Drug dose and drug choice: Optimizing medical therapy for veterinary cancer

Doxorubicin area under the curve is an important predictor of neutropenia in dogs with naturally occurring cancers

(2019) Luke A. Wittenburg et al.   Veterinary and Comparative Oncology

Increasing the dose intensity of chemotherapy by more frequent administration or sequential scheduling: a patient-level meta-analysis of 37 298 women with early breast cancer in 26 randomised trials

(2019) Richard Gray et al.   LANCET

A novel method to address the association between received dose intensity and survival outcome: benefits of approaching treatment intensification at a more individualised level in a trial of the European Osteosarcoma Intergroup

(2019) Carlo Lancia et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Evaluation of Pgp (MDR1) immunohistochemistry in canine lymphoma – prognostic and clinical aspects

(2018) Péter Vajdovich et al.   ACTA VETERINARIA HUNGARICA

Hodgkin lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up†

(2018) D A Eichenauer et al.   ANNALS OF ONCOLOGY

Canine T cell lymphoma treated with lomustine, vincristine, procarbazine, and prednisolone chemotherapy in 35 dogs

(2018) E. Morgan et al.   Veterinary and Comparative Oncology

Simultaneous absolute quantitation of ATP-binding cassette transporters in normal dog tissues by signature peptide analysis using a LC/MS/MS method

(2018) Luke A. Wittenburg et al.   RESEARCH IN VETERINARY SCIENCE

Validation of a Multiplexed Gene Signature Assay for Diagnosis of Canine Cancers from Formalin-Fixed Paraffin-Embedded Tissues

(2017) B. Davis et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

c-Kit Mutation and Localization Status as Response Predictors in Mast Cell Tumors in Dogs Treated with Prednisone and Toceranib or Vinblastine

(2017) K.M. Weishaar et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Dose escalation study to evaluate safety, tolerability and efficacy of intravenous etoposide phosphate administration in 27 dogs with multicentric lymphoma

(2017) Pierre Boyé et al.   PLoS One

LOPP chemotherapy as a first-line treatment for dogs with T-cell lymphoma

(2017) P. M. Brown et al.   Veterinary and Comparative Oncology

Intra- and interspecies gene expression models for predicting drug response in canine osteosarcoma

(2016) Jared S. Fowles et al.   BMC BIOINFORMATICS

Canine Osteosarcoma Treated by Post-Amputation Sequential Accelerated Doxorubicin and Carboplatin Chemotherapy: 38 Cases

(2016) Angela E. Frimberger et al.   JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION

Mechanisms of tumour resistance against chemotherapeutic agents in veterinary oncology

(2016) R. Klopfleisch et al.   VETERINARY JOURNAL

Treatment of canine non-indolent T cell lymphoma using the VELCAP-TSC protocol: A retrospective evaluation of 70 dogs (2003–2013)

(2016) Ingrid H. Goodman et al.   VETERINARY JOURNAL

Peripheral T-cell lymphomas: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

(2015) F. d'Amore et al.   ANNALS OF ONCOLOGY

Diffuse large B-cell lymphoma (DLBCL): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

(2015) H. Tilly et al.   ANNALS OF ONCOLOGY

Drug Selection in the Genomic Age: Application of the Coexpression Extrapolation Principle for Drug Repositioning in Cancer Therapy

(2015) Daniel L. Gustafson et al.   ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES

An Open-label Phase 1 Dose-escalation Clinical Trial of a Single Intravenous Administration of Gemcitabine in Dogs with Advanced Solid Tumors

(2015) L. Marconato et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Evaluation of the drug sensitivity and expression of 16 drug resistance-related genes in canine histiocytic sarcoma cell lines

(2015) Hajime ASADA et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Retrospective analysis for treatment of naïve canine multicentric lymphoma with a 15-week, maintenance-free CHOP protocol

(2015) K. Curran et al.   Veterinary and Comparative Oncology

A longitudinal study of ABC transporter expression in canine multicentric lymphoma

(2015) M. Zandvliet et al.   VETERINARY JOURNAL

Chemotherapy-induced neutropenia is associated with prolonged remission duration and survival time in canine lymphoma

(2015) S.L. Wang et al.   VETERINARY JOURNAL

Tolerability of Lomustine in Combination with Cyclophosphamide in Dogs with Lymphoma

(2014) Kenneth M. Rassnick et al.   JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION

Comparison of Carboplatin and Doxorubicin-Based Chemotherapy Protocols in 470 Dogs after Amputation for Treatment of Appendicular Osteosarcoma

(2014) L.E. Selmic et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

A community effort to assess and improve drug sensitivity prediction algorithms

(2014) James C Costello et al.   NATURE BIOTECHNOLOGY

Prospective Molecular Profiling of Canine Cancers Provides a Clinically Relevant Comparative Model for Evaluating Personalized Medicine (PMed) Trials

(2014) Melissa Paoloni et al.   PLoS One

Evaluation of the adverse event profile and pharmacodynamics of toceranib phosphate administered to dogs with solid tumors at doses below the maximum tolerated dose

(2013) Luis Bernabe et al.   BMC Veterinary Research

Masitinib (AB1010), from canine tumor model to human clinical development: Where we are?

