Article
Rehabilitation
Yan Gong, Xian-Ming Long, Ying Xu, Xiu-Ying Cai, Ming Ye
Summary: The study demonstrated that 1Hz rTMS combined with anodal tDCS stimulation protocol showed significant effects on motor function and cortex excitability in subacute stroke patients, making it a potential preferred rehabilitative strategy for motor recovery.
CLINICAL REHABILITATION
(2021)
Article
Clinical Neurology
Sinan Yasaroglu, Joachim Liepert
Summary: This study aimed to characterize the changes in motor excitability and motor performance induced by a single session of anodal and cathodal transcranial direct current stimulation (tDCS) in stroke patients. The results showed that anodal tDCS significantly reduced short interval intracortical inhibition (SICI) without affecting intracortical facilitation (ICF) or long interval intracortical inhibition (LICI). Cathodal tDCS did not change motor excitability. Both types of tDCS did not alter motor performance. The SICI in the affected hemisphere was lower than in the unaffected hemisphere even before anodal tDCS, and it was correlated with changes in motor performance after anodal tDCS.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Biology
Ji-Soo Baik, Jung-Hyun Yang, Sung-Hwa Ko, So-Jung Lee, Yong-Il Shin
Summary: The potential of transcranial direct current stimulation (tDCS) as a non-invasive brain stimulation technique for treating central post-stroke pain (CPSP) has been investigated. However, this study found no significant improvement in pain, depression, and quality of life in patients with CPSP who received tDCS compared to those who received sham stimulation. Nevertheless, significant changes were observed within the tDCS group, and pain trends appeared to be influenced by lesion location. These findings offer valuable insights into the use of tDCS in CPSP patients, informing further research and development of pain treatment options.
Article
Neurosciences
Qurat-ul-ain, Zafran Ahmad, Summaiya Ishtiaq, Saad Ilyas, Irum Shahid, Iqbal Tariq, Arshad Nawaz Malik, Tian Liu, Jue Wang
Summary: This study compared the effects of anodal transcranial direct current stimulation (tDCS) on the cerebellum and cerebral motor cortex in stroke patients. The results showed that tDCS improved gait, balance, and the risk of falls in stroke patients, but did not significantly improve cognitive function.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Neurosciences
Arislander Jonathan Lopes Dumont, Veronica Cimolin, Rodolfo Borges Parreira, Danilo Armbrust, Daniela Rosana Pedro Fonseca, Adriano Luis Fonseca, Lorraine Cordeiro, Renata Calhes Franco, Natalia Almeida Carvalho Duarte, Manuela Galli, Claudia Santos Oliveira
Summary: The study examined the effects of combining anodal tDCS and treadmill training on gait speed in stroke survivors. The experimental group received anodal tDCS over the damaged hemisphere's primary motor cortex (M1) during treadmill training, while the control group received sham tDCS. Results showed no significant differences in spatiotemporal variables between the two groups. However, the experimental group demonstrated improvements in kinematic variables of the knee and ankle, and these results were maintained one month after treatment.
Article
Clinical Neurology
Lorena Melo, Mohsen Mosayebi-Samani, Elham Ghanavati, Michael A. Nitsche, Min-Fang Kuo
Summary: The study found that acute serotonin enhancement can modulate tDCS after-effects and has similar modulatory effects on motor cortex neuroplasticity regardless of the specific dosage. Only a minor dosage-dependent effect was observed for cathodal tDCS.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2021)
Review
Chemistry, Analytical
Juan Antonio Chamorro-Hinojosa, Francisco Molina-Rueda, Maria Carratala-Tejada
Summary: This review analyzes the evidence for the application of transcranial direct current stimulation (tDCS) in the recovery of gait disturbance in stroke patients. The results show that moderate to low-quality evidence suggests a beneficial effect of tDCS on gait parameters, but the differences are not significant. Currently, there is insufficient evidence to recommend this treatment, and higher-quality studies are needed for stronger conclusions.
