Article
Pathology
Brad Bolon, Sabine Francke, Jessica M. Caverly Rae, Evelyne Polack, Karen S. Regan, Elizabeth F. McInnes, Jamie K. Young, Kevin Keane, Rick Perry, Annette Romeike, Karyn Colman, Karl Jensen, Kyoko Nakano-Ito, Elizabeth J. Galbreath
Summary: This article describes the Society of Toxicologic Pathology's (STP) five recommended practices for the appropriate use of informed versus masked microscopic evaluation in animal toxicity studies. The article emphasizes the advantages of informed microscopic evaluation, but also acknowledges the merits of masked evaluation in certain situations. The decision on whether to use masked evaluation should be made by an experienced toxicologic pathologist.
TOXICOLOGIC PATHOLOGY
(2022)
Review
Marine & Freshwater Biology
Maruthanayagam Veerabadhran, Nagarajan Manivel, Barathkumar Sarvalingam, Boopathi Seenivasan, Hemalatha Srinivasan, MubarakAli Davoodbasha, Fei Yang
Summary: Cyanobacteria are widely distributed in freshwater and marine environments worldwide, and their toxins have harmful effects on health. Microcystins, the toxic metabolites produced by cyanobacteria, cause significant damage to cells, influencing the morphological, biochemical, physiological, and genetic status of the host. Microcystins also have detrimental effects on animals, plants, agriculture, public health, ecotoxicology, and economic consequences. Comprehensive cellular assessment could provide opportunities for therapeutic implications.
AQUATIC TOXICOLOGY
(2023)
Article
Environmental Sciences
Supatta Chueycham, Chantragan Srisomsap, Daranee Chokchaichamnankit, Jisnuson Svasti, Karin Hummel, Katharina Nobauer, Omid Hekmat, Ebrahim Razzazi-Fazeli, Sutin Kingtong
Summary: The study investigated the toxic effects of DDT on hooded oysters, revealing alterations in mantle tissue and differential expression of stress response and cytoskeletal proteins in response to DDT exposure. These findings improve understanding of DDT toxicity and the molecular response of oyster proteome to DDT exposure.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Engineering, Environmental
Rene S. Shahmohamadloo, Xavier Ortiz Almirall, Denina B. D. Simmons, John S. Lumsden, Satyendra P. Bhavsar, Trudy Watson-Leung, Angela Vander Eyken, Gabrielle Hankins, Kate Hubbs, Polina Konopelko, Michael Sarnacki, Damon Strong, Paul K. Sibley
Summary: The study revealed that Rainbow Trout accumulated both intracellular and extracellular microcystins in all tissues within 24 hours after exposure to a certain concentration, leading to dysregulation of proteins associated with cytoskeletal structure, stress responses, and DNA repair, ultimately causing sublethal toxicity effects.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Environmental Sciences
Cecilia Gabellone, Gabriel Molina, Florencia Arrighetti, Aldana Laino, Carlos Fernando Garcia
Summary: The aim of this study was to evaluate the effects of the neonicotinoid insecticide imidacloprid on juveniles of the spider Misumenops maculissparsus. The results showed that spiders do not detect the insecticide on surfaces or in the form of droplets, but ingestion of imidacloprid resulted in paralysis and histopathologic damage. The study highlights the importance of considering different biomarkers to assess the effects of imidacloprid.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2022)
Article
Environmental Sciences
S. M. L. Lavarias, K. D. Colpo, S. M. Landro, E. S. Ambrosio, A. Rodrigues Capitulo, F. Arrighetti
Summary: The study evaluated the acute effects of two pesticides on prawns, finding that lipid peroxidation and protein oxidation levels were affected at the lowest concentrations. Additionally, histopathological damage was observed in a dose-dependent manner.
Article
Medicine, General & Internal
Je Seop Lee, Yong Sung Cha, Seonghoon Yeon, Tae Youn Kim, Yoonsuk Lee, Jin-Geul Choi, Kyoung-Chul Cha, Kang Hyun Lee, Hyun Kim
Summary: Diagnosing patients with poisoning can be challenging in the emergency room, but using systematic toxicological analysis (STA) can help confirm clinical diagnoses and improve accuracy. This study found that after implementing an Intoxication Analysis Service, the rate of confirmed diagnoses increased, demonstrating the importance of appropriate toxicological analysis in determining the cause of poisoning and guiding treatment decisions.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Article
Chemistry, Medicinal
Samriti Rana, Joga Singh, Aishani Wadhawan, Archna Khanna, Gurpal Singh, Mary Chatterjee
Summary: This study evaluated the toxicological profile of biosurfactant encapsulated polymeric nanoparticles in mice, showing no significant toxicological effects and confirming the safety of the treatment.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Environmental Sciences
S. M. L. Lavarias, F. Arrighetti, S. M. Landro, K. D. Colpo
Summary: This study evaluated the effects of a new generation insecticide on embryos and larvae of freshwater prawns. The larvae showed high sensitivity to the insecticide, while the embryos were highly resistant. The embryonic coat provided protection for the embryos, but the larvae were vulnerable to the toxicity of the insecticide.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2022)
Article
Marine & Freshwater Biology
Kirsten E. Nikel, Gerald R. Tetreault, Patricija Marjan, Keegan A. Hicks, Meghan L. M. Fuzzen, Nivetha Srikanthan, Emily K. McCann, Hadi Dhiyebi, Leslie M. Bragg, Pam Law, Dominika Celmer-Repin, Sonya Kleywegt, Jessie Cunningham, Thomas Clark, Mark E. McMaster, Mark R. Servos
Summary: Municipal wastewater treatment plant effluent can adversely affect aquatic life, but major upgrades in the Central Grand River have significantly reduced pollution levels. Prior to the upgrades, rainbow darters showed disruptions in various biological aspects, but these were no longer significant after the improvements. Capital investments in wastewater treatment have corresponded with a reduction in adverse responses in fish in the receiving environment.
