Uric acid regulates NLRP3/IL-1β signaling pathway and further induces vascular endothelial cells injury in early CKD through ROS activation and K+ efflux

MiR-29b aggravates lipopolysaccharide-induced endothelial cells inflammatory damage by regulation of NF-κB and JNK signaling pathways

(2018) Huifeng Yuan et al.   BIOMEDICINE & PHARMACOTHERAPY

International statistical classification of diseases and related health problems coding underestimates the incidence and prevalence of acute kidney injury and chronic kidney disease in general medical patients

(2018) Soe Ko et al.   INTERNAL MEDICINE JOURNAL

MicroRNA-495 Ameliorates Cardiac Microvascular Endothelial Cell Injury and Inflammatory Reaction by Suppressing the NLRP3 Inflammasome Signaling Pathway

(2018) Tao  Zhou et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Renal compartment–specific genetic variation analyses identify new pathways in chronic kidney disease

(2018) Chengxiang Qiu et al.   NATURE MEDICINE

A Membrane Potential- and Calpain-Dependent Reversal of Caspase-1 Inhibition Regulates Canonical NLRP3 Inflammasome

(2018) Yifei Zhang et al.   Cell Reports

Atypical Gasdermin D and Mixed Lineage Kinase Domain-like Protein Leakage Aggravates Tetrachlorobenzoquinone-Induced Nod-like Receptor Protein 3 Inflammasome Activation

(2018) Xiaomin Xia et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Negative regulators and their mechanisms in NLRP3 inflammasome activation and signaling

(2017) Jin Kyung Kim et al.   IMMUNOLOGY AND CELL BIOLOGY

Carbon monoxide-releasing molecule-2 suppresses thrombomodulin and endothelial protein C receptor expression of human umbilical vein endothelial cells induced by lipopolysaccharide in vitro

(2017) Xianglin Meng et al.   MEDICINE

Elevated uric acid and adenosine triphosphate concentrations in bronchoalveolar lavage fluid of eosinophilic pneumonia

(2017) Takehito Kobayashi et al.   ALLERGOLOGY INTERNATIONAL

Effects of Uric Acid on Hearts of Rats with Chronic Kidney Disease

(2017) Xiaorong Bao et al.   AMERICAN JOURNAL OF NEPHROLOGY

K + Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria

(2016) Christina J. Groß et al.   IMMUNITY

Relevance of uric acid and asymmetric dimethylarginine for modeling cardiovascular risk prediction in chronic kidney disease patients

(2016) Mehmet Kanbay et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

Uric acid regulates hepatic steatosis and insulin resistance through the NLRP3 inflammasome-dependent mechanism

(2016) Xingyong Wan et al.   JOURNAL OF HEPATOLOGY

Uric acid promotes chemokine and adhesion molecule production in vascular endothelium via nuclear factor-kappa B signaling

(2015) W.Y. Liang et al.   NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES

Relationship between Serum Uric Acid Levels and Chronic Kidney Disease in a Japanese Cohort with Normal or Mildly Reduced Kidney Function

(2015) Tadashi Toyama et al.   PLoS One

Iron Sucrose Accelerates Early Atherogenesis by Increasing Superoxide Production and Upregulating Adhesion Molecules in CKD

(2014) K.-L. Kuo et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

The role of uric acid in the pathogenesis of human cardiovascular disease

(2013) Mehmet Kanbay et al.   HEART

Association of Hyperuricemia with Renal Outcomes, Cardiovascular Disease, and Mortality

(2012) W.-C. Liu et al.   Clinical Journal of the American Society of Nephrology

The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP

(2012) Geun-Shik Lee et al.   NATURE

Uric Acid-Induced Endothelial Dysfunction Is Associated with Mitochondrial Alterations and Decreased Intracellular ATP Concentrations

(2012) Laura Gabriela Sánchez-Lozada et al.   NEPHRON EXPERIMENTAL NEPHROLOGY

Effects of down-regulation of microRNA-23a on TNF-α-induced endothelial cell apoptosis through caspase-dependent pathways

(2011) Wei Ruan et al.   CARDIOVASCULAR RESEARCH

Effect of Allopurinol in Chronic Kidney Disease Progression and Cardiovascular Risk

(2010) M. Goicoechea et al.   Clinical Journal of the American Society of Nephrology

A Peroxidase Contributes to ROS Production during Arabidopsis Root Response to Potassium Deficiency

(2010) Min Jung Kim et al.   Molecular Plant

Uric Acid and Long-term Outcomes in CKD

(2009) Magdalena Madero et al.   AMERICAN JOURNAL OF KIDNEY DISEASES