Article
Veterinary Sciences
Chengzhi Yu, Yayu Huang, Xin Ren, Leqiang Sun
Summary: In this study, antiviral active ingredients were extracted from medicinal and edible plants to prepare a drug called Ren's oligopeptide through biotransformation and enzymatic hydrolysis. The analysis showed that Ren's oligopeptide could inhibit the replication of influenza virus and SARS-CoV-2 virus with high antiviral activities. In vitro experiments demonstrated that the antiviral activity of Ren's oligopeptide mainly targeted the replication process after virus enters the cell. Therefore, Ren's oligopeptide is a promising drug against influenza and COVID-19.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Mahmoud Moustafa, Mona G. Zaghloul, Mohamed A. Sabry, Walaa S. Aboelmaaty, Refaat B. Hamed, Sherif S. Ebada, Weaam Ebrahim
Summary: Four sesquiterpene lactones and beta-sitosterol were isolated from the methanol extract of Saussurea lappa roots. These compounds showed potential antiviral, antibacterial, and cytotoxic activities. Molecular docking studies suggested similar binding interactions as acyclovir for antiviral activity. The discovery of these compounds highlights their potential as therapeutic agents.
Review
Virology
Mostafa Javanian, Mohammad Barary, Sam Ghebrehewet, Veerendra Koppolu, VeneelaKrishnaRekha Vasigala, Soheil Ebrahimpour
Summary: Influenza is an acute viral respiratory infection that affects all age groups and is associated with high mortality. Vaccination is the most effective method for prevention, but antiviral drugs are also available for treatment.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Review
Virology
Ralph A. Tripp, David E. Martin
Summary: Viral replication and transmissibility are the main causes of endemic and pandemic disease threats. Broad-spectrum antiviral agents are needed. The most common respiratory viruses are coronaviruses, respiratory syncytial viruses, and influenza viruses. Probenecid has been shown to be safe and effective in limiting the replication of influenza A virus and SARS-CoV-2, as well as inhibiting RSV replication in vitro and in vivo.
Review
Microbiology
Fanhua Wei, Chengjiang Gao, Yujiong Wang
Summary: Influenza virus infection can lead to cytokine storms, contributing to severe outcomes. Immunomodulatory drugs offer a promising approach for treating hypercytokinemia induced by acute viral infections.
CRITICAL REVIEWS IN MICROBIOLOGY
(2022)
Article
Microbiology
Weigang Ren, Shuli Pei, Wenming Jiang, Meixia Zhao, Le Jiang, Honggang Liu, Yongxiang Yi, Mizhou Hui, Junwei Li
Summary: A replication-deficient recombinant influenza virus was developed in this study, which stimulated robust immune response and conferred complete protection against H5N1 or H9N2 influenza virus infections in mice.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Plant Sciences
Zhi-hui Zhu, Xin-tong Xu, Chen-jun Shen, Si-yue Lou, Xiao-long Ma, Xi Chen, Bo Yang, Hua-jun Zhao
Summary: The study found that Eupatorium chinense L. extract (EChLESs) can inhibit the growth of hepatocellular carcinoma by regulating cell apoptosis and the NCOA4-mediated ferritinophagy. It may be a potential traditional Chinese medicine for treating hepatocellular carcinoma.
Article
Microbiology
Sari Mattila, Pirjo Merilahti, Sarah Wazir, Tania Quirin, Mirko M. Maksimainen, Yuezhou Zhang, Henri Xhaard, Lari Lehtio, Tero Ahola
Summary: The study found that compound MRS 2578 targeting human ADP-ribose glycohydrolase MacroD1 effectively inhibited Semliki Forest virus production and viral RNA replication, indicating its targeting of the viral RNA replication stage.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Review
Agricultural Engineering
Ranjana Soni, Gauri Shankar, Pradipto Mukhopadhyay, Vikrant Gupta
Summary: Malaria is a major global health concern and previous measures to control and cure it are being hampered by drug resistance. Artemisinin derived from sweet wormwood is highly effective against the malaria-causing parasite and is a major component of current treatments. However, there is a limited supply of artemisinin, and novel strategies and advanced scientific methods are needed to meet global demand.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Immunology
Lei Zhang, Xinxin Zheng, Jun Li, Guoqing Wang, Zenglei Hu, Yu Chen, Xiaoquan Wang, Min Gu, Ruyi Gao, Shunlin Hu, Xiaowen Liu, Xinan Jiao, Daxin Peng, Jiao Hu, Xiufan Liu
Summary: Lnc45 plays a crucial role in inhibiting viral replication and suppressing virus-induced cell apoptosis during different subtypes of influenza virus infection. Its broad-spectrum antiviral activity is likely mediated by its specific stem ring arms, inhibiting viral polymerase activity and nuclear accumulation of viral proteins NP and PA.
