Article
Oncology
Yue Chen, Jiayu Sun, Xinxin Dong, Deyu Sun, Yanli Qu
Summary: The prognosis and adjuvant chemotherapy of patients who underwent neoadjuvant chemoradiotherapy (nCRT) are currently based on pre-radiotherapy clinical TNM (cTNM) stage. However, the value of neoadjuvant pathologic TNM (ypTNM) stage is not clearly described.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Deborah Schrag, Qian Shi, Martin R. Weiser, Marc J. Gollub, Leonard B. Saltz, Benjamin L. Musher, Joel Goldberg, Tareq Al Baghdadi, Karyn A. Goodman, Robert R. McWilliams, Jeffrey M. Farma, Thomas J. George, Hagen F. Kennecke, Ardaman Shergill, Michael Montemurro, Garth D. Nelson, Brian Colgrove, Vallerie Gordon, Alan P. Venook, Eileen M. O'Reilly, Jeffrey A. Meyerhardt, Amylou C. Dueck, Ethan Basch, George J. Chang, Harvey J. Mamon
Summary: Preoperative FOLFOX chemotherapy is as effective as preoperative chemoradiotherapy for locally advanced rectal cancer eligible for sphincter-sparing surgery.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Oncology
Alina Desiree Sando, Jon Erik Gronbech, Erling Audun Bringeland
Summary: This study investigated the prognostic adequacy of the UICC staging system after neoadjuvant chemotherapy (NAC) in resectable gastric cancer. The results showed that the stage-matched survival curves of patients receiving NAC did not differ from those of chemo-naive patients. The findings suggest that NAC affects the disease stage in such a way that the final pathological stage provides similar prognostic information as the original clinical stage.
Article
Surgery
Ryota Otsuka, Koichi Hayano, Hideki Hayashi, Masaya Uesato, Kentaro Murakami, Takeshi Toyozumi, Yasunori Matsumoto, Yoshihiro Kurata, Akira Nakano, Hisahiro Matsubara
Summary: This retrospective study evaluated the value of the ypTNM staging system in all advanced gastric cancer patients who received chemotherapy prior to gastrectomy. The results showed that the ypTNM stage was significantly correlated with overall survival and relapse-free survival, and could be used as a useful tool for risk stratification.
LANGENBECKS ARCHIVES OF SURGERY
(2023)
Article
Oncology
Feng Pi, Gang Tang, Chaozheng Xie, Yukun Cao, Shilai Yang, Zhengqiang Wei
Summary: This study found that lymph node ratio is a strong predictor of stage III rectal cancer recurrence and suggests that Carbon Nanoparticles use significantly affects lymph node ratio and tumor recurrence.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Gianluca Pellino, Rafael Alos, Sebastiano Biondo, Antonio Codina-Cazador, Jose Maria Enriquez-Navascues, Eloy Espin-Basany, Jose Vicente Roig-Vila, Andres Cervantes, Eduardo Garcia-Granero
Summary: The study found an increasing trend in the use of neoadjuvant treatment in patients with rectal cancer, with a potential overuse in upper rectal cancer. Most patients received postoperative treatment, and involvement of CRM in lower third tumors was reduced after neoadjuvant treatment. Patients in stage III and MRcN stage benefited the most.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yaru Wei, Haojie Wang, Zhongwei Chen, Ying Zhu, Yingfa Li, Beichen Lu, Kehua Pan, Caiyun Wen, Guoquan Cao, Yun He, Jiejie Zhou, Zhifang Pan, Meihao Wang
Summary: This study developed a deep learning model based on multiparametric MRI for evaluation of rectal cancer and investigated its potential to improve T-staging accuracy. The results showed that the multiparametric DL-model had a higher Area Under Curve (AUC) compared to radiologist's assessment, clinical model, and single parameter DL-models. It suggests that the multiparametric DL-model has the potential to assist clinicians by providing more reliable and precise preoperative T staging diagnosis.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Oncology
Tian-Ming Gao, Dou-Sheng Bai, Jian-Jun Qian, Chi Zhang, Sheng-Jie Jin, Guo-Qing Jiang
Summary: Incorporating nonbiological factors (NBFs) into the TNM staging system can improve prognostic prediction accuracy and have a positive impact on clinical management in rectal cancer patients. Factors such as educational background, insurance status, employment status, and marital status are all associated with survival outcomes in rectal cancer.