Review
Clinical Neurology
Ke Dong, Shifeng Meng, Ziqi Guo, Rufang Zhang, Panpan Xu, Erfen Yuan, Tao Lian
Summary: Transcranial direct current stimulation (tDCS) shows short-term improvements in balance and gait functions in stroke patients, particularly in promoting improvements in the Timed Up and Go Test (TUGT) and Functional Ambulation Category (FAC).
FRONTIERS IN NEUROLOGY
(2021)
Article
Engineering, Biomedical
Dhaval Solanki, Zeynab Rezaee, Anirban Dutta, Uttama Lahiri
Summary: This study investigated the effects of lobule-specific cerebellar transcranial direct current stimulation (ctDCS) on overground gait performance in chronic stroke patients. The results showed that both lobule-specific bilateral ctDCS montages improved walking performance, with the mean electric field strength in cerebellar lobules correlated to changes in gait parameters. Clinical assessments found improvement in gait performance based on minimal clinically important differences, indicating the potential for further clinical validation with larger sample sizes.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2021)
Review
Clinical Neurology
Xavier Corominas-Teruel, Rosa Maria San Segundo Mozo, Montserrat Fibla Simo, Maria Teresa Colomina Fosch, Antoni Valero-Cabre
Summary: This systematic review summarizes the current state-of-the-art on the effects of tDCS for gait rehabilitation in stroke subjects. The results highlight the potential of tDCS to contribute to gait recovery following stroke, but also emphasize the urgent need to improve current stimulation strategies and subject-customized interventions.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Xiao-Hua Zhang, Tao Gu, Xuan-Wei Liu, Ping Han, Hui-Lan Lv, Yu-Long Wang, Peng Xiao
Summary: The study demonstrates that both tDCS and FES significantly promote the recovery of leg motor function in stroke patients, with tDCS being more effective in the stroke recovery stage. The application value of SEP in stroke patients needs further exploration.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Qiuwen Gong, Rubing Yan, Han Chen, Xia Duan, Xiaoyu Wu, Xin Zhang, Yi Zhou, Zhou Feng, Ya Chen, Jianbo Liu, Peng Xu, Jing Qiu, Hongliang Liu, Jingming Hou
Summary: This study found that cerebellar transcranial direct current stimulation (tDCS) therapy can effectively and safely promote the recovery of upper limb motor function in stroke patients through a randomized trial.
FRONTIERS IN NEUROLOGY
(2023)
Article
Neurosciences
Kangbo Yang, Xugang Xi, Ting Wang, Junhong Wang, Wanzeng Kong, Yun-Bo Zhao, Qizhong Zhang
Summary: Related experiments have shown that anodal transcranial direct current stimulation (tDCS) of the brain's primary motor cortex (M1) and supplementary motor area (SMA) can improve motor control in stroke patients. In a study with 35 healthy volunteers, it was found that tDCS anode stimulation of M1 and SMA had different effects on motor imagery. Specifically, SMA stimulation showed less obvious differences during the motor preparation phase, while M1 stimulation produced significant differences during the motor imagery task execution phase.
NEUROSCIENCE LETTERS
(2021)
Review
Neurosciences
Fateme Pol, Mohammad Ali Salehinejad, Hamzeh Baharlouei, Michael A. Nitsche
Summary: Studies have shown that tDCS targeting the motor cortex and supplementary motor area bilaterally appears promising for gait rehabilitation in PD, while targeting the dorosolateral prefrontal cortex or cerebellum has shown more heterogeneous results. Further research is needed to compare the efficacy of different tDCS protocols and optimize the intervention approach.
TRANSLATIONAL NEURODEGENERATION
(2021)
Article
Neurosciences
E. L. Pavlova, R. V. Semenov, M. P. Pavlova-Deb, A. B. Guekht
Summary: This study investigated the effects of single-session premotor and primary motor transcranial direct current stimulation (tDCS) in chronic stroke patients and found that the premotor cortex is a promising candidate area for non-invasive stimulation in these patients.
