Review
Urology & Nephrology
Katharina Beyer, Ravi Barod, Louis Fox, Mieke Van Hemelrijck, Netty Kinsella
Summary: This study identified key barriers and facilitators influencing treatment decision making in localized kidney cancer, categorized into kidney cancer specific characteristics, decision maker related criteria, and contextual factors. Future interventions to improve the decision making process should take these factors into consideration to ensure a better patient experience.
JOURNAL OF UROLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Renato N. Zangiacomo, Guilherme L. P. Martins, Publio C. C. Viana, Natally Horvat, Marco A. Arap, William C. Nahas, Miguel Srougi, Giovanni G. Cerri, Marcos R. Menezes
Summary: The study showed that percutaneous thermoablation is a feasible and effective first-line therapy for healthy surgical candidates with small renal masses (T1a). The 5-year LTPFS, OS, CSS, and MFS rates were 93.0%, 98.4%, 100% and 100%, respectively, with a major complication rate of only 2.3%.
EUROPEAN RADIOLOGY
(2021)
Article
Urology & Nephrology
Sunil H. Patel, Nirmish Singla, Phillip M. Pierorazio
Summary: Surveillance for small renal masses is increasingly chosen by physicians and patients. Biomarkers that can aid in decision making for patients with known renal cell carcinoma are currently lacking, although many show promise.
WORLD JOURNAL OF UROLOGY
(2021)
Article
Pathology
Mahmut Akgul, Sean R. Williamson, Dilek Ertoy, Pedram Argani, Sounak Gupta, Anna Calio, Victor Reuter, Satish Tickoo, Hikmat A. Al-Ahmadie, George J. Netto, Ondrej Hes, Michelle S. Hirsch, Brett Delahunt, Rohit Mehra, Stephanie Skala, Adeboye O. Osunkoya, Lara Harik, Priya Rao, Ankur R. Sangoi, Maya Nourieh, Debra L. Zynger, Steven Cristopher Smith, Tipu Nazeer, Berrak Gumuskaya, Ibrahim Kulac, Francesca Khani, Maria S. Tretiakova, Funda Vakar-Lopez, Guliz Barkan, Vincent Molinie, Virginie Verkarre, Qiu Rao, Lorand Kis, Angel Panizo, Ted Farzaneh, Martin J. Magers, Joseph Sanfrancesco, Carmen Perrino, Dibson Gondim, Ronald Araneta, Jeffrey S. So, Jae Y. Ro, Matthew Wasco, Omar Hameed, Antonio Lopez-Beltran, Hemamali Samaratunga, Sara E. Wobker, Jonathan Melamed, Liang Cheng, Muhammad T. Idrees
Summary: TFE3-rearranged renal cell carcinoma (TFE3-RCC) presents with heterogenous morphologic and IHC features, with pathologists primarily focusing on cytologic characteristics and TFE3 IHC expression in the diagnostic work-up. Variability and preferences exist among participants in the use of additional IHC assays, positive cut-off for TFE3 FISH, and the need for further molecular studies in confirming TFE3-RCC diagnosis.
JOURNAL OF CLINICAL PATHOLOGY
(2021)
Article
Oncology
Shohei Fukuda, Kazutaka Saito, Yosuke Yasuda, Toshiki Kijima, Soichiro Yoshida, Minato Yokoyama, Junichiro Ishioka, Yoh Matsuoka, Yukio Kageyama, Yasuhisa Fujii
Summary: The study found that the CRP flare-response group among mRCC patients was associated with significant tumor shrinkage and improved survival outcomes compared to the other two groups. Early CRP kinetics may be useful for evaluating the efficacy of nivolumab treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Huancheng Yang, Kai Wu, Hanlin Liu, Peng Wu, Yangguang Yuan, Lei Wang, Yaru Liu, Haoyang Zeng, Junkai Li, Weihao Liu, Song Wu
Summary: A retrospective study was conducted to determine the accuracy of using 3D-CT multi-level anatomical features in predicting surgical decision-making for renal cell carcinoma. The study found that the combination of multi-level features outperformed single-level features in predicting partial or radical nephrectomy. The automated surgical decision framework based on 3D-CT multi-level anatomical features showed robust performance in guiding surgery for renal cell carcinoma.