Article
Gastroenterology & Hepatology
Shoufeng Li, Ye Wang, Huajun Cai, Zhen Pan, Guoxian Guan
Summary: In this study, a new rectal immune prognostic index (RIPI) was developed by combining neutrophil-to-lymphocyte ratio (NLR) and serum lactate dehydrogenase (sLDH), and its association with the prognosis of locally advanced rectal cancer (LARC) patients undergoing neoadjuvant chemoradiotherapy (nCRT) was investigated. The research found that RIPI is significant in evaluating the prognosis of ypTNM stage II LARC patients who underwent radical resection after nCRT.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
Article
Medicine, Research & Experimental
Arash Abiri, Jonathan Pang, Karthik R. Prasad, Khodayar Goshtasbi, Edward C. Kuan, William B. Armstrong, Yarah M. Haidar, Tjoson Tjoa
Summary: This study evaluated the prognostic strengths of AJCC staging and ATA risk classification in well-differentiated thyroid cancer patients. The results show that AJCC staging may be a more predictive system for patient survival than ATA risk. The prognostic utility of these two systems converges when additional demographic and clinical factors are considered.
Article
Biochemistry & Molecular Biology
Mary Smithson, Regina Irwin, Gregory Williams, Katie L. Alexander, Lesley E. Smythies, Marie Nearing, M. Chandler McLeod, Sameer Al Diffalha, Susan L. Bellis, Karin M. Hardiman
Summary: ST6GAL-1 promotes resistance to chemoradiotherapy in rectal cancer by inhibiting apoptosis.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Jing Zhang, Lin Zhang, Yuanyuan Gou, Panya Diao, Yi Hu
Summary: The study explores a new system called the NLM score, which combines neutrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-monocyte ratio (LMR), and examines its prognostic value in patients with Stage II/III rectal cancer undergoing neoadjuvant chemoradiotherapy. The NLM score is found to be an independent prognostic factor with better predictive values than the individual ratios.
SCIENTIFIC REPORTS
(2022)
Review
Oncology
Zhen Yu, Yuying Hao, Yuhua Huang, Ling Ling, Xigang Hu, Simiao Qiao
Summary: Radiotherapy and chemotherapy are effective treatments for locally advanced rectal cancer. New neoadjuvant treatment options need to be explored for better outcomes. Targeted drugs and immunologic agents have shown efficacy in advanced rectal cancer but have not been commonly used in neoadjuvant therapy for LARC patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Mirat Shah, Christy L. Osgood, Anup K. Amatya, Mallorie H. Fiero, William F. Pierce, Abhilasha Nair, Jonathan Herz, Kim J. Robertson, Bronwyn D. Mixter, Shenghui Tang, Richard Pazdur, Julia A. Beaver, Laleh Amiri-Kordestani
Summary: The FDA has approved pembrolizumab in combination with chemotherapy for treating high-risk, early-stage triple-negative breast cancer. The addition of pembrolizumab significantly improves pathological complete response rate and event-free survival. Pembrolizumab demonstrates benefits regardless of tumor PD-L1 status.
CLINICAL CANCER RESEARCH
(2022)
Article
Oncology
S. M. Evans, K. Ivanova, R. Rome, D. Cossio, Chc Pilgrim, J. Zalcberg, Y. Antill, L. Blake, A. Du Guesclin, A. Garrett, D. Giffard, N. Golobic, D. Moir, S. Parikh, A. Parisi, K. Sanday, C. Shadbolt, M. Smith, L. Te Marvelde, K. Williams
Summary: In this paper, the completeness of stage information for endometrial cancer in Australian cancer registries is described, and a set of rules for calculating stage using available data is developed and validated.
Article
Surgery
Elvira L. Vos, Masaya Nakauchi, Mithat Gonen, Jason A. Castellanos, Alberto Biondi, Daniel G. Coit, Johan L. Dikken, Domenico D'ugo, Henk Hartgrink, Ping Li, Makoto Nishimura, Mark Schattner, Kyo Young Song, Laura H. Tang, Ichiro Uyama, Santosha Vardhana, Rob H. A. Verhoeven, Bas P. L. Wijnhoven, Vivian E. Strong
Summary: We aimed to identify criteria associated with low lymph node metastasis risk in patients with submucosal (pT1b) gastric cancer from different countries. Rates of lymph node metastasis were determined and predictors of metastasis were identified. A nomogram was developed and validated to predict lymph node metastasis risk. Overall survival was compared between Eastern and Western patients. The lowest lymph node metastasis rate was observed in patients with well differentiated tumors that were <= 3 cm and lacked lymphovascular invasion. These criteria may guide decisions regarding endoscopic resection as the definitive treatment for pT1b gastric cancer.