Article
Virology
Joao Trigueiro-Louro, Luis A. Santos, Filipe Almeida, Vanessa Correia, Rui M. M. Brito, Helena Rebelo-de-Andrade
Summary: Influenza NS1 is a promising target for anti-influenza treatment, but its identification and validation as a target lacks experimental data. By studying NS1 mutations in multiple consensus druggable pockets, it was found that these mutations significantly impaired the replication of A(H1N1)pdm09 virus, providing a theoretical basis for NS1 as a promising target.
Article
Biochemistry & Molecular Biology
Antoine Guillon, Deborah Brea-Diakite, Adeline Cezard, Alan Wacquiez, Thomas Baranek, Jerome Bourgeais, Frederic Picou, Virginie Vasseur, Lea Meyer, Christophe Chevalier, Adrien Auvet, Jose M. Carballido, Lydie Nadal Desbarats, Florent Dingli, Andrei Turtoi, Audrey Le Gouellec, Florence Fauvelle, Amelie Donchet, Thibaut Crepin, Pieter S. Hiemstra, Christophe Paget, Damarys Loew, Olivier Herault, Nadia Naffakh, Ronan Le Goffic, Mustapha Si-Tahar
Summary: Research has shown that influenza virus infection causes significant changes in lung metabolism, leading to the accumulation of succinate in respiratory fluids. Succinate exhibits powerful antiviral activity by inhibiting influenza virus replication and reducing metabolic disruptions and inflammatory responses. Administering succinate intranasally to mice reduces viral loads in the lungs and improves survival rates. The antiviral mechanism involves succinylation of viral nucleoproteins, which alters their interactions with viral RNA.
Article
Microbiology
Zhiyuan Qu, Fei Meng, Jianzhong Shi, Guohua Deng, Xianying Zeng, Jinying Ge, Yanbing Li, Liling Liu, Pucheng Chen, Yongping Jiang, Chengjun Li, Hualan Chen
Summary: This study reveals that upregulation of the circRNA AIVR in cells infected with influenza virus helps inhibit viral replication by absorbing miRNA to promote IFN-beta production. This provides new insights into the roles of circRNAs in the cellular innate antiviral response.
Article
Multidisciplinary Sciences
Beryl Mazel-Sanchez, Chengyue Niu, Nathalia Williams, Michael Bachmann, Helena Choltus, Filo Silva, Veronique Serre-Beinier, Wolfram Karenovics, Justyna Iwaszkiewicz, Vincent Zoete, Laurent Kaiser, Oliver Hartley, Bernhard Wehrle-Haller, Mirco Schmolke
Summary: Using proximity ligation and mass spectrometry, transferrin receptor 1 (TfR1) was identified as a candidate entry protein for influenza A virus (IAV). Genetic and chemical inhibition experiments confirmed TfR1's functional involvement in IAV entry, with recycling being essential for this function. Even without its head, TfR1 promotes IAV particle uptake, confirming its role as a directly acting entry factor.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Chemistry, Medicinal
Yejin Jang, Jinhe Han, Xiaoli Li, Hyunjin Shin, Won-Jea Cho, Meehyein Kim
Summary: Influenza viruses are major pathogens causing respiratory infections in humans. A newly discovered isoquinolone compound showed potential in inhibiting influenza A and B viruses, but exhibited cytotoxic effects. Through chemical optimization, compound 21 was developed with improved antiviral activity and reduced cytotoxicity.
Article
Biochemistry & Molecular Biology
Yu-Bo Zhang, Peng Wu, Xiao-Li Zhang, Chao Xia, Guo-Qiang Li, Wen-Cai Ye, Guo-Cai Wang, Yao-Lan Li
Article
Chemistry, Organic
Yu-Bo Zhang, Xiao-Li Zhang, Neng-Hua Chen, Zhong-Nan Wu, Wen-Cai Ye, Yao-Lan Li, Guo-Cai Wang
Article
Chemistry, Medicinal
Guo-Cai Wang, Xiao-Li Zhang, Yi-Fei Wang, Guo-Qiang Li, Wen-Cai Ye, Yao-Lan Li
CHEMICAL & PHARMACEUTICAL BULLETIN
(2012)
Article
Chemistry, Applied
Xiao-Li Zhang, Yu-Shan Guo, Chun-Hua Wang, Guo-Qiang Li, Jiao-Jiao Xu, Hau Yin Chung, Wen-Cai Ye, Yao-Lan Li, Guo-Cai Wang
Article
Immunology
Chun-Ni Lu, Zi-Guo Yuan, Xiao-Li Zhang, Ru Yan, Ya-Qin Zhao, Ming Liao, Jian-Xin Chen
INTERNATIONAL IMMUNOPHARMACOLOGY
(2012)
Article
Plant Sciences
Hua-Wei Geng, Xiao-Li Zhang, Guo-Cai Wang, Xin-Xin Yang, Xia Wu, Yi-Fei Wang, Wen-Cai Ye, Yao-Lan Li
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2011)
Article
Multidisciplinary Sciences
Li Yang, Jia Hao Zhang, Xiao Li Zhang, Guang Jie Lao, Guan Ming Su, Lei Wang, Yao Lan Li, Wen Cai Ye, Jun He