EUROPEAN RADIOLOGY
(2023)
Article
Oncology
Michael R. Harrison, Brian A. Costello, Nrupen A. Bhavsar, Ulka Vaishampayan, Sumanta K. Pal, Yousef Zakharia, Heather S. L. Jim, Mayer N. Fishman, Ana M. Molina, Christos E. Kyriakopoulos, Che-Kai Tsao, Leonard J. Appleman, Benjamin A. Gartrell, Arif Hussain, Walter M. Stadler, Neeraj Agarwal, Russell K. Pachynski, Thomas E. Hutson, Hans J. Hammers, Christopher W. Ryan, Brant A. Inman, Jack Mardekian, Azah Borham, Daniel J. George
Summary: Systemic therapy can be deferred in patients with metastatic renal cell carcinoma and slow-growing metastases. Active surveillance is a common and safe alternative to immediate systemic therapy for selected patients, leading to better quality of life outcomes compared to those who receive systemic therapy.
Article
Biochemistry & Molecular Biology
Ziad M. El-Zaatari, Luan D. Truong
Summary: Renal cell carcinoma (RCC) occurring in the setting of end-stage renal disease (ESRD) shows unique clinicopathological characteristics, with acquired cystic kidney disease-associated renal cell carcinoma (ACKD-RCC) and clear-cell papillary renal cell carcinoma (ccpRCC) being the most frequent types. Other types of RCC also occur in ESRD, albeit with different frequencies from the non-ESRD general population. While the histological features of RCC do not vary in the setting of ESRD vs. non-ESRD, other findings, such as multifocality and multiple tumor types, are more frequent in ESRD. Studies have generated novel and important knowledge of the etiology, epidemiology, diagnosis, treatment, immunophenotype, and molecular characteristics of ESRD-associated RCC.
Article
Radiology, Nuclear Medicine & Medical Imaging
James Lucocq, Sanjay Pillai, Richard Oparka, Ghulam Nabi
Summary: This study confirmed a good degree of agreement between radiologists in classifying complex renal masses using the Bosniak classification, with low progression rates of Bosniak IIF cysts but high malignancy rates of surgically resected cysts. Benign cysts were frequently resected, and the majority of histopathologically confirmed cancers in complex renal cysts were of low grade and stage.
EUROPEAN RADIOLOGY
(2021)
Article
Pathology
Julien Dagher, Angelique Brunot, Bertrand Evrard, Solene-Florence Kammerer-Jacquet, Marion Beaumont, Laurence Cornevin, Fanny Derquin, Gregory Verhoest, Karim Bensalah, Alexandra Lespagnol, Frederic Dugay, Marc-Antoine Belaud-Rotureau, Frederic Chalmel, Nathalie Rioux-Leclercq
Summary: Metastatic evolution in clear cell renal cell carcinoma is complex, with tumor heterogeneity resulting from clonal evolution playing a role in metastatic dissemination. Using an integrative multiomics strategy, it was found that all sites were heterogeneous and polyclonal, with each tumor site containing two aggressive subclonal populations.
JOURNAL OF CLINICAL PATHOLOGY
(2022)
Review
Medicine, General & Internal
Alfredo Distante, Laura Marandino, Riccardo Bertolo, Alexandre Ingels, Nicola Pavan, Angela Pecoraro, Michele Marchioni, Umberto Carbonara, Selcuk Erdem, Daniele Amparore, Riccardo Campi, Eduard Roussel, Anna Calio, Zhenjie Wu, Carlotta Palumbo, Leonardo D. D. Borregales, Peter Mulders, Constantijn H. J. Muselaers
Summary: Renal cell carcinoma (RCC) presents histopathological challenges for accurate diagnosis and prognosis. This literature review explores recent advancements in AI applications in RCC pathology, with the aim of improving precision, efficiency, and objectivity in histopathological analysis. AI-powered approaches demonstrate effective identification and classification abilities, enabling accurate diagnosis, grading, and prognosis prediction. Challenges include standardization, generalizability, performance benchmarking, and data integration into clinical workflows. Accurate interpretation of AI decisions by pathologists and robust validation workflows are crucial for enhancing patient care.