Article
Gastroenterology & Hepatology
Daan M. M. Voeten, Pauline A. J. Vissers, Rob H. A. Verhoeven, Richard van Hillegersberg, Mark I. van Berge I. Henegouwen
Summary: This study aimed to investigate whether hospitals offering surgery to a large proportion of patients have higher failure-to-cure rates than hospitals operating fewer patients. The results showed that hospitals with a high surgery rate and hospitals with a low rate had similar failure-to-cure rates.
Article
Urology & Nephrology
Janneke E. W. Walraven, Theodora M. Ripping, Jorg R. Oddens, Bas W. G. van Rhijn, Catharina A. Goossens-Laan, Maarten C. C. M. Hulshof, Lambertus A. Kiemeney, J. A. Witjes, Valery E. P. P. Lemmens, Jacobus J. M. van der Hoeven, Ingrid M. E. Desar, Katja K. H. Aben, Rob H. A. Verhoeven
Summary: This study investigated the role of specialised genitourinary multidisciplinary team meetings (MDTMs) in decision-making and identified factors that influenced the probability of receiving treatment with curative intent for patients with muscle invasive bladder cancer (MIBC). The study found that age, performance status, and the type of hospital were associated with the likelihood of being discussed in an MDTM and receiving curative treatment. Patient preference was the main reason for non-adherence to treatment advice.
Article
Oncology
Jolanda C. van Hoeve, Rob H. A. Verhoeven, Wouter B. Nagengast, Vera Oppedijk, Mitchell G. Lynch, Johan M. van Rooijen, Patrick Veldhuis, Sabine Siesling, Ewout A. Kouwenhoven
Summary: This study aimed to investigate the variation in esophageal cancer care between hospitals in the Managed Clinical Network (MCN) in the Netherlands. The results showed that there were differences in treatment strategies, lead time to treatment initiation, and 2-year survival rates among the hospitals in the MCN network from 2012 to 2016.
Article
Gastroenterology & Hepatology
Laura F. C. Fransen, Rob H. A. Verhoeven, Thijs H. J. B. Janssen, Marc J. van Det, Suzanne S. Gisbertz, Richard van Hillegersberg, Bastiaan Klarenbeek, Ewout A. Kouwenhoven, Grard A. P. Nieuwenhuijzen, Camiel Rosman, Jelle P. Ruurda, Mark van Berge Henegouwen, Misha D. P. Luyer
Summary: This study assesses the association between post-esophagectomy complications and long-term overall survival. The results show that overall postoperative complication rate, anastomotic leakage, and cardiopulmonary complications are associated with a decreased long-term survival after an esophagectomy.
DISEASES OF THE ESOPHAGUS
(2023)
Article
Gastroenterology & Hepatology
J. C. H. B. M. Luijten, M. H. P. Verstegen, F. van Workum, G. A. P. Nieuwenhuijzen, M. I. van Berge Henegouwen, S. S. Gisbertz, B. P. L. Wijnhoven, R. H. A. Verhoeven, C. Rosman
Summary: It is unclear whether Ivor Lewis (IL) or McKeown (McK) esophagectomy is preferred in patients with potentially curable esophageal or gastro-esophageal junction (GEJ) cancer. A study in the Netherlands found similar survival rates and complication rates between patients who underwent IL or McK esophagectomy. Therefore, both IL and McK esophagectomy can be considered for patients with mid to distal esophageal and GEJ cancer.
