Article
Biochemistry & Molecular Biology
Layal El-Hajjar, Judy Hindieh, Rana Andraos, Marwan El-Sabban, Jalil Daher
Summary: Cardiovascular disease caused by atherosclerosis is a major cause of death worldwide. This study explores the role of oxidized LDL and the LOX-1 scavenger receptor in endothelial dysfunction and inflammation, providing insight into the pathways involved in atherosclerosis progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Wenfeng Li, Chenggao Wang, Dandan Zhang, Kanghua Zeng, Shihui Xiao, Feng Chen, Jun Luo
Summary: Azilsartan may ameliorate ox-LDL-induced endothelial damage through elevating the expression of KLF2.
Article
Biochemistry & Molecular Biology
Zhiwen Wang, Juan Chen, Zhuanglin Zeng, Qing Zhang, Gaohui Du, Xiaopeng Guo, Yumiao Wei
Summary: In this study, the researchers investigated whether ectopic expression of LOX-1 receptor in the liver could eliminate circulating Ox-LDL and prevent its deposition in the vascular wall, thereby alleviating the progression of atherosclerosis.
MOLECULAR MEDICINE
(2022)
Article
Immunology
Xiaohong Fei, Xuejiang Cen, Ruochi Zhao, Jian Wang, Hanbin Cui
Summary: Atherosclerosis is the pathological basis of cardiovascular disease, which begins with endothelial dysfunction caused by vascular endothelial cell injury. PRMT5, a protein arginine methyltransferase, is highly related to cardiovascular events. This study aimed to explore the biological roles of PRMT5/PDCD4 in vascular endothelial cell injury during atherosclerosis. Results showed that PRMT5 was highly expressed in ox-LDL-stimulated HUVECs. Knockdown of PRMT5 enhanced cell viability and inhibited apoptosis, oxidative stress, inflammation, and endothelial dysfunction in HUVECs. PRMT5 was found to interact and bind with PDCD4. In conclusion, down-regulation of PRMT5 exerts protective effects against vascular endothelial cell injury during atherosclerosis by suppressing PDCD4 expression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Oncology
Takuya Tsumita, Nako Maishi, Dorcas Akuba-Muhyia Annan, Mohammad Alam Towfik, Aya Matsuda, Yasuhito Onodera, Jin-Min Nam, Yasuhiro Hida, Kyoko Hida
Summary: The study found that high metastatic tumor tissue contains a large amount of low-density lipoprotein (LDL) and forms more oxidized LDL (ox-LDL). Interestingly, the ox-LDL receptor LOX-1 is highly expressed in tumor endothelial cells (TECs). Neutrophils play an important role in ox-LDL formation. LOX-1 induces neutrophil migration through CCL2 secretion from TECs, and this process is enhanced by ox-LDL. Genetic manipulation of LOX-1 expression tends to reduce lung metastasis. Therefore, the LOX-1/ox-LDL axis in TECs may contribute to the formation of a high metastatic tumor microenvironment by attracting neutrophils.
INTERNATIONAL JOURNAL OF CANCER
(2022)
Article
Biochemistry & Molecular Biology
Akanksha Tomar, Sibasis Sahoo, Muthusankar Aathi, Shobhan Kuila, Mohd Azeem Khan, Guru Raj Rao Ravi, Jeyakanthan Jeyaraman, Jawahar L. Mehta, Kottayil I. Varughese, Arulandu Arockiasamy
Summary: This study identifies two druggable sites of lectin-like oxidized low-density lipoprotein (ox-LDL) receptor 1 (LOX-1) and shortlists small molecules targeting these sites. Experimental results show that four of the selected molecules bind to LOX-1 receptor with high affinity. The findings suggest that LOX-1 can be targeted with small molecules, providing strategies to identify novel inhibitors for attenuating ox-LDL - LOX-1 interaction.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Cardiac & Cardiovascular Systems
Xiao-Hong Chen, Yu Tan, ShuQin Yu, Lijun Lu, Youqing Deng
Summary: This study found that pinitol has the potential to reduce endothelial dysfunction caused by oxidized low-density lipoprotein (ox-LDL). Pinitol can decrease the production of reactive oxygen species, reduce the expression of IL-6 and monocyte chemoattractant protein-1, and decrease the attachment of monocytes to endothelial cells. Additionally, pinitol decreases the expression of LOX-1 and rescues the expression of KLF2.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
M. Murdocca, C. De Masi, S. Pucci, R. Mango, G. Novelli, C. Di Natale, F. Sangiuolo
Summary: Recent studies have demonstrated a strong correlation between metabolic disorders, tumor onset, and progression, leading to the exploration of new therapeutic strategies targeting metabolic targets. The OLR1 gene encodes the LOX-1 receptor protein, which has been shown to be involved in atherosclerosis and more recently in various tumors. Upregulation of LOX-1 in tumors has been linked to cancer initiation, progression, and metastasis, indicating it as a promising therapeutic target for enhancing current antineoplastic strategies.