Article
Oncology
Jiehui Zhong, Zezhen Liu, Chao Cai, Xiaolu Duan, Tuo Deng, Guohua Zeng
Summary: This study revealed the correlation between m(6)A modification and the tumor immune landscape in ccRCC patients. The m6Ascore was established to quantify the m(6)A modification pattern and was confirmed to be an independent prognostic factor for ccRCC. The findings provide a new approach for immunotherapeutic strategies in ccRCC patients.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Igal Kushnir, Naveen S. Basappa, Sunita Ghosh, Aly-Khan A. Lalani, Aaron R. Hansen, Lori Wood, Christian K. Kollmannsberger, Daniel Y. C. Heng, Georg A. Bjarnason, Denis Soulieres, David E. Dawe, Simon Tanguay, Rodney H. Breau, Frederic Pouliot, Anil Kapoor, Jeffrey Graham, M. Neil Reaume
Summary: Based on the analysis of 853 mRCC patients under AS, it was concluded that a subset of patients can be safely observed without immediate initiation of systemic therapy.
CLINICAL GENITOURINARY CANCER
(2021)
Article
Urology & Nephrology
Felix Couture, Sarah Hadj-Mimoune, Stephane Michael, Teodora Boblea Podasca, Maxime Noel-Lamy, Patrick O. Richard
Summary: This study aimed to evaluate the impact of the 2019 Bosniak classification on the diagnosis of Bosniak IIF renal cysts and determine their clinical outcomes. The study found that over 20% of cases had an initial overdiagnosis issue in the diagnosis of Bosniak IIF cysts. Upgrading and malignancy rates among Bosniak IIF cysts were markedly lower than previously reported, and no malignant progression was observed after 36 months.
JOURNAL OF UROLOGY
(2023)
Article
Oncology
Toni K. Choueiri, Harriet Kluger, Saby George, Scott S. Tykodi, Timothy M. Kuzel, Ruth Perets, Suresh Nair, Giuseppe Procopio, Michael A. Carducci, Vincent Castonguay, Edmund Folefac, Chung-Han Lee, Sebastien J. Hotte, Wilson H. Miller, Shruti Shally Saggi, Chung-Wei Lee, Heshani Desilva, Prabhu Bhagavatheeswaran, Robert J. Motzer, Bernard Escudier
Summary: This study evaluates the efficacy and safety of nivolumab plus ipilimumab therapy in patients with advanced renal cell carcinoma who progressed on or after first-line immuno-oncology (IO) therapy. The results show that nivolumab plus ipilimumab treatment may provide durable clinical benefits for patients previously treated with IO therapy, with manageable safety.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Steven P. Rowe, Andreas Buck, Ralph A. Bundschuh, Constantin Lapa, Sebastian E. Serfling, Thorsten Derlin, Takahiro Higuchi, Michael A. Gorin, Martin G. Pomper, Rudolf A. Werner
Summary: Prostate-specific membrane antigen (PSMA)-directed positron emission tomography (PET) has gained increasing interest for imaging of men affected by prostate cancer (PC). [ (18) F]DCFPyL has been widely utilized for staging, restaging, and change in management, and has shown promise for response assessment in patients under specific treatments.
NUKLEARMEDIZIN-NUCLEAR MEDICINE
(2022)
Article
Oncology
Shaan Setia, Jamaal Jackson, Demetri Cendo, Michael A. Gorin, Matthew Allaway, Srinivas Vourganti
Summary: The study evaluated the diagnostic performance of systematic freehand transperineal biopsy (fTPb), finding that combining it with the Prostate Biopsy Collaborative Group (PBCG) nomogram can effectively predict clinically significant cancers. Patients with prostate cancer who underwent pre-biopsy multiparametric magnetic resonance imaging had an increased number of biopsy cores and a significantly higher detection rate of clinically significant cancer.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2022)
Article
Biochemical Research Methods
Rudolf A. Werner, Bilel Habacha, Susanne Luetje, Lena Bundschuh, Takahiro Higuchi, Philipp Hartrampf, Sebastian E. Serfling, Thorsten Derlin, Constantin Lapa, Andreas K. Buck, Markus Essler, Kenneth J. Pienta, Mario A. Eisenberger, Mark C. Markowski, Laura Shinehouse, Rehab AbdAllah, Ali Salavati, Martin A. Lodge, Martin G. Pomper, Michael A. Gorin, Ralph A. Bundschuh, Steven P. Rowe
Summary: This study evaluated the test-retest repeatability of lesion uptake in patients imaged with F-18-DCFPyL PET/CT. The results showed that SUV parameters demonstrated high repeatability, especially in lymph nodes, while volumetric parameters showed low repeatability.
