Article
Genetics & Heredity
Kevin Nee, Dennis Ma, Quy H. Nguyen, Maren Pein, Nicholas Pervolarakis, Jacob Insua-Rodriguez, Yanwen Gong, Grace Hernandez, Hamad Alshetaiwi, Justice Williams, Maha Rauf, Kushal Rajiv Dave, Keerti Boyapati, Aliza Hasnain, Christian Calderon, Anush Markaryan, Robert Edwards, Erin Lin, Ritesh Parajuli, Peijie Zhou, Qing Nie, Sundus Shalabi, Mark A. LaBarge, Kai Kessenbrock
Summary: Premalignant stromal cells from women with germline BRCA1 mutations have increased expression of secreted factors regulating epithelial homeostasis, promoting premalignant epithelial changes and increased breast cancer risk. The stromal niche in BRCA1-driven tumor initiation promotes epithelial proliferation and mutant BRCA1-driven tumorigenesis through paracrine signals, such as matrix metalloproteinase 3 (MMP3), produced by pre-cancer-associated fibroblasts (pre-CAFs). This study highlights the importance of precancerous stroma in BRCA1(+/mut) in elevating breast cancer risk.
Editorial Material
Cell & Tissue Engineering
Michael Karl Melzer, Alexander Kleger
Summary: In this study, Jiang and colleagues investigate the function of Tff2+ transit-amplifying progenitor cells in the pancreatic acinar compartment of mice using various lineage-tracing approaches. The findings provide insights into the role of these progenitor cells in maintaining steady-state homeostasis and suppressing tumor development, as well as uncovering heterogeneity in acinar cells.
Article
Microbiology
Harika Nalluri, Eric Jensen, Christopher Staley
Summary: The study found that biliary stent placement and neoadjuvant chemotherapy may be associated with specific alterations that promote the infiltration and growth of intra-tumor bacteria in patients with PDAC. Further research on whether specific bacterial communities could lead to increased chemoresistance will be crucial for optimizing medical therapies in the future.
Article
Cell & Tissue Engineering
Markus Breunig, Jessica Merkle, Martin Wagner, Michael K. Melzer, Thomas F. E. Barth, Thomas Engleitner, Johannes Krumm, Sandra Wiedenmann, Christian M. Cohrs, Lukas Perkhofer, Gaurav Jain, Jana Kruger, Patrick C. Hermann, Maximilian Schmid, Tamara Madacsy, Arpad Varga, Joscha Griger, Ninel Azoitei, Martin Mueller, Oliver Wessely, Pamela G. Robey, Sandra Heller, Zahra Dantes, Maximilian Reichert, Cagatay Guenes, Christian Bolenz, Florian Kuhn, Jozsef Maleth, Stephan Speier, Stefan Liebau, Bence Sipos, Bernhard Kuster, Thomas Seufferlein, Roland Rad, Matthias Meier, Meike Hohwieler, Alexander Kleger
Summary: The study successfully differentiated hPSCs into pancreatic duct-like organoids (PDLOs) with features of human pancreatic ducts, and observed specific growth, structural, and molecular characteristics induced by different oncogenes. Transplanted PDLOs with oncogenic KRAS alone developed dysplastic lesions or cancer, while those with KRAS and CDKN2A loss formed dedifferentiated pancreatic ductal adenocarcinomas. PDLOs with mutant GNAS led to intraductal papillary mucinous neoplasia-like structures. The research highlights the potential of PDLOs for studying pancreatic plasticity, dysplasia, and cancer formation in vitro and in vivo.
Article
Endocrinology & Metabolism
Diane Yang, Sanjeet Patel, Wojciech J. Szlachcic, Jolanta Chmielowiec, Diane Scaduto, Nagireddy Putluri, Arun Sreekumar, James Suliburk, Michael Metzker, Ashok Balasubramanyam, Malgorzata Borowiak
Summary: This study investigates a diabetes syndrome in an adult patient, revealing a nucleotide variant in the PDX1 gene associated with cellular differentiation block, shedding light on the molecular pathogenesis of the syndrome. The results demonstrate the combination of genetic factors and cellular metabolic abnormalities leading to beta-cell dysfunction.