DISEASES OF THE ESOPHAGUS
(2023)
Article
Oncology
Tiuri E. Kroese, Yuko Takahashi, Florian Lordick, Peter S. N. van Rossum, Jelle P. Ruurda, Sjoerd M. Lagarde, Richard van Hillegersberg, Rob H. A. Verhoeven, Hanneke W. M. van Laarhoven
Summary: This population-based cohort study evaluated the treatment and survival outcomes in gastric cancer patients with liver metastases. The study found that liver oligometastatic disease and trastuzumab treatment were associated with better overall survival, while triplet chemotherapy was not significantly different from doublet chemotherapy.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Steven C. Kuijper, Marieke Pape, Nadia Haj Mohammad, Theo van Voorthuizen, Rob H. A. Verhoeven, Hanneke W. M. van Laarhoven
Summary: The study developed a new clinical prediction model called SOURCE beyond first-line, which predicted survival for patients with metastatic esophagogastric adenocarcinoma after failure of first-line palliative systemic therapy. The model was developed using patient, tumor, and treatment characteristics, and was internally validated, demonstrating good predictive performance and calibration.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Review
Oncology
Marieke Pape, Linde M. Veen, Thom M. Smit, Steven C. Kuijper, Pauline A. J. Vissers, Elisabeth D. Geijsen, Peter S. N. van Rossum, Mirjam A. G. Sprangers, Sarah Derks, Rob H. A. Verhoeven, Hanneke W. M. van Laarhoven
Summary: Definitive chemoradiotherapy (dCRT) for esophageal cancer can result in late toxicities and affect health-related quality of life (HRQoL). This study reviewed the literature and conducted a meta-analysis to investigate the effects of dCRT on late toxicities and HRQoL. The results showed that there were improvements in tumor-specific symptoms within 6 months after dCRT compared to baseline, but dyspnea worsened. The risk of late toxicities was also observed to be substantial.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Surgery
Irma C. C. Noordzij, Marije L. L. Hazen, Grard A. P. Nieuwenhuijzen, Rob H. A. Verhoeven, Erik J. J. Schoon
Summary: The proportion of patients receiving endoscopic treatment for early oesophageal and gastro-oesophageal junction cancer in the Netherlands increased over time, while the proportion receiving surgery decreased. The 5-year relative survival after endoscopic treatment was high and comparable to surgery.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Article
Health Care Sciences & Services
Janneke E. W. Walraven, Rob H. A. Verhoeven, Renske van der Meulen, Jacobus J. M. van der Hoeven, Valery E. P. P. Lemmens, Gijs Hesselink, Ingrid M. E. Desar
Summary: This study aims to identify the facilitators and barriers to conducting an efficient, competent, and high-quality multidisciplinary team meeting (MDTM) in oncological care. The findings reveal that organizational aspects, participants' responsibilities and requirements, competences, behavior and team dynamics, and meeting content are crucial factors for an optimal MDTM. Good organization, a sound structure, and functioning information and communication technology contribute to high-quality MDTMs, while multidisciplinary collaboration and adequate communication are essential competences for participants. Hierarchy and inadequate communication act as hindering factors.
Article
Oncology
Felice N. van Erning, Grard A. P. Nieuwenhuijzen, Hanneke W. M. van Laarhoven, Camiel Rosman, Suzanne S. Gisbertz, Joos Heisterkamp, Sjoerd M. Lagarde, Marije Slingerland, Jan-Willem van den Berg, Ewout A. Kouwenhoven, Rob H. A. Verhoeven, Pauline A. J. Vissers
Summary: This study examines the incidence of gastrointestinal symptoms after resection of esophageal or gastric cancer and their impact on health-related quality of life, functioning, work productivity, and daily activities. Results show that gastrointestinal symptoms significantly change over time after the surgery and have a negative impact on patients' overall well-being and daily functioning.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Benthe H. Doeve, Jeanne A. C. Bakx, Peter D. Siersema, Camiel Rosman, Nicole C. T. van Grieken, Mark I. van Berge I. Henegouwen, Johanna W. van Sandick, Marcel Verheij, Maarten F. Bijlsma, Rob H. A. Verhoeven, Hanneke W. M. van Laarhoven
Summary: This study investigated the impact of the COVID-19 pandemic on the diagnosis, stage, and treatment of esophagogastric cancer in the Netherlands. The number of diagnoses decreased during the first two months of the pandemic, and more patients were diagnosed with incurable disease. Additionally, the proportion of patients undergoing surgical resection and neoadjuvant chemoradiotherapy decreased.
JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Oncology
Marieke Pape, Pauline A. J. Vissers, Marije Slingerland, Nadia Haj Mohammad, Peter S. N. van Rossum, Rob H. A. Verhoeven, Hanneke W. M. van Laarhoven, DUCG
Summary: This study investigated the impact of systemic therapy on the health-related quality of life in patients with advanced esophagogastric cancer. The results showed significant improvements in symptoms such as odynophagia, anxiety, and dysphagia during systemic therapy. However, there was a significant deterioration in quality of life at and after disease progression.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Oncology
Marieke Pape, Pauline A. J. Vissers, Willemieke P. M. Dijksterhuis, David Bertwistle, Laura McDonald, Bianca Mostert, Sarah Derks, Irma M. M. Oving, Rob H. A. Verhoeven, Hanneke W. M. van Laarhoven
Summary: This retrospective cohort study investigated the treatment and survival of patients with advanced esophageal adenocarcinoma (EAC), gastroesophageal junction adenocarcinoma (GEJC), and gastric adenocarcinoma (GAC). Despite differences in clinical characteristics and treatment strategies, the survival of patients with advanced EAC, GEJC, and GAC was similar. Therefore, excluding EAC patients from clinical trials for patients with molecularly similar GEJC/GAC should be reconsidered.
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY
(2023)
