Review
Medicine, General & Internal
Tadao Maeda, Sunao Sugita, Yasuo Kurimoto, Masayo Takahashi
Summary: Age-related macular degeneration (AMD) is a prevalent irreversible impairment in the elderly population, and stem cell therapies are being considered as a potentially viable treatment option. Clinical studies and applications focusing on pluripotent stem cell-derived retinal pigment epithelial (RPE) cells are progressing, while controversy surrounds the use of somatic stem cells in clinical trials. The field of retinal regenerative medicine using stem cells is expected to advance steadily with the incorporation of new technologies from various fields, emphasizing the importance of ophthalmologists in this area.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Arezou Zarepour, Ayca Bal Ozturk, Duygu Koyuncu Irmak, Gokcen Yasayan, Aylin Gokmen, Erdal Karaoz, Atefeh Zarepour, Ali Zarrabi, Ebrahim Mostafavi
Summary: Spinal cord injury (SCI) has a significant impact on patients' quality of life and is known as one of the most challenging diseases in the world. Different therapeutic strategies, including the use of stem cells and nanomaterials, show promising potential for SCI treatment.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Erik Leemhuis, Francesca Favieri, Giuseppe Forte, Mariella Pazzaglia
Summary: This review article provides an overview of the latest interventions for the treatment of spinal cord injury (SCI), including rehabilitation, neuromodulation, and virtual reality applications. Combining existing resources has the potential to improve the short to medium-term living conditions of patients.
Review
Cell & Tissue Engineering
Anusree Dey, Sheetal Uppal, Jayeeta Giri, Hari Sharan Misra
Summary: Understanding the mechanism of fate decision in stem cells is crucial for therapeutic applications. BRD4, as an epigenetic regulator, plays a key role in maintaining stem cell potency and controlling lineage commitment, making it a potential target for stem cell therapeutics.
Review
Chemistry, Multidisciplinary
He Shen, Caixia Fan, Zhifeng You, Zhifeng Xiao, Yannan Zhao, Jianwu Dai
Summary: Spinal cord injury (SCI) leads to the loss of motor and sensory functions and understanding the pathophysiological changes and inhibitory microenvironment is crucial for potential mechanisms of functional restoration. Implantation of functionalized biomaterials and transplantation of spinal cord tissue grafts have shown promising results for SCI repair, opening up new avenues for treatment.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Review
Materials Science, Biomaterials
Chen Zhao, Zheng Xing, Chunchen Zhang, Yubo Fan, Haifeng Liu
Summary: Spinal cord injury (SCI) results in loss of perceptive and athletic function, lacking effective treatment methods and facing limitations in drug therapy. Nanopharmaceuticals show great potential in SCI treatment, with the ability to enhance therapeutic effects and reduce side effects.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Medicine, Research & Experimental
Jamileh Saremi, Narges Mahmoodi, Mehdi Rasouli, Faezeh Esmaeili Ranjbar, Elham Lak Mazaheri, Marziyeh Akbari, Elham Hasanzadeh, Mahmoud Azami
Summary: Spinal cord injury (SCI) is a devastating event that lacks an effective treatment for complete repair. Strategies such as using cells, biomaterials, biomolecules, drugs, and combinatorial treatments have shown promise in promoting SCI recovery and spinal cord regeneration. This article aims to provide an overview of SCI pathophysiology, latest intervention modes, advanced approaches for treatment, and the potential of combinatorial treatments in preclinical and clinical trials to guide further research towards breakthroughs in spinal cord regeneration.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biology
Tomaso Caporossi, Alessandra Scampoli, Antonio Baldascino, Gloria Gambini, Bianca Pacini, Lorenzo Governatori, Daniela Bacherini, Matteo Mario Carla, Emanuele Crincoli, Clara Rizzo, Raphael Kilian, Stanislao Rizzo
Summary: This retrospective study evaluated the use of subretinal implant of human amniotic membrane (hAM) as a source of pluripotent stem cells for treating complications of age-related macular degeneration (AMD). The results showed that this treatment method can significantly improve visual acuity in patients and prevent MNV recurrence without complications.