Article
Endocrinology & Metabolism
Nelly Saber, Cara E. E. Ellis, Diepiriye G. G. Iworima, Robert K. K. Baker, Alireza Rezania, Timothy J. J. Kieffer
Summary: This study investigates the differentiation of human embryonic stem cell-derived pancreatic endoderm cells (PECs) in different implantation sites. It is found that PECs implanted in the TheraCyte device display faster secretion of human C-peptide, while cells implanted under the kidney capsule or in the gonadal fat pad show slower secretion. Interestingly, PECs implanted under the kidney capsule in female mice exhibit faster differentiation to endocrine cells and higher levels of arginine-stimulated glucagon and glucagon-like peptide 1 secretion.
Article
Oncology
Tianyuan Liu, Xuan Zhao, Yuan Lin, Qi Luo, Shaosen Zhang, Yiyi Xi, Yamei Chen, Lin Lin, Wenyi Fan, Jie Yang, Yuling Ma, Alok K. Maity, Yanyi Huang, Jianbin Wang, Jiang Chang, Dongxin Lin, Andrew E. Teschendorff, Chen Wu
Summary: This study develops a computational strategy to identify stem-like preneoplastic cells that may drive cancer progression by dissecting the heterogeneity of differentiation states within a preneoplastic cell population.
Review
Pharmacology & Pharmacy
Wence Zhou, Xinlong Chen, Qigang Fan, Haichuan Yu, Wenkai Jiang
Summary: This study conducted a systematic review and meta-analysis to assess the association between proton pump inhibitor (PPI) use and hepato-biliary-pancreatic cancer. The findings suggest that PPI use may increase the risk of this type of cancer, particularly at normal doses.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Oncology
Ilias P. Nikas, Giannis Mountzios, Guy I. Sydney, Kalliopi J. Ioakim, Jae-Kyung Won, Panagiotis Papageorgis
Summary: Summary: Pancreatic cancer and cholangiocarcinoma are aggressive diseases that are often diagnosed at an advanced and inoperable stage. This review discusses the use of next-generation sequencing (NGS) on small biopsies, such as fine-needle aspiration/biopsy samples, brushings, pancreatic juice and bile, and blood, in the field of pancreatobiliary neoplasia. NGS has been shown to be a valuable tool for diagnosing and stratifying pancreatic and biliary lesions, as well as for monitoring the disease and assessing prognosis in cancer patients. However, standardization of the pre-analytical and analytical assay parameters is necessary for the routine implementation of NGS in clinical practice.
Review
Gastroenterology & Hepatology
Fredy Nehme, Jeffrey H. Lee
Summary: Pancreatic adenocarcinoma is a leading cause of cancer-related morbidity and mortality with most patients presenting with advanced disease. Preoperative biliary drainage (PBD) has traditionally been used to improve surgical outcomes, but recent data suggests potential increased complications with systematic PBD. Indications for PBD include cholangitis, delayed surgery, and jaundice relief in patients planned to receive neoadjuvant therapy. Endoscopic retrograde cholangiopancreatography is the preferred method for PBD, with self-expanding metal stents shown to be cost-effective and safe compared to plastic stents.
DIGESTIVE ENDOSCOPY
(2022)
Review
Oncology
Siqi Yang, Haijie Hu, Yafei Hu, Yushi Dai, Ruiqi Zou, Tianrun Lv, Fuyu Li
Summary: This study evaluates the associations of tumor necrosis with survival outcomes and clinicopathological features in hepato-biliary-pancreatic cancer patients, and finds that tumor necrosis is associated with poor prognosis and aggressive tumor behavior.
Review
Immunology
Sophie Curio, Gabrielle T. Belz
Summary: This article discusses the role of ILCs in cancer, focusing on their relationship with liver and liver-related diseases. NK cells and ILC1s play important roles in hepatic diseases, but are underexplored areas of research.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Article
Oncology
Xiaofeng Chen, Deqiang Wang, Jing Liu, Jingrong Qiu, Jun Zhou, Jieer Ying, Yan Shi, Zhaoxia Wang, Haizhou Lou, Jiuwei Cui, Jingdong Zhang, Yunpeng Liu, Fengjiao Zhao, Lanlan Pan, Jianyi Zhao, Dongqin Zhu, Shiqing Chen, Xiangcheng Li, Xue Li, Liuqing Zhu, Yang Shao, Yongqian Shu
Summary: This study found that KRAS and TP53 mutations are more frequent in advanced BTC, with KRAS-TP53 co-mutations associated with a favorable response to immunotherapy. Compared to GBC, CHOL has more mutations in genes involved in KRAS signaling, potentially leading to inferior immunotherapy outcomes. Additionally, a genomic signature including 11 genes was developed to predict prognosis and immunotherapy outcomes in CHOL and GBC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Endocrinology & Metabolism
Valerie Schreiber, Reuben Mercier, Sara Jimenez, Tao Ye, Emmanuel Garcia-Sanchez, Annabelle Klein, Aline Meunier, Sabitri Ghimire, Catherine Birck, Bernard Jost, Kristian Honnens de Lichtenberg, Christian Honore, Palle Serup, Gerard Gradwohl
Summary: The study mapped the genome occupancy of the NEUROG3 gene in endocrine progenitors and revealed a broad, direct control of endocrine genes by NEUROG3. NEUROG3 not only promotes the development of pancreatic progenitors into islet cells but may also initiate essential endocrine programs for beta cell function.