CANCER GENE THERAPY
(2021)
Review
Cardiac & Cardiovascular Systems
Torben Mentrup, Florencia Cabrera-Cabrera, Bernd Schroeder
Summary: The LOX-1 receptor plays a crucial role in atherosclerosis, promoting oxLDL uptake and signaling cascade leading to foam cell formation. Proteolysis acts as a regulatory mechanism for LOX-1 function, generating cleavage products with different biological functions and potential diagnostic value.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Nikolaos Pyrpyris, Kyriakos Dimitriadis, Eirini Beneki, Panagiotis Iliakis, Stergios Soulaidopoulos, Panagiotis Tsioufis, Elena Adamopoulou, Alexandros Kasiakogias, Athanasios Sakalidis, George Koutsopoulos, Konstantina Aggeli, Konstantinos Tsioufis
Summary: This article reviews the role of LOX-1 in atherogenesis and explores its potential as a diagnostic tool and therapeutic target.
CURRENT PROBLEMS IN CARDIOLOGY
(2024)
Article
Cell Biology
Xiaopeng Guo, Yishan Guo, Zhiwen Wang, Bingxin Cao, Chuansheng Zheng, Zhuanglin Zeng, Yumiao Wei
Summary: This study found that immune intervention can protect the barrier function of vascular endothelial cells, thus inhibiting the progression of atherosclerosis.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2022)
Article
Biochemistry & Molecular Biology
Ying Wu, Meiyan Song, Wen Chen, Kaizu Xu, Meifang Wu, Liming Lin
Summary: The study aimed to investigate the effects of liraglutide, a GLP-1R agonist, on endothelial dysfunction in LDLR-KO mice and ox-LDL-challenged HUVECs. The results showed that liraglutide effectively improved endothelial function, reduced LOX-1 expression, and decreased oxidative and inflammatory markers in LDLR-KO mice.
Review
Pharmacology & Pharmacy
Shiv Sharma, Swathi Sridhar, Alasdair McIntosh, Claudia-Martina Messow, Eva Munoz Aguilera, Rita Del Pinto, Davide Pietropaoli, Renata Gorska, Mateusz Siedlinski, Pasquale Maffia, Maciej Tomaszewski, Tomasz J. Guzik, Francesco D'Aiuto, Marta Czesnikiewicz-Guzik
Summary: The study compared the effects of intensive periodontal treatment and conventional periodontal treatment on arterial blood pressure, endothelial function, and inflammatory/metabolic biomarkers. The results showed that intensive periodontal treatment improved cardiovascular health in hypertensive and prehypertensive individuals, with no significant effect observed in normotensive individuals.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Surgery
Yu Gao, Jianwei Yue, Zhiliang Huang
Summary: MIAT expression was up-regulated in ox-LDL-induced HUVECs, while knockdown of MIAT promoted cell viability, invasion, migration, EMT, and inhibited apoptosis, as well as the levels of inflammatory factors, affecting the regulation of miR206/RAB22A axis.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Chemistry, Medicinal
Rajshekhar A. Kore, Ashim K. Bagchi, Kottayil Varughese, Jawahar L. Mehta
Summary: In this review, we focus on the newly studied and developed LOX-1 inhibitors that may have potential for treating diseases characterized by LOX-1 activation.
FUTURE MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)