Review
Biochemistry & Molecular Biology
Hidenori Suzuki, Takashi Sakai
Summary: Chronic spinal cord injury is a devastating condition with significant neurological deficits and socio-economic burdens. Symptomatic management is currently the main approach, but innovative regenerative strategies involving stem cells and other supportive drugs show promise in accelerating the pathway from bench to bedside. Future therapies targeting persistent barriers to regeneration, such as glial scarring and immunorejection, will likely require a combination of stem cells and synergistic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jinqi Wang, Xuanhao Zeng, Yating Liu, Weiling Lian, Haozhen Lv, Kelu Wei, Qi Zhang, Jinhua Xu
Summary: Embryonic stem cell-derived melanocytes have low immunogenicity in vitro and show potential for treating vitiligo.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Hidenori Suzuki, Yasuaki Imajo, Masahiro Funaba, Hiroaki Ikeda, Norihiro Nishida, Takashi Sakai
Summary: Spinal cord injury (SCI) is a devastating condition that causes significant neurological impairment and imposes substantial social and financial burdens. Current management approaches focus on symptomatic treatment, lacking effective therapeutic strategies. However, recent advancements in regenerative medicine have shown promise in preclinical and clinical studies. The utilization of biomaterial scaffolds, combined with stem cell therapy or other regenerative therapies, holds great potential in accelerating the development of novel therapeutic strategies for SCI. This review summarizes the latest insights from preclinical and clinical studies utilizing biomaterial scaffolds for regenerative therapy and provides a comprehensive overview of the biomaterial strategies employed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Michal Szymoniuk, Jakub Litak, Leon Sakwa, Aleksandra Dryla, Wojciech Zezulinski, Wojciech Czyzewski, Piotr Kamieniak, Tomasz Blicharski
Summary: Spinal Cord Injury (SCI) is a common neurological disorder that causes permanent disability in most patients. Stem Cell Therapy (SCT) shows promise in regenerating the injured spinal cord through the use of various types of stem cells. Understanding the pathogenesis of SCI and the molecular mechanisms of stem cell action can improve the efficacy of SCT and lead to the development of new therapeutic approaches.
Review
Biochemistry & Molecular Biology
Chi Feng, Lan Deng, Yuan-Yuan Yong, Jian-Ming Wu, Da-Lian Qin, Lu Yu, Xiao-Gang Zhou, An-Guo Wu
Summary: The spinal cord and brain are vital to the central nervous system (CNS), but spinal cord injury (SCI) caused by external forces is challenging to treat and results in loss of motor, sensory, and autonomic functions. The incidence of SCI is increasing globally, emphasizing the urgent need for treatments. Various approaches, such as surgery, drug therapy, stem cell transplantation, regenerative medicine, and rehabilitation therapy, have been developed. Among them, biomaterials using tissue engineering and bioscaffolds show promise for transporting cells or drugs to injured sites. However, clinical evidence for the treatment of SCI with biomaterials remains limited. This review provides inspiration and guidance for future studies and applications of biomaterials in SCI treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Neurosciences
Hidenori Suzuki, Yasuaki Imajo, Masahiro Funaba, Norihiro Nishida, Takuya Sakamoto, Takashi Sakai
Summary: Chronic spinal cord injury is a devastating condition without effective treatment. Clinical studies using neural stem/neural progenitor cells (NSCs/NPCs) are ongoing and show potential for regenerating neural circuits, demyelinating denuded axons, and providing trophic support to endogenous cells.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Biology
Chih-Wei Zeng
Summary: Spinal cord injury (SCI) has a significant impact on quality of life, necessitating new treatment options. Multipotent mesenchymal stem cells (MSCs) have emerged as a promising candidate for SCI treatment due to their regenerative capabilities. This comprehensive review discusses the molecular mechanisms involved in MSC-mediated tissue repair in SCI. It also examines various clinical applications of MSCs in SCI treatment, and highlights the challenges associated with MSC-based therapies.
