Journal
VIRUSES-BASEL
Volume 11, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/v11100883
Keywords
quasienveloped virus; receptor; lysosomal acid lipase; NPC1
Categories
Funding
- National Institute of Allergy and Infectious Diseases [AI137912, AI139511]
- Gilead Science Research Scholars Program in Liver Disease
- Nationwide Children's Hospital
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Hepatitis E virus (HEV) infection is a major cause of acute hepatitis worldwide. It is transmitted enterically but replicates in the liver. Recent studies indicate that HEV exists in two forms: naked, nonenveloped virions that are shed into feces to mediate inter-host transmission, and membrane-cloaked, quasienveloped virions that circulate in the bloodstream to mediate virus spread within a host. Both virion types are infectious, but differ in the way they infect cells. Elucidating the entry mechanism for both virion types is essential to understand HEV biology and pathogenesis, and is relevant to the development of treatments and preventions for HEV. This review summarizes the current understanding of the cell entry mechanism for these two HEV virion types.
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