AQUATIC TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Mark Stroh, Michelle Green, Bjorn L. Millard, Joshua F. Apgar, John M. Burke, Will Garner, Hong Lu, Susan K. Lyman, Luc R. Desnoyers, Jennifer Richardson, Alison Hannah, W. Michael Kavanaugh
Summary: CX-072 is an anti-PD-L1 Probody therapeutic designed to be preferentially activated by proteases in the tumor microenvironment. Model-guided drug development showed that the in vivo activity of CX-072 is consistent with theoretical predictions.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Oncology
Ruth M. Lunn, Suril S. Mehta, Gloria D. Jahnke, Amy Wang, Mary S. Wolfe, Brian R. Berridge
Summary: The National Toxicology Program aims to increase awareness of cancer hazards in the environment and promote primary prevention, public health decision-making, and reducing the global cancer burden. The latest report added 8 new substances, including Helicobacter pylori, antimony trioxide, and 6 haloacetic acids found in water disinfection by-products. The program also conducted a cancer hazard assessment on circadian disruption, revealing that night shift work and certain lighting conditions may cause cancer. Their approaches are evolving to address modern challenges, focusing on real-world exposures and refining methods for cancer hazard assessments.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Social Work
Charles C. C. Daniels Jr.
Summary: Black fathers with histories of incarceration and trauma face multiple stressors that hinder their ability to navigate life, parent their children, and develop self-parenting skills. These stressors stem from racism, masculine stereotypes, and trauma. The Evidence Informed Fatherhood Program (EIFP) is effective in helping these fathers gain self-parenting skills, address their trauma, and reduce recidivism rates. This study examined the program's effectiveness by analyzing changes in scores over time and found significant improvements in life distress and emotional regulation.
JOURNAL OF SOCIAL WORK
(2023)
Article
Computer Science, Interdisciplinary Applications
Youngkyu Kim, Youngsoo Choi, David Widemann, Tarek Zohdi
Summary: Traditional linear subspace reduced order models are not effective in approximating solutions for advection-dominated flow phenomena. Therefore, we have developed a fast and accurate nonlinear manifold reduced order model that can better approximate high-fidelity solutions. The model takes advantage of existing numerical methods and achieves efficiency through hyper-reduction techniques. Numerical results demonstrate the model's ability to approximate solutions more efficiently and achieve high speedup.
JOURNAL OF COMPUTATIONAL PHYSICS
(2022)
Article
Medicine, Legal
Peter S. R. Wright, Katharine A. Briggs, Robert Thomas, Graham F. Smith, Gareth Maglennon, Paulius Mikulskis, Melissa Chapman, Nigel Greene, Benjamin U. Phillips, Andreas Bender
Summary: By comparing histopathological findings and target organ toxicities across different preclinical species, this study found that positive concordance is more common than negative concordance in histopathological results, and there is low concordance in target organ toxicities. It provides new statistically significant associations between preclinical species but finds that concordance is rare.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2023)
Article
Toxicology
Georgia K. Roberts, Cynthia J. Willson, Dorian S. Olivera, David E. Malarkey, Daniel L. Morgan
INHALATION TOXICOLOGY
(2017)
Article
Pathology
Natasha R. Catlin, Cynthia J. Willson, Dianne M. Creasy, Deepa B. Rao, Grace E. Kissling, Barry S. McIntyre, Michael Wyde
TOXICOLOGIC PATHOLOGY
(2018)
Article
Pathology
Susan A. Elmore, Vinicius Carreira, Caralyn S. Labriola, Debabrata Mahapatra, Sean R. McKeag, Matthias Rinke, Cynthia Shackelford, Bhanu Singh, Ashley Talley, Shannon M. Wallace, Lyn M. Wancket, Cynthia J. Willson
TOXICOLOGIC PATHOLOGY
(2018)
Article
Multidisciplinary Sciences