(2013) Ilaria Marech et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Clinicopathologic Significance of Histologic Grade, Pgp, and P53 Expression in Canine Lymphoma

(2013) Ravinder S. Dhaliwal et al.   JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION

Determination of MDR1 gene expression for prediction of chemotherapy tolerance and treatment outcome in dogs with lymphoma

(2013) I. Gramer et al.   Veterinary and Comparative Oncology

Development of a limited-sampling model for prediction of doxorubicin exposure in dogs

(2012) L. A. Wittenburg et al.   Veterinary and Comparative Oncology

Evaluation of a 15-week CHOP protocol for the treatment of canine multicentric lymphoma

(2012) J. H. Burton et al.   Veterinary and Comparative Oncology

Overexpression of P-glycoprotein, STAT3, phospho-STAT3 and KIT in spontaneous canine cutaneous mast cell tumours before and after prednisolone treatment

(2012) Shr-Ping Teng et al.   VETERINARY JOURNAL

Vincristine-induced central neurotoxicity in a collie homozygous for the ABCB1Δ mutation

(2011) L. Krugman et al.   JOURNAL OF SMALL ANIMAL PRACTICE

Multicenter Prospective Trial of Hypofractionated Radiation Treatment, Toceranib, and Prednisone for Measurable Canine Mast Cell Tumors

(2011) K.S. Carlsten et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Chemosensitivity testing with ChemoFx and overall survival in primary ovarian cancer

(2010) Thomas J. Herzog et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Complete response of anaplastic pancreatic carcinoma to paclitaxel treatment selected by chemosensitivity testing

(2010) Takeru Wakatsuki et al.   International Journal of Clinical Oncology

Response rate after administration of a single dose of doxorubicin in dogs with B-cell or T-cell lymphoma: 41 cases (2006–2008)

(2010) Lynda M. Beaver et al.   JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION

Pilot Study Using Molecular Profiling of Patients' Tumors to Find Potential Targets and Select Treatments for Their Refractory Cancers

(2010) Daniel D. Von Hoff et al.   JOURNAL OF CLINICAL ONCOLOGY

Expression of Multidrug Resistance-Associated P-Glycoprotein in Feline Tumours

(2010) S. Van der Heyden et al.   JOURNAL OF COMPARATIVE PATHOLOGY

Pharmacokinetic Modeling of Doxorubicin Pharmacokinetics in Dogs Deficient in ABCB1 Drug Transporters

(2010) D.L. Gustafson et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Immunohistochemical Detection of Proteins Associated with Multidrug Resistance to Anti-Cancer Drugs in Canine and Feline Primary Pulmonary Carcinoma

(2010) Tatsuro HIFUMI et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Quantitative Analysis of mRNA for 10 Different Drug Resistance Factors in Dogs with Lymphoma

(2010) Hirotaka TOMIYASU et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

CHOP chemotherapy for the treatment of canine multicentric T-cell lymphoma

(2010) R. B. Rebhun et al.   Veterinary and Comparative Oncology

Multi-center, Placebo-controlled, Double-blind, Randomized Study of Oral Toceranib Phosphate (SU11654), a Receptor Tyrosine Kinase Inhibitor, for the Treatment of Dogs with Recurrent (Either Local or Distant) Mast Cell Tumor Following Surgical Excision

(2009) C. A. London et al.   CLINICAL CANCER RESEARCH

Effect of Tyrosine Kinase Inhibition by Imatinib Mesylate on Mast Cell Tumors in Dogs

(2009) M. Isotani et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

ABCB1-1Δ Polymorphism Can Predict Hematologic Toxicity in Dogs Treated with Vincristine

(2009) K.L. Mealey et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Masitinib is Safe and Effective for the Treatment of Canine Mast Cell Tumors

(2009) K.A. Hahn et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Asparaginase and MOPP Treatment of Dogs with Lymphoma

(2009) E.M. Brodsky et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Evaluation of P-glycoprotein expression in feline lymphoma and correlation with clinical outcome

(2008) S. H. Brenn et al.   Veterinary and Comparative Oncology

Dose-escalating vinblastine for the treatment of canine mast cell tumour

(2008) K. R. Vickery et al.   Veterinary and Comparative Oncology