Article
Multidisciplinary Sciences
Yasuyuki Takamatsu, Satoko Koganemaru, Tatsunori Watanabe, Sumiya Shibata, Yoshihiro Yukawa, Masatoshi Minakuchi, Ryota Shimomura, Tatsuya Mima
Summary: This study investigates the effects of transcranial static magnetic stimulation (tSMS) on cortical excitability and interhemispheric inhibition between the left and right primary motor cortex (M1) in healthy subjects. The findings show a decrease in corticospinal excitability in the left M1 and an increase in the right M1 after tSMS, along with a reduction in interhemispheric inhibition from the left to the right M1.
SCIENTIFIC REPORTS
(2021)
Article
Rehabilitation
Kaoru Sakuma, Hiroshige Tateuchi, Satoru Nishishita, Yusuke Okita, Ryosuke Kitatani, Yumiko Koyama, Satoko Ibuki, Noriaki Ichihashi
Summary: Among stroke patients, stance training may be more effective for those with slower Timed Up and Go outcomes and weaker hip muscles compared to swing training.
INTERNATIONAL JOURNAL OF REHABILITATION RESEARCH
(2021)
Article
Multidisciplinary Sciences
Sumiya Shibata, Tatsunori Watanabe, Yoshihiro Yukawa, Masatoshi Minakuchi, Ryota Shimomura, Sachimori Ichimura, Hikari Kirimoto, Tatsuya Mima
Summary: Transcranial static magnetic stimulation (tSMS) over the left primary motor cortex (M1) for 20 min modulates local cortical activity and interregional functional coupling in the theta band, suggesting its potential role in inducing neural oscillations and neurophysiological effects in the frontal cortex.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Tomoya Gyoda, Ippei Nojima, Su-Chuan Lin, Satoko Koganemaru, Tatsuya Mima, Shigeo Tanabe, Ying-Zu Huang
Summary: This study aimed to investigate the effect of GABA activity strengthening through real-time neurofeedback training on subsequent motor learning. The results showed that the NFT intervention led to enhanced GABA activity and suppressed online learning but not offline learning.
Article
Behavioral Sciences
Akari Ogawa, Satoko Koganemaru, Toshimitsu Takahashi, Yuu Takemura, Hiroshi Irisawa, Masao Matsuhashi, Tatsuya Mima, Takashi Mizushima, Kenji Kansaku
Summary: This study investigated the brain activity during volitional swallowing in two ALS patients. The results showed individual differences in cortical motor outputs during swallowing, suggesting the need for a personalized therapeutic approach using ERD for ALS patients with dysphagia.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Editorial Material
Behavioral Sciences
Yuichi Takeuchi, Qun Li, Takeshi Kawano, Jun Nagai, Tatsuya Mima
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Editorial Material
Clinical Neurology
Sumiya Shibata, Tatsunori Watanabe, Naofumi Otsuru, Hideaki Onishi, Tatsuya Mima
Article
Neurosciences
Atsushi Shima, Tomoaki Miyake, Kazuki Tanaka, Akari Ogawa, Erika Omae, Yui Nagamori, Yusuke Miyata, Koji Ohata, Takakuni Maki, Yumie Ono, Tatsuya Mima, Ryosuke Takahashi, Satoko Koganemaru
Summary: Closed-loop brain stimulation combined with robot-assisted training targeting the swing phase of gait can enhance the recovery of gait function in post-stroke patients. Short-term and long-term interventions showed significant improvements in gait speed, the Timed Up and Go test result, and muscle strength. Further studies with a larger number of patients are needed.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Engineering, Biomedical
Sumiya Shibata, Tatsunori Watanabe, Takuya Matsumoto, Keisuke Yunoki, Takayuki Horinouchi, Hikari Kirimoto, Jianxu Zhang, Hen Wang, Jinglong Wu, Hideaki Onishi, Tatsuya Mima
Summary: This study developed a novel transcranial static magnetic field stimulation (tSMS) system for non-invasive deep brain stimulation. The results showed that the system was able to generate a sufficient magnetic field for neuromodulation in deep brain areas. This stimulation method could potentially be used for brain function regulation therapy.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2022)
