult approval and pediatric labeling. This article provides an overview of regulatory frameworks, current landscape, challenges, and progress in drug development for children with CKD.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Transplantation
Rianne W. de Jong, Vianda S. Stel, James G. Heaf, Mark Murphy, Ziad A. Massy, Kitty J. Jager
Summary: This study identified modifiable, non-medical barriers reported by nephrologists when providing renal replacement therapy modalities and comprehensive conservative management. The barriers were categorized into three levels: patient, healthcare professional, and healthcare system. These barriers could be targeted through education and optimizing financing structure to improve access to appropriate treatments.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Review
Medicine, General & Internal
Jihan Sleiman, Gervasio Soler Pujol, Erika Montanez, Veronica Roatta, Gustavo Laham
Summary: Sex and gender are often used interchangeably, but gender is a more fluid and dynamic concept that encompasses psychosocial and cultural aspects. Inequality in medicine, particularly gender inequality, has been overlooked for a long time and is now a pressing concern. This study investigates gender equality in patients with chronic kidney disease (CKD) and highlights disparities in access to different treatment modalities.
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Jang-Hee Cho, Jeong-Hoon Lim, Yeongwoo Park, Yena Jeon, Yon Su Kim, Shin-Wook Kang, Chul Woo Yang, Nam-Ho Kim, Hee-Yeon Jung, Ji-Young Choi, Sun-Hee Park, Chan-Duck Kim, Yong-Lim Kim
Summary: This study investigated factors associated with the selection of dialysis modalities in elderly patients compared to younger patients. The results showed that older patients were more likely to choose hemodialysis (HD) over peritoneal dialysis (PD), and factors such as dialysis planning and congestive heart failure (CHF) played a significant role in the modality selection for elderly patients. Tumor, on the other hand, influenced the modality selection for younger patients. The study also found that socioeconomic status had a lesser impact on modality selection in elderly patients compared to younger patients.
FRONTIERS IN MEDICINE
(2022)
Article
Urology & Nephrology
Roberto Minutolo, Michele Provenzano, Paolo Chiodini, Silvio Borrelli, Carlo Garofalo, Michele Andreucci, Maria Elena Liberti, Vincenzo Bellizzi, Giuseppe Conte, Luca De Nicola
Summary: This study found that new-onset anemia in patients with chronic kidney disease is associated with increased risk of adverse outcomes, especially severe anemia. The incidence of anemia increased with the severity of renal damage and proteinuria level.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Transplantation
Phil McEwan, Rebecca Boyce, Juan Jose Garcia Sanchez, C. David Sjostrom, Bergur Stefansson, Stephen Nolan, Ricardo Correa-Rotter, Peter Rossing, Glenn M. Chertow, John J. McMurray, David C. Wheeler, Hiddo J. L. Heerspink
Summary: The DAPA-CKD trial demonstrated that dapagliflozin has significant benefits in patients with chronic kidney disease and albuminuria. Using a Markov model, it was predicted that dapagliflozin treatment would lead to longer time in lower CKD stages, reduced mortality, and fewer complications such as heart failure and kidney function decline.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Medicine, General & Internal
Cristina Techy Roth-Stefanski, Naiane Rodrigues de Almeida, Gilson Biagini, Natalia K. Scatone, Fabiana B. Nerbass, Thyago Proenca de Moraes
Summary: The study found only moderate concordance between anthropometry and BIS in diagnosing PEW in chronic peritoneal dialysis patients, with muscle mass measurement discrepancies potentially leading to differences in diagnosis.
FRONTIERS IN MEDICINE
(2021)
Review
Urology & Nephrology
Abhijat Kitchlu, Kenar D. Jhaveri, Ben Sprangers, Motoko Yanagita, Rimda Wanchoo
Summary: ICI therapy has substantially improved prognosis of patients with advanced malignancy, with similar incidence of immune-related adverse events in ESKD patients compared with the general population. Severe reactions have been seen in some cases, but cancer remission was observed in close to 30% of patients. More data from prospective studies are needed to assess outcomes more accurately.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Physiology
Vedrana Sember, Spela Bogataj, Jose Carlos Ribeiro, Armin Paravlic, Maja Pajek, Jernej Pajek
Summary: The study revealed that hemodialysis (HD) patients are less active during dialysis days compared to non-dialysis days, and sedentary behavior increases the risk of death. Additionally, findings showed that body composition, physical fitness, and disease burden in HD patients are related to objectively measured physical activity.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Urology & Nephrology