MOLECULAR METABOLISM
(2021)
Article
Biochemical Research Methods
Hiroyuki Koike, Kentaro Iwasawa, Rie Ouchi, Mari Maezawa, Masaki Kimura, Asuka Kodaka, Shozo Nishii, Wendy L. Thompson, Takanori Takebe
Summary: This study introduces a method for continuous patterning of hepatic, biliary and pancreatic structures from human pluripotent stem cells (PSCs) in 3D culture. By fusing anterior and posterior gut spheroids together in one well, the self-patterning of multi-organ (HBP) domains occurs within the boundary region of the two spheroids. Long-term culture of these structures leads to the differentiation of segregated organs with developmentally relevant features.
Article
Oncology
Domenico Tamburrino, Paolo Cortesi, Rita Facchetti, Nicolo de Pretis, Enrique Perez-Cuadrado-Robles, Laura Uribarri-Gonzalez, Zeeshan Ateeb, Giulio Belfiori, Paolo Giorgio Arcidiacono, Lorenzo Giovanni Mantovani, Marco Del Chiaro, Johanna Laukkarinen, Massimo Falconi, Stefano Crippa, Gabriele Capurso
Summary: This study evaluated the rate of correct indication for pancreatectomy in low-risk BD-IPMN patients who underwent surveillance. Only 23.8% had a high grade dysplasia, while 59.7% had a low grade dysplasia and 14.9% had invasive cancer among those who were operated. The mean surveillance cost was 194.9 euros per patient-year, with higher costs in the correct surgery group compared to the overtreatment and undertreatment groups. The rate of appropriate surgery in BD-IPMNs under surveillance is low.
Article
Gastroenterology & Hepatology
Vik Meadows, Corinn Marakovits, Burcin Ekser, Debjyoti Kundu, Tianhao Zhou, Konstantina Kyritsi, Linh Pham, Lixian Chen, Lindsey Kennedy, Ludovica Ceci, Nan Wu, Guido Carpino, Wenjun Zhang, Abdulkadir Isidan, Alison Meyer, Travis Owen, Eugenio Gaudio, Paolo Onori, Gianfranco Alpini, Heather Francis
Summary: Primary sclerosing cholangitis (PSC) is characterized by increased ductular reaction, liver fibrosis, hepatic total bile acid levels, and mast cell infiltration. Inhibition of apical sodium bile acid transporter (ASBT) reduces PSC phenotypes. This study evaluates the role of ASBT in PSC and has clinical significance.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Konstantina Kyritsi, Nan Wu, Tianhao Zhou, Guido Carpino, Leonardo Baiocchi, Lindsey Kennedy, Lixian Chen, Ludovica Ceci, Alison Ann Meyer, Nipuni Barupala, Antonio Franchitto, Paolo Onori, Burcin Ekser, Eugenio Gaudio, Chaodong Wu, Corinn Marakovits, Sanjukta Chakraborty, Heather Francis, Shannon Glaser, Gianfranco Alpini
Summary: This study evaluated the role of secretin/secretin receptor axis in alcohol-related liver disease (ALD) phenotypes, and found that targeting Sct/SR signaling may be important for modulating ALD phenotypes.