Letter
Clinical Neurology
Ryota Shimomura, Sumiya Shibata, Satoko Koganemaru, Masatoshi Minakuchi, Sachimori Ichimura, Akihiro Itoh, Katsumi Shimotake, Tatsuya Mima
Article
Neurosciences
Atsushi Shima, Kazuki Tanaka, Akari Ogawa, Erika Omae, Tomoaki Miyake, Yui Nagamori, Yusuke Miyata, Koji Ohata, Yumie Ono, Tatsuya Mima, Ryosuke Takahashi, Satoko Koganemaru
Summary: This article introduces a novel treatment approach for progressive supranuclear palsy (PSP) patients, which combines backward gait training with synchronized cerebellar transcranial alternating current stimulation (tACS). Through short-term and long-term interventions, it was found that synchronized stimulation significantly reduced postural instability and improved gait speed, balance function, and fall-related self-efficacy in daily life.
FRONTIERS IN HUMAN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Ippei Nojima, Mitsuya Horiba, Kento Sahashi, Satoko Koganemaru, Satona Murakami, Kiminori Aoyama, Noriyuki Matsukawa, Yumie Ono, Tatsuya Mima, Yoshino Ueki
Summary: This study developed a closed-loop transcranial electrical stimulation (tES) intervention for Parkinsonian gait disturbances, which significantly improved gait speed, stride length, gait symmetry, and subjective feelings about freezing. This non-pharmacological and non-invasive treatment approach could be a breakthrough in restoring gait function in patients with Parkinson's disease and related disorders.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Neurosciences
Tatsunori Watanabe, Xiaoxiao Chen, Keisuke Yunoki, Takuya Matsumoto, Takayuki Horinouchi, Kanami Ito, Haruki Ishida, Toru Sunagawa, Tatsuya Mima, Hikari Kirimoto
Summary: The effects of transcranial static magnetic stimulation (tSMS) on cognitive performance and brain activity were investigated in relation to left and right dorsolateral prefrontal cortex (DLPFC) stimulation. Both left and right DLPFC stimulation impaired working memory performance to a similar extent, but had different effects on brain oscillatory responses. Left DLPFC stimulation increased event-related synchronization in the beta band, while right DLPFC stimulation did not show this effect.
Article
Multidisciplinary Sciences
Yoshihiro Yukawa, Sumiya Shibata, Satoko Koganemaru, Masatoshi Minakuchi, Ryota Shimomura, Kazuhito Nakamura, Tatsuya Mima
Summary: This study aimed to investigate the effects of low-frequency rTMS combined with OT on the motor function recovery of the affected upper limb in chronic stroke patients with severe hemiparesis. The results showed that patients with severe hemiparesis exhibited increased upper limb use, improved movement quality, and reduced spasticity after receiving rTMS combined with OT. Patients with mild hemiparesis showed significant improvements in FMA scores and manual dexterity, increased upper limb use and MEP, and reduced spasticity after the treatment.
Review
Clinical Neurology
Ippei Nojima, Hisato Sugata, Hiroki Takeuchi, Tatsuya Mima
Summary: This meta-analysis evaluated the effect sizes of clinical studies investigating the use of BCI-based rehabilitation interventions in restoring upper extremity function in post-stroke patients. The results suggest that BCI-based training is superior to conventional interventions for motor recovery of the upper limbs, with a focus on the effectiveness of sensorimotor rhythm algorithm in detecting brain activity. Further studies involving larger cohorts are needed to confirm these results due to high risk of bias and heterogeneity among the studies.
NEUROREHABILITATION AND NEURAL REPAIR
(2022)