Esther N. M. de Rooij, Yvette Meuleman, Johan W. W. de Fijter, Kitty J. J. Jager, Nicholas C. C. Chesnaye, Marie Evans, Fergus J. J. Caskey, Claudia Torino, Gaetana Porto, Maciej Szymczak, Christiane Drechsler, Christoph Wanner, Friedo W. W. Dekker, Ellen K. K. Hoogeveen
Summary: For older patients with kidney failure, symptom burden worsened considerably before and stabilized after dialysis initiation. Fatigue, decreased interest in sex, and difficulty becoming sexually aroused were considered most burdensome, of which only fatigue somewhat improved after dialysis initiation.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Transplantation
Morgan E. Grams, Aditya Surapaneni, Lawrence J. Appel, James P. Lash, Jesse Hsu, Clarissa J. Diamantidis, Sylvia E. Rosas, Jeffrey C. Fink, Julia J. Scialla, James Sondheimer, Chi-Yuan Hsu, Alfred K. Cheung, Bernard G. Jaar, Sankar Navaneethan, Debbie L. Cohen, Sarah Schrauben, Dawei Xie, Pandu Rao, Harold Feldman
Summary: This study examined the multidimensional trajectories of CKD patients and found that more advanced CKD stages were associated with a higher risk of clinical events and faster eGFR decline, but only weakly related to changes in patient-reported metrics over time.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Urology & Nephrology
Moustapha Faye, Karine Legrand, Lisa Le Gall, Karen Leffondre, Abdou Y. Omorou, Natalia Alencar de Pinho, Christian Combe, Denis Fouque, Christian Jacquelinet, Maurice Laville, Sophie Liabeuf, Ziad A. Massy, Elodie Speyer, Roberto Pecoits Filho, Benedicte Stengel, Luc Frimat, Carole Ayav
Summary: This study focuses on the significant worsening of symptoms in about one third of the participants, while the majority reported low symptom severity throughout the study.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Review
Urology & Nephrology
Sandawana William Majoni, Paul D. Lawton, Geetha Rathnayake, Federica Barzi, Jaquelyne T. Hughes, Alan Cass
Summary: Indigenous Australians have high rates of chronic kidney disease, leading to challenges in managing anemia due to common iron deficiency issues. The accuracy of serum ferritin concentration as a marker for iron deficiency is questioned in this population.
KIDNEY INTERNATIONAL REPORTS
(2021)
Review
Urology & Nephrology
Philip Kam-Tao Li, Gordon Chun-Kau Chan, Jianghua Chen, Hung-Chun Chen, Yuk-Lun Cheng, Stanley L-S Fan, John Cijiang He, Weixin Hu, Wai-Hon Lim, York Pei, Boon Wee Teo, Ping Zhang, Xueqing Yu, Zhi-Hong Liu
Summary: CKD is a global problem that requires early detection, prompt treatment, promotion of home-based dialysis therapy, and kidney transplantation for effective management.
Article
Urology & Nephrology
Ankur A. Dashputre, Praveen K. Potukuchi, Keiichi Sumida, Suryatapa Kar, Yoshitsugu Obi, Fridtjof Thomas, Miklos Z. Molnar, Elani Streja, Kamyar Kalantar-Zadeh, Csaba P. Kovesdy
Summary: Higher potassium variability before dialysis initiation is associated with increased all-cause mortality after dialysis initiation, but not with cardiovascular mortality.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Transplantation
Esmee M. van der Willik, Fenna van Breda, Brigit C. van Jaarsveld, Marlon van de Putte, Isabelle W. Jetten, Friedo W. Dekker, Yvette Meuleman, Frans J. van Ittersum, Caroline B. Terwee
Summary: This study compared the content, validity, and reliability of PROMIS CATs and SF-12 in patients with chronic kidney disease. The results showed that PROMIS CATs had sufficient construct validity and test-retest reliability, and had a lower minimal detectable change compared to SF-12. The study suggests the need for further research on the feasibility of PROMIS CATs in nephrology care.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Urology & Nephrology
Juan Jesus Carrero, Edouard L. Fu, Soren V. Vestergaard, Simon Kok Jensen, Alessandro Gasparini, Viyaasan Mahalingasivam, Samira Bell, Henrik Birn, Uffe Heide-Jorgensen, Catherine M. Clase, Faye Cleary, Josef Coresh, Friedo W. Dekker, Ron T. Gansevoort, Brenda R. Hemmelgarn, Kitty J. Jager, Tazeen H. Jafar, Csaba P. Kovesdy, Manish M. Sood, Benedicte Stengel, Christian F. Christiansen, Masao Iwagami, Dorothea Nitsch
Summary: The availability of electronic health records and routine measurements in kidney disease research provide opportunities but also pose challenges in terms of patient identification, marker usage, and outcome evaluation. The heterogeneity of definitions and the need to address biases are discussed, along with a proposed framework for reporting exposures and outcomes.