CELL AND BIOSCIENCE
(2023)
Review
Gastroenterology & Hepatology
Giuseppe Vanella, Michiel Bronswijk, Paolo Giorgio Arcidiacono, Alberto Larghi, Roy Wanrooij, Ynto De Boer, Mihai Rimbas, Mouen Khashab, Schalk Van der Merwe
Summary: Therapeutic EUS has experienced significant growth and is now recognized as a clinical practice method. It offers clear advantages in managing complex HPB and GI conditions and is being incorporated into treatment algorithms. This review discusses the available evidence and clinical role of therapeutic EUS, providing a graphical summary for each scenario and highlighting its impact on current and future GI practice.
ENDOSCOPIC ULTRASOUND
(2023)
Article
Gastroenterology & Hepatology
Stefano Francesco Crino, Bertrand Napoleon, Antonio Facciorusso, Sundeep Lakhtakia, Ivan Borbath, Fabrice Caillol, Khanh Do-Cong Pham, Gianenrico Rizzatti, Edoardo Forti, Laurent Palazzo, Arthur Belle, Peter Vilmann, Jean-Luc van Laethem, Mehdi Mohamadnejad, Sebastien Godat, Pieter Hindryckx, Ariel Benson, Matteo Tacelli, Germana De Nucci, Cecilia Binda, Bojan Kovacevic, Harold Jacob, Stefano Partelli, Massimo Falconi, Roberto Salvia, ERASING Study Collaborators, Alberto Larghi
Summary: Endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) is a safe and effective treatment for pancreatic insulinoma (PI), outperforming surgical resection in terms of safety and clinical efficacy.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Oncology
Daniele Campa, Manuel Gentiluomo, Angelika Stein, Mateus Nobrega Aoki, Martin Oliverius, Ludmila Vodickova, Krzysztof Jamroziak, George Theodoropoulos, Claudio Pasquali, William Greenhalf, Paolo Giorgio Arcidiacono, Faik Uzunoglu, Raffaele Pezzilli, Claudio Luchini, Marta Puzzono, Martin Loos, Matteo Giaccherini, Verena Katzke, Andrea Mambrini, Edita Kiudeliene, Kauffmann Emanuele Federico, Julia Johansen, Tamas Hussein, Beatrice Mohelnikova-Duchonova, Casper H. J. van Eijck, Hermann Brenner, Riccardo Farinella, Juan Sainz Perez, Martin Lovecek, Markus W. Buechler, Viktor Hlavac, Jakob R. Izbicki, Thilo Hackert, Roger Chammas, Alessandro Zerbi, Rita Lawlor, Alessio Felici, Mara Goetz, Gabriele Capurso, Laura Ginocchi, Maria Gazouli, Juozas Kupcinskas, Giulia Martina Cavestro, Pavel Vodicka, Stefania Moz, John P. Neoptolemos, Lumir Kunovsky, Stig E. Bojesen, Silvia Carrara, Domenica Gioffreda, Egidijus Morkunas, Olga Abian, Stefania Bunduc, Daniela Basso, Ugo Boggi, Barbara Wlodarczyk, Andrea Szentesi, Giuseppe Vanella, Inna Chen, Maarten F. Bijlsma, Vytautas Kiudelis, Stefano Landi, Ben Schoettker, Chiara Corradi, Nathalia Giese, Rudolf Kaaks, Giulia Peduzzi, Peter Hegyi, Luca Morelli, Niccolo Furbetta, Pavel Soucek, Anna Latiano, Renata Talar-Wojnarowska, Sidsel C. Lindgaard, Frederik Dijk, Anna Caterina Milanettoj, Francesca Tavano, Klara Cervena, Balint Eross, Sabrina G. Testoni, Judith H. E. Verhagen-Oldenampsen, E. Malecka-Wojciesko, Eithne Costello, Roberto Salvia, Evaristo Maiello, Stefano Ermini, Cosimo Sperti, Bernd Holleczek, Francesco Perri, Jurgita Skieceviciene, Livia Archibugi, Maurizio Lucchesi, Cosmeri Rizzato, Federico Canzian
