Article
Engineering, Environmental
Titus Cooray, Junya Zhang, Hui Zhong, Libing Zheng, Yuansong Wei, Sujithra K. Weragoda, K. B. S. N. Jinadasa, Rohan Weerasooriya
Summary: This study investigated the response of microbial community and antibiotic resistome to CKDu prevalence in the groundwater through high throughput sequencing and qPCR respectively. Results showed that CKDu prevalence significantly influenced the distribution of antibiotic resistome and microbial community composition.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Urology & Nephrology
Pasan Hewavitharana, Stephen Schensul, Edison Lee, Maria Montez-Rath, Sachintha Senarathne, Sai Liu, Kaitlin Harold, Santhushya Hewapathiranage, Naduni Erandika, Hemalika T. K. Abeysundara, Xue Yu, Vivek Bhalla, Andrew Fire, Adeera Levin, Shuchi Anand, Penny Vlahos, Rohana Chandrajith, Nishantha Nanayakkara
Summary: Chronic kidney disease of uncertain etiology is a leading cause of death in Sri Lanka's dry region. This study followed 292 patients with CKDu and found that kidney function decline was slow and there was no difference in event rates between men and women. Further research could focus on specific residence locale and water use.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Pediatrics
P. Mangala C. S. De Silva, T. D. K. S. C. Gunasekara, S. D. Gunarathna, P. M. M. A. Sandamini, R. A. Pinipa, E. M. D. Ekanayake, W. A. K. G. Thakshila, S. S. Jayasinghe, E. P. S. Chandana, Nishad Jayasundara
Summary: This study aimed to determine reference intervals for KIM-1 and NGAL in a pediatric population in Sri Lanka affected by CKDu. The findings provide valuable information for screening and detecting early renal damage in rural communities impacted by CKDu.
Article
Engineering, Civil
Chandima Nikagolla, Les A. Dawes, Graeme J. Millar, Karina T. Meredith, Richard B. Banati
Summary: Groundwater in the arid, agricultural regions of Sri Lanka has been under study for over two decades, revealing that agricultural activities, population growth, and environmental factors are threatening water quality. The use of POM, environmental isotopes, and water chemistry helps identify the sources and dynamics of solutes in groundwater, aiding in understanding groundwater quality and addressing complex environmental health issues like CKDu.
JOURNAL OF HYDROLOGY
(2021)
Article
Marine & Freshwater Biology
Ling-Kang Bu, Pan-Pan Jia, Wei-Guo Li, Yong-Zhi Li, Tian-Yun Li, De-Sheng Pei
Summary: This study investigates the potential mitigating effects of probiotics on kidney damage induced by Sri Lanka's contaminated groundwater using zebrafish as a model organism. The results show that exposure to local groundwater caused abnormalities in zebrafish larvae, but the addition of probiotics improved various parameters and positively influenced the expression of kidney development and immunity-related genes. Furthermore, exposure to contaminated groundwater decreased the diversity and abundance of microbiota in zebrafish larvae, but probiotic treatment partially restored the disrupted gut microbiota and impacted the microbial community's cellular processes.
AQUATIC TOXICOLOGY
(2023)
Article
Engineering, Environmental
M. R. D. L. Kulathunga, M. A. A. Wijayawardena, Ravi Naidu
Summary: Research in Sri Lanka has shown that intake of heavy metals and metalloids through diet, particularly from rice, vegetables, and fish, exceeds recommended daily limits in areas with high prevalence of CKDu. The entire population in the study area faces a risk of high exposure to lead, with no significant difference in estimated daily intake between different age and gender categories. Immediate interventions are needed to reduce dietary exposure to heavy metals and metalloids.
ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
(2022)
Article
Environmental Sciences
Dazhou Hu, Suresh Indika, Hui Zhong, Sujithra K. Weragoda, K. B. S. N. Jinadasa, Rohan Weerasooriya, Yuansong Wei
Summary: The structure, composition, source, and spatial distribution of dissolved organic matter (DOM) in groundwater samples from the North Central Province (NCP) in Sri Lanka were studied. The results revealed differences in the concentration and composition of DOM in different aquifers, as well as its susceptibility to environmental factors.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Multidisciplinary Sciences
T. D. K. S. C. Gunasekara, P. Mangala C. S. De Silva, E. M. D. Ekanayake, W. A. K. G. Thakshila, R. A. Pinipa, P. M. M. A. Sandamini, S. D. Gunarathna, E. P. S. Chandana, S. S. Jayasinghe, C. Herath, Sisira Siribaddana, Nishad Jayasundara
Summary: This study investigated the early detection of renal abnormalities in selected pediatric communities in Sri Lanka using kidney injury molecule (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL). The results showed significantly elevated levels of urinary KIM-1 expression in children from CKDu affected regions, indicating low-grade early renal damage. NGAL levels showed no significant differences. Urinary albumin-creatinine ratio (UACR) did not vary significantly by gender or residency.
SCIENTIFIC REPORTS
(2022)
Article
Water Resources
Syprose Nyachoti, Tewodros R. Godebo, Onoja F. Okwori, Marc A. Jeuland, Herath Manthrithilake
Summary: The study found that exposure to low levels of nephrotoxic metals and inadequate selenium in staple grains is not clearly linked to CKDu, suggesting that the disease could be multifactorial. Further research is needed to determine the contribution of other risk factors to plan preventive strategies for reducing CKDu cases in Sri Lanka.