Article
Oncology
Andrew F. Voter, Rudolf A. Werner, Kenneth J. Pienta, Michael A. Gorin, Martin G. Pomper, Lilja B. Solnes, Steven P. Rowe
Summary: This article provides an overview of PSMA, F-18-DCFPyL, and compares their performance to conventional prostate imaging modalities. The clinical trials OSPREY and CONDOR have shown the superiority of F-18-DCFPyL in staging and restaging prostate cancer. The remarkable diagnostic accuracy of PSMA-PET is reshaping prostate cancer imaging.
EXPERT REVIEW OF ANTICANCER THERAPY
(2022)
Article
Oncology
Hiten D. Patel, Elizabeth L. Koehne, Keshava Gali, Nicholas J. Lanzotti, Goran Rac, Shalin Desai, Gaurav Pahouja, Marcus L. Quek, Gopal N. Gupta
Summary: This study compared the perioperative, functional, and oncologic outcomes of robotic-assisted tumor enucleation (TE) to standard margin partial nephrectomy (SPN). The results showed that TE had lower blood loss, shorter operative time, shorter length of stay, and fewer complications compared to SPN. TE also resulted in better preserved renal function in the first year, with a lower rate of stage >= 3 chronic kidney disease by 12 months. Although TE had higher positive margin rates, long-term recurrence rates were similar, suggesting that disruption of the tumor pseudocapsule during TE has limited impact on oncologic outcomes.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2022)
Article
Oncology
Hiten D. Patel, Amy Man, Elizabeth L. Koehne, Goran Rac, Alessa P. Aragao, Robert C. Flanigan, Alex Gorbonos, Gopal N. Gupta, Michael E. Woods, Maria M. Picken, Marcus L. Quek
Summary: Sarcomatoid dedifferentiation in renal cell carcinoma is associated with worse overall survival and recurrence-free survival. The degree of sarcomatoid histology is positively correlated with survival outcomes.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2022)
Article
Urology & Nephrology
Hiten D. Patel, Elizabeth L. Koehne, Steven M. Shea, Andrew M. Fang, Marielia Gerena, Alex Gorbonos, Marcus L. Quek, Robert C. Flanigan, Ari Goldberg, Soroush Rais-Bahrami, Gopal N. Gupta
Summary: A prostate cancer risk calculator incorporating multiparametric magnetic resonance imaging (mpMRI) has been developed and validated, outperforming other risk calculators in diagnosing high-risk prostate cancer and potentially reducing unnecessary biopsies.
Article
Oncology
Andrew M. Fang, Luke A. Shumaker, Kimberly D. Martin, Jamaal C. Jackson, Richard E. Fan, Ghazal Khajir, Hiten D. Patel, Nachiketh Soodana-Prakash, Srinivas Vourganti, Christopher P. Filson, Geoffrey A. Sonn, Preston C. Sprenkle, Gopal N. Gupta, Sanoj Punnen, Soroush Rais-Bahrami
Summary: Elevated PSA density, older age, and a biopsy-naive status are associated with clinically significant prostate cancer (CSPCa) in men with PI-RADS 3 lesions, while a prior negative biopsy is negatively associated. A predictive model can prevent unnecessary biopsies for PI-RADS 3 lesions while missing only a few cases of CSPCa.
Article
Oncology
Hiten D. Patel, Yudai Okabe, Goran Rac, Gaurav Pahouja, Shalin Desai, Steven M. Shea, Alex Gorbonos, Marcus L. Quek, Robert C. Flanigan, Ari Goldberg, Gopal N. Gupta
Summary: This study compared the impact of MRI vs. non-MRI diagnostic pathways on surgical outcomes for patients undergoing radical prostatectomy (RP). The results showed that MRI-based diagnostic approach was associated with lower positive surgical margin rates, higher utilization of bilateral nerve-sparing, and improved cancer control by biochemical recurrence.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2023)
Article
Oncology
Charles D. Logan, Ashorne K. Mahenthiran, Mohammad R. Siddiqui, Dustin D. French, Matthew T. Hudnall, Hiten D. Patel, Adam B. Murphy, Joshua A. Halpern, David J. Bentrem
Summary: Most radical prostatectomies are done with robotic assistance. This study examined disparities in access and outcomes of robot-assisted radical prostatectomy (RARP) and found that non-Hispanic Black and Hispanic patients were less likely to receive RARP, and underinsured patients had lower rates of RARP. RARP was associated with decreased perioperative mortality and improved overall survival compared to open radical prostatectomy (ORP).
JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Anas Elgenidy, Ahmed K. Awad, Huzaifa Ahmad Cheema, Abia Shahid, Salah Eddine Oussama Kacimi, Mostafa G. Aly, Nirmish Singla, Ahmed M. Afifi, Hiten D. Patel
Summary: This study aimed to assess the frequency and risk of different causes of death in patients with renal cell carcinoma (RCC) in the United States. The majority of deaths were due to kidney cancer, but a significant proportion was caused by non-cancerous reasons. The proportion of deaths attributed to RCC decreased with increasing follow-up, and cardiovascular diseases and cerebrovascular diseases were the most common non-RCC-related causes of death. Coordination of multidisciplinary care is needed to prevent death from non-cancerous causes, depending on the stage of the disease.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2023)
Article
Medicine, Research & Experimental
Kyungho Lee, Elizabeth A. Thompson, Sepideh Gharaie, Chirag H. Patel, Johanna T. Kurzhagen, Phillip M. Pierorazio, Lois J. Arend, Ajit G. Thomas, Sanjeev Noel, Barbara S. Slusher, Hamid Rabb
Summary: T cells in acute kidney injury (AKI) undergo metabolic reprogramming, and targeting the T cell glutamine pathway could be a promising therapeutic approach. Ischemic AKI in mice showed the presence of a distinct T cell subset with altered expression of certain metabolic proteins. Similarly, human nonischemic and ischemic kidney tissue exhibited similar findings. Inhibition of glutamine with JHU083 attenuated renal injury and reduced T cell activation and proliferation in AKI.
Article
Urology & Nephrology
Hiten D. Patel, Chirag P. Doshi, Elizabeth L. Koehne, Spencer Hart, Michelle Van Kuiken, Marcus L. Quek, Robert C. Flanigan, Gopal N. Gupta
Summary: The study aimed to compare the frequency of anterior prostate lesions on mpMRI between African American and non-African American men and evaluate the implications for prostate cancer detection. Results showed that men with APLs were twice as likely to have PCa or csPCa, but there was no significant difference in the proportion of APL PCa or csPCa between African American and non-African American men, indicating similar rates of APLs on mpMRI between the two groups.
Review
Urology & Nephrology
Spyridon P. Basourakos, Mark N. Alshak, Patrick J. Lewicki, Emily Cheng, Michael Tzeng, Antonio P. DeRosa, Mathew J. Allaway, Ashley E. Ross, Edward M. Schaeffer, Hiten D. Patel, Jim C. Hu, Michael A. Gorin
Summary: A systematic review and meta-analysis were conducted to evaluate infectious complications after transperineal prostate biopsy with or without the administration of prophylactic antibiotics. The study found that prophylactic antibiotics do not decrease the rate of postbiopsy sepsis but may have a small benefit in terms of preventing less serious infections.
EUROPEAN UROLOGY OPEN SCIENCE
(2022)
Article
Oncology
Michael A. Gorin, Hiten D. Patel, Steven P. Rowe, Noah M. Hahn, Hans J. Hammers, Alice Pons, Bruce J. Trock, Phillip M. Pierorazio, Thomas R. Nirschl, Daniela C. Salles, Julie E. Stein, Tamara L. Lotan, Janis M. Taube, Charles G. Drake, Mohamad E. Allaf
Summary: In this study, the safety and tolerability of preoperative administration of three doses of the immune checkpoint inhibitor nivolumab in patients with clinically localized high-risk renal cell carcinoma were evaluated. The study demonstrated the safety of this approach and found that a subset of patients may have features of an immune-related pathologic response.
EUROPEAN UROLOGY ONCOLOGY
(2022)