Jian Liu, Tianyuan Wang, Chad J. Creighton, San-Pin Wu, Madhumita Ray, Kyathanahalli S. Janardhan, Cynthia J. Willson, Sung-Nam Cho, Patricia D. Castro, Michael M. Ittmann, Jian-Liang Li, Roger J. Davis, Francesco J. DeMayo
NATURE COMMUNICATIONS
(2019)
Article
Cell Biology
Jian Liu, Tianyuan Wang, Cynthia J. Willson, Kyathanahalli S. Janardhan, San-Pin Wu, Jian-Liang Li, Francesco J. DeMayo
Article
Pathology
Susan A. Elmore, Mark F. Cesta, Torrie A. Crabbs, Kyathanahalli S. Janardhan, Gregory A. Krane, Debabrata Mahapatra, Erin M. Quist, Matthias Rinke, George W. Schaaf, Gregory S. Travlos, Haoan Wang, Cynthia J. Willson, Jeffrey C. Wolf
TOXICOLOGIC PATHOLOGY
(2019)
Article
Allergy
Payel Sil, Jutamas Suwanpradid, Ginger Muse, Artiom Gruzdev, Liwen Liu, David L. Corcoran, Cynthia J. Willson, Kyathanahalli Janardhan, Sara Grimm, Page Myers, Laura Miller Degraff, Amanda S. MacLeod, Jennifer Martinez
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2020)
Article
Reproductive Biology
Mamta Behl, Cynthia J. Willson, Helen Cunny, Paul M. D. Foster, Barry McIntyre, Cynthia Shackelford, Keith R. Shockley, Sandra McBride, Katie Turner, Suramya Waidyanatha, Chad R. Blystone
REPRODUCTIVE TOXICOLOGY
(2020)
Article
Reproductive Biology
Karina F. Rodriguez, Namya Mellouk, Erica K. Ungewitter, Barbara Nicol, Chang Liu, Paula R. Brown, Cynthia J. Willson, Humphrey H-C Yao
REPRODUCTIVE TOXICOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Margeaux Wetendorf, Rong Li, San-Pin Wu, Jian Liu, Chad J. Creighton, Tianyuan Wang, Kyathanahalli S. Janardhan, Cynthia J. Willson, Rainer B. Lanz, Bruce D. Murphy, John P. Lydon, Francesco J. DeMayo
Article
Pathology
Cynthia J. Willson
Summary: This study explores the toxicology studies of environmental chemicals with a focus on phthalates and its relevance to male reproductive disorders and diseases. The research found similarities in Testicular Dysgenesis Syndrome hypothesis in humans and rats, as well as histological findings of abnormal testicular development in both species.
TOXICOLOGIC PATHOLOGY
(2021)
Article
Toxicology
Madelyn C. Huang, Cynthia J. Willson, Sridhar Jaligama, Gregory L. Baker, Alan W. Singer, Yu Cao, Jessica Pierfelice, Esra Mutlu, Brian Burback, Guanhua Xie, David E. Malarkey, Barney Sparrow, Kristen Ryan, Matthew Stout, Georgia K. Roberts
Summary: This study found that exposure to 2-ethyltoluene (2-ET) at concentrations of >= 600 ppm resulted in acute toxicity in rats and mice, with decreased survival, body weight, and nasal olfactory epithelium degeneration or necrosis. Lower exposure concentrations did not significantly affect reproductive performance or littering, but exposed rats and mice had lower body weights.
INHALATION TOXICOLOGY
(2021)
Article
Pathology
Thomas Forest, Famke Aeffner, Dinesh S. Bangari, Bhupinder Bawa, Jonathan Carter, James Fikes, Wanda B. High, Shim-Mo Hayashi, Matthew Jacobsen, LuAnn McKinney, Daniel Rudmann, Thomas Steinbach, Vanessa Schumacher, Oliver C. Turner, Jerrold M. Ward, Cynthia J. Willson
Summary: This article presents the results of a survey on the use of digital pathology in nonclinical toxicology studies before the COVID-19 pandemic. The survey showed that digital histopathology was not widely used for routine GLP histopathology assessment. However, many institutions started investigating or adopting digital WSI systems during the pandemic to reduce employee exposure to COVID-19.
TOXICOLOGIC PATHOLOGY
(2022)
Article
Pathology
Thomas Forest, Famke Aeffner, Dinesh S. Bangari, Bhupinder Bawa, Jonathan Carter, James Fikes, Wanda High, Shim-Mo Hayashi, Matthew Jacobsen, LuAnn McKinney, Daniel Rudmann, Thomas Steinbach, Vanessa Schumacher, Oliver Turner, Jerrold M. Ward, Cynthia J. Willson
Summary: The use of digital pathology in toxicologic pathology has the potential to enhance evaluation and collaboration, but comes with significant resource requirements. This article provides a comprehensive perspective on digital whole-slide imaging and offers points to consider for organizations implementing digital pathology workflows.
TOXICOLOGIC PATHOLOGY
(2022)