Leveraging Human Genetics to Estimate Clinical Risk Reductions Achievable by Inhibiting Factor XI
Published 2019 View Full Article
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Title
Leveraging Human Genetics to Estimate Clinical Risk Reductions Achievable by Inhibiting Factor XI
Authors
Keywords
-
Journal
STROKE
Volume -, Issue -, Pages -
Publisher
Ovid Technologies (Wolters Kluwer Health)
Online
2019-09-27
DOI
10.1161/strokeaha.119.026545
References
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Related references
Note: Only part of the references are listed.- Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
- (2018) Rainer Malik et al. NATURE GENETICS
- Genetically Determined FXI (Factor XI) Levels and Risk of Stroke
- (2018) Dipender Gill et al. STROKE
- Interpreting findings from Mendelian randomization using the MR-Egger method
- (2017) Stephen Burgess et al. EUROPEAN JOURNAL OF EPIDEMIOLOGY
- Factor XI deficiency is associated with lower risk for cardiovascular and venous thromboembolism events
- (2016) Meir Preis et al. BLOOD
- The Intrinsic Pathway of Coagulation as a Target for Antithrombotic Therapy
- (2016) Allison P. Wheeler et al. HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA
- Precision medicine, genomics and drug discovery: Table 1.
- (2016) Lon R. Cardon et al. HUMAN MOLECULAR GENETICS
- Why factor XI deficiency is a clinical concern
- (2016) Allison P. Wheeler et al. Expert Review of Hematology
- Factor XI Antisense Oligonucleotide for Prevention of Venous Thrombosis
- (2015) Harry R. Büller et al. NEW ENGLAND JOURNAL OF MEDICINE
- Novel oral anticoagulants in secondary prevention of stroke
- (2013) H.C. Diener et al. BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY
- Validating therapeutic targets through human genetics
- (2013) Robert M. Plenge et al. NATURE REVIEWS DRUG DISCOVERY
- Genetic Associations for Activated Partial Thromboplastin Time and Prothrombin Time, their Gene Expression Profiles, and Risk of Coronary Artery Disease
- (2012) Weihong Tang et al. AMERICAN JOURNAL OF HUMAN GENETICS
- HaploReg: a resource for exploring chromatin states, conservation, and regulatory motif alterations within sets of genetically linked variants
- (2011) L. D. Ward et al. NUCLEIC ACIDS RESEARCH
- Patients with severe factor XI deficiency have a reduced incidence of deep-vein thrombosis
- (2010) Ophira Salomon et al. THROMBOSIS AND HAEMOSTASIS
- Reduced incidence of ischemic stroke in patients with severe factor XI deficiency
- (2008) O. Salomon et al. BLOOD
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