EXPOSURE AND HEALTH
(2022)
Review
Environmental Sciences
Dinushi Arambegedara, Saroj Jayasinghe, Preethi Udagama
Summary: The increasing prevalence of CKDu in Sri Lanka since the 1990s has posed a major health problem, with a lack of comprehensive action plan identified from a systematic literature review of 119 publications. To alleviate the CKDu epidemic, the One Health approach combined with a systems dynamics model is proposed as a potential way forward to address the research gaps and mitigate the situation.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Urology & Nephrology
Christoph Daniel, Philipp Enghard, Neelakanthi Ratnatunga, Sulochana Wijetunge, A. W. M. Wazil, Christian Zwiener, Johannes A. C. Barth, Rohana Chandrajith, Monika Klewer, Kai-Uwe Eckhardt, Kerstin Amann, Paul Freund, Shakila Premarathne, W. D. R. N. Pushpakumara, Nishantha Nanayakkara
Summary: This study collected 13 renal biopsies from patients with symptomatic chronic kidney disease in Sri Lanka and compared them with 100 biopsies from German patients. The results showed that early tubulointerstitial changes were evident in symptomatic chronic kidney disease patients in Sri Lanka, while glomerular changes were mild. These ultrastructural changes were significantly more frequent in symptomatic chronic kidney disease cases than in the control group, but they do not provide concrete evidence of the cause of the disease.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Environmental Sciences
D. N. D. Liyanage, Saranga Diyabalanage, S. P. Dunuweera, Sanath Rajapakse, R. M. G. Rajapakse, Rohana Chandrajith
Summary: The study conducted in the Monaragala district of Sri Lanka revealed a CKDu prevalence of about 6.7%. Analysis of groundwater samples showed significant differences in the concentrations of certain ions between CKDu-prevalent locations and control locations. Higher levels of alkali and alkaline earth cations, as well as fluoride, were found in the drinking water sources used by CKDu patients, potentially relating to the disease.
ENVIRONMENTAL RESEARCH
(2022)
Article
Marine & Freshwater Biology
Yi-Fan Yang, Wei-Guo Li, Ping-Ping Wen, Pan -Pan Jia, Yong-Zhi Li, Tian-Yun Li, De-Sheng Pei
Summary: This study investigates the impacts of Sri Lanka's local groundwater on chronic kidney disease and reveals possible pathogenic mechanisms using zebrafish models. The results show that exposure to Sri Lanka's local groundwater causes developmental toxicity, kidney damage, and abnormal behavior in zebrafish. The study also suggests that high water hardness and fluoride may be the environmental factors for the cause of chronic kidney disease.
AQUATIC TOXICOLOGY
(2022)
Article
Environmental Sciences
Sen Xu, Si-Liang Li, Fujun Yue, Charitha Udeshani, Rohana Chandrajith
Summary: The groundwater quality in Sri Lanka shows significant spatial heterogeneity, with various parameters having clear relationships with environmental factors. Further research reveals the close correlation between water quality and geology, land use, and climate, with environmental factors explaining 58% of the spatial variation in groundwater geochemistry.
Article
Urology & Nephrology
Alberto Ortiz
Summary: Iceland has a low incidence of kidney replacement therapy (KRT) and chronic kidney disease (CKD), suggesting a low need for KRT. The country also provides a well-characterized population for studying the influence of genetics, environment, and lifestyle on CKD. Risk factors such as obesity and sleep apnea are associated with increased CKD incidence, highlighting the importance of early diagnosis.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Public, Environmental & Occupational Health
Ambepitiyawaduge Pubudu De Silva, Sudirikku Hennadige Padmal De Silva, Rashan Haniffa, Isurujith Kongala Liyanage, Saroj Jayasinghe, Prasad Katulanda, Chandrika Neelakanthi Wijeratne, Sumedha Wijeratne, Lalini Chandika Rajapaksa
INTERNATIONAL JOURNAL FOR EQUITY IN HEALTH
(2018)
Meeting Abstract
Medicine, General & Internal
Lasantha K. Hirimuthugoda, Sunil P. K. Wathudura, Hemachandra Edirimanna, Thushari K. Vithanage, Pubudu A. de Silva
Article
Health Policy & Services
A. Pubudu De Silva, Isurujith Kongala Liyanage, S. Terrance G. R. De Silva, Mahesha B. Jayawardana, Chiranthi K. Liyanage, Indika M. Karunathilake
HUMAN RESOURCES FOR HEALTH
(2013)
Article
Public, Environmental & Occupational Health
Ambepitiyawaduge Pubudu De Silva, Sudirikku Hennadige Padmal De Silva, Isurujith Kongala Liyanage, Lalini Chandika Rajapakse, Kosala Saroj Amarasiri Jayasinghe, Prasad Katulanda, Chandrika Neelakanthi Wijeratne, Sumedha Wijeratne
INTERNATIONAL JOURNAL FOR EQUITY IN HEALTH
(2012)
Article
Public, Environmental & Occupational Health
Isurujith K. Liyanage, Tskrd Caldera, Rajapaksha Rwma, C. K. Liyange, Pubudu De Silva, I. M. Karunathilake
INTERNATIONAL JOURNAL OF OCCUPATIONAL MEDICINE AND ENVIRONMENTAL HEALTH
(2012)