KIDNEY INTERNATIONAL
(2023)
Article
Sport Sciences
Floriana Samantha Luppino, Margien Elisabeth Den Hollander-Gijsman, Friedo Wilhelm Dekker, Kornelis Alexander Bartlema, Merel van Diepen
Summary: The study aimed to develop a validated instrument to accurately estimate the actual skills level of recreational skiers. The instrument was validated using multiple methods and proved to better reflect the actual skills levels compared with self-reportage.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Transplantation
Denise M. J. Veltkamp, Yiman Wang, Yvette Meuleman, Friedo W. Dekker, Wieneke M. Michels, Paul J. M. van der Boog, Aiko P. J. de Vries
Summary: This study investigated the relationship between symptom prevalence and burden with health-related quality of life (HRQOL) in kidney transplant recipients (KTRs). The results showed that female KTRs reported more symptoms and younger KTRs experienced more symptoms related to depression and changes in physical appearance.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Transplantation
Robin Lengton, Esmee M. van der Willik, Esther N. M. de Rooij, Yvette Meuleman, Saskia Le Cessie, Wieneke M. Michels, Marc Hemmelder, Friedo W. Dekker, Ellen K. Hoogeveen
Summary: This study investigated the association between residual estimated glomerular filtration rate (eGFR), dialysis adequacy, or serum phosphate level and chronic kidney disease-associated pruritus (CKD-aP) in incident dialysis patients. The results showed that higher residual eGFR and lower serum phosphate level, but not the dialysis dose, were related to a lower burden of CKD-aP in dialysis patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Edouard L. Fu, Andrew S. Levey, Josef Coresh, Carl-Gustaf Elinder, Joris I. Rotmans, Friedo W. Dekker, Julie M. Paik, Peter Barany, Morgan E. Grams, Lesley A. Inker, Juan-Jesus Carrero
Summary: Cystatin C is recommended as a confirmatory test to eGFR when more precise estimates are needed for clinical decision making. However, it is uncertain whether eGFR(cr-cys) is the most accurate estimate in real-world settings, especially when there are large discordances between eGFR(cr) and eGFR(cys).
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Multidisciplinary Sciences
Mikko Haapio, Merel van Diepen, Retha Steenkamp, Jaakko Helve, Friedo W. Dekker, Fergus Caskey, Patrik Finne
Summary: Mortality prediction is crucial in long-term kidney replacement therapy (KRT) for treatment decisions and resource planning. Existing models have mostly been internally validated, but this study externally validated the performance of two previously constructed models in the Dutch and UK KRT populations. The models showed good performance and encourage widespread implementation in European KRT populations.
Article
Psychology, Clinical
Yvette Meuleman, Yvonne van der Bent, Leandra Gentenaar, Fergus J. Caskey, Hans A. J. Bart, Wanda S. Konijn, Willem Jan W. Bos, Marc H. Hemmelder, Friedo W. Dekker
Summary: This study aims to identify and modify unhelpful illness perceptions in patients with chronic kidney disease (CKD) prior to kidney failure, and explore the needs and requirements for identifying and supporting these patients in nephrology care. It was found that illness perceptions related to the seriousness and manageability of CKD were the most meaningful. Implementing tools to identify and discuss patients' illness perceptions and offering support for patients with unhelpful illness perceptions are important.
INTERNATIONAL JOURNAL OF BEHAVIORAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Caroline B. Terwee, Esmee M. van der Willik, Fenna van Breda, Brigit C. van Jaarsveld, Marlon van de Putte, Isabelle W. Jetten, Friedo W. Dekker, Yvette Meuleman, Frans J. van Ittersum
Summary: This study evaluated the responsiveness and minimal important change of seven PROMIS CATs in Dutch patients. The results showed that PROMIS CATs had high responsiveness in physical function, fatigue, sleep disturbance, and depression domains, but did not perform as expected in anxiety and ability to participate in social roles and activities.
JOURNAL OF PATIENT-REPORTED OUTCOMES
(2023)
Article
Health Care Sciences & Services
Liselotte F. S. Langenhuijsen, Roemer J. Janse, Esmee Venema, David M. Kent, Merel van Diepen, Friedo W. Dekker, Ewout W. Steyerberg, Ype de Jong
Summary: Using the PROBAST, researchers explored the trends of risk of bias in prediction research and assessed the inter-rater agreement. They found that high bias was prevalent in the Analysis domain and the overall bias trends remained relatively stable over time. The inter-rater agreement was low and could potentially be improved by altering the PROBAST or providing training.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2023)
Article
Transplantation
Mathijs van Oevelen, Anna A. Bonenkamp, Anita van Eck van der Sluijs, Willem Jan W. Bos, Caroline E. Douma, Marjolijn van Buren, Yvette Meuleman, Friedo W. Dekker, Brigit C. van Jaarsveld, Alferso C. Abrahams
Summary: Compared with younger patients, older hemodialysis patients generally have better mental health-related quality of life (HRQoL) and a lower symptom burden. However, their physical HRQoL declines more rapidly with increasing symptom burden.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Surgery
Yiman Wang, Paul van der Boog, Marc H. Hemmelder, Friedo W. Dekker, Aiko De Vries, Yvette Meuleman
Summary: The purpose of this article is to investigate the impact of symptom experience on health related quality of life (HRQOL) in kidney transplant recipients (KTRs) and whether illness perceptions mediated this impact. The findings suggest that worse symptom experiences could cause more unhelpful illness perceptions and consequently lead to lower HRQOL. The study highlights the importance of addressing symptom experiences and illness perceptions to improve HRQOL in kidney transplant recipients.
TRANSPLANT INTERNATIONAL
(2023)