Article
Multidisciplinary Sciences
Nicolo Caporale, Michelle Leemans, Lina Birgersson, Pierre-Luc Germain, Cristina Cheroni, Gabor Borbely, Elin Engdahl, Christian Lindh, Raul Bardini Bressan, Francesca Cavallo, Nadav Even Chorev, Giuseppe Alessandro D'Agostino, Steven M. Pollard, Marco Tullio Rigoli, Erika Tenderini, Alejandro Lopez Tobon, Sebastiano Trattaro, Flavia Troglio, Matteo Zanella, Ake Bergman, Pauliina Damdimopoulou, Maria Jonsson, Wieland Kiess, Efthymia Kitraki, Hannu Kiviranta, Eewa Nanberg, Mattias Oberg, Panu Rantakokko, Christina Ruden, Olle Soder, Carl-Gustaf Bornehag, Barbara Demeneix, Jean-Baptiste Fini, Chris Gennings, Joelle Ruegg, Joachim Sturve, Giuseppe Testa
Summary: This study found that exposure to EDC mixtures during early pregnancy is associated with language delay in offspring. The experimental results showed that at human-relevant concentrations, this mixture disrupts hormone-regulated and disease-relevant regulatory networks in the brain, as well as behavioral responses. Reanalyzing epidemiological data, it was found that up to 54% of children had prenatal exposures above experimentally derived levels of concern, resulting in a 3.3 times higher risk of language delay compared to the lowest decile of exposure.
Article
Genetics & Heredity
Valentina Di Nisio, Sevastiani Antonouli, Pauliina Damdimopoulou, Andres Salumets, Sandra Cecconi
Summary: This paper is an updated review on the consequences of postovulatory aging (POA) on oocyte quality, either in vivo or in vitro, with a focus on the modifications caused by POA on oocyte nuclear, cytoplasmic, genomic, and epigenetic maturation, as well as embryo development. The research highlights the importance of considering the effects of POA in assisted reproductive technologies, particularly when the fertilization of mature oocytes is delayed due to unforeseen circumstances.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Clinical Neurology
Jijing Wang, Cong Guo, Zhaowei Meng, Marissa D. Zwan, Xin Chen, Sven Seelow, Susanna L. Lundstrom, Sergey Rodin, Charlotte E. Teunissen, Roman A. Zubarev
Summary: This study strengthens the association between isoAsp and Alzheimer's disease (AD) using novel approaches to isoAsp analysis in blood samples. The findings demonstrate elevated isoAsp levels, reduced anti-isoAsp antibodies, increased A beta concentration, and more protein aggregation in AD blood compared to controls. Additionally, deamidation reduces the binding capacity of blood protein HSA with A beta and p-tau.
ALZHEIMERS & DEMENTIA
(2023)
Article
Pharmacology & Pharmacy
May Wenche Joraholmen, Pauliina Damdimopoulou, Ganesh Acharya, Natasa Skalko-Basnet
Summary: A formulation using liposomes loaded with resveratrol (RES) and incorporated into a chitosan hydrogel has been developed for delivering RES to the vaginal site. In vitro experiments showed that this formulation is non-irritant and biocompatible with vaginal tissue at therapeutic concentrations.
Article
Biochemical Research Methods
Loren Mear, Thanadol Sutantiwanichkul, Josephine Ostman, Pauliina Damdimopoulou, Cecilia Lindskog
Summary: In the search for missing proteins, researchers used an integrated omics approach to identify and explore the proteins in human ovaries. They successfully validated the existence of seven proteins at the single-cell type level. This study provides a starting point for further analysis of human ovaries and highlights the importance of the Human Protein Atlas database for the identification of proteins in specialized tissues.
JOURNAL OF PROTEOME RESEARCH
(2023)
Letter
Cardiac & Cardiovascular Systems
Johan O. Wedin, Sergey Rodin, Karl-Henrik Grinnemo
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Article
Reproductive Biology
Eleftheria Maria Panagiotou, Monica Kam Draskau, Tianyi Li, Angelica Hirschberg, Terje Svingen, Pauliina Damdimopoulou
Summary: This article proposes a method for formally recognizing Key Event Relationships (KERs) as building blocks of Adverse Outcome Pathways (AOPs), and provides an independent KER example. The KER connects androgen receptor (AR) antagonism to reduced fertility in females. The article presents systematic retrieval of relevant supporting evidence, highlighting the importance of early-stage follicular development and providing both biological plausibility and empirical evidence.
REPRODUCTIVE TOXICOLOGY
(2022)
Editorial Material
Cell & Tissue Engineering
Masahito Yoshihara, Magdalena Wagner, Anastasios Damdimopoulos, Cheng Zhao, Sophie Petropoulos, Shintaro Katayama, Juha Kere, Fredrik Lanner, Pauliina Damdimopoulou
Summary: Ovaries play a crucial role in the development, fertility, and reproduction of women. They age faster than other tissues and their function is lost before other organs undergo senescence. While there have been debates about the presence of germline stem cells and neo-oogenesis in adult human ovaries, our recent analysis did not find evidence of such stem cells. However, we welcome discussions on different protocols and acknowledge the importance of excellence in methods.