Summary: Pancreatic cancer is a deadly disease with few known risk factors and susceptibility loci. The rarity of the disease and lack of adequate research power have hindered progress in understanding its genetic mechanisms. However, the PANDoRA consortium, the largest in Europe, has made significant contributions in discovering susceptibility loci, which will be crucial in developing preventive strategies.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Ylenia Nodari, Manuel Gentiluomo, Beatrice Mohelnikova-Duchonova, Edita Kreivenaite, Anna Caterina Milanetto, Jurgita Skieceviciene, Stefano Landi, Rita Lawlor, Maria Chiara Petrone, Paolo Giorgio Arcidiacono, Martin Lovecek, Maria Gazouli, Maarten F. Bijlsma, Luca Morelli, Vytautas Kiudelis, Matteo Tacelli, Dalila Luciola Zanette, Pavel Soucek Kaaks, Faik Uzunoglu, Rudolf Kaaks, Jakob Izbicki, Ugo Boggi, Raffaele Pezzilli, Andrea Mambrini, Claudio Pasquali, Hanneke W. van Laarhove, Verena Katzke, Giulia Martina Cavestro, Cosimo Sperti, Martin Loos, Anna Latiano, Balint Eross, Martin Oliverius, Theron Johnson, Daniela Basso, John P. Neoptolemos, Mateus Nobrega Aoki, William Greenhalf, Pavel Vodick, Livia Archibugi, Giuseppe Vanella, Maurizio Lucchesi, Renata Talar-Wojnarowska, Krzysztof Jamroziak, Mohammed Al Saeedi, Casper H. J. van Eijck, Juozas Kupcinskas, Tamas Hussein, Marta Puzzono, Stefania Bunduc, Mara Gotz, Silvia Carrara, Andrea Szentesi, Francesca Tavano, Stefania Moz, Peter Hegyi, Claudio Luchini, Gabriele Capurso, Francesco Perri, Stefano Ermini, George Theodoropoulos, Giovanni Capretti, Orazio Palmieri, Laura Ginocchi, Niccolo Furbetta, Federico Canzian, Daniele Campa
Summary: This study found that established risk factors for pancreatic cancer may not have a strong age-related effect on early-onset pancreatic cancer (EOPC) patients. Furthermore, smoking and diabetes play important roles in EOPC.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Gastroenterology & Hepatology
Anthony Yuen Bun Teoh, Betrand Napoleon, Rastislav Kunda, Paolo Giorgio Arcidiacono, Pradermchai Kongkam, Alberto Larghi, Schalk Van der Merwe, Jeremies Jacques, Romain Legros, Ratanachu-Ek Thawee, Payal Saxena, Maridi Aerts, Livia Archibugi, Shannon Melissa Chan, Fabien Fumex, Arthur J. Kaffes, Mark Tsz Wah Ma, Nouredin Messaoudi, Gianenrico Rizzatti, Kelvin Kwok Chai Ng, Enders Kwok Wai Ng, Philip Wai Yan Chiu
Summary: This study compared primary endoscopic ultrasound (EUS)-guided biliary drainage with endoscopic retrograde cholangiopancreatography (ERCP) for treating unresectable malignant distal biliary obstruction (MDBO). The results showed no significant difference in 1-year stent patency rates between the two procedures, but EUS-guided biliary drainage had higher technical success and shorter procedural time.
Article
Gastroenterology & Hepatology
Nan Wu, Tianhao Zhou, Guido Carpino, Leonardo Baiocchi, Konstantina Kyritsi, Lindsey Kennedy, Ludovica Ceci, Lixian Chen, Chaodong Wu, Debjyoti Kundu, Nipuni Barupala, Antonio Franchitto, Paolo Onori, Burcin Ekser, Eugenio Gaudio, Heather Francis, Shannon Glaser, Gianfranco Alpini
Summary: Secretin and secretin receptor play key roles in modulating liver phenotypes. Long-term treatment with SCT 5-27 can decrease ductular reaction and liver fibrosis in PSC mice. The increased expression of miR-125b and FoxA2 induced by SCT 5-27 treatment can reverse the downregulation of FoxA2 and reduce biliary damage in PSC.
Article
Gastroenterology & Hepatology
Debjyoti Kundu, Lindsey Kennedy, Tianhao Zhou, Burcin Ekser, Vik Meadows, Amelia Sybenga, Konstantina Kyritsi, Lixian Chen, Ludovica Ceci, Nan Wu, Chaodong Wu, Shannon Glaser, Guido Carpino, Paolo Onori, Eugenio Gaudio, Gianfranco Alpini, Heather Francis
Summary: Inhibiting hepatic p16 expression may be a therapeutic approach for improving NAFLD/NASH phenotypes.