Meeting Abstract
Toxicology
P. Vazakidou, C. Koopmans, S. Kuru, T. Li, K. Asimaki, S. Evangelista, J. Koekkoek, P. Leonards, B. Gadella, P. Damdimopoulou, M. van Duursen
TOXICOLOGY LETTERS
(2022)
Meeting Abstract
Toxicology
E. M. Panagiotou, M. K. Draskau, T. Li, A. Linden Hirschberg, P. Damdimopoulou, T. Svingen
TOXICOLOGY LETTERS
(2022)
Letter
Cell & Tissue Engineering
Masahito Yoshihara, Magdalena Wagner, Anastasios Damdimopoulos, Cheng Zhao, Sophie Petropoulos, Shintaro Katayama, Juha Kere, Fredrik Lanner, Pauliina Damdimopoulou
Article
Environmental Sciences
Eva Bongaerts, Katariina Mamia, Ilmatar Rooda, Richelle D. Bjorvang, Kiriaki Papaikonomou, Sebastian B. Gidlof, Jan I. Olofsson, Marcel Ameloot, Ernesto Alfaro-Moreno, Tim S. Nawrot, Pauliina Damdimopoulou
Summary: There is evidence indicating a link between exposure to ambient air pollution and decreased female fertility. This study found that black carbon particles from air pollution can reach the ovaries and follicular fluid, potentially impacting fertility.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Environmental Sciences
Ida Hallberg, Richelle D. Bjoervang, Nermin Hadziosmanovic, Jacco Koekkoekk, Anne Pikki, Majorie van Duursen, Virissa Lenters, Ylva Sjunnesson, Jan Holte, Lars Berglund, Sara Persson, Matts Olovsson, Pauliina Damdimopoulou
Summary: This study identifies associations between lifestyle factors and concentrations of endocrine-disrupting chemicals (EDCs) in ovarian follicular fluid. The results suggest that multiple lifestyle variables affect chemical contamination of the follicular fluid.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2023)
Article
Obstetrics & Gynecology
Jasmin Hassan, Katri Knuus, Atte Lahtinen, Ilmatar Rooda, Marjut Otala, Timo Tuuri, Sebastian Gidlof, Erik Edlund, Judith Menezes, Johan Malmros, Petra Bystrom, Mikael Sundin, Cecilia Langenskiold, Hartmut Vogt, Per Frisk, Cecilia Petersen, Pauliina Damdimopoulou, Kirsi Jahnukainen
Summary: This study investigated the adequacy of age-normalized reference values for ovarian cortical follicular density in fertility preservation tissue quality control. The results showed that there was no significant difference in Z-scores between samples from treated and untreated patients. However, Z-scores were significantly lower in younger treated patients and patients with Turner syndrome. A Z-score of -1.7 was identified as a good diagnostic cutoff for identifying Turner syndrome patients with reduced ovarian reserve.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Article
Endocrinology & Metabolism
Julie Boberg, Tianyi Li, Sofie Christiansen, Monica K. Draskau, Pauliina Damdimopoulou, Terje Svingen, Hanna K. L. Johansson
Summary: A prevailing challenge in testing chemical substances for their potential to cause female reproductive toxicity is the lack of suitable toxicological test methods. This study suggests that starting a 28-day experiment at weaning and including assessment of vaginal opening can increase the sensitivity to detect endocrine disruptors.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Anna Collins, Annie Jacob, Esther Moss
Summary: This article reviews the current evidence on minimally-invasive surgery in high-risk endometrial cancer patients and identifies areas that require further research.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)
Editorial Material
Obstetrics & Gynecology
Thomas D'Hooghe
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)
Editorial Material
Obstetrics & Gynecology
Thomas M. D'Hooghe
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)
Article
Obstetrics & Gynecology
Lina Youssef, Lea Testa, Francesca Crovetto, Fatima Crispi
Summary: Preeclampsia is a pregnancy-specific disease with an unknown precise cause. Multi-omics approaches have been used to study the molecular mechanisms of preeclampsia, and various genetic variants, altered gene expressions, potential biomarkers, and metabolic changes have been identified. Microbiomics studies have also found dysbiosis in the microbiota of pregnant women with preeclampsia. Further research is needed to integrate and translate these findings into clinical practice.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2024)