Article
Gastroenterology & Hepatology
Diego Calvisi, Luke Boulter, Javier Vaquero, Anna Saborowski, Luca M. Fabris, Pedro Rodrigues, Cedric E. Coulouarn, Rui Castro, Oreste Segatto, Chiara Raggi, Luc J. W. van der Laan, Guido Carpino, Benjamin Goeppert, Stephanie J. Roessler, Timothy Kendall, Matthias Evert, Ester W. Gonzalez-Sanchez, Juan Valle, Arndt Vogel, John J. Bridgewater, Mitesh J. Borad, Gregory R. Gores, Lewis Roberts, Jose J. G. B. Marin, Jesper Andersen, Domenico Alvaro, Alejandro M. Forner, Jesus Banales, Vincenzo Cardinale, Rocio I. R. Macias, Silve Vicent, Xin Chen, Chiara Braconi, Monique M. A. Verstegen, Laura Fouassier, Lewis Roberts, Alexander Scheiter, Florin M. Selaru, Katja Evert, Kirsten Utpatel, Laura Broutier, Massimiliano Cadamuro, Meritxell Huch, Robert Goldin, Sergio A. Gradilone, Yoshimasa Saito
Summary: In this Consensus Statement, experts provide recommendations on the criteria for preclinical models of cholangiocarcinoma (CCA) to increase disease understanding and develop novel therapeutic approaches.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Endocrinology & Metabolism
Z. M. Besharat, S. Trocchianesi, A. Verrienti, R. Ciampi, S. Cantara, C. Romei, C. Sabato, T. M. R. Noviello, A. Po, A. Citarella, F. P. Caruso, I. Panariello, F. Gianno, G. Carpino, E. Gaudio, M. Chiacchiarini, L. Masuelli, M. Sponziello, V. Pecce, T. Ramone, F. Maino, F. Dotta, M. Ceccarelli, L. Pezzullo, C. Durante, M. G. Castagna, R. Elisei, E. Ferretti
Summary: The study aimed to identify non-invasive circulating biomarkers in medullary thyroid carcinoma (MTC). By analyzing tissue and plasma extracellular vesicle samples from MTC patients, a set of circulating miRNAs, including miR-26b-5p and miR-451a, were identified as diagnostic biomarkers. These miRNAs showed high expression levels and their expression decreased in disease-free patients during follow-up. The results provide a novel non-invasive tool for the molecular diagnosis of MTC.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2023)
Article
Oncology
Elie M. Ghabi, Joseph R. Habib, Sami Shoucair, Ammar A. Javed, Jonathan Sham, William R. Burns, John L. Cameron, Syed Z. Ali, Eun Ji Shin, Paolo Giorgio Arcidiacono, Claudio Doglioni, Massimo Falconi, Jun Yu, Stefano Partelli, Jin He
Summary: The study investigated the feasibility of detecting somatic mutations in endoscopic ultrasound-guided, fine-needle aspiration (EUS-FNA) specimens of well-differentiated pancreatic neuroendocrine tumors (PanNETs). The results showed that next-generation sequencing (NGS) can detect somatic mutations in EUS-FNA specimens and there was mutational concordance between EUS-FNA specimens and primary tumors.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Stefano Francesco Crino, Stefano Partelli, Bertrand Napoleon, Maria Cristina Conti Bellocchi, Antonio Facciorusso, Roberto Salvia, Edoardo Forti, Marcello Cintolo, Michele Mazzola, Giovanni Ferrari, Silvia Carrara, Alessandro Repici, Alessandro Zerbi, Andrea Lania, Matteo Tacelli, Paolo Giorgio Arcidiacono, Massimo Falconi, Alberto Larghi, Gianenrico Rizzatti, Sergio Alfieri, Francesco Panzuto, Pieter Hindryckx, Frederik Berrevoet, Bruno Lapauw, Sundeep Lakhtakia, Sridhar Sundaram, Jayanta Samanta, Ashu Rastogi, Luca Landoni
Summary: This study compares the safety and efficacy of endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) with surgery for the management of insulinoma. The aim is to determine if EUS-RFA can be the first-line therapy for small, sporadic pancreatic insulinoma and be included in a step-up approach in case of clinical failure.
DIGESTIVE AND LIVER DISEASE
(2023)
Letter
Gastroenterology & Hepatology
Michiel Bronswijk, Roy L. J. van Wanrooij, Giuseppe Vanella, Rogier P. Voermans, Paul Fockens, Paolo Giorgio Arcidiacono, Schalk Van der Merwe
ENDOSCOPY INTERNATIONAL OPEN
(2023)
